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High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial

Moghaddam et al., Journal of Health, Population and Nutrition, doi:10.1186/s41043-023-00409-y, IRCT20110726007117N11
Jul 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
RCT 140 hospitalized patients in Iran, showing patients treated with high dose vitamin D had a significant decrease in serum alkaline phosphatase compared to the control group receiving lower dose vitamin D. No significant differences were seen for ALT, AST, GGT, and LDH. No major side effects were reported with the high vitamin D doses used.
Moghaddam et al., 25 Jul 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, mean age 59.2, 15 authors, study period September 2020 - December 2020, trial IRCT20110726007117N11. Contact: mrassaran78@gmail.com, ghayourm@mums.ac.ir.
This PaperVitamin DAll
High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial
Reza Rezvani Moghaddam, Zahra Khorasanchi, Ayad Rasool Noor, Mohammadreza Shadmand Foumani Moghadam, Ali Jafarzadeh Esfahani, Abdullah Khalaf Merhej Alyakobi, Mohammedhadi Lafta Alboresha, Payam Sharifan, Ali Bahari, Reza Rezvani, Malihe Aghasizade, Maryam Heshmati, Reza Assaran Darban, Gordon Ferns, Majid Ghayour Mobarhan
Journal of Health, Population and Nutrition, doi:10.1186/s41043-023-00409-y
Background The benefits and harms of vitamin D supplementation in the treatment of have not yet been fully documented. In this study, we aimed to evaluate the effects of high-dose vitamin D supplementation on liver function tests in COVID-19. Method This double-blinded randomized clinical trial was conducted on 140 hospitalized patients aged > 30 years. Patients were randomly allocated to receive either intervention group (n = 70 receiving 50,000 IU of vitamin D capsules orally as a single dose and then 10,000 IU syrup daily from the second day of admission for 30 days) and the control group (n = 70 receiving 1000 IU vitamin D syrup orally per day). Liver function tests (LFT), including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and Lactate Dehydrogenase (LDH) were evaluated at baseline and at the end of the intervention. Decision tree analysis was performed to identify the predictors for change in liver enzymes. Results Among COVID-19 patients, a significant decrease was observed in serum level of ALP between intervention and placebo groups (p = 0.04). In addition, decision tree analysis revealed that GGT, temperature, serum magnesium level at baseline and gender were the most important predictors of ALT changes in COVID-19 patients. Conclusion High-dose vitamin D supplementation improved ALP markers among COVID-19 patients. More randomized controlled trials with longer follow-up times will be required.
Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s41043-023-00409-y. Additional file 1. Decision tree analysis to identify the predictors for change in AST and ALP enzymes in COVID-19 patients. Author contributions MGHM and RAD initially conceptualized and designed the study, ZKH, AB, AJE and RRM upgraded the design. The manuscript was written by RR and ZKH. AJE were responsible for the design optimizing and statistical analysis. MLA, MH, MA, AKMA, ARN and MSHFM contribute sampling. GF performed English editing. All authors read and approved the final manuscript. Declarations Ethics approval and consent to participate This study was approved by the Ethics Committee of MUMS (Mashhad University of Medical Sciences), Mashhad, Iran. (Ethic Number: IR.MUMS. REC.1399.237) and carried out based on the Declaration of Helsinki. Informed consent was obtained from all subjects involved in the study. Consent for publication Not applicable as no personal data were used in this article. Competing interests The authors declare no competing interests. • fast, convenient online submission • thorough peer review by experienced researchers in your field • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year • At BMC,..
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The effects of high dose vitamin D supplementation as a ' 'nutritional intervention strategy on biochemical and inflammatory ' 'factors in adults with COVID-19: Study protocol for a randomized ' 'controlled trial. Nutr Health. 2022;02601060221082384.', 'DOI': '10.1177/02601060221082384'}, { 'issue': '1', 'key': '409_CR19', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1186/1745-6215-11-32', 'volume': '11', 'author': 'KF Schulz', 'year': '2010', 'unstructured': 'Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated ' 'guidelines for reporting parallel group randomised trials. Trials. ' '2010;11(1):1–8.', 'journal-title': 'Trials'}, { 'issue': '1', 'key': '409_CR20', 'doi-asserted-by': 'publisher', 'first-page': '97', 'DOI': '10.3390/covid1010008', 'volume': '1', 'author': 'P Das', 'year': '2021', 'unstructured': 'Das P, Samad N, Ahinkorah BO, Hagan JE, Peprah P, Mohammed A, Seidu A-A. ' 'Effect of vitamin D deficiency on COVID-19 status: a systematic review. ' 'COVID. 2021;1(1):97–104.', 'journal-title': 'COVID'}, { 'issue': '7', 'key': '409_CR21', 'doi-asserted-by': 'publisher', 'first-page': '1195', 'DOI': '10.1007/s40520-020-01570-8', 'volume': '32', 'author': 'PC Ilie', 'year': '2020', 'unstructured': 'Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention ' 'of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. ' '2020;32(7):1195–8.', 'journal-title': 'Aging Clin Exp Res'}, { 'issue': '4', 'key': '409_CR22', 'doi-asserted-by': 'publisher', 'first-page': '988', 'DOI': '10.3390/nu12040988', 'volume': '12', 'author': 'WB Grant', 'year': '2020', 'unstructured': 'Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, ' 'Bhattoa HP. Evidence that vitamin D supplementation could reduce risk of ' 'influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988.', 'journal-title': 'Nutrients'}, { 'issue': '3', 'key': '409_CR23', 'doi-asserted-by': 'publisher', 'first-page': '335', 'DOI': '10.1002/biof.1496', 'volume': '45', 'author': 'H Tavakoli', 'year': '2019', 'unstructured': 'Tavakoli H, Rostami H, Avan A, Bagherniya M, Ferns GA, Khayyatzadeh SS, ' 'Ghayour-Mobarhan M. High dose vitamin D supplementation is associated ' 'with an improvement in serum markers of liver function. BioFactors. ' '2019;45(3):335–42.', 'journal-title': 'BioFactors'}, { 'issue': '7', 'key': '409_CR24', 'doi-asserted-by': 'publisher', 'first-page': '2124', 'DOI': '10.1007/s10620-011-1707-x', 'volume': '56', 'author': 'S Liangpunsakul', 'year': '2011', 'unstructured': 'Liangpunsakul S, Chalasani N. Serum vitamin D concentrations and ' 'unexplained elevation in ALT among US adults. Dig Dis Sci. ' '2011;56(7):2124–9.', 'journal-title': 'Dig Dis Sci'}, { 'issue': '1', 'key': '409_CR25', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1186/s12986-016-0112-z', 'volume': '13', 'author': 'A Mohamed Ahmed', 'year': '2016', 'unstructured': 'Mohamed Ahmed A, Abdel Ghany M, Abdel Hakeem GL, Kamal A, Khattab R, ' 'Abdalla A, Abou El Fotoh LEM, El Mazary AA, Sayed MA, Abdel Fadil AM. ' 'Assessment of Vitamin D status in a group of Egyptian children with non ' 'alcoholic fatty liver disease (multicenter study). Nutr Metabolism. ' '2016;13(1):1–6.', 'journal-title': 'Nutr Metabolism'}, { 'key': '409_CR26', 'doi-asserted-by': 'publisher', 'first-page': '205873922110383', 'DOI': '10.1177/20587392211038315', 'volume': '19', 'author': 'M Almehmadi', 'year': '2021', 'unstructured': 'Almehmadi M, Turjoman A, El-Askary A, Shafie A, Rebh F, Alenazi M, ' 'Halawi M, Gharib AF. Association of vitamin D deficiency with clinical ' 'presentation of COVID-19. Eur J Inflamm. 2021;19:20587392211038316.', 'journal-title': 'Eur J Inflamm'}, { 'issue': '5', 'key': '409_CR27', 'doi-asserted-by': 'publisher', 'first-page': '2992', 'DOI': '10.1002/jmv.26832', 'volume': '93', 'author': 'M Demir', 'year': '2021', 'unstructured': 'Demir M, Demir F, Aygun H. Vitamin D deficiency is associated with ' 'COVID-19 positivity and severity of the disease. J Med Virol. ' '2021;93(5):2992–9.', 'journal-title': 'J Med Virol'}, { 'issue': '1', 'key': '409_CR28', 'doi-asserted-by': 'publisher', 'first-page': '13', 'DOI': '10.1007/s10753-020-01337-3', 'volume': '44', 'author': 'M Iwasaki', 'year': '2021', 'unstructured': 'Iwasaki M, Saito J, Zhao H, Sakamoto A, Hirota K, Ma D. Inflammation ' 'triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure ' 'of severe COVID-19: molecular mechanisms and implications. Inflammation. ' '2021;44(1):13–34.', 'journal-title': 'Inflammation'}, { 'issue': '4', 'key': '409_CR29', 'doi-asserted-by': 'publisher', 'first-page': '1249', 'DOI': '10.1002/hep.28740', 'volume': '64', 'author': 'J Clària', 'year': '2016', 'unstructured': 'Clària J, Stauber RE, Coenraad MJ, Moreau R, Jalan R, Pavesi M, Amorós ' 'À, Titos E, Alcaraz-Quiles J, Oettl K. Systemic inflammation in ' 'decompensated cirrhosis: characterization and role in acute-on-chronic ' 'liver failure. Hepatology. 2016;64(4):1249–64.', 'journal-title': 'Hepatology'}, { 'key': '409_CR30', 'doi-asserted-by': 'crossref', 'unstructured': 'Zafari N, Velayati M, Fahim M, Maftooh M, Pourali G, Khazaei M, Nassiri ' 'M, Hassanian SM, Ghayour-Mobarhan M, Ferns GA. Role of gut bacterial and ' 'non-bacterial microbiota in alcohol-associated liver disease: molecular ' 'mechanisms, biomarkers, and therapeutic prospective. Life Sci. ' '2022;120760.', 'DOI': '10.1016/j.lfs.2022.120760'}, { 'key': '409_CR31', 'unstructured': 'Hoseinpour S, Aghaei M, Aghasizadeh M, Hasanzadeh E, Foroughipour M, ' 'Ghayour-Mobarhan M. a case of possible motor-sensory symptoms event ' 'associated with SARS-coronavirus-2. J Cardio-Thoracic Med. 2022;10(4)'}, { 'issue': '5', 'key': '409_CR32', 'doi-asserted-by': 'publisher', 'first-page': '7432', 'DOI': '10.3892/mmr.2017.7546', 'volume': '16', 'author': 'J Xu', 'year': '2017', 'unstructured': 'Xu J, Yang J, Chen J, Luo Q, Zhang Q, Zhang H. Vitamin D alleviates ' 'lipopolysaccharide-induced acute lung injury via regulation of the ' 'renin-angiotensin system. Mol Med Rep. 2017;16(5):7432–8.', 'journal-title': 'Mol Med Rep'}, { 'issue': '2', 'key': '409_CR33', 'doi-asserted-by': 'publisher', 'first-page': '409', 'DOI': '10.1136/jim-2021-001948', 'volume': '70', 'author': 'R Sharma', 'year': '2022', 'unstructured': 'Sharma R, Heidari A, Johnson RH, Advani S, Petersen G. Serum magnesium ' 'levels in hospitalized patients with SARS-CoV-2. J Investig Med. ' '2022;70(2):409–14.', 'journal-title': 'J Investig Med'}, { 'issue': '2', 'key': '409_CR34', 'doi-asserted-by': 'publisher', 'first-page': '625', 'DOI': '10.1007/s00394-021-02704-y', 'volume': '61', 'author': 'V Trapani', 'year': '2022', 'unstructured': 'Trapani V, Rosanoff A, Baniasadi S, Barbagallo M, Castiglioni S, ' 'Guerrero-Romero F, Iotti S, Mazur A, Micke O, Pourdowlat G, Scarpati G, ' 'Wolf FI, Maier JA. The relevance of magnesium homeostasis in COVID-19. ' 'Eur J Nutr. 2022;61(2):625–36.', 'journal-title': 'Eur J Nutr'}, { 'issue': '4', 'key': '409_CR35', 'doi-asserted-by': 'publisher', 'first-page': '1001', 'DOI': '10.1007/s10787-021-00826-7', 'volume': '29', 'author': 'P Kumar', 'year': '2021', 'unstructured': 'Kumar P, Kumar M, Bedi O, Gupta M, Kumar S, Jaiswal G, Rahi V, Yedke NG, ' 'Bijalwan A, Sharma S. Role of vitamins and minerals as immunity boosters ' 'in COVID-19. Inflammopharmacology. 2021;29(4):1001–16.', 'journal-title': 'Inflammopharmacology'}, { 'key': '409_CR36', 'doi-asserted-by': 'publisher', 'first-page': '5313', 'DOI': '10.2147/IJGM.S319717', 'volume': '14', 'author': 'R Wang', 'year': '2021', 'unstructured': 'Wang R, He M, Kang Y. Hypophosphatemia at admission is associated with ' 'increased mortality in COVID-19 patients. Int J General Med. ' '2021;14:5313.', 'journal-title': 'Int J General Med'}, { 'key': '409_CR37', 'doi-asserted-by': 'crossref', 'unstructured': 'Xie P, Ma W, Tang H, Liu D. Severe COVID-19: a review of recent progress ' 'with a look toward the future. Front Public Health. 2020;8', 'DOI': '10.3389/fpubh.2020.00189'}, { 'issue': '9', 'key': '409_CR38', 'doi-asserted-by': 'publisher', 'first-page': '852', 'DOI': '10.3390/biology10090852', 'volume': '10', 'author': 'YD Nechipurenko', 'year': '2021', 'unstructured': 'Nechipurenko YD, Semyonov DA, Lavrinenko IA, Lagutkin DA, Generalov EA, ' 'Zaitceva AY, Matveeva OV, Yegorov YE. The role of acidosis in the ' 'pathogenesis of severe forms of COVID-19. Biology. 2021;10(9):852.', 'journal-title': 'Biology'}, { 'key': '409_CR39', 'doi-asserted-by': 'crossref', 'unstructured': 'Samprathi M, Jayashree M. Biomarkers in COVID-19: an up-to-date review. ' 'Front Pediatr. 2021;8.', 'DOI': '10.3389/fped.2020.607647'}], 'container-title': 'Journal of Health, Population and Nutrition', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s41043-023-00409-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s41043-023-00409-y/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s41043-023-00409-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 7, 25]], 'date-time': '2023-07-25T15:35:11Z', 'timestamp': 1690299311000}, 'score': 1, 'resource': {'primary': {'URL': 'https://jhpn.biomedcentral.com/articles/10.1186/s41043-023-00409-y'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 7, 25]]}, 'references-count': 39, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 12]]}}, 'alternative-id': ['409'], 'URL': 'http://dx.doi.org/10.1186/s41043-023-00409-y', 'relation': {}, 'ISSN': ['2072-1315'], 'subject': [ 'Health, Toxicology and Mutagenesis', 'Public Health, Environmental and Occupational Health', 'Food Science'], 'container-title-short': 'J Health Popul Nutr', 'published': {'date-parts': [[2023, 7, 25]]}, 'assertion': [ { 'value': '3 January 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 June 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '25 July 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'This study was approved by the Ethics Committee of MUMS (Mashhad University of ' 'Medical Sciences), Mashhad, Iran. (Ethic Number: IR.MUMS.REC.1399.237) and ' 'carried out based on the Declaration of Helsinki. Informed consent was obtained ' 'from all subjects involved in the study.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable as no personal data were used in this article.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '71'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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