Virucidal activity of nasal sprays against severe acute respiratory syndrome coronavirus-2
T L Meister, D Todt, Y Brüggemann, J Steinmann, S Banava, F H H Brill, J Steinmann, S Pfaender, E Steinmann
Journal of Hospital Infection, doi:10.1016/j.jhin.2021.10.019
The highest viral loads of severe acute respiratory syndrome coronavirus-2 are detectable in the oral cavity, so a potential reduction of infectious virus by nasal and oral sprays could reduce transmission. Therefore, the inactivation capacity of nine nasal and oral sprays was evaluated according to EN 14476. One nasal spray based on sodium hypochlorite and one oral spray containing essential oils reduced viral titres by two to three orders of magnitude. Although clinical data are still sparse, nasal and oral sprays display a more convenient application for elderly people or those who are unable to rinse/gargle.
References
Fazekas, Eickhoff, Pruckner, Vollnhofer, Fischmeister et al., Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold, BMC Complement Altern Med
Herrera, Serrano, Rolda ´n, Sanz, Is the oral cavity relevant in SARS-CoV-2 pandemic?, Clin Oral Investig
Kramer, Eggers, Hu ¨bner N-O, Walger, Steinmann et al., Virucidal gargling and virucidal nasal spray, GMS Hyg Infect Control
Meister, Bru ¨ggemann, Todt, Conzelmann, Mu ¨ller et al., Virucidal efficacy of different oral rinses against severe acute respiratory syndrome coronavirus 2, J Infect Dis
Meister, Fortmann, Todt, Heinen, Ludwig et al., Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351, J Infect Dis,
doi:10.1093/infdis/jiab260Morokutti-Kurz, ¨ba, Graf, Große, Grassauer et al., Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro, PLoS One
O'donnell, Thomas, Stanton, Maillard, Murphy et al., Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection, Function
Sanekata, Fukuda, Miura, Morino, Lee et al., Evaluation of the antiviral activity of chlorine dioxide and sodium hypochlorite against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus, Biocontrol Sci
Schu ¨tz, Conzelmann, Fois, Groß, Weil et al., Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures, Am J Physiol Lung Cell Mol Physiol
