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Does Favipiravir interact with DNA? Design of electrochemical DNA nanobiosensor to investigate the interaction between DNA and Favipiravir used in the treatment of COVID-19

Cenikli et al., Talanta, doi:10.1016/j.talanta.2025.128084, Apr 2025
Favipiravir exhibits a direct interaction with DNA, as detected by a novel electrochemical nanobiosensor. Authors observed a decrease in guanine oxidation signals that suggests favipiravir may bind to or alter DNA structure, raising concerns about potential genotoxic effects. While clinical side effects such as hyperuricemia, liver enzyme elevation, QT interval prolongation, and possible teratogenicity have been previously reported, this study introduces a plausible molecular basis for such risks, particularly in relation to DNA damage.
Potential risks of favipiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-6.
Cenikli et al., 6 Apr 2025, peer-reviewed, 4 authors.
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