Report on 10 patients treated with sodium bicarbonate gargling, suggesting no significant improvements. There was no control group and gargling only, without inhalation or nasal spray/rinse.
Mahto et al., 7 Jul 2021, India, peer-reviewed, 1 author.
Contact:
neeraj.jlnmc@gmail.com.
Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience
Neeraj Kumar, Abhyuday Kumar, Mala Mahto, Prabhat K Singh
Indian Journal of Critical Care Medicine, doi:10.5005/jp-journals-10071-23901
Background: Gargling had been reported to have some roles in the prevention and treatment of respiratory tract infections. The purpose of this study was to assess the ability of regular gargling using 7.5% sodium bicarbonate to eliminate SARS-CoV-2 in the oropharynx and nasopharynx.
Materials and methods: This pilot, open-labeled, nonrandomized, parallel single-center study. The effect of 30 seconds, three times per day gargling using 7.5% sodium bicarbonate solution-25 mL on SARS-CoV-2 viral clearance among coronavirus disease-2019 (COVID-19) patients in a dedicated COVID hospital at
References
Bettermann, Viral infections are pH sensitive
Ecdc, novel coronavirus (SARS-CoV-2) discharge criteria for confirmed COVID-19 Cases -when is it safe to discharge COVID-19 cases from the hospital or end home isolation
Neil, The Merck Index -an encyclopedia of chemicals, drugs, and biologicals
Sturman, Ricard, Holmes, Conformational change of the coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates with virus aggregation and virus-induced cell fusion, J Virol,
doi:10.1128/JVI.64.6.3042-3050.1990
Uhm, Ahn, Hyun, Sohn, Kim et al., Patterns of viral clearance in the natural course of asymptomatic COVID
Wölfel, Corman, Guggemos, Seilmaier, Zange et al., Virological assessment of hospitalized patients with COVID-2019, Nature,
doi:10.1038/s41586-020-2196-x
Yang, Huang, Ganesh, Leung, Kong et al., pH-dependent entr y of severe acute respirator y syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN, J Virol,
doi:10.1128/JVI.78.11.5642-5650.2004
Yang, Shen, Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19, Int J Biol Sci,
doi:10.7150/ijbs.45498