Experimental evaluation of favipiravir (T-705)-induced liver and kidney toxicity in rats

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J. Armed Forces India", "key": "10.1016/j.fct.2025.115472_bib1", "volume": "76", "year": "2020" }, { "DOI": "10.1186/s12879-020-05706-z", "article-title": "Effects of undernutrition on mortality and morbidity among adults living with HIV in Sub-Saharan Africa: a systematic review and meta-analysis", "author": "Alebel", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "BMC Infect. Dis.", "key": "10.1016/j.fct.2025.115472_bib2", "volume": "21", "year": "2021" }, { "DOI": "10.1007/s11894-009-0007-5", "article-title": "'Granulomatous liver disease'", "author": "Bhardwaj", "doi-asserted-by": "crossref", "first-page": "42", "journal-title": "Curr. Gastroenterol. Rep.", "key": "10.1016/j.fct.2025.115472_bib3", "volume": "11", "year": "2009" }, { "DOI": "10.1002/bdr2.2073", "article-title": "Investigation of developmental toxicity of favipiravir on fetal bone and embryonic development", "author": "Bilir", "doi-asserted-by": "crossref", "first-page": "1092", "journal-title": "Birth Defects. Res.", "key": "10.1016/j.fct.2025.115472_bib4", "volume": "114", "year": "2022" }, { "DOI": "10.1016/j.antiviral.2017.12.020", "article-title": "Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus", "author": "Bixler", "doi-asserted-by": "crossref", "first-page": "50", "journal-title": "Antivir. Res.", "key": "10.1016/j.fct.2025.115472_bib5", "volume": "151", "year": "2018" }, { "DOI": "10.1038/s41598-018-37866-z", "article-title": "'Synthesis of [(18)F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography'", "author": "Bocan", "doi-asserted-by": "crossref", "first-page": "1785", "journal-title": "Sci. 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Agents Chemother.", "key": "10.1016/j.fct.2025.115472_bib11", "volume": "64", "year": "2020" }, { "DOI": "10.1038/s41467-021-21992-w", "article-title": "'Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model'", "author": "Driouich", "doi-asserted-by": "crossref", "first-page": "1735", "journal-title": "Nat. Commun.", "key": "10.1016/j.fct.2025.115472_bib12", "volume": "12", "year": "2021" }, { "DOI": "10.1002/jbt.23536", "article-title": "'Assessment of toxicological effects of favipiravir (T-705) on the lung tissue of rats: an experimental study'", "author": "Erbaş", "doi-asserted-by": "crossref", "journal-title": "J. Biochem. Mol. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib13", "volume": "38", "year": "2024" }, { "DOI": "10.1098/rsob.200160", "article-title": "'Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines'", "author": "Fara", "doi-asserted-by": "crossref", "journal-title": "Open Biol.", "key": "10.1016/j.fct.2025.115472_bib14", "volume": "10", "year": "2020" }, { "DOI": "10.1016/j.antiviral.2013.09.015", "article-title": "'Favipiravir (T-705), a novel viral RNA polymerase inhibitor'", "author": "Furuta", "doi-asserted-by": "crossref", "first-page": "446", "journal-title": "Antivir. Res.", "key": "10.1016/j.fct.2025.115472_bib15", "volume": "100", "year": "2013" }, { "DOI": "10.2183/pjab.93.027", "article-title": "'Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase'", "author": "Furuta", "doi-asserted-by": "crossref", "first-page": "449", "journal-title": "Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.", "key": "10.1016/j.fct.2025.115472_bib16", "volume": "93", "year": "2017" }, { "DOI": "10.1007/s10238-020-00671-y", "article-title": "'Emerging treatment strategies for COVID-19 infection'", "author": "Gavriatopoulou", "doi-asserted-by": "crossref", "first-page": "167", "journal-title": "Clin. Exp. Med.", "key": "10.1016/j.fct.2025.115472_bib17", "volume": "21", "year": "2021" }, { "DOI": "10.1016/j.cotox.2017.11.001", "article-title": "DNA damage by oxidative stress: measurement strategies for two genomes", "author": "Gonzalez-Hunt", "doi-asserted-by": "crossref", "first-page": "87", "journal-title": "Curr. Opin. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib18", "volume": "7", "year": "2018" }, { "DOI": "10.1016/j.toxlet.2022.09.011", "article-title": "Favipiravir induces oxidative stress and genotoxicity in cardiac and skin cells", "author": "Gunaydin-Akyildiz", "doi-asserted-by": "crossref", "first-page": "9", "journal-title": "Toxicol. Lett.", "key": "10.1016/j.fct.2025.115472_bib19", "volume": "371", "year": "2022" }, { "DOI": "10.1097/QCO.0000000000000532", "article-title": "Influenza virus polymerase inhibitors in clinical development", "author": "Hayden", "doi-asserted-by": "crossref", "first-page": "176", "journal-title": "Curr. Opin. Infect. Dis.", "key": "10.1016/j.fct.2025.115472_bib20", "volume": "32", "year": "2019" }, { "DOI": "10.3390/ijms17111826", "article-title": "'Role of oxidative stress in drug-induced kidney injury'", "author": "Hosohata", "doi-asserted-by": "crossref", "first-page": "1826", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.fct.2025.115472_bib21", "volume": "17", "year": "2016" }, { "key": "10.1016/j.fct.2025.115472_bib22", "unstructured": "Information provided by Dr. Reddy's Laboratories Limited. Clinical Trial Evaluating the Efficacy and Safety of Favipiravir in Moderate to Severe COVID-19 Patients. Responsible. s.l. : National library of medicine. Mar. https://beta.clinicaltrials.gov/study/NCT04529499?tab=results." }, { "DOI": "10.1111/jocd.14790", "article-title": "'Angioedema after favipiravir treatment: two cases'", "author": "Islamoglu", "doi-asserted-by": "crossref", "first-page": "3704", "journal-title": "J. Cosmet. Dermatol.", "key": "10.1016/j.fct.2025.115472_bib23", "volume": "21", "year": "2022" }, { "DOI": "10.1093/cid/ciaa1176", "article-title": "AVIFAVIR for treatment of patients with moderate coronavirus disease 2019 (COVID-19): interim results of a phase II/III multicenter randomized clinical trial", "author": "Ivashchenko", "doi-asserted-by": "crossref", "first-page": "531", "journal-title": "Clin. Infect. Dis.", "key": "10.1016/j.fct.2025.115472_bib24", "volume": "73", "year": "2021" }, { "article-title": "COVID-19 tedavisinde favipiravir ve hidroksiklorokinin Karaciğer Güvenliğinin Karşılaştırılması", "author": "İzci-Çetinkaya", "journal-title": "Klimik J. Klimik Dergisi", "key": "10.1016/j.fct.2025.115472_bib25", "volume": "33", "year": "2020" }, { "article-title": "Gastrointestinal and hepatic manifestations of systemic disease", "author": "Jain", "first-page": "739", "key": "10.1016/j.fct.2025.115472_bib26", "series-title": "Sleisenger and Fordtran's Gastrointestinal and Liver Disease", "year": "2006" }, { "DOI": "10.1016/j.ijid.2020.10.069", "article-title": "'Role of favipiravir in the treatment of COVID-19'", "author": "Joshi", "doi-asserted-by": "crossref", "first-page": "501", "journal-title": "Int. J. Infect. Dis.", "key": "10.1016/j.fct.2025.115472_bib27", "volume": "102", "year": "2021" }, { "DOI": "10.1073/pnas.2014441117", "article-title": "'Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity'", "author": "Kaptein", "doi-asserted-by": "crossref", "first-page": "26955", "journal-title": "Proc. Natl. Acad. Sci. U. S. A.", "key": "10.1016/j.fct.2025.115472_bib28", "volume": "117", "year": "2020" }, { "DOI": "10.1080/01480545.2022.2066116", "article-title": "'Evaluation of the toxicological effects of favipiravir (T-705) on liver and kidney in rats: biochemical and histopathological approach'", "author": "Kara", "doi-asserted-by": "crossref", "first-page": "546", "journal-title": "Drug Chem. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib29", "volume": "46", "year": "2023" }, { "article-title": "In vitro cytotoxic effects of some Covid-19 drugs on lung cancer cells", "author": "Karakuş", "first-page": "173", "journal-title": "Trakya Univ. J. Nat. Sci.", "key": "10.1016/j.fct.2025.115472_bib30", "volume": "22", "year": "2021" }, { "article-title": "Favipiravir-induced liver injury in patients with coronavirus disease 2019", "author": "Kumar", "first-page": "276", "journal-title": "J. Clin. Transl. Hepatol", "key": "10.1016/j.fct.2025.115472_bib31", "volume": "9", "year": "2021" }, { "DOI": "10.3390/ijms161125942", "article-title": "The role of oxidative stress and antioxidants in liver diseases", "author": "Li", "doi-asserted-by": "crossref", "first-page": "26087", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.fct.2025.115472_bib32", "volume": "16", "year": "2015" }, { "DOI": "10.2147/DDDT.S259058", "article-title": "Antiviral agent therapy optimization in special populations of COVID-19 patients", "author": "Li", "doi-asserted-by": "crossref", "first-page": "3001", "journal-title": "Drug Des. Dev. Ther.", "key": "10.1016/j.fct.2025.115472_bib33", "volume": "14", "year": "2020" }, { "DOI": "10.1016/j.ecoenv.2019.110073", "article-title": "Study on potential toxic material base and mechanisms of hepatotoxicity induced by Dysosma versipellis based on toxicological evidence chain (TEC) concept", "author": "Liu", "doi-asserted-by": "crossref", "journal-title": "Ecotoxicol. Environ. Saf.", "key": "10.1016/j.fct.2025.115472_bib34", "volume": "190", "year": "2020" }, { "DOI": "10.1016/j.ajogmf.2020.100159", "article-title": "'Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019'", "author": "Louchet", "doi-asserted-by": "crossref", "journal-title": "Am. J. Obstet. Gynecol. MFM", "key": "10.1016/j.fct.2025.115472_bib35", "volume": "2", "year": "2020" }, { "DOI": "10.1007/s40268-020-00333-0", "article-title": "Recommendations for dosing of repurposed COVID-19 medications in patients with renal and hepatic impairment", "author": "Marra", "doi-asserted-by": "crossref", "first-page": "9", "journal-title": "Drugs R&D", "key": "10.1016/j.fct.2025.115472_bib36", "volume": "21", "year": "2021" }, { "DOI": "10.1007/s00204-022-03306-1", "article-title": "The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro", "author": "Merches", "doi-asserted-by": "crossref", "first-page": "2341", "journal-title": "Arch. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib37", "volume": "96", "year": "2022" }, { "author": "Mishima", "first-page": "183", "key": "10.1016/j.fct.2025.115472_bib38", "series-title": "Granulomatous Liver Diseases", "year": "2019" }, { "DOI": "10.1620/tjem.251.87", "article-title": "Uric acid elevation by Favipiravir, an antiviral drug", "author": "Mishima", "doi-asserted-by": "crossref", "first-page": "87", "journal-title": "Tohoku J. Exp. Med.", "key": "10.1016/j.fct.2025.115472_bib39", "volume": "251", "year": "2020" }, { "DOI": "10.1093/intimm/dxh044", "article-title": "Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms", "author": "Morimoto", "doi-asserted-by": "crossref", "first-page": "477", "journal-title": "Int. Immunol.", "key": "10.1016/j.fct.2025.115472_bib40", "volume": "16", "year": "2004" }, { "DOI": "10.1016/j.fct.2023.113847", "article-title": "'Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver'", "author": "Nygaard", "doi-asserted-by": "crossref", "journal-title": "Food Chem. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib41", "volume": "177", "year": "2023" }, { "DOI": "10.1016/j.antiviral.2014.02.014", "article-title": "Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model", "author": "Oestereich", "doi-asserted-by": "crossref", "first-page": "17", "journal-title": "Antivir. Res.", "key": "10.1016/j.fct.2025.115472_bib42", "volume": "105", "year": "2014" }, { "DOI": "10.1007/s00467-021-05111-x", "article-title": "Favipiravir use in children with COVID-19 and acute kidney injury: is it safe?", "author": "Ozsurekci", "doi-asserted-by": "crossref", "first-page": "3771", "journal-title": "Pediatr. Nephrol.", "key": "10.1016/j.fct.2025.115472_bib43", "volume": "36", "year": "2021" }, { "DOI": "10.3109/03602532.2011.604086", "article-title": "Central role of mitochondria in drug-induced liver injury", "author": "Pessayre", "doi-asserted-by": "crossref", "first-page": "34", "journal-title": "Drug Metab. Rev.", "key": "10.1016/j.fct.2025.115472_bib44", "volume": "44", "year": "2012" }, { "DOI": "10.1111/ced.14953", "article-title": "'Favipiravir-induced cutaneous adverse reactions in patients infected with COVID-19'", "author": "Punyaratabandhu", "doi-asserted-by": "crossref", "first-page": "573", "journal-title": "Clin. Exp. Dermatol.", "key": "10.1016/j.fct.2025.115472_bib45", "volume": "47", "year": "2022" }, { "DOI": "10.1517/17425255.3.4.519", "article-title": "'Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury'", "author": "Ramaiah", "doi-asserted-by": "crossref", "first-page": "519", "journal-title": "Expet Opin. Drug Metabol. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib46", "volume": "3", "year": "2007" }, { "DOI": "10.1016/j.bbrc.2012.07.034", "article-title": "'Favipiravir (T-705) inhibits in vitro norovirus replication'", "author": "Rocha-Pereira", "doi-asserted-by": "crossref", "first-page": "777", "journal-title": "Biochem. Biophys. Res. Commun.", "key": "10.1016/j.fct.2025.115472_bib47", "volume": "424", "year": "2012" }, { "DOI": "10.1007/s00134-020-05991-x", "article-title": "Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China", "author": "Ruan", "doi-asserted-by": "crossref", "first-page": "846", "journal-title": "Intensive Care Med.", "key": "10.1016/j.fct.2025.115472_bib48", "volume": "46", "year": "2020" }, { "DOI": "10.1016/S0046-8177(80)80026-8", "article-title": "Iatrogenic hepatic injury", "author": "Rubin", "doi-asserted-by": "crossref", "first-page": "312", "journal-title": "Hum. Pathol.", "key": "10.1016/j.fct.2025.115472_bib49", "volume": "11", "year": "1980" }, { "DOI": "10.1002/jcp.26429", "article-title": "'Macrophage plasticity, polarization, and function in health and disease'", "author": "Shapouri-Moghaddam", "doi-asserted-by": "crossref", "first-page": "6425", "journal-title": "J. Cell. Physiol.", "key": "10.1016/j.fct.2025.115472_bib50", "volume": "233", "year": "2018" }, { "DOI": "10.1128/AAC.01051-06", "article-title": "Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice", "author": "Sidwell", "doi-asserted-by": "crossref", "first-page": "845", "journal-title": "Antimicrob. Agents Chemother.", "key": "10.1016/j.fct.2025.115472_bib51", "volume": "51", "year": "2007" }, { "DOI": "10.1556/650.2022.32455", "article-title": "[Sinus bradycardia as a potential side effect of favipiravir treatment]", "author": "Szigeti", "doi-asserted-by": "crossref", "first-page": "267", "journal-title": "Orv. Hetil.", "key": "10.1016/j.fct.2025.115472_bib52", "volume": "163", "year": "2022" }, { "DOI": "10.1016/j.ejogrb.2021.12.001", "article-title": "'Favipiravir exposure and pregnancy outcome of COVID-19 patients'", "author": "Tırmıkçıoğlu", "doi-asserted-by": "crossref", "first-page": "110", "journal-title": "Eur. J. Obstet. Gynecol. Reprod. Biol.", "key": "10.1016/j.fct.2025.115472_bib53", "volume": "268", "year": "2022" }, { "DOI": "10.1179/acb.2001.051", "article-title": "'Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature'", "author": "Tjwa", "doi-asserted-by": "crossref", "first-page": "341", "journal-title": "Acta Clin. Belg.", "key": "10.1016/j.fct.2025.115472_bib54", "volume": "56", "year": "2001" }, { "DOI": "10.1016/j.ijid.2020.11.142", "article-title": "'Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: a randomized, comparative, open-label, multicenter, phase 3 clinical trial'", "author": "Udwadia", "doi-asserted-by": "crossref", "first-page": "62", "journal-title": "Int. J. Infect. Dis.", "key": "10.1016/j.fct.2025.115472_bib55", "volume": "103", "year": "2021" }, { "DOI": "10.1016/j.jchemneu.2021.101958", "article-title": "The effect of erythropoietin and umbilical cord-derived mesenchymal stem cells on nerve regeneration in rats with sciatic nerve injury", "author": "Ülger", "doi-asserted-by": "crossref", "journal-title": "J. Chem. Neuroanat.", "key": "10.1016/j.fct.2025.115472_bib56", "volume": "114", "year": "2021" }, { "DOI": "10.1016/j.fct.2025.115235", "article-title": "Evaluation of the effects of favipiravir (T-705) on the lung tissue of healty rats: an experimental study", "author": "Ülger", "doi-asserted-by": "crossref", "journal-title": "Food Chem. Toxicol.", "key": "10.1016/j.fct.2025.115472_bib57", "volume": "196", "year": "2025" }, { "DOI": "10.1038/s41422-020-0282-0", "article-title": "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "269", "journal-title": "Cell Res.", "key": "10.1016/j.fct.2025.115472_bib58", "volume": "30", "year": "2020" }, { "DOI": "10.2174/1389200218666171108154419", "article-title": "Drug-Induced nephrotoxicity: pathogenic mechanisms, biomarkers and prevention strategies", "author": "Wu", "doi-asserted-by": "crossref", "first-page": "559", "journal-title": "Curr. Drug Metabol.", "key": "10.1016/j.fct.2025.115472_bib60", "volume": "19", "year": "2018" }, { "DOI": "10.1016/j.jiac.2020.12.021", "article-title": "Suspected cholestatic liver injury induced by favipiravir in a patient with COVID-19", "author": "Yamazaki", "doi-asserted-by": "crossref", "first-page": "390", "journal-title": "J. Infect. Chemother.", "key": "10.1016/j.fct.2025.115472_bib61", "volume": "27", "year": "2021" }, { "DOI": "10.1016/j.intimp.2021.107702", "article-title": "Favipiravir in the treatment of patients with SARS-CoV-2 RNA recurrent positive after discharge: a multicenter, open-label, randomized trial", "author": "Zhao", "doi-asserted-by": "crossref", "journal-title": "Int. Immunopharmacol.", "key": "10.1016/j.fct.2025.115472_bib62", "volume": "97", "year": "2021" } ], "reference-count": 61, "references-count": 61, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0278691525002406" } }, "score": 1, "short-title": [], "source": "Crossref", "special_numbering": "C", "subject": [], "subtitle": [], "title": "Experimental evaluation of favipiravir (T-705)-induced liver and kidney toxicity in rats", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "volume": "202" }