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Effect of 8.4% Soda-Bicarbonate Steam Inhalation on the Course of Disease in Mild to Moderate Cases of Covid-19

Mody, K., Acta Scientific Orthopaedics, 4:4, CTRI/2020/07/026535
Mar 2021  
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Improvement 64% Improvement Relative Risk Sodium Bicarbonate  Mody et al.  LATE TREATMENT  RCT Is late treatment with sodium bicarbonate beneficial for COVID-19? RCT 60 patients in India (July - September 2020) Greater improvement with sodium bicarbonate (p=0.00066) Mody, K., Acta Scientific Orthopaedics, Mar 2021 Favorssodium bicarbonate Favorscontrol 0 0.5 1 1.5 2+
37th treatment shown to reduce risk in May 2022
*, now with p = 0.00015 from 7 studies.
Lower risk for mortality, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments.
RCT 60 hospitalized patients in India, showing significantly greater clinical improvement with inhaled sodium bicarbonate.
Nasal and oral inhalation of nebulized 50ml 8.4% sodium bicarbonate for 5 minutes twice daily for 5 days.
6 studies use direct respiratory tract administration1-6
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of no improvement, 63.6% lower, RR 0.36, p < 0.001, treatment 8 of 30 (26.7%), control 22 of 30 (73.3%), NNT 2.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mody et al., 19 Mar 2021, Randomized Controlled Trial, India, peer-reviewed, 1 author, study period July 2020 - September 2020, trial CTRI/2020/07/026535.
This PaperSodium Bicarb..All
Effect of 8.4% Soda-Bicarbonate Steam Inhalation on the Course of Disease in Mild to Moderate Cases of Covid-19
Kshitij Mody
Background: A prospective, randomized open label parallel group trial was carried out to evaluate the effect of 8.4% soda-bicarbonate steam inhalation on the course of covid-19 infection in mild to moderate confirmed cases of covid-19. Methods: 30 patients were enrolled and compared with 30 patients in a control group, giving a total sample size of 60 patients. Randomisation was achieved by sealed envelope technique. The 30 patients in the SB group received SB inhalation in addition to all other therapeutic measures as part of covid-19 treatment protocol. The control group was treated according to same treatment protocol, but without SB inhalation therapy. Clinical symptoms and lab markers were recorded on Day 1 and Day 5 of patients' stay at hospital. Results: Patients receiving 8.4% SB inhalation as part of their treatment showed faster improvement in symptomatology and quicker normalization of inflammatory lab markers. Conclusion: The results of this study show a highly significant improvement in the clinical picture of covid-19 affected patients treated with inhalations of steam impregnated with 8.4% sodium bicarbonate.
Proportion of subjects showing clinical symptomatic improvement was statistically significantly higher in the SB group as compared to the non-SB group. Proportion of improvement was found to be 73.33 and 26.67 in the SB and non-SB groups respectively (p-value 0.0003). Further studies with a larger patient population can establish further proof for the application of sodium bicarbonate as a useful agent to combat the covid-19 infection.
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Late treatment
is less effective
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