Clinical Features and Prognosis of Acute Kidney Injury in Hospital-Admitted Patients with COVID-19 in Egypt: A Single-Center Experience
Hoda M M Abdulaziz, Aya Ahmed Mohamed Elsayed, Elshahat A Yousef
Mansoura Medical Journal, doi:10.58775/2735-3990.1433
Background: While coronavirus disease 2019 primarily manifests clinically as a respiratory disease, it can also impact other organs, such as the kidneys. Acute kidney injury (AKI) is frequently seen in hospital-admitted patients with COVID-19 and is linked to poorer outcomes. This research sought to explore the rate, contributing elements, and consequences of AKI in individuals with COVID-19. Patients and methods: Data from 236 COVID-19-infected patients hospitalized in isolation wards and ICUs between September 2020 and February 2021 were analyzed. Comparisons between patients with and without AKI were done using statistical tests as appropriate. Binary logistic regression analyses were performed at the univariable and multivariable levels to identify the risk factors for AKI. Survival data based on AKI status was analyzed using the KaplaneMeier curve. Results: Overall, 81 (34.3 %) of the 236 participants developed AKI during hospitalization. Hospitalized COVID-19 individuals with age more than 64 years, those who received Favipiravir or vasopressors, and those with pH less than or equal to 7.4, HCO3 less than or equal to 19.2, and blood glucose more than 212 mg/dl have 2.4, 2.5, 2.4, 3.4, 3.2, and 2.9times higher odds to exhibit AKI. A significantly lower survival probability was found in individuals with AKI than in non-AKI [log-rank c 2 (2) ¼ 41.187, P < 0.001]. A shorter median survival time for patients with AKI compared with those without was also noticed [8 days (95 % confidence interval: 7.132e8.868) vs. 12 days (95 % confidence interval: 10.910e13.090)]. Conclusion: AKI is not uncommonly encountered in patients with COVID-19 in the course of their hospitalization and is linked to increased mortality.
Ethics information The Mansoura Faculty of Medicine Institutional Research Board (MFM-IRB) (code MS.22.08.2103)
Conflicts of interest There are no conflicts of interest.
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