The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients in Bali, Indonesia

{ 'indexed': {'date-parts': [[2022, 3, 30]], 'date-time': '2022-03-30T12:47:26Z', 'timestamp': 1648644446076}, 'reference-count': 0, 'publisher': 'Kesmas: Jurnal Kesehatan Masyarakat Nasional', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2021, 11, 1]], 'date-time': '2021-11-01T00:00:00Z', 'timestamp': 1635724800000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-sa/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>COVID-19 is a major public health problem, with still questionable specific cure. ' 'Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study ' 'aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. ' 'This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali ' 'Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 ' 'in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). ' 'Effectivity was measured by assessing the clinical condition at the end of the isolation ' 'period of 14 days. The favipiravir group showed better clinical conditions than the ' 'non-favipiravir group (79.2% vs. 56.3%; adjusted RR = 2.196; 95% CI = 1.084 – 4.451; p-value= ' '0.029), seen from being free of fever and respiratory problems. Stratification analysis ' 'demonstrated that the clinical improvement was significantly differentin the severe/critical ' 'group in favor of favipiravir (RR = 1.573; 95% CI = 1.139-2.172). The most common non-serious ' 'adverse events (AE) found in the use offavipiravir were gastrointestinal disturbances ' '(12.5%). In brief, favipiravir is effective in severe/critical cases, and less serious AE ' 'were found in its use. Appropriate treatment is expected to help in reducing the public ' 'health burden.</jats:p>', 'DOI': '10.21109/kesmas.v16i4.5433', 'type': 'journal-article', 'created': {'date-parts': [[2021, 11, 3]], 'date-time': '2021-11-03T01:05:07Z', 'timestamp': 1635901507000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients at Tertiary ' 'Referral Hospital, Bali, Indonesia', 'prefix': '10.21109', 'volume': '16', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2437-5072', 'authenticated-orcid': False, 'given': 'Herni', 'family': 'Damayanti', 'sequence': 'first', 'affiliation': []}, {'given': 'I Gede K', 'family': 'Sajinadiyasa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hindun Wilda', 'family': 'Risni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rani', 'family': 'Sauriasari', 'sequence': 'additional', 'affiliation': []}], 'member': '8818', 'published-online': {'date-parts': [[2021, 11, 1]]}, 'container-title': 'Kesmas: National Public Health Journal', 'original-title': [], 'link': [ { 'URL': 'https://journal.fkm.ui.ac.id/kesmas/article/viewFile/5433/1245', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://journal.fkm.ui.ac.id/kesmas/article/viewFile/5433/1245', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 12, 6]], 'date-time': '2021-12-06T13:17:05Z', 'timestamp': 1638796625000}, 'score': 1, 'resource': {'primary': {'URL': 'https://journal.fkm.ui.ac.id/kesmas/article/view/5433'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 11, 1]]}, 'references-count': 0, 'journal-issue': {'issue': '4', 'published-online': {'date-parts': [[2021, 11, 1]]}}, 'URL': 'http://dx.doi.org/10.21109/kesmas.v16i4.5433', 'relation': {}, 'ISSN': ['2460-0601', '1907-7505'], 'subject': ['Public Health, Environmental and Occupational Health', 'Health Policy', 'Epidemiology'], 'container-title-short': 'Kesmas: National Public Health Journal', 'published': {'date-parts': [[2021, 11, 1]]}}