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Home   COVID-19 treatment studies for Tixagevimab/cilgavimab  COVID-19 treatment studies for Tixagev../c..  C19 studies: Tixagev../c..  Tixagev../c..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 59% Improvement Relative Risk Case 25% c19early.org/tc Najjar-Debbiny et al. Tixagev../c.. for COVID-19 Prophylaxis Favors tixagevimab/ci.. Favors control
Effectiveness of Evusheld in Immunocompromised Patients: Propensity Score-Matched Analysis
Najjar-Debbiny et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac855
31 Oct 2022    Source   PDF   Share   Tweet
Retrospective 732 immunocompromised patients in Israel treated with tixagevimab/cilgavimab, and 2,812 matched controls, showing significantly lower cases and hospitalization with treatment.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2.75.2, BA.4.6, and BQ.1.1 [Planas].
risk of hospitalization, 59.0% lower, HR 0.41, p = 0.02, treatment 72 of 703 (10.2%), control 377 of 2,812 (13.4%), Cox proportional hazards.
risk of case, 25.0% lower, HR 0.75, p = 0.03, treatment 72 of 703 (10.2%), control 377 of 2,812 (13.4%), NNT 32, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Najjar-Debbiny et al., 31 Oct 2022, retrospective, Israel, peer-reviewed, 5 authors.
Contact: ronzana@clalit.org.il, ronza.najjar@gmail.com.
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