E cacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-patients
Ahmed Mostafa, Abdullah Salah Alanazi, Xu Wang, Wang T Zhang, Tairong Wang, Yue Zhang, Rong Zhang, Ye Mao, Junhai Yan, Yiwen Long, Qiaofeng Chen, Xiaojing Li, Huixiang Wang, Shuai Huang, Chao Zhu, Bin Teng
and Wang X ( ) E cacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-patients.
Ethics statement The studies involving human participants were reviewed and approved by Institutional Review Board of RuiJin Hospital LuWan Branch. The patients/participants provided their written informed consent to participate in this study.
Author contributions TW, YZ, RZ, YM, JY, YL, QC, XL, HW, SH, CZ, and BT: methodology, investigation, and data curation. XW: writingoriginal draft, review and editing, conceptualization, supervision, and funding acquisition. All authors contributed to the article and approved the submitted version.
Conflict of interest XW is employed by company Nanning Jiuzhouyuan Biotechnology Co Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
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'abstract': '<jats:sec><jats:title>Background</jats:title><jats:p>Recent studies have shown that the '
'infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reduced under '
'alkaline conditions. The purpose of this study is to assess the effect of nasal irrigation '
'and oral rinse with sodium bicarbonate solution on virus clearance among COVID-19 '
'patients.</jats:p></jats:sec><jats:sec><jats:title>Materials and '
'methods</jats:title><jats:p>COVID-19 patients were recruited and randomly divided into two '
'group, i.e., the experimental group and the control group. The experimental group received '
'regular care plus nasal irrigation and oral rinse with 5% sodium bicarbonate solution, while '
'the control group only received regular care. Nasopharyngeal and oropharyngeal swab samples '
'were collected daily for reverse transcription-polymerase chain reaction (RT-PCR) assays. The '
'negative conversion time and hospitalization time of the patients were recorded, and the '
'results were statistically '
'analyzed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 55 '
'COVID-19 patients with mild or moderate symptoms were included in our study. There was no '
'significant difference in gender, age and health status between the two groups. The average '
'negative conversion time was 1.63 days after treatment with sodium bicarbonate, and the '
'average hospitalization time of the control group and the experimental group were 12.53 and '
'7.7 days, '
'respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Nasal '
'irrigation and oral rinse with 5% sodium bicarbonate solution is effective in virus clearance '
'for COVID-19 patients.</jats:p></jats:sec>',
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