The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients in Bali, Indonesia

DOI record: { "DOI": "10.21109/kesmas.v16i4.5433", "ISSN": [ "2460-0601", "1907-7505" ], "URL": "http://dx.doi.org/10.21109/kesmas.v16i4.5433", "abstract": "<jats:p>COVID-19 is a major public health problem, with still questionable specific cure. Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). Effectivity was measured by assessing the clinical condition at the end of the isolation period of 14 days. The favipiravir group showed better clinical conditions than the non-favipiravir group (79.2% vs. 56.3%; adjusted RR = 2.196; 95% CI = 1.084 – 4.451; p-value= 0.029), seen from being free of fever and respiratory problems. Stratification analysis demonstrated that the clinical improvement was significantly differentin the severe/critical group in favor of favipiravir (RR = 1.573; 95% CI = 1.139-2.172). The most common non-serious adverse events (AE) found in the use offavipiravir were gastrointestinal disturbances (12.5%). In brief, favipiravir is effective in severe/critical cases, and less serious AE were found in its use. Appropriate treatment is expected to help in reducing the public health burden.</jats:p>", "author": [ { "ORCID": "http://orcid.org/0000-0002-2437-5072", "affiliation": [], "authenticated-orcid": false, "family": "Damayanti", "given": "Herni", "sequence": "first" }, { "affiliation": [], "family": "Sajinadiyasa", "given": "I Gede K", "sequence": "additional" }, { "affiliation": [], "family": "Risni", "given": "Hindun Wilda", "sequence": "additional" }, { "affiliation": [], "family": "Sauriasari", "given": "Rani", "sequence": "additional" } ], "container-title": "Kesmas: National Public Health Journal", "container-title-short": "Kesmas: National Public Health Journal", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 11, 3 ] ], "date-time": "2021-11-03T01:05:07Z", "timestamp": 1635901507000 }, "deposited": { "date-parts": [ [ 2021, 12, 6 ] ], "date-time": "2021-12-06T13:17:05Z", "timestamp": 1638796625000 }, "indexed": { "date-parts": [ [ 2022, 3, 30 ] ], "date-time": "2022-03-30T12:47:26Z", "timestamp": 1648644446076 }, "is-referenced-by-count": 0, "issue": "4", "issued": { "date-parts": [ [ 2021, 11, 1 ] ] }, "journal-issue": { "issue": "4", "published-online": { "date-parts": [ [ 2021, 11, 1 ] ] } }, "license": [ { "URL": "http://creativecommons.org/licenses/by-sa/4.0", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 11, 1 ] ], "date-time": "2021-11-01T00:00:00Z", "timestamp": 1635724800000 } } ], "link": [ { "URL": "https://journal.fkm.ui.ac.id/kesmas/article/viewFile/5433/1245", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://journal.fkm.ui.ac.id/kesmas/article/viewFile/5433/1245", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "8818", "original-title": [], "prefix": "10.21109", "published": { "date-parts": [ [ 2021, 11, 1 ] ] }, "published-online": { "date-parts": [ [ 2021, 11, 1 ] ] }, "publisher": "Kesmas: Jurnal Kesehatan Masyarakat Nasional", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://journal.fkm.ui.ac.id/kesmas/article/view/5433" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Public Health, Environmental and Occupational Health", "Health Policy", "Epidemiology" ], "subtitle": [], "title": "The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients at Tertiary Referral Hospital, Bali, Indonesia", "type": "journal-article", "volume": "16" }