Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All alkalinization studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAlkalinizationAlkalinization (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience

Mahto, M., Indian Journal of Critical Care Medicine, doi:10.5005/jp-journals-10071-23901
Jul 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
28th treatment shown to reduce risk in November 2021, now with p = 0.0000000046 from 14 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Report on 10 patients treated with sodium bicarbonate gargling, suggesting no significant improvements. There was no control group and gargling only, without inhalation or nasal spray/rinse.
Mahto et al., 7 Jul 2021, India, peer-reviewed, 1 author. Contact: neeraj.jlnmc@gmail.com.
This PaperAlkalinizationAll
Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience
Neeraj Kumar, Abhyuday Kumar, Mala Mahto, Prabhat K Singh
Indian Journal of Critical Care Medicine, doi:10.5005/jp-journals-10071-23901
Background: Gargling had been reported to have some roles in the prevention and treatment of respiratory tract infections. The purpose of this study was to assess the ability of regular gargling using 7.5% sodium bicarbonate to eliminate SARS-CoV-2 in the oropharynx and nasopharynx. Materials and methods: This pilot, open-labeled, nonrandomized, parallel single-center study. The effect of 30 seconds, three times per day gargling using 7.5% sodium bicarbonate solution-25 mL on SARS-CoV-2 viral clearance among coronavirus disease-2019 (COVID-19) patients in a dedicated COVID hospital at
References
Bettermann, Viral infections are pH sensitive
Ecdc, novel coronavirus (SARS-CoV-2) discharge criteria for confirmed COVID-19 Cases -when is it safe to discharge COVID-19 cases from the hospital or end home isolation
Kitamura, Satomura, Kawamura, Yamada, Takashima et al., Can we prevent influenza-like illnesses by gargling?, Intern Med, doi:10.2169/internalmedicine.46.0104
Neil, The Merck Index -an encyclopedia of chemicals, drugs, and biologicals
Sturman, Ricard, Holmes, Conformational change of the coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates with virus aggregation and virus-induced cell fusion, J Virol, doi:10.1128/JVI.64.6.3042-3050.1990
Uhm, Ahn, Hyun, Sohn, Kim et al., Patterns of viral clearance in the natural course of asymptomatic COVID
Wölfel, Corman, Guggemos, Seilmaier, Zange et al., Virological assessment of hospitalized patients with COVID-2019, Nature, doi:10.1038/s41586-020-2196-x
Yang, Huang, Ganesh, Leung, Kong et al., pH-dependent entr y of severe acute respirator y syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN, J Virol, doi:10.1128/JVI.78.11.5642-5650.2004
Yang, Shen, Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19, Int J Biol Sci, doi:10.7150/ijbs.45498
{ 'indexed': {'date-parts': [[2022, 7, 16]], 'date-time': '2022-07-16T09:40:43Z', 'timestamp': 1657964443464}, 'reference-count': 11, 'publisher': 'Jaypee Brothers Medical Publishing', 'issue': '7', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 7, 7]]}, 'DOI': '10.5005/jp-journals-10071-23901', 'type': 'journal-article', 'created': {'date-parts': [[2021, 6, 30]], 'date-time': '2021-06-30T13:04:44Z', 'timestamp': 1625058284000}, 'page': '791-794', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our ' 'Institutional Clinical Experience', 'prefix': '10.5005', 'volume': '25', 'author': [{'given': 'Mala', 'family': 'Mahto', 'sequence': 'first', 'affiliation': []}], 'member': '2914', 'published-online': {'date-parts': [[2021, 7, 7]]}, 'reference': [ { 'key': 'ref=1', 'doi-asserted-by': 'crossref', 'unstructured': '1. Mady LJ, Kubik MW, Baddour K, Snyderman CH, Rowan NR. Consideration ' 'of povidone-iodine as a public health intervention for COVID-19: ' 'utilization as “personal protective equipment’ for frontline providers ' 'exposed in high-risk head and neck and skull base oncology care.” Oral ' 'Oncol 2020;105:104724.2020. DOI: 10.1016/j.oraloncology.2020.104724.', 'DOI': '10.1016/j.oraloncology.2020.104724'}, { 'key': 'ref=2', 'doi-asserted-by': 'crossref', 'unstructured': '2. Pattanshetty S, Narayana A, Radhakrishnan R. Povidone-iodine gargle ' 'as a prophylactic intervention to interrupt the transmission of ' 'SARS-CoV-2. Oral Dis 2020;27(Suppl. 3):752–753. DOI: 10.1111/odi.13378.', 'DOI': '10.1111/odi.13378'}, { 'key': 'ref=3', 'unstructured': '3. ECDC. 2020. Technical report: novel coronavirus (SARS-CoV-2) ' 'discharge criteria for confirmed COVID-19 Cases – when is it safe to ' 'discharge COVID-19 cases from the hospital or end home isolation? ' 'Available from: ' 'https://www.Ecdc.Europa.Eu/Sites/Default/Files/Documents/COVID-19-Discharge-Criteria.Pdf. ' '2020. p. 3.'}, { 'key': 'ref=4', 'doi-asserted-by': 'crossref', 'unstructured': '4. Sturman LS, Ricard CS, Holmes KV. Conformational change of the ' 'coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates ' 'with virus aggregation and virus-induced cell fusion. J Virol. ' '1990;64(6):3042-3050. DOI:10.1128/JVI.64.6.3042-3050.1990', 'DOI': '10.1128/jvi.64.6.3042-3050.1990'}, { 'key': 'ref=5', 'doi-asserted-by': 'crossref', 'unstructured': '5. Yang N, Shen HM. Targeting the endocytic pathway and autophagy ' 'process as a novel therapeutic strategy in COVID-19. Int J Biol Sci ' '2020;16(10):1724–1731. DOI: 10.7150/ijbs.45498.', 'DOI': '10.7150/ijbs.45498'}, { 'key': 'ref=6', 'unstructured': '6. Bettermann E. Viral infections are pH sensitive; 2019. Available ' 'from: https://dreddymd.com/2019/02/06/viral-infections-are-ph-sensitive/ ' '[Accessed on December 28, 2020].'}, { 'key': 'ref=7', 'doi-asserted-by': 'crossref', 'unstructured': '7. Uhm JS, Ahn JY, Hyun J, Sohn Y, Kim JH, Jeong SJ, et al. Patterns of ' 'viral clearance in the natural course of asymptomatic COVID-19: ' 'comparison with symptomatic non-severe COVID-19. Int J Infect Dis ' '2020;99:279–285. DOI: 10.1016/j.ijid.2020.07.070.', 'DOI': '10.1016/j.ijid.2020.07.070'}, { 'key': 'ref=8', 'doi-asserted-by': 'crossref', 'unstructured': '8. Yang ZY, Huang Y, Ganesh L, Leung K, Kong WP, Schwartz O, et al. ' 'pH-dependent entry of severe acute respiratory syndrome coronavirus is ' 'mediated by the spike glycoprotein and enhanced by dendritic cell ' 'transfer through DC-SIGN. J Virol 2004;78(11):5642–5650. DOI: ' '10.1128/JVI.78.11.5642-5650.2004.', 'DOI': '10.1128/JVI.78.11.5642-5650.2004'}, { 'key': 'ref=9', 'doi-asserted-by': 'crossref', 'unstructured': '9. Kitamura T, Satomura K, Kawamura T, Yamada S, Takashima K, Suganuma ' 'N, et al. Can we prevent influenza-like illnesses by gargling? Intern ' 'Med 2007;46(18):1623–1624. DOI: 10.2169/internalmedicine.46.0104.', 'DOI': '10.2169/internalmedicine.46.0104'}, { 'key': 'ref=10', 'unstructured': "10. O'Neil MJ, editor. The Merck Index – an encyclopedia of chemicals, " 'drugs, and biologicals. Cambridge, UK: Royal Society of Chemistry; 2013. ' 'p. 1594.'}, { 'key': 'ref=11', 'doi-asserted-by': 'crossref', 'unstructured': '11. Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et ' 'al. Virological assessment of hospitalized patients with COVID-2019. ' 'Nature 2020;581(7809):465–469. DOI: 10.1038/s41586-020-2196-x.', 'DOI': '10.1038/s41586-020-2196-x'}], 'container-title': 'Indian Journal of Critical Care Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.ijccm.org/doi/pdf/10.5005/jp-journals-10071-23901', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 15]], 'date-time': '2022-07-15T16:22:27Z', 'timestamp': 1657902147000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.ijccm.org/doi/10.5005/jp-journals-10071-23901'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 7, 7]]}, 'references-count': 11, 'journal-issue': {'issue': '7', 'published-online': {'date-parts': [[2021]]}}, 'alternative-id': ['10.5005/jp-journals-10071-23901'], 'URL': 'http://dx.doi.org/10.5005/jp-journals-10071-23901', 'relation': {}, 'ISSN': ['0972-5229', '1998-359X'], 'subject': ['Critical Care and Intensive Care Medicine'], 'published': {'date-parts': [[2021, 7, 7]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit