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All Studies   Meta Analysis    Recent:   

Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19

Gandhi et al., The Laryngoscope, doi:10.1002/lary.31761, PROSPERO CRD42024500158
Sep 2024  
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PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 95 treatments. c19early.org
Review of the efficacy of nasal irrigation with saline, povidone-iodine (PVP-I), and intranasal corticosteroids (INCS) at reducing SARS-CoV-2 nasopharyngeal viral load (NVL) and transmissibility. Saline nasal irrigation (SNI) showed the greatest efficacy in 9 out of 10 studies, with benefits manifesting as an earlier time to a negative COVID-19 test ranging from 2-11 days and greater proportional decline in NVL during early time points. Both isotonic and hypertonic saline were effective, with most studies using saline alone without additives. Results for PVP-I were mixed and heterogenous across 7 studies, with 4 showing greater viral clearance and 3 showing no impact. No studies were found for INCS. Four studies also found that SNI and PVP-I reduced COVID-19 transmission.
Reviews covering povidone-iodine for COVID-19 include1-7.
Gandhi et al., 13 Sep 2024, Canada, peer-reviewed, 3 authors, trial PROSPERO CRD42024500158. Contact: leigh.sowerby@sjhc.london.on.ca.
This PaperPovidone-Iod..All
Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19
MD Karan Gandhi, BHSc Freeman Paczkowski, MD, MHM, FRCSC Leigh J Sowerby
The Laryngoscope, doi:10.1002/lary.31761
Objective: Nasal irrigation is a common treatment for sinonasal disorders; however, it is unknown if it can reduce SARS-CoV-2 nasopharyngeal viral load (NVL). This systematic review investigated the efficacy of nasal irrigation with saline, povidone iodine (PVP-I), and intranasal corticosteroids (INCS) at reducing SARS-CoV-2 NVL and transmissibility.
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This systematic review investigated the efficacy of nasal irrigation with ' 'saline, povidone iodine (PVP‐I), and intranasal corticosteroids (INCS) at reducing SARS‐CoV‐2 ' 'NVL and transmissibility.</jats:p></jats:sec><jats:sec><jats:title>Data ' 'Sources</jats:title><jats:p>Databases including Embase, MEDLINE, Web of Science, and ' 'ClinicalTrials.gov.</jats:p></jats:sec><jats:sec><jats:title>Review ' 'Methods</jats:title><jats:p>A systematic review was completed with pre‐defined search ' 'criteria using keywords related to nasal irrigation and COVID‐19 from 1946 through January ' '2024. This review followed PRISMA reporting guidelines and was registered on PROSPERO. Only ' 'in‐vivo studies testing nasal irrigation with either saline, PVP‐I, or INCS for reducing NVL ' 'were included.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Nine out ' 'of ten studies on saline‐based solutions reported positive effects in reducing NVL, with ' 'benefits noted in earlier time to negative nasopharyngeal PCR and a greater decline in NVL ' 'during early study time points, compared with controls. Isotonic and hypertonic saline ' 'mediums were found to be effective with three studies demonstrating enhanced efficacy with ' 'additives. Four out of seven studies on PVP‐I showed a positive effect on reducing NVL, but ' 'results were heterogenous. Four studies demonstrated reduction of transmission with saline or ' 'PVP‐I. No studies were found on ' 'INCS.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Saline nasal ' 'irrigation showed the best efficacy in reducing SARS‐CoV‐2 NVL. Additives to saline may have ' 'a clinical benefit, but further studies are needed to elucidate their isolated impacts on ' 'NVL. 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