Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): a phase 3, randomized, double-blind, placebo-controlled trial

{ 'indexed': {'date-parts': [[2024, 2, 17]], 'date-time': '2024-02-17T00:25:26Z', 'timestamp': 1708129526685}, 'reference-count': 10, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2024, 2, 1]], 'date-time': '2024-02-01T00:00:00Z', 'timestamp': 1706745600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2024, 2, 9]], 'date-time': '2024-02-09T00:00:00Z', 'timestamp': 1707436800000}, 'content-version': 'vor', 'delay-in-days': 8, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.com', 'journalofinfection.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 2]]}, 'DOI': '10.1016/j.jinf.2024.106120', 'type': 'journal-article', 'created': {'date-parts': [[2024, 2, 16]], 'date-time': '2024-02-16T13:49:08Z', 'timestamp': 1708091348000}, 'page': '106120', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 ' '(DisCoVeRy): a phase 3, randomized, double-blind, placebo-controlled trial', 'prefix': '10.1016', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-6961-6039', 'authenticated-orcid': False, 'given': 'Maya', 'family': 'Hites', 'sequence': 'first', 'affiliation': []}, {'given': 'Clément R.', 'family': 'Massonnaud', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simon', 'family': 'Jamard', 'sequence': 'additional', 'affiliation': []}, {'given': 'François', 'family': 'Goehringer', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3907-0658', 'authenticated-orcid': False, 'given': 'François', 'family': 'Danion', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean', 'family': 'Reignier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nathalie', 'family': 'de Castro', 'sequence': 'additional', 'affiliation': []}, {'given': 'Denis', 'family': 'Garot', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eva Larranaga', 'family': 'Lapique', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karine', 'family': 'Lacombe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Violaine', 'family': 'Tolsma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emmanuel', 'family': 'Faure', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1948-9355', 'authenticated-orcid': False, 'given': 'Denis', 'family': 'Malvy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thérèse', 'family': 'Staub', 'sequence': 'additional', 'affiliation': []}, {'given': 'Johan', 'family': 'Courjon', 'sequence': 'additional', 'affiliation': []}, {'given': 'France', 'family': 'Cazenave-Roblot', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne Ma Dyrhol', 'family': 'Riise', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Leturnier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guillaume', 'family': 'Martin-Blondel', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'Roger', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karolina', 'family': 'Akinosoglou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vincent Le', 'family': 'Moing', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lionel', 'family': 'Piroth', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pierre', 'family': 'Sellier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xavier', 'family': 'Lescure', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marius', 'family': 'Trøseid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Philippe', 'family': 'Clevenbergh', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4470-3181', 'authenticated-orcid': False, 'given': 'Olav', 'family': 'Dalgard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sébastien', 'family': 'Gallien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marie', 'family': 'Gousseff', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Loubet', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fanny', 'family': 'Vardon-Bounes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clotilde', 'family': 'Visée', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1701-7584', 'authenticated-orcid': False, 'given': 'Leila', 'family': 'Belkhir', 'sequence': 'additional', 'affiliation': []}, {'given': 'Élisabeth', 'family': 'Botelho-Nevers', 'sequence': 'additional', 'affiliation': []}, {'given': 'André', 'family': 'Cabié', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anastasia', 'family': 'Kotanidou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fanny', 'family': 'Lanternier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elisabeth', 'family': 'Rouveix-Nordon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susana', 'family': 'Silva', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guillaume', 'family': 'Thiery', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0021-7192', 'authenticated-orcid': False, 'given': 'Pascal', 'family': 'Poignard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guislaine', 'family': 'Carcelain', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alpha', 'family': 'Diallo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Noémie', 'family': 'Mercier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vida', 'family': 'Terzic', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Maude', 'family': 'Bouscambert-Duchamp', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8194-6126', 'authenticated-orcid': False, 'given': 'Alexandre', 'family': 'Gaymard', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-8614-1071', 'authenticated-orcid': False, 'given': 'Mary-Anne', 'family': 'Trabaud', 'sequence': 'additional', 'affiliation': []}, {'given': 'Grégory', 'family': 'Destras', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laurence', 'family': 'Josset', 'sequence': 'additional', 'affiliation': []}, {'given': 'Drifa', 'family': 'Belhadi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicolas', 'family': 'Billard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jérémie', 'family': 'Guedj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thi-Hong-Lien', 'family': 'Han', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Sandrine', 'family': 'Couffin-Cadiergues', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aline', 'family': 'Dechanet', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christelle', 'family': 'Delmas', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1654-4868', 'authenticated-orcid': False, 'given': 'Hélène', 'family': 'Esperou', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2736-6769', 'authenticated-orcid': False, 'given': 'Claire', 'family': 'Fougerou-Leurent', 'sequence': 'additional', 'affiliation': []}, {'given': 'Soizic Le', 'family': 'Mestre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anabelle', 'family': 'Métois', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marion', 'family': 'Noret', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8315-6080', 'authenticated-orcid': False, 'given': 'Isabelle', 'family': 'Bally', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sebastián', 'family': 'Dergan-Dylon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Tubiana', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ouifiya', 'family': 'Kalif', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nathalie', 'family': 'Bergaud', 'sequence': 'additional', 'affiliation': []}, {'given': 'Benjamin', 'family': 'Leveau', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joe', 'family': 'Eustace', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard', 'family': 'Greil', 'sequence': 'additional', 'affiliation': []}, {'given': 'Edit', 'family': 'Hajdu', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-9011-2238', 'authenticated-orcid': False, 'given': 'Monika', 'family': 'Halanova', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jose-Artur', 'family': 'Paiva', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna', 'family': 'Piekarska', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jesus Rodriguez', 'family': 'Baño', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kristian', 'family': 'Tonby', 'sequence': 'additional', 'affiliation': []}, {'given': 'Milan', 'family': 'Trojánek', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0463-4321', 'authenticated-orcid': False, 'given': 'Sotirios', 'family': 'Tsiodras', 'sequence': 'additional', 'affiliation': []}, {'given': 'Serhat', 'family': 'Unal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charles', 'family': 'Burdet', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-0765-0869', 'authenticated-orcid': False, 'given': 'Dominique', 'family': 'Costagliola', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yazdan', 'family': 'Yazdanpanah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nathan', 'family': 'Peiffer-Smadja', 'sequence': 'additional', 'affiliation': []}, {'given': 'France', 'family': 'Mentré', 'sequence': 'additional', 'affiliation': []}, {'given': 'Florence', 'family': 'Ader', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.jinf.2024.106120_bib1', 'doi-asserted-by': 'crossref', 'first-page': '282', 'DOI': '10.1016/j.jinf.2023.06.024', 'volume': '87', 'author': 'Kamboj', 'year': '2023', 'journal-title': 'J Infection'}, { 'issue': '10', 'key': '10.1016/j.jinf.2024.106120_bib2', 'doi-asserted-by': 'crossref', 'first-page': '985', 'DOI': '10.1016/S2213-2600(22)00180-1', 'article-title': 'Efficacy and safety of intramuscular administration of ' 'tixagevimab–cilgavimab for early outpatient treatment of COVID-19 ' '(TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial', 'volume': '10', 'author': 'Montgomery', 'year': '2022', 'journal-title': 'Lancet Respir Med'}, { 'issue': '10', 'key': '10.1016/j.jinf.2024.106120_bib3', 'doi-asserted-by': 'crossref', 'first-page': '972', 'DOI': '10.1016/S2213-2600(22)00215-6', 'article-title': 'Tixagevimab–cilgavimab for treatment of patients hospitalised with ' 'COVID-19: a randomised, doubleblind, phase 3 trial', 'volume': '10', 'author': 'Holland', 'year': '2022', 'journal-title': 'Lancet Respir Med'}, { 'key': '10.1016/j.jinf.2024.106120_bib4', 'doi-asserted-by': 'crossref', 'article-title': 'SARS-CoV-2 variant biology: immune escape, transmission and fitness', 'author': 'Carabelli', 'year': '2023', 'journal-title': 'Nat Rev Microbiol [Internet]', 'DOI': '10.1038/s41579-022-00841-7'}, { 'issue': '4', 'key': '10.1016/j.jinf.2024.106120_bib5', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.isci.2023.106413', 'article-title': 'Enhanced neutralization escape to therapeutic monoclonal antibodies by ' 'SARS-CoV-2 omicron sublineages', 'volume': '26', 'author': 'Touret', 'year': '2023', 'journal-title': 'iScience'}, { 'issue': '5', 'key': '10.1016/j.jinf.2024.106120_bib6', 'doi-asserted-by': 'crossref', 'first-page': '468', 'DOI': '10.1056/NEJMc2207519', 'article-title': 'Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, ' 'BA.4, and BA.5 Subvariants', 'volume': '387', 'author': 'Takashita', 'year': '2022', 'journal-title': 'NEngl J Med'}, { 'issue': '1', 'key': '10.1016/j.jinf.2024.106120_bib7', 'doi-asserted-by': 'crossref', 'first-page': '141', 'DOI': '10.1038/s41392-022-00997-x', 'article-title': 'SARS-CoV-2 Omicron variant: recent progress and future perspectives', 'volume': '7', 'author': 'Fan', 'year': '2022', 'journal-title': 'Signal Transduct Target Ther'}, { 'key': '10.1016/j.jinf.2024.106120_bib8', 'unstructured': 'European Medical Agency. Summary report of the Joint EMA-FDA workshop on ' 'the efficacy of monoclonal antibodies in the context of rapidly evolving ' 'SARS-CoV-2 variants [Internet]. [cited 2023 Nov 3]. Available from: ' '〈https://www.ema.europa.eu/en/documents/report/summary-report-joint-ema-fdaworkshop-efficacy-monoclonal-antibodies-context-rapidly-evolving-sars_en.pdf〉'}, { 'key': '10.1016/j.jinf.2024.106120_bib9', 'unstructured': 'European Centre for Disease Prevention and Control. SARS-CoV-2 variant ' 'mutations conferring reduced susceptibility to antiviral drugs and ' 'monoclonal antibodies: a non systematic literature review for ' 'surveillance purposes. [Internet]. LU: Publications Office; 2023 [cited ' '2023 Nov 3]. Available from: ' '〈https://data.europa.eu/doi/10.2900/192733〉'}, { 'issue': '5', 'key': '10.1016/j.jinf.2024.106120_bib10', 'doi-asserted-by': 'crossref', 'first-page': '1404', 'DOI': '10.1093/jac/dkac048', 'article-title': 'Effect of remdesivir on viral dynamics in COVID-19 hospitalized ' 'patients: a modelling analysis of the randomized, controlled, ' 'open-label DisCoVeRy trial', 'volume': '77', 'author': 'Lingas', 'year': '2022', 'journal-title': 'J Antimicrob Chemother'}], 'container-title': 'Journal of Infection', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0163445324000549?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0163445324000549?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 2, 16]], 'date-time': '2024-02-16T13:49:15Z', 'timestamp': 1708091355000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0163445324000549'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 2]]}, 'references-count': 10, 'alternative-id': ['S0163445324000549'], 'URL': 'http://dx.doi.org/10.1016/j.jinf.2024.106120', 'relation': {}, 'ISSN': ['0163-4453'], 'subject': ['Infectious Diseases', 'Microbiology (medical)'], 'container-title-short': 'Journal of Infection', 'published': {'date-parts': [[2024, 2]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized ' 'with COVID-19 (DisCoVeRy): a phase 3, randomized, double-blind, ' 'placebo-controlled trial', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Journal of Infection', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jinf.2024.106120', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'simple-article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2024 Published by Elsevier Ltd on behalf of The British Infection ' 'Association.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '106120'}