High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial

{ 'indexed': {'date-parts': [[2023, 7, 26]], 'date-time': '2023-07-26T04:31:41Z', 'timestamp': 1690345901778}, 'reference-count': 39, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 7, 25]], 'date-time': '2023-07-25T00:00:00Z', 'timestamp': 1690243200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2023, 7, 25]], 'date-time': '2023-07-25T00:00:00Z', 'timestamp': 1690243200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'DOI': '10.13039/501100004748', 'name': 'Mashhad University of Medical Sciences', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>The benefits and harms of vitamin D supplementation in the treatment ' 'of COVID-19 have not yet been fully documented. In this study, we aimed to evaluate the ' 'effects of high-dose vitamin D supplementation on liver function tests in COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Method</jats:title>\n' ' <jats:p>This double-blinded randomized clinical trial was conducted on 140 ' 'hospitalized patients aged\u2009&gt;\u200930\xa0years. Patients were randomly allocated to ' 'receive either intervention group (<jats:italic>n</jats:italic>\u2009=\u200970 receiving ' '50,000\xa0IU of vitamin D capsules orally as a single dose and then 10,000\xa0IU syrup daily ' 'from the second day of admission for 30\xa0days) and the control group ' '(<jats:italic>n</jats:italic>\u2009=\u200970 receiving 1000\xa0IU vitamin D syrup orally per ' 'day). Liver function tests (LFT), including\xa0alanine aminotransferase (ALT), aspartate ' 'aminotransferase (AST), alkaline phosphatase\xa0(ALP), gamma-glutamyl transferase (GGT), and ' 'Lactate Dehydrogenase (LDH) were evaluated at baseline and at the end of the intervention. ' 'Decision tree analysis was performed to identify the predictors for change in liver ' 'enzymes.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Among COVID-19 patients, a significant decrease was observed in serum ' 'level of ALP between intervention and placebo groups (<jats:italic>p</jats:italic>\u2009' '=\u20090.04). In addition, decision tree analysis revealed that GGT, temperature, serum ' 'magnesium level at baseline and gender were the most important predictors of ALT changes in ' 'COVID-19 patients.\n' '</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>High-dose vitamin D supplementation improved ALP markers among ' 'COVID-19 patients. More randomized controlled trials with longer follow-up times will be ' 'required.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s41043-023-00409-y', 'type': 'journal-article', 'created': {'date-parts': [[2023, 7, 25]], 'date-time': '2023-07-25T15:30:06Z', 'timestamp': 1690299006000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase ' 'in COVID-19 patients; a randomized double-blinded clinical trial', 'prefix': '10.1186', 'volume': '42', 'author': [ {'given': 'Reza Rezvani', 'family': 'Moghaddam', 'sequence': 'first', 'affiliation': []}, {'given': 'Zahra', 'family': 'Khorasanchi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ayad Rasool', 'family': 'Noor', 'sequence': 'additional', 'affiliation': []}, { 'given': 'MohammadReza Shadmand Foumani', 'family': 'Moghadam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ali Jafarzadeh', 'family': 'Esfahani', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Abdullah Khalaf Merhej', 'family': 'Alyakobi', 'sequence': 'additional', 'affiliation': []}, { 'given': 'MohammedHadi Lafta', 'family': 'Alboresha', 'sequence': 'additional', 'affiliation': []}, {'given': 'Payam', 'family': 'Sharifan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ali', 'family': 'Bahari', 'sequence': 'additional', 'affiliation': []}, {'given': 'Reza', 'family': 'Rezvani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Malihe', 'family': 'Aghasizade', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maryam', 'family': 'Heshmati', 'sequence': 'additional', 'affiliation': []}, {'given': 'Reza Assaran', 'family': 'Darban', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gordon', 'family': 'Ferns', 'sequence': 'additional', 'affiliation': []}, {'given': 'Majid Ghayour', 'family': 'Mobarhan', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 7, 25]]}, 'reference': [ { 'issue': '1', 'key': '409_CR1', 'doi-asserted-by': 'publisher', 'first-page': '130', 'DOI': '10.1186/s40795-022-00633-5', 'volume': '8', 'author': 'Z Khorasanchi', 'year': '2022', 'unstructured': 'Khorasanchi Z, Ahmadihoseini A, Hajhoseini O, Zare-Feyzabadi R, Haghighi ' 'M, Heidari M, Esfehani AJ, Dehnavi Z, Sharifan P, Rashidianyazd S. 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' 'Front Pediatr. 2021;8.', 'DOI': '10.3389/fped.2020.607647'}], 'container-title': 'Journal of Health, Population and Nutrition', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s41043-023-00409-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s41043-023-00409-y/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s41043-023-00409-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 7, 25]], 'date-time': '2023-07-25T15:35:11Z', 'timestamp': 1690299311000}, 'score': 1, 'resource': {'primary': {'URL': 'https://jhpn.biomedcentral.com/articles/10.1186/s41043-023-00409-y'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 7, 25]]}, 'references-count': 39, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 12]]}}, 'alternative-id': ['409'], 'URL': 'http://dx.doi.org/10.1186/s41043-023-00409-y', 'relation': {}, 'ISSN': ['2072-1315'], 'subject': [ 'Health, Toxicology and Mutagenesis', 'Public Health, Environmental and Occupational Health', 'Food Science'], 'container-title-short': 'J Health Popul Nutr', 'published': {'date-parts': [[2023, 7, 25]]}, 'assertion': [ { 'value': '3 January 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 June 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '25 July 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'This study was approved by the Ethics Committee of MUMS (Mashhad University of ' 'Medical Sciences), Mashhad, Iran. (Ethic Number: IR.MUMS.REC.1399.237) and ' 'carried out based on the Declaration of Helsinki. Informed consent was obtained ' 'from all subjects involved in the study.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable as no personal data were used in this article.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '71'}