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Home   COVID-19 treatment studies for Tixagevimab/cilgavimab  COVID-19 treatment studies for Tixagev../c..  C19 studies: Tixagev../c..  Tixagev../c..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 30% Improvement Relative Risk Recovery 7% primary c19early.org/tc Holland et al. NCT04501978 ACTIV-3-TICO Tixagev../c.. RCT LATE Favors tixagevimab/ci.. Favors control
Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial
Holland et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(22)00215-6, ACTIV-3-TICO, NCT04501978 (history)
8 Jul 2022    Source   PDF   Share   Tweet
RCT with 710 hospitalized patients treated with tixagevimab/cilgavimab, and 707 placebo patients, showing lower mortality with treatment.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2.75.2, BA.4.6, and BQ.1.1 [Planas].
risk of death, 30.0% lower, RR 0.70, p = 0.03, treatment 61 of 710 (8.6%), control 86 of 707 (12.2%), NNT 28, day 90.
risk of no recovery, 7.4% lower, RR 0.93, p = 0.21, treatment 710, control 707, inverted to make RR<1 favor treatment, sustained recovery, day 90, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Holland et al., 8 Jul 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 103 authors, study period 10 February, 2021 - 30 September, 2021, average treatment delay 8.0 days, trial NCT04501978 (history) (ACTIV-3-TICO).
Contact: adit.ginde@cuanschutz.edu.
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Late treatment
is less effective
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