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Can povidone Iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Chopra et al., Japanese Dental Science Review, doi:10.1016/j.jdsr.2021.03.001
Mar 2021  
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PVP-I for COVID-19
12th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Review discussing the rationale, safety, recommendations, and dosage of PVP-I gargle/mouthwash as an effective method to decrease the viral load of SARS-CoV-2.
Reviews covering povidone-iodine for COVID-19 include Chavda, Chopra, Lim, O’Donnell, Ting.
Chopra et al., 15 Mar 2021, peer-reviewed, 5 authors.
This PaperPovidone-Iod..All
Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update
Aditi Chopra, Karthik Sivaraman, Raghu Radhakrishnan, Dhanasekar Balakrishnan, Aparna Narayana
Japanese Dental Science Review, doi:10.1016/j.jdsr.2021.03.001
The Coronavirus disease in 2019 , also referred to as the novel 'CoV19 (nCov19)' is caused by a new coronavirus strain similar to Severe Acute Respiratory Syndrome (SARS-CoV-2). SARS-CoV-2 spreads via respiratory droplets, saliva, or direct contact. Therefore it is important to control the viral load in the saliva and respiratory secretions. One of the most simple and cost-effective measures that can be adopted by the public and healthcare professionals to prevent cross-contamination and community transmission, is the implementation of effective oral and throat hygiene. Recent evidence has confirmed that 0.5% povidone iodine (PVP-I) mouthrinse/gargle for 30 s can reduce SARS-CoV-2 virus infectivity to below detectable levels. PVP-I can even interrupt SARS-CoV-2 attachment to oral and nasopharyngeal tissues and lower the viral particles in the saliva and respiratory droplets. Thus, the use of PVP-I mouthrinse as a prophylactic measure has been advocated across the globe to reduce disease transmission. Although the efficacy of PVP-I against SARS-CoV-2 is proven, no review articles have yet discussed the evidence and mechanisms of PVP-I against the SARS-CoV-2. Thus, this paper highlights the rationale, safety, recommendations, and dosage of PVP-I gargle/mouthrinse as an effective method to decrease the viral loads during the pressing times of COVID-19.
Conflict of interest None. Source of funding None. Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at https://doi.org/10.1016/j.jdsr.2021.03.001.
References
Amstey, Metcalf, Effect of povidone-iodine on herpesvirus type 2, in vitro, Obstet Gynecol
Andersen, Rambaut, Lipkin, Holmes, Garry, The proximal origin of SARS-CoV-2, Nat Med
Anon, Prevention of hospital-acquired pneumonia (strategies for prevention of hospital-acquired infections), Respirology, doi:10.1093/function/zqaa002
Azarpazhooh, Leake, Systematic review of the association between respiratory diseases and oral health, J Periodontol
Backer, Klinkenberg, Wallinga, Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travelers from Wuhan, China, 20-28 January 2020, Euro Surveill, doi:10.2807/1560-7917.ES.2020.25.5.2000062
Beukelman, Van Den Berg, Hoekstra, Uhl, Reimer et al., Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel) for wound healing in vitro, Burns
Bidra, Pelletier, Westover, Frank, Brown et al., Comparison of in vitro inactivation of SARS CoV-2 with hydrogen peroxide and povidone-iodine oral antiseptic rinses, J Prosthodont
Bidra, Pelletier, Westover, Frank, Brown et al., Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse, J Prosthodont
Brennan, Bahrani-Mougeot, Fox, The role of oral microbial colonization in ventilator-associated pneumonia, Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Castagnoli, Votto, Licari, Brambilla, Bruno et al., Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review, JAMA Pediatr, doi:10.2807/1560-7917.ES.2020.25.5.2000062
Castro-Ruiz, Vergara-Buenaventura, Solution, A potential antiseptic to minimize the risk of COVID-19? A narrative review, J Int Soc Prev Community Dent, doi:10.4103/jispcd.JISPCD30420
Challacombe, Kirk-Bayley, Sunkaraneni, Combes, Povidone-iodine, Br Dent J
Chan, Yuan, Kok, A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster, Lancet, doi:10.1001/jama.2020.1097
Chin, Chu, Perera, Stability of SARS-CoV-2 in different environmental conditions, Lancet Microbe, doi:10.1111/odi.13526
Cole, Cook, Characterization of infectious aerosols in health care facilities: an aid to effective engineering controls and preventive strategies, Am J Infect Control
Del Rio, Malani, 2019 novel coronavirus-important information for clinicians, JAMA, doi:10.1001/jama.2020.1490
Dexter, Parra, Brown, Loftus, Perioperative COVID-19 defense: an evidence-based approach for optimization of infection control and operating room management, Anesth Analg, doi:10.1177/0145561320957237
Edwards, Man, Brand, Inhaling to mitigate exhaled bioaerosols, Proc Natl Acad Sci U S A
Eggers, Infectious disease management and control with povidone iodine, Infect Dis Ther
Eggers, Markus, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther, doi:10.1007/s40121-018-0200-7
Feng, Li, Yao, Sun, Xu et al., Interpretation of policies for group standards and the practice of group standardizations in Chinese Preventive Medicine Association, Zhonghua Liu Xing Bing Xue Za Zhi, doi:10.3760/cma.j.issn.0254-6450.2019.04.001
Frank, Capriotti, Brown, Tessema, Povidone-iodine use in sinonasal and oral cavities: a review of safety in the COVID-19 era, Ear Nose Throat J, doi:10.1177/0145561320932318
Gabriel De Toledo, Caminha, Kallás, Sipahi, Da et al., Potential mouth rinses and nasal sprays that reduce SARS-CoV-2 viral load: what we know so far?, Clinics, doi:10.4103/jispcd.JISPCD_304_20
Gralton, Tovey, Mclaws, Rawlinson, Respiratory virus RNA is detectable in airborne and droplet particles, J Med Virol, doi:10.1001/jama.2020.1490
Hitosugi, Tsukamoto, Yokoyama, Pneumonia due to aspiration of povidone iodine after preoperative disinfection of the oral cavity, Oral Maxillofac Surg
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-cov-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Holshue, Debolt, Lindquist, First case of 2019 novel coronavirus in the United States, N Engl J Med
Hua, Xie, Worthington, Furness, Zhang et al., Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia, Cochrane Database Syst Rev
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Ito, Ito, Hikida, Outbreak of highly pathogenic avian influenza in Japan and anti-influenza virus activity of povidone-iodine products, Dermatology
Kanagalingam, Feliciano, Hah, Labib, Le et al., Practical use of povidone-iodine antiseptic in the maintenance of oral health and in the prevention and treatment of common oropharyngeal infections, Int J Clin Pract
Kariwa, Fujii, Takashima, Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents, Dermatology
Kariwa, Fujii, Takashima, Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions, and chemical reagents, Jpn J Vet Res
Kawana, Kitamura, Nakagomi, Inactivation of human viruses by povidone-iodine in comparison with other antiseptics, Dermatology
Kirk-Bayley, Challacombe, Sunkaraneni, Combes, The use of povidone iodine nasal spray and mouthwash during the current COVID-19 pandemic may protect healthcare workers and reduce cross infection, SSRN Electron J
Kohn, Harte, Malvitz, Collins, Cleveland et al., Guidelines for infection control in dental health care settings -2003, J Am Dent Assoc
Kövesi, The use of Betadine antiseptic in the treatment of oral surgical, parodontological and oral mucosal diseases, Fogorv Sz
Lamas, Dios, Rodríguez, Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests, Oral Dis, doi:10.1111/odi.13526
Liang, Yuan, Wei, In-vivo toxicity studies and in-vitro inactivation of SARS-CoV-2 by povidone-iodine in-situ gel forming formulations, bioRxiv Prepr Serv Biol
Liu, Cao, Lin, Oral care measures for preventing nursing home-acquired pneumonia, Cochrane Database Syst Rev
Liu, Liao, Qian, Community transmission of severe acute respiratory syndrome coronavirus 2, Shenzhen, China, 2020, Emerg Infect Dis
Mady, Kubik, Baddour, Snyderman, Rowan, Personal Protective Equipment" for frontline providers exposed in high-risk head and neck and, Oral Oncol, doi:10.1016/j.oraloncology.2020.104724
Malik, Sircar, Bhat, Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments, Vet Q, doi:10.3760/cma.j.issn.0254-6450.2019.04.001
Manger, Walshaw, Fitzgerald, Evidence summary: the relationship between oral health and pulmonary disease, Br Dent J
Meister, Brüggemann, Todt, Virucidal efficacy of different oral rinses against severe acute respiratory syndrome coronavirus 2, J Infect Dis
Nagatake, Ahmed, Oishi, Prevention of respiratory infections by povidone-iodine gargle, Dermatology
O'donnell, Thomas, Stanton, Maillard, Murphy et al., Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection, Function, doi:10.1093/function/zqaa002
Paju, Scannapieco, Oral biofilms, periodontitis, and pulmonary infections, Oral Dis, doi:10.1177/0145561320932318
Parhar, Tasche, Brody, Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery, Head Neck
Pedersen, Uhrenfeldt, Larsen, Oral hygiene in patients with chronic obstructive pulmonary disease: a scoping review protocol, JBI Database Syst Rev Implement Rep
Pelletier, Efficacy of povidone-iodine nasal and oral antiseptic preparations against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), Ear Nose Throat J, doi:10.1177/0145561320957237
Peng, Xu, Li, Cheng, Zhou et al., Transmission routes of 2019-nCoV and controls in dental practice, Int J Oral Sci
Phelan, Katz, Lo, The novel coronavirus originating in Wuhan, China: challenges for Global Health Governance, JAMA, doi:10.1001/jama.2020.1097
Rahn, Adamietz, Boettcher, Schaefer, Reimer et al., Povidone-iodine to prevent mucositis in patients during antineoplastic radiochemotherapy, Dermatology
Rothe, Schunk, Sothmann, Transmission of 2019-nCoV infection from an asymptomatic contact in Germany, N Engl J Med, doi:10.1001/jama.2020.2648
Sato, Miyake, Hazama, Omori, Povidone-iodine-induced cell death in cultured human epithelial HeLa cells and rat oral mucosal tissue, Drug Chem Toxicol
Scannapieco, Ho, Potential associations between chronic respiratory disease and periodontal disease: analysis of National Health and Nutrition Examination Survey III, J Periodontol, doi:10.1001/jamapediatrics.2020.1467
Schreier, Erdos, Reimer, Konig, Konig et al., Molecular effects of povidone-iodine on relevant microorganisms: an electron-microscopic and biochemical study, Dermatology
Shankar, Saha, Jamir, Kakkar, Protection at Portal of Entry (PPE) with povidone iodine for COVID-19, Int J Med Public Health, doi:10.1016/j.oraloncology.2020.104724
Sriwilaijaroen, Wilairat, Hiramatsu, Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities, Virol J
Tang, Li, Eames, Chan, Ridgway, Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises, J Hosp Infect
Tessema, Frank, Bidra, SARS-CoV-2 viral inactivation using low dose povidone-iodine oral rinse -immediate application for the prosthodontic practice, J Prosthodont
To, Tsang, Yip, Consistent detection of 2019 novel coronavirus in saliva, Clin Infect Dis
Van Der Maarel-Wierink, Vanobbergen, Bronkhorst, Schols, De Baat, Oral health care and aspiration pneumonia in frail older people: a systematic literature review, Gerodontology
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA, doi:10.1001/jama.2020.1585
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention, JAMA, doi:10.1001/jama.2020.1585
Wutzler, Sauerbrei, Klocking, Brogmann, Reimer, Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodine, Antiviral Res
Xu, Cui, Duan, Zhang, Zhou et al., Saliva: potential diagnostic value and transmission of 2019-nCoV, Int J Oral Sci
Zhang, Liu, Potential interventions for novel coronavirus in China: a systematic review, J Med Virol
Zou, Ruan, Huang, SARS-CoV-2 viral load in upper respiratory specimens of infected patients, N Engl J Med
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and operating room management', 'author': 'Dexter', 'doi-asserted-by': 'crossref', 'first-page': '37', 'journal-title': 'Anesth Analg', 'key': '10.1016/j.jdsr.2021.03.001_bib0070', 'volume': '131', 'year': '2020'}, { 'article-title': 'SARS-CoV-2 viral inactivation using low dose povidone-iodine oral rinse ' '– immediate application for the prosthodontic practice', 'author': 'Tessema', 'first-page': '204', 'journal-title': 'J Prosthodont', 'key': '10.1016/j.jdsr.2021.03.001_bib0075', 'year': '2020'}, { 'DOI': '10.1002/hed.26200', 'article-title': 'Topical preparations to reduce SARS-CoV-2 aerosolization in head and ' 'neck mucosal surgery', 'author': 'Parhar', 'doi-asserted-by': 'crossref', 'first-page': '1268', 'journal-title': 'Head Neck', 'key': '10.1016/j.jdsr.2021.03.001_bib0080', 'volume': '42', 'year': '2020'}, { 'DOI': '10.1111/jopr.13209', 'article-title': 'Rapid in-vitro inactivation of severe acute respiratory syndrome ' 'coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse', 'author': 'Bidra', 'doi-asserted-by': 'crossref', 'first-page': '529', 'journal-title': 'J Prosthodont', 'key': '10.1016/j.jdsr.2021.03.001_bib0085', 'volume': '29', 'year': '2020'}, { 'DOI': '10.1111/jopr.13220', 'article-title': 'Comparison of in vitro inactivation of SARS CoV-2 with hydrogen ' 'peroxide and povidone-iodine oral antiseptic rinses', 'author': 'Bidra', 'doi-asserted-by': 'crossref', 'first-page': '599', 'journal-title': 'J Prosthodont', 'key': '10.1016/j.jdsr.2021.03.001_bib0090', 'volume': '29', 'year': '2020'}, { 'DOI': '10.1093/infdis/jiaa471', 'article-title': 'Virucidal efficacy of different oral rinses against severe acute ' 'respiratory syndrome coronavirus 2', 'author': 'Meister', 'doi-asserted-by': 'crossref', 'first-page': '1289', 'issue': '8', 'journal-title': 'J Infect Dis', 'key': '10.1016/j.jdsr.2021.03.001_bib0095', 'volume': '222', 'year': '2020'}, { 'DOI': '10.1016/j.tripleo.2004.06.005', 'article-title': 'The role of oral microbial colonization in ventilator-associated ' 'pneumonia', 'author': 'Brennan', 'doi-asserted-by': 'crossref', 'first-page': '665', 'journal-title': 'Oral Surg Oral Med Oral Pathol Oral Radiol Endod', 'key': '10.1016/j.jdsr.2021.03.001_bib0100', 'volume': '98', 'year': '2004'}, { 'DOI': '10.1159/000246032', 'article-title': 'Povidone-iodine to prevent mucositis in patients during antineoplastic ' 'radiochemotherapy', 'author': 'Rahn', 'doi-asserted-by': 'crossref', 'first-page': '57', 'issue': '2', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0105', 'volume': '195', 'year': '1997'}, { 'DOI': '10.1177/0145561320932318', 'article-title': 'Povidone-iodine use in sinonasal and oral cavities: a review of safety ' 'in the COVID-19 era', 'author': 'Frank', 'doi-asserted-by': 'crossref', 'first-page': '586', 'issue': '9', 'journal-title': 'Ear Nose Throat J', 'key': '10.1016/j.jdsr.2021.03.001_bib0110', 'volume': '99', 'year': '2020'}, { 'DOI': '10.1111/j.1601-0825.2007.01410a.x', 'article-title': 'Oral biofilms, periodontitis, and pulmonary infections', 'author': 'Paju', 'doi-asserted-by': 'crossref', 'first-page': '508', 'journal-title': 'Oral Dis', 'key': '10.1016/j.jdsr.2021.03.001_bib0115', 'volume': '13', 'year': '2007'}, { 'DOI': '10.1038/sj.bdj.2017.315', 'article-title': 'Evidence summary: the relationship between oral health and pulmonary ' 'disease', 'author': 'Manger', 'doi-asserted-by': 'crossref', 'first-page': '527', 'journal-title': 'Br Dent J', 'key': '10.1016/j.jdsr.2021.03.001_bib0120', 'volume': '222', 'year': '2017'}, { 'article-title': 'Oral hygiene care for critically ill patients to prevent ' 'ventilator-associated pneumonia', 'author': 'Hua', 'first-page': 'CD008367', 'journal-title': 'Cochrane Database Syst Rev', 'key': '10.1016/j.jdsr.2021.03.001_bib0125', 'volume': '10', 'year': '2016'}, { 'DOI': '10.11124/JBISRIR-2016-003047', 'article-title': 'Oral hygiene in patients with chronic obstructive pulmonary disease: a ' 'scoping review protocol', 'author': 'Pedersen', 'doi-asserted-by': 'crossref', 'first-page': '1236', 'journal-title': 'JBI Database Syst Rev Implement Rep', 'key': '10.1016/j.jdsr.2021.03.001_bib0130', 'volume': '15', 'year': '2017'}, { 'article-title': 'Oral care measures for preventing nursing home-acquired pneumonia', 'author': 'Liu', 'first-page': 'CD012416', 'journal-title': 'Cochrane Database Syst Rev', 'key': '10.1016/j.jdsr.2021.03.001_bib0135', 'volume': '9', 'year': '2018'}, { 'DOI': '10.1038/s41368-020-0075-9', 'article-title': 'Transmission routes of 2019-nCoV and controls in dental practice', 'author': 'Peng', 'doi-asserted-by': 'crossref', 'first-page': '9', 'journal-title': 'Int J Oral Sci', 'key': '10.1016/j.jdsr.2021.03.001_bib0140', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1093/cid/ciaa149', 'article-title': 'Consistent detection of 2019 novel coronavirus in saliva', 'author': 'To', 'doi-asserted-by': 'crossref', 'journal-title': 'Clin Infect Dis', 'key': '10.1016/j.jdsr.2021.03.001_bib0145', 'year': '2020'}, { 'DOI': '10.1002/jmv.25707', 'article-title': 'Potential interventions for novel coronavirus in China: a systematic ' 'review', 'author': 'Zhang', 'doi-asserted-by': 'crossref', 'first-page': '479', 'journal-title': 'J Med Virol', 'key': '10.1016/j.jdsr.2021.03.001_bib0150', 'volume': '92', 'year': '2020'}, { 'DOI': '10.1038/s41368-020-0080-z', 'article-title': 'Saliva: potential diagnostic value and transmission of 2019-nCoV', 'author': 'Xu', 'doi-asserted-by': 'crossref', 'first-page': '11', 'journal-title': 'Int J Oral Sci', 'key': '10.1016/j.jdsr.2021.03.001_bib0155', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1016/j.cell.2020.02.052', 'article-title': 'SARS-cov-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a ' 'clinically proven protease inhibitor', 'author': 'Hoffmann', 'doi-asserted-by': 'crossref', 'journal-title': 'Cell', 'key': '10.1016/j.jdsr.2021.03.001_bib0160', 'volume': '181', 'year': '2020'}, { 'DOI': '10.14219/jada.archive.2004.0019', 'article-title': 'Guidelines for infection control in dental health care settings – 2003', 'author': 'Kohn', 'doi-asserted-by': 'crossref', 'first-page': '33', 'journal-title': 'J Am Dent Assoc', 'key': '10.1016/j.jdsr.2021.03.001_bib0165', 'volume': '135', 'year': '2004'}, { 'DOI': '10.1016/j.jhin.2006.05.022', 'article-title': 'Factors involved in the aerosol transmission of infection and control ' 'of ventilation in healthcare premises', 'author': 'Tang', 'doi-asserted-by': 'crossref', 'first-page': '100', 'journal-title': 'J Hosp Infect', 'key': '10.1016/j.jdsr.2021.03.001_bib0170', 'volume': '64', 'year': '2006'}, { 'DOI': '10.1016/S0196-6553(98)70046-X', 'article-title': 'Characterization of infectious aerosols in health care facilities: an ' 'aid to effective engineering controls and preventive strategies', 'author': 'Cole', 'doi-asserted-by': 'crossref', 'first-page': '453', 'journal-title': 'Am J Infect Control', 'key': '10.1016/j.jdsr.2021.03.001_bib0175', 'volume': '26', 'year': '1998'}, { 'DOI': '10.1073/pnas.0408159101', 'article-title': 'Inhaling to mitigate exhaled bioaerosols', 'author': 'Edwards', 'doi-asserted-by': 'crossref', 'first-page': '17383', 'journal-title': 'Proc Natl Acad Sci U S A', 'key': '10.1016/j.jdsr.2021.03.001_bib0180', 'volume': '101', 'year': '2004'}, { 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'author': 'Huang', 'doi-asserted-by': 'crossref', 'first-page': '497', 'journal-title': 'Lancet (London, England)', 'key': '10.1016/j.jdsr.2021.03.001_bib0185', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1001/jama.2020.1585', 'article-title': 'Clinical characteristics of 138 hospitalized patients with 2019 novel ' 'coronavirus-infected pneumonia in Wuhan, China', 'author': 'Wang', 'doi-asserted-by': 'crossref', 'first-page': '1061', 'issue': '11', 'journal-title': 'JAMA', 'key': '10.1016/j.jdsr.2021.03.001_bib0190', 'volume': '323', 'year': '2020'}, { 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and important lessons from the coronavirus disease ' '2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases ' 'from the Chinese Center for Disease Control and Prevention', 'author': 'Wu', 'doi-asserted-by': 'crossref', 'first-page': '1239', 'issue': '13', 'journal-title': 'JAMA', 'key': '10.1016/j.jdsr.2021.03.001_bib0195', 'volume': '323', 'year': '2020'}, { 'DOI': '10.1056/NEJMc2001468', 'article-title': 'Transmission of 2019-nCoV infection from an asymptomatic contact in ' 'Germany', 'author': 'Rothe', 'doi-asserted-by': 'crossref', 'first-page': '970', 'journal-title': 'N Engl J Med', 'key': '10.1016/j.jdsr.2021.03.001_bib0200', 'volume': '382', 'year': '2020'}, { 'DOI': '10.2807/1560-7917.ES.2020.25.5.2000062', 'article-title': 'Incubation period of 2019 novel coronavirus (2019-nCoV) infections ' 'among travelers from Wuhan, China, 20–28 January 2020', 'author': 'Backer', 'doi-asserted-by': 'crossref', 'first-page': '2000062', 'issue': '5', 'journal-title': 'Euro Surveill', 'key': '10.1016/j.jdsr.2021.03.001_bib0205', 'volume': '25', 'year': '2020'}, { 'DOI': '10.1001/jamapediatrics.2020.1467', 'article-title': 'Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection ' 'in children and adolescents: a systematic review', 'author': 'Castagnoli', 'doi-asserted-by': 'crossref', 'first-page': '882', 'issue': '9', 'journal-title': 'JAMA Pediatr', 'key': '10.1016/j.jdsr.2021.03.001_bib0210', 'volume': '174', 'year': '2020'}, { 'DOI': '10.1902/jop.2001.72.1.50', 'article-title': 'Potential associations between chronic respiratory disease and ' 'periodontal disease: analysis of National Health and Nutrition ' 'Examination Survey III', 'author': 'Scannapieco', 'doi-asserted-by': 'crossref', 'first-page': '50', 'journal-title': 'J Periodontol', 'key': '10.1016/j.jdsr.2021.03.001_bib0215', 'volume': '72', 'year': '2001'}, { 'DOI': '10.1111/j.1741-2358.2012.00637.x', 'article-title': 'Oral health care and aspiration pneumonia in frail older people: a ' 'systematic literature review', 'author': 'van der Maarel-Wierink', 'doi-asserted-by': 'crossref', 'first-page': '3', 'journal-title': 'Gerodontology', 'key': '10.1016/j.jdsr.2021.03.001_bib0220', 'volume': '30', 'year': '2013'}, { 'DOI': '10.1056/NEJMc2001737', 'article-title': 'SARS-CoV-2 viral load in upper respiratory specimens of infected ' 'patients', 'author': 'Zou', 'doi-asserted-by': 'crossref', 'first-page': '1177', 'journal-title': 'N Engl J Med', 'key': '10.1016/j.jdsr.2021.03.001_bib0225', 'volume': '382', 'year': '2020'}, { 'article-title': 'Effect of povidone-iodine on herpesvirus type 2, in vitro', 'author': 'Amstey', 'first-page': '528', 'journal-title': 'Obstet Gynecol', 'key': '10.1016/j.jdsr.2021.03.001_bib0230', 'volume': '46', 'year': '1975'}, { 'DOI': '10.1159/000246027', 'article-title': 'Inactivation of human viruses by povidone-iodine in comparison with ' 'other antiseptics', 'author': 'Kawana', 'doi-asserted-by': 'crossref', 'first-page': '29', 'issue': 'Suppl', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0235', 'volume': '195', 'year': '1997'}, { 'DOI': '10.1111/ijcp.12707', 'article-title': 'Practical use of povidone-iodine antiseptic in the maintenance of oral ' 'health and in the prevention and treatment of common oropharyngeal ' 'infections', 'author': 'Kanagalingam', 'doi-asserted-by': 'crossref', 'first-page': '1247', 'journal-title': 'Int J Clin Pract', 'key': '10.1016/j.jdsr.2021.03.001_bib0240', 'volume': '69', 'year': '2015'}, { 'DOI': '10.1159/000246043', 'article-title': 'Molecular effects of povidone-iodine on relevant microorganisms: an ' 'electron-microscopic and biochemical study', 'author': 'Schreier', 'doi-asserted-by': 'crossref', 'first-page': '111', 'issue': 'Suppl', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0245', 'volume': '195', 'year': '1997'}, { 'DOI': '10.1016/j.burns.2007.11.014', 'article-title': 'Anti-inflammatory properties of a liposomal hydrogel with ' 'povidone-iodine (Repithel) for wound healing in vitro', 'author': 'Beukelman', 'doi-asserted-by': 'crossref', 'first-page': '845', 'journal-title': 'Burns', 'key': '10.1016/j.jdsr.2021.03.001_bib0250', 'volume': '34', 'year': '2008'}, { 'DOI': '10.1016/S0166-3542(01)00213-3', 'article-title': 'Virucidal activity and cytotoxicity of the liposomal formulation of ' 'povidone-iodine', 'author': 'Wutzler', 'doi-asserted-by': 'crossref', 'first-page': '89', 'journal-title': 'Antiviral Res', 'key': '10.1016/j.jdsr.2021.03.001_bib0255', 'volume': '54', 'year': '2002'}, { 'DOI': '10.1186/1743-422X-6-124', 'article-title': 'Mechanisms of the action of povidone-iodine against human and avian ' 'influenza A viruses: its effects on hemagglutination and sialidase ' 'activities', 'author': 'Sriwilaijaroen', 'doi-asserted-by': 'crossref', 'first-page': '124', 'journal-title': 'Virol J', 'key': '10.1016/j.jdsr.2021.03.001_bib0260', 'volume': '6', 'year': '2009'}, { 'DOI': '10.1093/function/zqaa002', 'article-title': 'Potential role of oral rinses targeting the viral lipid envelope in ' 'SARS-CoV-2 infection', 'author': 'O’Donnell', 'doi-asserted-by': 'crossref', 'first-page': 'zqaa002', 'issue': '1', 'journal-title': 'Function (Oxf)', 'key': '10.1016/j.jdsr.2021.03.001_bib0265', 'volume': '1', 'year': '2020'}, { 'article-title': 'Prevention of hospital-acquired pneumonia (strategies for prevention of ' 'hospital-acquired infections)', 'author': 'Anon', 'first-page': 'S48', 'issue': 'Suppl. 1', 'journal-title': 'Respirology', 'key': '10.1016/j.jdsr.2021.03.001_bib0270', 'volume': '9', 'year': '2004'}, { 'DOI': '10.1159/000089210', 'article-title': 'Outbreak of highly pathogenic avian influenza in Japan and ' 'anti-influenza virus activity of povidone-iodine products', 'author': 'Ito', 'doi-asserted-by': 'crossref', 'first-page': '115', 'issue': 'Suppl', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0275', 'volume': '212', 'year': '2006'}, { 'article-title': 'Inactivation of SARS coronavirus by means of povidone-iodine, physical ' 'conditions, and chemical reagents', 'author': 'Kariwa', 'first-page': '105', 'journal-title': 'Jpn J Vet Res', 'key': '10.1016/j.jdsr.2021.03.001_bib0280', 'volume': '52', 'year': '2004'}, { 'DOI': '10.1159/000089211', 'article-title': 'Inactivation of SARS coronavirus by means of povidone-iodine, physical ' 'conditions and chemical reagents', 'author': 'Kariwa', 'doi-asserted-by': 'crossref', 'first-page': '119', 'issue': 'Suppl', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0285', 'volume': '212', 'year': '2006'}, { 'DOI': '10.1007/s40121-018-0200-7', 'article-title': 'In vitro bactericidal and virucidal efficacy of povidone-iodine ' 'gargle/mouthwash against respiratory and oral tract pathogens', 'author': 'Eggers', 'doi-asserted-by': 'crossref', 'first-page': '249', 'journal-title': 'Infect Dis Ther', 'key': '10.1016/j.jdsr.2021.03.001_bib0290', 'volume': '7', 'year': '2018'}, { 'DOI': '10.1159/000057722', 'article-title': 'Prevention of respiratory infections by povidone-iodine gargle', 'author': 'Nagatake', 'doi-asserted-by': 'crossref', 'first-page': '32', 'issue': 'Suppl', 'journal-title': 'Dermatology', 'key': '10.1016/j.jdsr.2021.03.001_bib0295', 'volume': '204', 'year': '2002'}, { 'article-title': 'In-vivo toxicity studies and in-vitro inactivation of SARS-CoV-2 by ' 'povidone-iodine in-situ gel forming formulations', 'author': 'Liang', 'journal-title': 'bioRxiv Prepr Serv Biol', 'key': '10.1016/j.jdsr.2021.03.001_bib0300', 'year': '2020'}, { 'DOI': '10.1111/odi.13526', 'article-title': 'Is povidone iodine mouthwash effective against SARS-CoV-2? First in ' 'vivo tests', 'author': 'Martínez Lamas', 'doi-asserted-by': 'crossref', 'journal-title': 'Oral Dis', 'key': '10.1016/j.jdsr.2021.03.001_bib0305', 'year': '2020'}, { 'DOI': '10.1016/S2666-5247(20)30003-3', 'article-title': 'Stability of SARS-CoV-2 in different environmental conditions', 'author': 'Chin', 'doi-asserted-by': 'crossref', 'first-page': 'e10', 'journal-title': 'Lancet Microbe', 'key': '10.1016/j.jdsr.2021.03.001_bib0310', 'volume': '1', 'year': '2020'}, { 'DOI': '10.1038/s41415-020-1589-4', 'article-title': 'Povidone-iodine', 'author': 'Challacombe', 'doi-asserted-by': 'crossref', 'first-page': '656', 'journal-title': 'Br Dent J', 'key': '10.1016/j.jdsr.2021.03.001_bib0315', 'volume': '228', 'year': '2020'}, { 'DOI': '10.1016/j.oraloncology.2020.104724', 'article-title': '“Personal Protective Equipment” for frontline providers exposed in ' 'high-risk head and neck and', 'author': 'Mady', 'doi-asserted-by': 'crossref', 'first-page': '104724', 'journal-title': 'Oral Oncol', 'key': '10.1016/j.jdsr.2021.03.001_bib0320', 'year': '2020'}, { 'DOI': '10.5530/ijmedph.2020.4.36', 'article-title': 'Protection at Portal of Entry (PPE) with povidone iodine for COVID-19', 'author': 'Shankar', 'doi-asserted-by': 'crossref', 'first-page': '166', 'issue': '4', 'journal-title': 'Int J Med Public Health', 'key': '10.1016/j.jdsr.2021.03.001_bib0325', 'volume': '10', 'year': '2020'}, { 'DOI': '10.3109/01480545.2013.846364', 'article-title': 'Povidone-iodine-induced cell death in cultured human epithelial HeLa ' 'cells and rat oral mucosal tissue', 'author': 'Sato', 'doi-asserted-by': 'crossref', 'first-page': '268', 'journal-title': 'Drug Chem Toxicol', 'key': '10.1016/j.jdsr.2021.03.001_bib0330', 'volume': '37', 'year': '2014'}, { 'article-title': 'The use of Betadine antiseptic in the treatment of oral surgical, ' 'parodontological and oral mucosal diseases', 'author': 'Kövesi', 'first-page': '243', 'journal-title': 'Fogorv Sz', 'key': '10.1016/j.jdsr.2021.03.001_bib0335', 'volume': '92', 'year': '1999'}, { 'DOI': '10.1007/s10006-019-00800-2', 'article-title': 'Pneumonia due to aspiration of povidone iodine after preoperative ' 'disinfection of the oral cavity', 'author': 'Hitosugi', 'doi-asserted-by': 'crossref', 'first-page': '507', 'journal-title': 'Oral Maxillofac Surg', 'key': '10.1016/j.jdsr.2021.03.001_bib0340', 'volume': '23', 'year': '2019'}, { 'DOI': '10.4103/jispcd.JISPCD_304_20', 'article-title': 'A potential antiseptic to minimize the risk of COVID-19? A narrative ' 'review', 'author': 'Castro-Ruiz', 'doi-asserted-by': 'crossref', 'first-page': '681', 'issue': '6', 'journal-title': 'J Int Soc Prev Community Dent', 'key': '10.1016/j.jdsr.2021.03.001_bib0345', 'volume': '10', 'year': '2020'}, { 'DOI': '10.6061/clinics/2020/e2328', 'article-title': 'Potential mouth rinses and nasal sprays that reduce SARS-CoV-2 viral ' 'load: what we know so far?', 'author': 'Gabriel de Toledo', 'doi-asserted-by': 'crossref', 'first-page': 'e2328', 'journal-title': 'Clinics', 'key': '10.1016/j.jdsr.2021.03.001_bib0350', 'volume': '75', 'year': '2020'}], 'reference-count': 70, 'references-count': 70, 'relation': {}, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1882761621000065'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial ' 'and community transmission during the COVID-19 pandemic? An evidence-based update', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'volume': '57'}
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