Association between Average Vitamin D Levels and COVID-19 Mortality in 19 European Countries—A Population-Based Study
Amar S Ahmad, Nirmin F Juber, Heba Al-Naseri, Christian Heumann, Raghib Ali, Tim Oliver
Nutrients, doi:10.3390/nu15224818
Early epidemic reports have linked low average 25(OH) vitamin D levels with increased COVID-19 mortality. However, there has been limited updated research on 25(OH) vitamin D and its impact on COVID-19 mortality. This study aimed to update the initial report studying the link between vitamin D deficiency and COVID-19 mortality by using multi-country data in 19 European countries up to the middle of June 2023. COVID-19 data for 19 European countries included in this study were
Conflicts of Interest: The authors declare no conflict of interest.
References
Annweiler, Corvaisier, Gautier, Dubée, Legrand et al., Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: The GERIA-COVID quasi-experimental study, Nutrients,
doi:10.3390/nu12113377
Bakaloudi, Chourdakis, A critical update on the role of mild and serious vitamin D deficiency prevalence and the COVID-19 epidemic in Europe, Nutrition,
doi:10.1016/j.nut.2021.111441
Basi Ńska-Lewandowska, Lewandowski, Horzelski, Lewi Ński, Skowro Ńska-Jóźwiak, Frequency of COVID-19 infection as a function of vitamin D levels, Nutrients,
doi:10.3390/nu15071581
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet,
doi:10.1016/S0140-6736(20)30211-7
Core, R: A Language and Environment for Statistical Computing
Demir, Demir, Aygun, Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease, J. Med. Virol,
doi:10.1002/jmv.26832
Dyer, COVID-19: Excess deaths point to hidden toll in South Africa as cases surge, BMJ,
doi:10.1136/bmj.m3038
Fang, Kasperzyk, Shui, Hendrickson, Hollis et al., Prediagnostic plasma vitamin D metabolites and mortality among patients with prostate cancer, PLoS ONE,
doi:10.1371/journal.pone.0018625
Farhadi, Ovchinnikov, The relationship between nutrition and infectious diseases: A review, Biomed. Biotechnol. Res. J
Gerken, Zapata, Kuivinen, Zapata, Comorbidities, sociodemographic factors, and determinants of health on COVID-19 fatalities in the United States, Front. Public Health,
doi:10.3389/fpubh.2022.993662
Gonçalves, Andrade-Silva, Basso, Câmara, Vitamin D and chronic kidney disease: Insights on lipid metabolism of tubular epithelial cell and macrophages in tubulointerstitial fibrosis, Front. Physiol,
doi:10.3389/fphys.2023.1145233
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients,
doi:10.3390/nu12040988
Gröber, Kisters, Influence of drugs on vitamin D and calcium metabolism, Derm. Endocrinol,
doi:10.4161/derm.20731
Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab. Syndr,
doi:10.1016/j.dsx.2020.04.050
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin. Exp. Res,
doi:10.1007/s40520-020-01570-8
Jayawardena, Jeyakumar, Francis, Misra, Impact of the vitamin D deficiency on COVID-19 infection and mortality in Asian countries, Diabetes Metab. Syndr. Clin. Res. Rev,
doi:10.1016/j.dsx.2021.03.006
Jolliffe, Camargo, Sluyter, Aglipay, Aloia et al., Vitamin D supplementation to prevent acute respiratory infections: Systematic review and meta-analysis of aggregate data from randomised controlled trials, medRxiv,
doi:10.1016/S2213-8587(21)00051-6
Jääskeläinen, Itkonen, Lundqvist, Erkkola, Koskela et al., The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: Evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data, Am. J. Clin. Nutr,
doi:10.3945/ajcn.116.151415
Karahan, Katkat, Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey, J. Nutr. Health Aging,
doi:10.1007/s12603-020-1479-0
Kümmel, Krumbein, Fragkou, Hünerbein, Reiter et al., Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials, Front. Immunol,
doi:10.3389/fimmu.2022.1023903
Li, Guan, Wu, Wang, Zhou et al., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia, N. Engl. J. Med,
doi:10.1056/NEJMoa2001316
Lim, Subramaniam, Reddy, Blecher, Kadam et al., Case fatality rates for patients with COVID-19 requiring invasive mechanical ventilation. a meta-analysis, Am. J. Respir. Crit. Care Med,
doi:10.1164/rccm.202006-2405OC
Lips, Cashman, Lamberg-Allardt, Bischoff-Ferrari, Obermayer-Pietsch et al., Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society, Eur. J. Endocrinol,
doi:10.1530/EJE-18-0736
Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE,
doi:10.1371/journal.pone.0239799
Mariani, Antonietti, Tajer, Ferder, Inserra et al., High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: Multicentre randomized controlled clinical trial, PLoS ONE,
doi:10.1371/journal.pone.0267918
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data, BMJ,
doi:10.1136/bmj.i6583
Mathieu, Ritchie, Rodés-Guirao, Appel, Giattino et al., Coronavirus Pandemic (COVID-19): Our World Data
Mckenna, Lyons, Flynn, Crowley, Twomey et al., COVID-19 pandemic and vitamin D: Rising trends in status and in daily amounts of vitamin D provided by supplements, BMJ Open,
doi:10.1136/bmjopen-2021-059477
Mele, Magazzino, Pollution, economic growth, and COVID-19 deaths in India: A machine learning evidence, Environ. Sci. Pollut. Res. Int,
doi:10.1007/s11356-020-10689-0
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2020.19722
Moghaddam, Khorasanchi, Noor, Moghadam, Esfahani et al., High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial, J. Health Popul. Nutr,
doi:10.1186/s41043-023-00409-y
Nikniaz, Akbarzadeh, Hosseinifard, Hosseini, Vitamin D supplementation on mortality rate and clinical outcomes of COVID-19 patients: A systematic review and meta-analysis, medRxiv,
doi:10.34172/PS.2021.13
Okonji, Okonji, Mukumbang, Van Wyk, Understanding varying COVID-19 mortality rates reported in Africa compared to Europe, Americas and Asia, Trop. Med. Int. Health,
doi:10.1111/tmi.13575
Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clin. Endocrinol
Pechlivanidou, Vlachakis, Tsarouhas, Panidis, Tsitsimpikou et al., The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review, Food Chem. Toxicol,
doi:10.1016/j.fct.2022.112901
Pereira, Dantas Damascena, Galvao Azevedo, De Almeida Oliveira, Da Mota Santana, Vitamin D deficiency aggravates COVID-19: Systematic review and meta-analysis, Crit. Rev. Food Sci. Nutr,
doi:10.1080/10408398.2020.1841090
Pham, Analyzing the relationship between the vitamin D deficiency and COVID-19 mortality rate and modeling the time-delay interactions between body's immune healthy cells, infected cells, and virus particles with the effect of vitamin D levels, Math. Biosci. Eng,
doi:10.3934/mbe.2022417
Pilz, Frisch, Koertke, Kuhn, Dreier et al., Effect of vitamin D supplementation on testosterone levels in men, Horm. Metab. Res,
doi:10.1055/s-0030-1269854
Pugach, Pugach, Strong correlation between prevalence of severe vitamin D deficiency and population mortality rate from COVID-19 in Europe, Wien. Klin. Wochenschr,
doi:10.1007/s00508-021-01833-y
Radujkovic, Merle, Reply to: Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act
Singh, Kaur, Singh, Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak, Aging Clin. Exp. Res,
doi:10.1007/s40520-020-01619-8
Spiro, Buttriss, Vitamin, An overview of vitamin D status and intake in Europe, Nutr. Bull,
doi:10.1111/nbu.12108
Strang, Furst, Schultz, Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region, Upsala J. Med. Sci,
doi:10.1080/03009734.2020.1828513
Sulli, Gotelli, Casabella, Paolino, Pizzorni et al., Vitamin D and lung outcomes in elderly COVID-19 patients, Nutrients,
doi:10.3390/nu13030717
Sun, Chen, Viboud, Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: A population-level observational study, Lancet Digit. Health,
doi:10.1016/S2589-7500(20)30026-1
Szeto, Zucker, Lasota, Rubin, Walker et al., Vitamin D status and COVID-19 clinical outcomes in hospitalized patients, Endocr. Res,
doi:10.1080/07435800.2020.1867162
Söderström, Rosenblad, Adolfsson, Bergkvist, Malnutrition is associated with increased mortality in older adults regardless of the cause of death, Br. J. Nutr,
doi:10.1017/S0007114517000435
Tylavsky, Cheng, Lyytikäinen, Viljakainen, Lamberg-Allardt, Strategies to improve vitamin D status in northern European children: Exploring the merits of vitamin D fortification and supplementation, J. Nutr,
doi:10.1093/jn/136.4.1130
Varikasuvu, Thangappazham, Vykunta, Duggina, Manne et al., COVID-19 andvitamin D (Co-VIVID study): A systematic review and meta-analysis of randomized controlled trials, Expert Rev. Anti Infect. Ther,
doi:10.1080/14787210.2022.2035217
Wacker, Holick, Sunlight and Vitamin D: A global perspective for health, Derm. Endocrinol,
doi:10.4161/derm.24494