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All Studies   Meta Analysis    Recent:   

Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19 Pneumonia: A Preliminary Report

El-Badrawy et al., Indian Journal of Respiratory Care, doi:10.4103/ijrc.ijrc_48_21, NCT04374591
Jun 2022  
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Mortality 57% Improvement Relative Risk Progression 39% Recovery 19% CT score 73% Recovery time 66% Sodium Bicarbonate  El-Badrawy et al.  LATE TREATMENT Is late treatment with sodium bicarbonate beneficial for COVID-19? Prospective study of 182 patients in Egypt (April - August 2020) Improved recovery with sodium bicarbonate (p=0.034) c19early.org El-Badrawy et al., Indian J. Respirato.., Jun 2022 Favorssodium bicarbonate Favorscontrol 0 0.5 1 1.5 2+
38th treatment shown to reduce risk in May 2022
 
*, now with p = 0.00015 from 7 studies.
Lower risk for mortality, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Prospective study of 182 COVID-19 pneumonia patients, 127 treated with sodium bicarbonate inhalation and nasal drops, showing significantly faster recovery and improved CT scores with treatment.
Authors note that contacts of index cases also received sodium bicarbonate treatment, with none reporting COVID-19.
Inhalation of nebulized sodium bicarbonate 8.4% (5ml every 4h) 7:00am to 23:00pm every day for 30 days together with 8.4% nasal drops 4 times daily (three drops for each nostril).
6 studies use direct respiratory tract administration1-6
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of death, 56.7% lower, RR 0.43, p = 0.37, treatment 3 of 127 (2.4%), control 3 of 55 (5.5%), NNT 32.
risk of progression, 39.4% lower, RR 0.61, p = 0.52, treatment 7 of 127 (5.5%), control 5 of 55 (9.1%), NNT 28, deterioration or death, day 30.
risk of no recovery, 19.2% lower, RR 0.81, p = 0.03, treatment 84 of 127 (66.1%), control 45 of 55 (81.8%), NNT 6.4, day 30.
relative CT score, 72.7% better, RR 0.27, p < 0.001, treatment 127, control 55, day 30.
recovery time, 66.2% lower, relative time 0.34, p < 0.001, treatment mean 3.31 (±0.99) n=127, control mean 9.79 (±6.29) n=55, time to clinical improvement.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
El-Badrawy et al., 12 Jun 2022, prospective, Egypt, peer-reviewed, 7 authors, study period 15 April, 2020 - 31 August, 2020, trial NCT04374591 (history).
This PaperSodium Bicarb..All
Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19 Pneumonia: A Preliminary Report
Abdelbaset Mohammad Khairy El-Badrawy, Mohamed Saleh, Adel El-Badrawy, Ali Tamer, Mohamed Abd El-Hadidy, Ellatif, Dr Rehab Ahmad Elmorsey, Ahmed A Shokeir
doi:10.4103/ijrc.ijrc_48_21
when China reported the first cluster of cases with a novel coronavirus COVID-19, the disease has been rapidly transmitted to almost all countries worldwide. [1, 2] Owing to the absence of definitive treatment options of COVID-19, investigating alternative adjuvant treatments is appropriate until production of a specific effective medication. The suggestion that sodium bicarbonate (SB) could help to restrain coronavirus 2 (SARS-CoV-2) infection is based upon its anti-influenza properties and its widespread use during the "Spanish flu" pandemic of 1918. SB solution 8.4% is sterile, with a pH >8.6, nonpyrogenic, and is used for the treatment of metabolic acidosis. Bronchoalveolar lavage with SB 8.4% is inhibitory to bacteria, fungi, and tuberculosis in cultures. [3] [4] [5] SB is also a disinfectant against feline calicivirus and coxsackievirus. [6, 7] The severity of COVID-19 in adults is clinically classified into mild, moderate, severe, and critical disease according to the WHO interim guidelines published on May 2020. [8, 9] The location of care as recommended by the WHO depends on the epidemiologic scenario and should be either at a designated COVID-19 health facility, community facility, or where not possible, at home. [10] In the present study, we aimed at investigating the role of SB 8.4% as adjuvant therapy in the treatment of patients with moderate clinical stage and moderate radiological chest
Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
References
Abd-Elsalam, Esmail, Khalaf, Abdo, Medhat et al., Hydroxychloroquine in the treatment of COVID-19: A multicenter randomized controlled study, Am J Trop Med Hyg
Abdalla, Badrawy, Elela, El-Khier, Abdelgawad et al., Effect of bronchoalveolar lavage with sodium bicarbonate on lower respiratory tract pathogens, Chest
Ai, Yang, Hou, Zhan, Chen et al., Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: A report of 1014 cases, Radiology
Badrawy, Elela, Yousef, El-Khier, Abdelgawad et al., Effect of sodium bicarbonate 8.4% on respiratory tract pathogens, Chest Lung Res
Bavari, Bosio, Wiegand, Ruthel, Will et al., Lipid raft microdomains: A gateway for compartmentalized trafficking of Ebola and Marburg viruses, J Exp Med
Berlin, Gulick, Martinez, Severe Covid-19, N Engl J Med
Bernheim, Mei, Huang, Yang, Fayad et al., Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection, Radiology
Chandel, Khan, Singh, Agrawal, Khare, The effect of sodium bicarbonate oral rinse on salivary pH and oral microflora: A prospective cohort study, Natl J Maxillofac Surg
Da Poian, Carneiro, Stauffer, Viral membrane fusion: Is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins?, Braz J Med Biol Res
Darquenne, Prisk, Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox, J Aerosol Med
El-Badrawy, Arram, Abdalla, Al-Sagheer, Zahran et al., Effect of adding inhalation of sodium bicarbonate 8.4% to the usual treatment on smear-positive pulmonary tuberculosis: A prospective controlled study, Egypt J Bronchol
Fang, Zhang, Xie, Lin, Ying et al., Sensitivity of chest CT for COVID-19: Comparison to RT-PCR, Radiology
Gietema, Zelis, Nobel, Lambriks, Van Alphen et al., CT in relation to RT-PCR in diagnosing COVID-19 in the Netherland: A prospective study, PloS One
Hope, Raptis, Henry, Chest computed tomography for detection of coronavirus disease 2019 (COVID-19): Don't rush the science, Ann Intern Med
Hsu, Stone, Worsdell, Busst, Chung, Coughing frequency in patients with persistent cough: Assessment using a 24 hour ambulatory recorder, Eur Respir J
Li, Pei, Chen, Song, Zhang et al., Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2), Science
Liu, Maruyama, Masuda, Honda, Arai, The influence of virus infection on the extracellular pH of the host cell detected on cell membrane, Front Microbiol
Mackenzie, Smith, COVID-19: A novel zoonotic disease caused by a coronavirus from China: What we know and what we don't, Microbiol Aust
Madshus, Olsnes, Sandvig, Mechanism of entry into the cytosol of poliovirus type 1: Requirement for low pH, J Cell Biol
Maheshwari, Sidhu, Bhartiya, Friedman, Primary amines enhance the antiviral activity of interferon against a membrane virus: Role of intracellular pH, J Gen Virol
Malik, Goyal, Virucidal efficacy of sodium bicarbonate on a food contact surface against feline calicivirus, a norovirus surrogate, Int J Food Microbiol
Mir, Mansoor, Sheikh & Bhat, A Review on Probable Lysosomotropic Properties of Sodium Bicarbonate to Restrain Viral Entry of Coronavirus 2 (SARS-CoV-2), SSRN Electronic Journal, doi:10.2139/ssrn.3578406
Mwachari, Nduba, Nguti, Park, Sanguli et al., Validation of a new clinical scoring system for acute bronchitis, Int J Tuberc Lung Dis
Spiri, Meli, Riond, Herbert, Hosie et al., Environmental Contamination and Hygienic Measures After Feline Calicivirus Field Strain Infections of Cats in a Research Facility, Viruses
Sturman, Ricard, Holmes, Conformational change of the coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates with virus aggregation and virus-induced cell fusion, J Virol
Sundh, Janson, Lisspers, Ställberg, Montgomery, The Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index is predictive of mortality in COPD, Prim Care Respir J
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention, JAMA
Zheng, Huang, Yin, Zhang, Ye et al., Comparative study of the lymphocyte change between COVID-19 and non-COVID-19 pneumonia cases suggesting uncontrolled inflammation might not be the main reason of tissue injury, medRxiv
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Mackenzie JS, Smith DW. COVID-19: A novel zoonotic disease caused by ' "a coronavirus from China: What we know and what we don't. Microbiol Aust " '2020; 41: 45-50.', 'DOI': '10.1071/MA20013'}, { 'key': 'ref=2', 'doi-asserted-by': 'crossref', 'unstructured': '2. Li R, Pei S, Chen B, Song Y, Zhang T, Yang W, et al. Substantial ' 'undocumented infection facilitates the rapid dissemination of novel ' 'coronavirus (SARS-CoV-2). Science 2020;368:489-93.', 'DOI': '10.1126/science.abb3221'}, { 'key': 'ref=3', 'unstructured': '3. El Badrawy MK, Elela MA, Yousef AM, Abou El-Khier NT, Abdelgawad TT, ' 'Abdalla DA, et al. Effect of sodium bicarbonate 8.4% on respiratory ' 'tract pathogens. Chest Lung Res 2018;1:3-7.'}, { 'key': 'ref=4', 'unstructured': '4. El-Badrawy MK, Arram EO, Abdalla DA, Al-Sagheer D, Zahran A, AboElEla ' 'MA, et al. Effect of adding inhalation of sodium bicarbonate'}, { 'key': 'ref=5', 'doi-asserted-by': 'crossref', 'unstructured': '8.4% to the usual treatment on smear-positive pulmonary tuberculosis: A ' 'prospective controlled study. Egypt J Bronchol 2019;13:531-8.', 'DOI': '10.4103/ejb.ejb_18_19'}, { 'key': 'ref=6', 'doi-asserted-by': 'crossref', 'unstructured': '5. AbdAlla D, El Badrawy M, Elela MA, El-Khier NA, Abdelgawad T, Moawad ' 'A, Yousef A. Effect of bronchoalveolar lavage with sodium bicarbonate on ' 'lower respiratory tract pathogens. Chest 2016;149:A88.', 'DOI': '10.1016/j.chest.2016.02.093'}, { 'key': 'ref=7', 'doi-asserted-by': 'crossref', 'unstructured': '6. Malik YS, Goyal SM. Virucidal efficacy of sodium bicarbonate on a ' 'food contact surface against feline calicivirus, a norovirus surrogate. ' 'Int J Food Microbiol 2006;109:160-3.', 'DOI': '10.1016/j.ijfoodmicro.2005.08.033'}, { 'key': 'ref=8', 'doi-asserted-by': 'crossref', 'unstructured': '7. Spiri AM, Meli ML, Riond B, Herbert I, Hosie MJ, Hofmann- Lehmann R. ' 'Environmental Contamination and Hygienic Measures After Feline ' 'Calicivirus Field Strain Infections of Cats in a Research Facility. ' 'Viruses 2019; 11: 958.', 'DOI': '10.3390/v11100958'}, { 'key': '#cr-split#-ref=9.1', 'doi-asserted-by': 'crossref', 'unstructured': '8. World Health Organization. Clinical Management of COVID-19: Interim ' 'Guidance, 27 May 2020 (No. WHO/2019-nCoV/clinical/2020.5). World Health ' 'Organization', 'DOI': '10.15557/PiMR.2020.0004'}, { 'key': '#cr-split#-ref=9.2', 'unstructured': '2020. Available from: ' 'https://apps.who.int/iris/bitstream/handle/10665/332196/WHO-2019-nCoV-clinical-2020.5- ' 'eng.pdf. [Last accessed on 2020 Jun 27].'}, { 'key': 'ref=10', 'doi-asserted-by': 'crossref', 'unstructured': '9. Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19. N Engl J Med ' '2020;383:2451-60.', 'DOI': '10.1056/NEJMcp2009575'}, { 'key': '#cr-split#-ref=11.1', 'doi-asserted-by': 'crossref', 'unstructured': '10. World Health Organization. Operational Considerations for Case ' 'Management of COVID-19 in Health Facility and Community: Interim ' 'Guidance, 19 March 2020 (No. WHO/2019-nCoV/HCF_operations/2020.1). World ' 'Health Organization', 'DOI': '10.15557/PiMR.2020.0004'}, { 'key': '#cr-split#-ref=11.2', 'unstructured': '2020. Available from: ' 'https://www.who.int/publications/i/item/10665-331492. [Last accessed on ' '2020 April 15].'}, { 'key': 'ref=12', 'unstructured': '11. Egyptian Ministry of Health and Population (MOH), 2020. Diagnosis ' 'and Treatment Protocol for COVID-19. Available from: ' 'http://www.mohp.gov.eg/QuickServiceDetails.aspx?subject_id=3686. [Last ' 'accessed on 2020 Mar 24].'}, { 'key': 'ref=13', 'doi-asserted-by': 'crossref', 'unstructured': '12. Abd-Elsalam S, Esmail ES, Khalaf M, Abdo EF, Medhat MA, Abd El ' 'Ghafar MS, et al. Hydroxychloroquine in the treatment of COVID-19: A ' 'multicenter randomized controlled study. Am J Trop Med Hyg ' '2020;103:1635-9.', 'DOI': '10.4269/ajtmh.20-0873'}, { 'key': 'ref=14', 'unstructured': '13. Infection Prevention and Control for the Care of Patients with ' '2019-nCoV in Healthcare Settings. ECDC Technical Report. European Centre ' 'for Disease Prevention and Control Website. Available from: ' 'https://www.ecdc.europa.eu/sites/default/files/documents/novecoronavirus-infection-prevention-control-patients-healthcare-settings. ' 'pdf. [Last accessed on 2020 Apr 27].'}, { 'key': 'ref=15', 'doi-asserted-by': 'crossref', 'unstructured': '14. Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest ' 'CT findings in coronavirus disease-19 (COVID-19): Relationship to ' 'duration of infection. Radiology 2020;295:200463.', 'DOI': '10.1148/radiol.2020200463'}, { 'key': 'ref=16', 'doi-asserted-by': 'crossref', 'unstructured': '15. Hsu JY, Stone RA, Logan-Sinclair RB, Worsdell M, Busst CM, Chung KF. ' 'Coughing frequency in patients with persistent cough: Assessment using a ' '24 hour ambulatory recorder. Eur Respir J 1994;7:1246-53.', 'DOI': '10.1183/09031936.94.07071246'}, { 'key': 'ref=17', 'unstructured': '16. Mwachari C, Nduba V, Nguti R, Park DR, Sanguli L, Cohen CR. ' 'Validation of a new clinical scoring system for acute bronchitis. Int J ' 'Tuberc Lung Dis 2007;11:1253-9.'}, { 'key': 'ref=18', 'doi-asserted-by': 'crossref', 'unstructured': '17. Sundh J, Janson C, Lisspers K, Ställberg B, Montgomery S. The ' 'Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index is predictive ' 'of mortality in COPD. Prim Care Respir J 2012;21:295-301.', 'DOI': '10.4104/pcrj.2012.00054'}, { 'key': 'ref=19', 'doi-asserted-by': 'crossref', 'unstructured': '18. Liu H, Maruyama H, Masuda T, Honda A, Arai F. The influence of virus ' 'infection on the extracellular pH of the host cell detected on cell ' 'membrane. Front Microbiol 2016;7:1127.', 'DOI': '10.3389/fmicb.2016.01127'}, { 'key': 'ref=20', 'doi-asserted-by': 'crossref', 'unstructured': '19. Da Poian AT, Carneiro FA, Stauffer F. Viral membrane fusion: Is ' 'glycoprotein G of rhabdoviruses a representative of a new class of viral ' 'fusion proteins? Braz J Med Biol Res 2005;38:813-23.', 'DOI': '10.1590/S0100-879X2005000600002'}, { 'key': 'ref=21', 'doi-asserted-by': 'crossref', 'unstructured': '20. Bavari S, Bosio CM, Wiegand E, Ruthel G, Will AB, Geisbert TW, et ' 'al. Lipid raft microdomains: A gateway for compartmentalized trafficking ' 'of Ebola and Marburg viruses. J Exp Med 2002;195:593-602.', 'DOI': '10.1084/jem.20011500'}, { 'key': 'ref=22', 'doi-asserted-by': 'crossref', 'unstructured': '21. Madshus IH, Olsnes S, Sandvig K. Mechanism of entry into the cytosol ' 'of poliovirus type 1: Requirement for low pH. J Cell Biol ' '1984;98:1194-200.', 'DOI': '10.1083/jcb.98.4.1194'}, { 'key': 'ref=23', 'doi-asserted-by': 'crossref', 'unstructured': '22. Maheshwari RK, Sidhu GS, Bhartiya D, Friedman RM. Primary amines ' 'enhance the antiviral activity of interferon against a membrane virus: ' 'Role of intracellular pH. J Gen Virol 1991;72 (Pt 9):2143-52.', 'DOI': '10.1099/0022-1317-72-9-2143'}, { 'key': 'ref=24', 'doi-asserted-by': 'crossref', 'unstructured': '23. Mir, Mudasir and Mansoor, Sheikh and Bhat, Abida. (2020). A Review ' 'on Probable Lysosomotropic Properties of Sodium Bicarbonate to Restrain ' 'Viral Entry of Coronavirus 2 (SARS-CoV-2). SSRN Electronic Journal. ' '10.2139/ssrn.3578406.', 'DOI': '10.2139/ssrn.3578406'}, { 'key': 'ref=25', 'doi-asserted-by': 'crossref', 'unstructured': '24. Sturman LS, Ricard CS, Holmes KV. Conformational change of the ' 'coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates ' 'with virus aggregation and virus-induced cell fusion. J Virol ' '1990;64:3042-50.', 'DOI': '10.1128/jvi.64.6.3042-3050.1990'}, { 'key': 'ref=26', 'doi-asserted-by': 'crossref', 'unstructured': '25. Darquenne C, Prisk GK. Aerosol deposition in the human respiratory ' 'tract breathing air and 80:20 heliox. J Aerosol Med 2004;17:278-85.', 'DOI': '10.1089/jam.2004.17.278'}, { 'key': 'ref=27', 'doi-asserted-by': 'crossref', 'unstructured': '26. Chandel S, Khan MA, Singh N, Agrawal A, Khare V. The effect of ' 'sodium bicarbonate oral rinse on salivary pH and oral microflora: A ' 'prospective cohort study. Natl J Maxillofac Surg 2017;8:106-9.', 'DOI': '10.4103/njms.NJMS_36_17'}, { 'key': 'ref=28', 'doi-asserted-by': 'crossref', 'unstructured': '27. Wu Z, McGoogan JM. Characteristics of and important lessons from the ' 'coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a ' 'report of 72 314 cases from the Chinese center for disease control and ' 'prevention. JAMA 2020;323:1239-42.', 'DOI': '10.1001/jama.2020.2648'}, { 'key': 'ref=29', 'doi-asserted-by': 'crossref', 'unstructured': '28. Zheng Y, Huang Z, Yin G, Zhang X, Ye W, Hu Z, et al. Comparative ' 'study of the lymphocyte change between COVID-19 and non-COVID-19 ' 'pneumonia cases suggesting uncontrolled inflammation might not be the ' 'main reason of tissue injury. medRxiv 2020.02.19.20024885.', 'DOI': '10.1101/2020.02.19.20024885'}, { 'key': 'ref=30', 'doi-asserted-by': 'crossref', 'unstructured': '29. Gietema HA, Zelis N, Nobel JM, Lambriks LJ, van Alphen LB, Lashof ' 'AM, et al. CT in relation to RT- PCR in diagnosing COVID-19 in the ' 'Netherland: A prospective study. PloS One 2020;15:E0235844.', 'DOI': '10.1371/journal.pone.0235844'}, { 'key': 'ref=31', 'doi-asserted-by': 'crossref', 'unstructured': '30. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of ' 'chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in ' 'China: A report of 1014 cases. Radiology 2020;296:E32-40.', 'DOI': '10.1148/radiol.2020200642'}, { 'key': 'ref=32', 'doi-asserted-by': 'crossref', 'unstructured': '31. Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, et al. Sensitivity of ' 'chest CT for COVID-19: Comparison to RT-PCR. Radiology 2020;296:E115-7.', 'DOI': '10.1148/radiol.2020200432'}, { 'key': 'ref=33', 'doi-asserted-by': 'crossref', 'unstructured': '32. Hope MD, Raptis CA, Henry TS. Chest computed tomography for ' "detection of coronavirus disease 2019 (COVID-19): Don't rush the " 'science. Ann Intern Med 2020;173:147-8.', 'DOI': '10.7326/M20-1382'}], 'container-title': 'Indian Journal of Respiratory Care', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.ijrc.in/doi/pdf/10.4103/ijrc.ijrc_48_21', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 7, 29]], 'date-time': '2023-07-29T06:10:36Z', 'timestamp': 1690611036000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.ijrc.in/doi/10.4103/ijrc.ijrc_48_21'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 9, 13]]}, 'references-count': 35, 'journal-issue': {'issue': '3', 'published-online': {'date-parts': [[2021]]}}, 'alternative-id': ['10.4103/ijrc.ijrc_48_21'], 'URL': 'http://dx.doi.org/10.4103/ijrc.ijrc_48_21', 'relation': {}, 'ISSN': ['2277-9019', '2321-4899'], 'subject': ['Anesthesiology and Pain Medicine'], 'published': {'date-parts': [[2021, 9, 13]]}}
Late treatment
is less effective
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