Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2
et al., Food & Function, doi:10.1039/D0FO02017F, Aug 2020
In vitro study showing significant antiviral activity of marine sulfated polysaccharides iota-carrageenan, sea cucumber sulfated polysaccharide, and fucoidan.
18 preclinical studies support the efficacy of iota-carrageenan for COVID-19:
1.
Krylova et al., Carrageenans and the Carrageenan-Echinochrome Complex as Anti-SARS-CoV-2 Agents, International Journal of Molecular Sciences, doi:10.3390/ijms26136175.
2.
Rohilla et al., Algae Polysaccharides (Carrageenan and Alginate)—A Treasure-Trove of Antiviral Compounds: An In Silico Approach to Identify Potential Candidates for Inhibition of S1-RBD Spike Protein of SARS-CoV-2, Stresses, doi:10.3390/stresses3030039.
3.
Thet, H., The potential of carrageenan for the drug discovery of COVID-19 via molecular docking with angiotensin-converting enzyme 2 (ACE2) and the main protease (Mpro) of SARS-CoV-2, Journal of Bioinformatics and Genomics, doi:10.18454/jbg.2022.18.2.001.
4.
Alsaidi et al., Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model, Marine Drugs, doi:10.3390/md19080418.
5.
Sattari et al., Repositioning Therapeutics for COVID-19: Virtual Screening of the Potent Synthetic and Natural Compounds as SARS-CoV-2 3CLpro Inhibitors, Research Square, doi:10.21203/rs.3.rs-37994/v1.
6.
Hoffmann et al., Controlling the Sulfation Density of Glycosaminoglycan Glycopolymer Mimetics Enables High Antiviral Activity against SARS-CoV-2 and Reduces Anticoagulant Activity, Biomacromolecules, doi:10.1021/acs.biomac.5c00576.
7.
Yathindranath et al., Lipid Nanoparticle-Based Inhibitors for SARS-CoV-2 Host Cell Infection, International Journal of Nanomedicine, doi:10.2147/IJN.S448005.
8.
Setz et al., Iota-Carrageenan Inhibits Replication of the SARS-CoV-2 Variants of Concern Omicron BA.1, BA.2 and BA.5, Nutraceuticals, doi:10.3390/nutraceuticals3030025.
9.
Meister et al., Virucidal activity of nasal sprays against severe acute respiratory syndrome coronavirus-2, Journal of Hospital Infection, doi:10.1016/j.jhin.2021.10.019.
10.
Bovard et al., Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia, Biochemistry and Biophysics Reports, doi:10.1016/j.bbrep.2021.101187.
11.
Fröba et al., Iota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and Delta, International Journal of Molecular Sciences, doi:10.3390/ijms222413202.
12.
Varese et al., Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model, bioRxiv, doi:10.1101/2021.04.27.441512.
13.
Morokutti-Kurz et al., Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro, PLoS ONE, doi:10.1371/journal.pone.0237480.
14.
Song et al., Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2, Food & Function, doi:10.1039/D0FO02017F.
Song et al., 24 Aug 2020, peer-reviewed, 10 authors.
In vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: Food &
Function
View Article Online
View Journal
Linking the chemistry and physics of food with health and nutrition
Accepted Manuscript
This article can be cited before page numbers have been issued, to do this please use: S. Song, H. Peng,
Q. Wang, Z. Liu, X. Dong, C. Wen, C. Ai, Y. Zhang, Z. Wang and B. Zhu, Food Funct., 2020, DOI:
10.1039/D0FO02017F.
Food &
Function
Linking the chemistry and physics of food with health and nutrition
rsc.li/food-function
Volume 9
Number 1
January 2018
Pages 1-658
This is an Accepted Manuscript, which has been through the
Royal Society of Chemistry peer review process and has been
accepted for publication.
Accepted Manuscripts are published online shortly after acceptance,
before technical editing, formatting and proof reading. Using this free
service, authors can make their results available to the community, in
citable form, before we publish the edited article. We will replace this
Accepted Manuscript with the edited and formatted Advance Article as
soon as it is available.
You can find more information about Accepted Manuscripts in the
Information for Authors.
ISSN 2042-650X
PAPER
Xian Wu, Hang Xiao et al.
A metabolite of nobiletin, 4' -demethylnobiletin and
atorvastatin synergistically inhibits human colon cancer cell
growth by inducing G0/G1 cell cycle arrest and apoptosis
Please note that technical editing may introduce minor changes to the
text and/or graphics, which may alter content. The journal’s standard
Terms & Conditions and the Ethical guidelines still apply. In no event
shall the Royal Society of Chemistry be held responsible for any errors
or omissions in this Accepted Manuscript or any consequences arising
from the use of any information it contains.
rsc.li/food-function
Food & Function
Page 1 of 17
Inhibitory activities of marine sulfated polysaccharides against
View Article Online
DOI: 10.1039/D0FO02017F
SARS-CoV-2
Chengrong Wen1, Chunqing Ai1, Yujiao Zhang1, Zhongfu Wang5, Beiwei Zhu1,*
Published on 24 August 2020.
1National
Engineering Research Center of Seafood, School of Food Science and Technology,
Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University,
Dalian 116034, China
2
Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University
(Second Military Medical University), Shanghai 200433, China
3
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology,
Chinese Academy of Sciences, Beijing 100101, China
4
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food
Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China
5 Key
Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education
and Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University,
Xi’an 710069, China
Food & Function Accepted Manuscript
Shuang Song1, Haoran Peng2, Qingling Wang3, Zhengqi Liu1,4, Xiuping Dong1,
Food & Function
Page 2 of 17
View Article Online
DOI: 10.1039/D0FO02017F
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an
unprecedented rate. In the present study, 4 marine sulfated polysaccharides were
screened for their inhibitory activity against SARS-CoV-2, including sea cucumber
red algae, and chondroitin sulfate C from..
DOI record:
{
"DOI": "10.1039/d0fo02017f",
"ISSN": [
"2042-6496",
"2042-650X"
],
"URL": "http://dx.doi.org/10.1039/D0FO02017F",
"abstract": "<p>Sulfated polysaccharide from sea cucumber (SCSP), fucoidan from brown algae, and iota-carrageenan from red algae show inhibitory activities against SARS-CoV-2.</p>",
"assertion": [
{
"explanation": {
"URL": "https://www.crossref.org/services/similarity-check/"
},
"group": {
"label": "SIMILARITY CHECK",
"name": "similarity_check"
},
"name": "similarity_check",
"value": "This document is Similarity Check deposited"
},
{
"URL": "http://orcid.org/0000-0001-9718-8254",
"group": {
"label": "IDENTIFIERS",
"name": "author_identifiers"
},
"name": "identifier",
"value": "Shuang Song (ORCID)"
},
{
"URL": "http://orcid.org/0000-0003-2172-3198",
"group": {
"label": "IDENTIFIERS",
"name": "author_identifiers"
},
"name": "identifier",
"value": "Chunqing Ai (ORCID)"
},
{
"URL": "http://orcid.org/0000-0003-1616-5056",
"group": {
"label": "IDENTIFIERS",
"name": "author_identifiers"
},
"name": "identifier",
"value": "Zhongfu Wang (ORCID)"
},
{
"URL": "http://orcid.org/0000-0003-4674-2993",
"group": {
"label": "IDENTIFIERS",
"name": "author_identifiers"
},
"name": "identifier",
"value": "Beiwei Zhu (ORCID)"
},
{
"group": {
"label": "PEER REVIEW METHOD",
"name": "peer_review_method"
},
"name": "peer_review_method",
"order": 2,
"value": "Single-blind"
},
{
"group": {
"label": "PUBLICATION HISTORY",
"name": "publication_history"
},
"name": "history",
"order": 1,
"value": "Received 1 August 2020; Accepted 24 August 2020; Accepted Manuscript published 24 August 2020; Advance Article published 2 September 2020; Version of Record published 23 September 2020"
}
],
"author": [
{
"ORCID": "http://orcid.org/0000-0001-9718-8254",
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"authenticated-orcid": false,
"family": "Song",
"given": "Shuang",
"sequence": "first"
},
{
"affiliation": [
{
"name": "Department of Biomedical Defense"
},
{
"name": "Faculty of Naval Medicine"
},
{
"name": "Naval Medical University (Second Military Medical University)"
},
{
"name": "Shanghai 200433"
},
{
"name": "China"
}
],
"family": "Peng",
"given": "Haoran",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "CAS Key Laboratory of Pathogenic Microbiology and Immunology"
},
{
"name": "Institute of Microbiology"
},
{
"name": "Chinese Academy of Sciences"
},
{
"name": "Beijing 100101"
},
{
"name": "China"
}
],
"family": "Wang",
"given": "Qingling",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"family": "Liu",
"given": "Zhengqi",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"family": "Dong",
"given": "Xiuping",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"family": "Wen",
"given": "Chengrong",
"sequence": "additional"
},
{
"ORCID": "http://orcid.org/0000-0003-2172-3198",
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"authenticated-orcid": false,
"family": "Ai",
"given": "Chunqing",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"family": "Zhang",
"given": "Yujiao",
"sequence": "additional"
},
{
"ORCID": "http://orcid.org/0000-0003-1616-5056",
"affiliation": [
{
"name": "Key Laboratory of Resource Biology and Biotechnology in Western China"
},
{
"name": "Ministry of Education and Provincial Key Laboratory of Biotechnology"
},
{
"name": "College of Life Sciences"
},
{
"name": "Northwest University"
},
{
"name": "Xi'an 710069"
}
],
"authenticated-orcid": false,
"family": "Wang",
"given": "Zhongfu",
"sequence": "additional"
},
{
"ORCID": "http://orcid.org/0000-0003-4674-2993",
"affiliation": [
{
"name": "National Engineering Research Center of Seafood"
},
{
"name": "School of Food Science and Technology"
},
{
"name": "Collaborative Innovation Center of Seafood Deep Processing"
},
{
"name": "Dalian Polytechnic University"
},
{
"name": "Dalian 116034"
}
],
"authenticated-orcid": false,
"family": "Zhu",
"given": "Beiwei",
"sequence": "additional"
}
],
"container-title": "Food & Function",
"container-title-short": "Food Funct.",
"content-domain": {
"crossmark-restriction": true,
"domain": [
"rsc.org"
]
},
"created": {
"date-parts": [
[
2020,
8,
24
]
],
"date-time": "2020-08-24T15:25:27Z",
"timestamp": 1598282727000
},
"deposited": {
"date-parts": [
[
2020,
9,
23
]
],
"date-time": "2020-09-23T19:59:16Z",
"timestamp": 1600891156000
},
"funder": [
{
"DOI": "10.13039/501100012166",
"award": [
"2019YFD0902005"
],
"doi-asserted-by": "publisher",
"name": "National Basic Research Program of China"
},
{
"DOI": "10.13039/501100001809",
"award": [
"31972084"
],
"doi-asserted-by": "publisher",
"name": "National Natural Science Foundation of China"
}
],
"indexed": {
"date-parts": [
[
2023,
12,
25
]
],
"date-time": "2023-12-25T11:17:01Z",
"timestamp": 1703503021043
},
"is-referenced-by-count": 130,
"issue": "9",
"issued": {
"date-parts": [
[
2020
]
]
},
"journal-issue": {
"issue": "9",
"published-print": {
"date-parts": [
[
2020,
9,
23
]
]
}
},
"language": "en",
"license": [
{
"URL": "http://rsc.li/journals-terms-of-use",
"content-version": "am",
"delay-in-days": 601,
"start": {
"date-parts": [
[
2021,
8,
24
]
],
"date-time": "2021-08-24T00:00:00Z",
"timestamp": 1629763200000
}
}
],
"link": [
{
"URL": "http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO02017F",
"content-type": "unspecified",
"content-version": "vor",
"intended-application": "similarity-checking"
}
],
"member": "292",
"original-title": [],
"page": "7415-7420",
"prefix": "10.1039",
"published": {
"date-parts": [
[
2020
]
]
},
"published-online": {
"date-parts": [
[
2020
]
]
},
"publisher": "Royal Society of Chemistry (RSC)",
"reference": [
{
"DOI": "10.1016/j.carres.2013.07.010",
"author": "Huang",
"doi-asserted-by": "crossref",
"first-page": "64",
"journal-title": "Carbohydr. Res.",
"key": "D0FO02017F-(cit1)/*[position()=1]",
"volume": "380",
"year": "2013"
},
{
"DOI": "10.1089/aid.2012.0156",
"author": "Jinno-Oue",
"doi-asserted-by": "crossref",
"first-page": "621",
"journal-title": "AIDS Res. Hum. Retroviruses",
"key": "D0FO02017F-(cit2)/*[position()=1]",
"volume": "29",
"year": "2013"
},
{
"DOI": "10.1016/j.antiviral.2010.09.002",
"author": "Kato",
"doi-asserted-by": "crossref",
"first-page": "236",
"journal-title": "Antiviral Res.",
"key": "D0FO02017F-(cit3)/*[position()=1]",
"volume": "88",
"year": "2010"
},
{
"DOI": "10.1371/journal.ppat.0020069",
"author": "Buck",
"doi-asserted-by": "crossref",
"first-page": "e69",
"journal-title": "PLoS Pathog.",
"key": "D0FO02017F-(cit4)/*[position()=1]",
"volume": "2",
"year": "2006"
},
{
"DOI": "10.1371/journal.pone.0014320",
"author": "Leibbrandt",
"doi-asserted-by": "crossref",
"first-page": "e14320",
"journal-title": "PLoS One",
"key": "D0FO02017F-(cit5)/*[position()=1]",
"volume": "5",
"year": "2010"
},
{
"DOI": "10.1016/j.lfs.2020.118056",
"author": "Sternberg",
"doi-asserted-by": "crossref",
"first-page": "118056",
"journal-title": "Life Sci.",
"key": "D0FO02017F-(cit6)/*[position()=1]",
"year": "2020"
},
{
"DOI": "10.1016/j.antiviral.2020.104873",
"author": "Kim",
"doi-asserted-by": "crossref",
"first-page": "104873",
"journal-title": "Antiviral Res.",
"key": "D0FO02017F-(cit7)/*[position()=1]",
"year": "2020"
},
{
"author": "Ayerbe",
"first-page": "1",
"journal-title": "J. Thromb. Thrombolysis",
"key": "D0FO02017F-(cit8)/*[position()=1]",
"year": "2020"
},
{
"DOI": "10.1109/TDEI.2018.007508",
"author": "Dunne",
"doi-asserted-by": "crossref",
"first-page": "229",
"journal-title": "IEEE Trans. Dielectr. Electr. Insul.",
"key": "D0FO02017F-(cit9)/*[position()=1]",
"volume": "26",
"year": "2019"
},
{
"DOI": "10.1002/mnfr.201800446",
"author": "Zhu",
"doi-asserted-by": "crossref",
"first-page": "1800446",
"journal-title": "Mol. Nutr. Food Res.",
"key": "D0FO02017F-(cit10)/*[position()=1]",
"volume": "62",
"year": "2018"
},
{
"DOI": "10.1016/j.ijbiomac.2018.08.098",
"author": "Zhu",
"doi-asserted-by": "crossref",
"first-page": "502",
"journal-title": "Int. J. Biol. Macromol.",
"key": "D0FO02017F-(cit11)/*[position()=1]",
"volume": "120",
"year": "2018"
},
{
"DOI": "10.1016/j.carbpol.2017.12.071",
"author": "Usoltseva",
"doi-asserted-by": "crossref",
"first-page": "260",
"journal-title": "Carbohydr. Polym.",
"key": "D0FO02017F-(cit12)/*[position()=1]",
"volume": "184",
"year": "2018"
},
{
"DOI": "10.3390/md9020196",
"author": "Jiao",
"doi-asserted-by": "crossref",
"first-page": "196",
"journal-title": "Mar. Drugs",
"key": "D0FO02017F-(cit13)/*[position()=1]",
"volume": "9",
"year": "2011"
},
{
"DOI": "10.1016/j.carres.2015.07.009",
"author": "Wang",
"doi-asserted-by": "crossref",
"first-page": "48",
"journal-title": "Carbohydr. Res.",
"key": "D0FO02017F-(cit14)/*[position()=1]",
"volume": "415",
"year": "2015"
},
{
"author": "Sun",
"first-page": "1",
"journal-title": "Emerging Microbes Infect.",
"key": "D0FO02017F-(cit15)/*[position()=1]",
"year": "2020"
},
{
"DOI": "10.1021/acs.jafc.9b00970",
"author": "Gao",
"doi-asserted-by": "crossref",
"first-page": "7496",
"journal-title": "J. Agric. Food Chem.",
"key": "D0FO02017F-(cit16)/*[position()=1]",
"volume": "67",
"year": "2019"
},
{
"DOI": "10.1016/j.bbagen.2013.06.006",
"author": "Mikami",
"doi-asserted-by": "crossref",
"first-page": "4719",
"journal-title": "Biochim. Biophys. Acta",
"key": "D0FO02017F-(cit17)/*[position()=1]",
"volume": "1830",
"year": "2013"
},
{
"DOI": "10.17221/6758-VETMED",
"author": "Necas",
"doi-asserted-by": "crossref",
"first-page": "187",
"journal-title": "Veter. Med.",
"key": "D0FO02017F-(cit18)/*[position()=1]",
"volume": "58",
"year": "2013"
},
{
"DOI": "10.1038/s41421-020-00192-8",
"author": "Kwon",
"doi-asserted-by": "crossref",
"first-page": "50",
"journal-title": "Cell Discovery",
"key": "D0FO02017F-(cit19)/*[position()=1]",
"volume": "6",
"year": "2020"
},
{
"DOI": "10.1021/jm000412i",
"author": "Marks",
"doi-asserted-by": "crossref",
"first-page": "2178",
"journal-title": "J. Med. Chem.",
"key": "D0FO02017F-(cit20)/*[position()=1]",
"volume": "44",
"year": "2001"
},
{
"DOI": "10.1080/22221751.2020.1719902",
"author": "Chan",
"doi-asserted-by": "crossref",
"first-page": "221",
"journal-title": "Emerging Microbes Infect.",
"key": "D0FO02017F-(cit21)/*[position()=1]",
"volume": "9",
"year": "2020"
}
],
"reference-count": 21,
"references-count": 21,
"relation": {},
"resource": {
"primary": {
"URL": "http://xlink.rsc.org/?DOI=D0FO02017F"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [
"General Medicine",
"Food Science"
],
"subtitle": [],
"title": "Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2",
"type": "journal-article",
"update-policy": "http://dx.doi.org/10.1039/rsc_crossmark_policy",
"volume": "11"
}