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Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture
Bansal et al., PLoS ONE, doi:10.1371/journal.pone.0259943 (date from earlier preprint) (In Vitro)
Bansal et al., Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture, PLoS ONE, doi:10.1371/journal.pone.0259943 (date from earlier preprint) (In Vitro)
Aug 2020   Source   PDF  
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In Vitro study showing that iota-carrageenan in concentrations as low as 6 µg/mL (easily achievable with existing nasal sprays) inhibits SARS-CoV-2 in Vero cell cultures.
9 In Vitro studies support the efficacy of iota-carrageenan [Alsaidi, Bansal, Bovard, Fröba, Meister, Morokutti-Kurz, Morokutti-Kurz (B), Song, Varese].
Bansal et al., 21 Aug 2020, peer-reviewed, 7 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Abstract: PLOS ONE RESEARCH ARTICLE Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture Shruti Bansal1☯, Colleen B. Jonsson2☯, Shannon L. Taylor3☯, Juan Manuel Figueroa4☯, Andrea Vanesa Dugour ID4☯, Carlos Palacios ID4☯, Julio César Vega ID5* a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 1 Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 2 Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 3 LogixBio, Holly Springs, North Carolina, United States of America, 4 Respiratory Research Group, Instituto de Ciencia y Tecnologı́a Dr. César Milstein—(Consejo Nacional de Investigaciones Cientı́ficas y Técnicas CONICETFundación Pablo Cassará), Ciudad de Buenos Aires, Argentina, 5 Department of Research and Development, Amcyte Pharma Inc., Cambridge, Massachusetts, United States of America ☯ These authors contributed equally to this work. * julio.vega@amcytepharma.com Abstract OPEN ACCESS Citation: Bansal S, Jonsson CB, Taylor SL, Figueroa JM, Dugour AV, Palacios C, et al. (2021) Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture. PLoS ONE 16(11): e0259943. https://doi.org/10.1371/journal.pone.0259943 Editor: Stephen J. Polyak, University of Washington, UNITED STATES Received: July 18, 2020 Accepted: November 1, 2021 Published: November 19, 2021 Copyright: © 2021 Bansal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the manuscript and in the supporting information. Funding: Amcyte Pharma Inc. funded the study and decided to publish it, but did not have any additional role in the study design or, data collection. JCV has a commercial affiliation to Amcyte Pharma Inc and has contributed to data analysis and preparation of the manuscript. Samples for this study were prepared by personnel from Laboratorio Pablo Cassará S.R.L. JCV receives a salary from Laboratorio Pablo Cassará Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment for this disease. Since the nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2, a nasal spray may be an effective option to target SARS-CoV-2 infection. In this study, we tested the antiviral action of three candidate nasal spray formulations against SARS-CoV-2 in vitro. We determined that iotacarrageenan in concentrations as low as 6 μg/mL inhibits SARS-CoV-2 in vitro. The concentrations of iota-carrageenan with activity against SARS-CoV-2 in vitro may be easily achieved through the application of nasal sprays as commonly used in several countries. Recently a double-blind, placebo-controlled study showed that iota-carrageenan in isotonic sodium chloride reduces ca. five times the risk of infection by SARS-CoV-2 in health care personnel. Further, xylitol at a concentration of 50 mg/mL (ca. 329 mM) was found to exert some antiviral action, though this preliminary finding..
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