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All Studies   Meta Analysis    Recent:   

COVID-19 infection among CAR-T cell therapy recipients: A single center experience

Aug 2023  
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Hospitalization 19% Improvement Relative Risk Tixagevimab/c.. for COVID-19  Din et al.  Prophylaxis Is prophylaxis with tixagevimab/cilgavimab beneficial for COVID-19? Retrospective 64 patients in the USA (June 2020 - February 2022) Study underpowered to detect differences c19early.org Din et al., Hemasphere, August 2023 Favorstixagevimab/ci.. Favorscontrol 0 0.5 1 1.5 2+
39th treatment shown to reduce risk in May 2022
 
*, now with p = 0.000029 from 17 studies, recognized in 31 countries. Efficacy is variant dependent.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 64 COVID+ CAR-T cell therapy recipients, showing lower hospitalization with tixagevimab/cilgavimab prophylaxis in unadjusted results, without statistical significance.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2.75.2, BA.4.6, BQ.1.11, BA.5, BA.2.75, XBB2, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.13.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of hospitalization, 19.0% lower, RR 0.81, p = 0.77, treatment 5 of 23 (21.7%), control 11 of 41 (26.8%), NNT 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Din et al., 8 Aug 2023, retrospective, USA, peer-reviewed, 24 authors, study period June 2020 - February 2022.
This PaperTixagev../c..All
### P1540 COVID-19 INFECTION AMONG CAR-T CELL THERAPY RECIPIENTS: A SINGLE CENTER EXPERIENCE Topic: 30. Infections in hematology (incl. supportive care/therapy)
Mohammad Ammad, Ud Din, Nayeon Oh, Aliyah Baluch, Olga Klinkova, Rod Quilitz, Melissa Alsina, Nelli Bejanyan, Omar Castaneda, Julio Chavez, Hany Elmariah, Ciara Freeman, Doris Hansen, Michael Jain, Farhad Khimani, Aleksandr Lazaryan, Hien Liu, Asmita Mishra, Leonel Ochoa, Lia Perez, Joseph Pidala, Bijal Shah, Taiga Nishihori, Frederick Locke, Rawan Faramand
Book distributed under the Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) which allows third parties to download the articles and share them with others as long as they credit the author and the Abstract Book, but they cannot change the content in any way or use them commercially.
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