Can povidone Iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update
Chopra et al.,
Can povidone Iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community..,
Japanese Dental Science Review, doi:10.1016/j.jdsr.2021.03.001 (Review)
Review discussing the rationale, safety, recommendations, and dosage of PVP-I gargle/mouthwash as an effective method to decrease the viral load of SARS-CoV-2.
Chopra et al., 15 Mar 2021, peer-reviewed, 5 authors.
Abstract: Japanese Dental Science Review 57 (2021) 39–45
Contents lists available at ScienceDirect
Japanese Dental Science Review
journal homepage: www.elsevier.com/locate/jdsr
Review Article
Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and
decrease the risk of nosocomial and community transmission during
the COVID-19 pandemic? An evidence-based update
Aditi Chopra a , Karthik Sivaraman b , Raghu Radhakrishnan c , Dhanasekar Balakrishnan b ,
Aparna Narayana b,∗
a
Department of Periodontology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal 576104, India
Department of Prosthodontics and Crown and Bridge, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal
576104, India
c
Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal 576104,
India
b
a r t i c l e
i n f o
Article history:
Received 11 December 2020
Received in revised form 28 February 2021
Accepted 2 March 2021
Keywords:
COVID-19
SARS-CoV-2
Coronavirus
Povidone-iodine
Mouthwash
Global health
Viral infection
Oral health
a b s t r a c t
The Coronavirus disease in 2019 (COVID-19), also referred to as the novel ‘CoV19 (nCov19)’ is caused
by a new coronavirus strain similar to Severe Acute Respiratory Syndrome (SARS-CoV-2). SARS-CoV-2
spreads via respiratory droplets, saliva, or direct contact. Therefore it is important to control the viral
load in the saliva and respiratory secretions. One of the most simple and cost-effective measures that can
be adopted by the public and healthcare professionals to prevent cross-contamination and community
transmission, is the implementation of effective oral and throat hygiene. Recent evidence has confirmed
that 0.5% povidone iodine (PVP-I) mouthrinse/gargle for 30 s can reduce SARS-CoV-2 virus infectivity to
below detectable levels. PVP-I can even interrupt SARS-CoV-2 attachment to oral and nasopharyngeal tissues and lower the viral particles in the saliva and respiratory droplets. Thus, the use of PVP-I mouthrinse
as a prophylactic measure has been advocated across the globe to reduce disease transmission. Although
the efficacy of PVP-I against SARS-CoV-2 is proven, no review articles have yet discussed the evidence
and mechanisms of PVP-I against the SARS-CoV-2. Thus, this paper highlights the rationale, safety, recommendations, and dosage of PVP-I gargle/mouthrinse as an effective method to decrease the viral loads
during the pressing times of COVID-19.
© 2021 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental
Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/
licenses/by-nc-nd/4.0/).
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