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Home   COVID-19 treatment studies for Tixagevimab/cilgavimab  COVID-19 treatment studies for Tixagev../c..  C19 studies: Tixagev../c..  Tixagev../c..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Death/hospitalization 92% Improvement Relative Risk Case 47% c19early.org/tc Kertes et al. Tixagev../c.. for COVID-19 Prophylaxis Favors tixagevimab/ci.. Favors control
Association between AZD7442 (tixagevimab-cilgavimab) administration and SARS-CoV-2 infection, hospitalization and mortality
Kertes et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac625
29 Jul 2022    Source   PDF   Share   Tweet
Retrospective 825 immunocompromised individuals treated with tixagevimab-cilgavimab and 4229 untreated in Israel, showing significantly lower infection and hospitalization/death with treatment. Omicron was the dominant variant.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2.75.2, BA.4.6, and BQ.1.1 [Planas].
risk of death/hospitalization, 91.9% lower, RR 0.08, p = 0.01, treatment 1 of 825 (0.1%), control 63 of 4,299 (1.5%), NNT 74, adjusted per study, odds ratio converted to relative risk, multivariable.
risk of case, 47.1% lower, RR 0.53, p = 0.01, treatment 29 of 825 (3.5%), control 308 of 4,299 (7.2%), NNT 27, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kertes et al., 29 Jul 2022, retrospective, Israel, peer-reviewed, 10 authors.
Contact: dortal_j@mac.org.il, zeny@013.net.
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