Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies

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Zhejiang Univ. - Sci. B", "key": "10.1016/j.heliyon.2023.e23662_bib2", "volume": "21", "year": "2020" }, { "DOI": "10.1001/jama.2020.2648", "article-title": "Characteristics of and important oessons from the coronavirus disease 2019 (COVID-19) sutbreak in China: pummary of a report of 72 314 cases from the Chinese center for disease control and frevention", "author": "Wu", "doi-asserted-by": "crossref", "first-page": "1239", "issue": "13", "journal-title": "JAMA", "key": "10.1016/j.heliyon.2023.e23662_bib3", "volume": "323", "year": "2020" }, { "DOI": "10.3389/fpubh.2020.00152", "article-title": "Gender differences in patients with COVID-19: rocus on severity and mortality", "author": "Jin", "doi-asserted-by": "crossref", "first-page": "152", "journal-title": "Front. Public Health", "key": "10.1016/j.heliyon.2023.e23662_bib4", "volume": "8", "year": "2020" }, { "DOI": "10.1002/jgm.3310", "article-title": "The impact of certain genetic variants (single nucleotide polymorphisms) on incidence and severity of COVID-19", "author": "Abobaker", "doi-asserted-by": "crossref", "issue": "2", "journal-title": "J. Gene Med.", "key": "10.1016/j.heliyon.2023.e23662_bib5", "volume": "23", "year": "2021" }, { "DOI": "10.3389/bjbs.2021.10238", "article-title": "ACE2 and TMPRSS2 SNPs as determinants of susceptibility to, and severity of, a COVID-19 infection", "author": "Abdelsattar", "doi-asserted-by": "crossref", "journal-title": "Br. J. Biomed. Sci.", "key": "10.1016/j.heliyon.2023.e23662_bib6", "volume": "79", "year": "2022" }, { "DOI": "10.3390/ijms23169171", "article-title": "Allelic variations in the human genes TMPRSS2 and CCR5, and the Resistance to viral infection by SARS-CoV-2", "author": "Vitello", "doi-asserted-by": "crossref", "issue": "16", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.heliyon.2023.e23662_bib7", "volume": "23", "year": "2022" }, { "DOI": "10.3389/fmicb.2022.943877", "article-title": "TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility", "author": "Sekiya", "doi-asserted-by": "crossref", "journal-title": "Front. Microbiol.", "key": "10.1016/j.heliyon.2023.e23662_bib8", "volume": "13", "year": "2022" }, { "article-title": "Association of the transmembrane serine protease-2 (TMPRSS2) polymorphisms with COVID-19", "author": "Posadas-Sanchez", "issue": "9", "journal-title": "Vasc. Pharmacol.", "key": "10.1016/j.heliyon.2023.e23662_bib9", "volume": "14", "year": "2022" }, { "DOI": "10.1371/journal.pone.0270627", "article-title": "Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: a systematic review and meta-analysis", "author": "Dieter", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "PLoS One", "key": "10.1016/j.heliyon.2023.e23662_bib10", "volume": "17", "year": "2022" }, { "DOI": "10.1002/rmv.2323", "article-title": "Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID-19 severity: a systematic review with meta-analysis", "author": "Saengsiwaritt", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "Rev. Med. 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Cranio-Maxillo-Fac. Surg.", "key": "10.1016/j.heliyon.2023.e23662_bib16", "volume": "39", "year": "2011" }, { "author": "Organization", "key": "10.1016/j.heliyon.2023.e23662_bib17", "series-title": "Clinical Management of COVID-19: Living Guideline, 23 June 2022", "year": "2022" }, { "DOI": "10.1007/s10654-010-9491-z", "article-title": "Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses", "author": "Stang", "doi-asserted-by": "crossref", "first-page": "603", "issue": "9", "journal-title": "Eur. J. Epidemiol.", "key": "10.1016/j.heliyon.2023.e23662_bib18", "volume": "25", "year": "2010" }, { "DOI": "10.1016/j.cca.2022.09.006", "article-title": "Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of Iran", "author": "Abbaszadeh", "doi-asserted-by": "crossref", "first-page": "39", "journal-title": "Clin. Chim. 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Evol.", "key": "10.1016/j.heliyon.2023.e23662_bib20", "volume": "96", "year": "2021" }, { "DOI": "10.3390/genes12060830", "article-title": "Association between interferon-lambda-3 rs12979860, TLL1 rs17047200 and DDR1 rs4618569 variant polymorphisms with the course and outcome of SARS-CoV-2 patients", "author": "Agwa", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "Genes", "key": "10.1016/j.heliyon.2023.e23662_bib21", "volume": "12", "year": "2021" }, { "DOI": "10.1155/2021/5509280", "article-title": "Human cce D/I polymorphism could affect the Clinicobiological course of COVID-19", "author": "Aladag", "doi-asserted-by": "crossref", "journal-title": "J Renin Angiotensin Aldosterone Syst", "key": "10.1016/j.heliyon.2023.e23662_bib22", "volume": "2021", "year": "2021" }, { "article-title": "Polymorphism in promotor region of IL6 gene as a predictor for severity in COVID -19 patients, Egypt", "author": "Aladawy", "first-page": "1", "issue": "2", "journal-title": "J. Immunol.", "key": "10.1016/j.heliyon.2023.e23662_bib23", "volume": "29", "year": "2022" }, { "DOI": "10.3390/nu13113680", "article-title": "Associations between genetic variants in the vitamin D petabolism rathway and severity of COVID-19 among UAE lesidents", "author": "Al-Anouti", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "Nutrients", "key": "10.1016/j.heliyon.2023.e23662_bib24", "volume": "13", "year": "2021" }, { "DOI": "10.1016/j.ygeno.2021.04.002", "article-title": "Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality", "author": "Alghamdi", "doi-asserted-by": "crossref", "first-page": "1733", "issue": "4", "journal-title": "Genomics", "key": "10.1016/j.heliyon.2023.e23662_bib25", "volume": "113", "year": "2021" }, { "DOI": "10.1186/s12985-022-01782-6", "article-title": "SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease", "author": "Alimoradi", "doi-asserted-by": "crossref", "first-page": "48", "issue": "1", "journal-title": "Virol. J.", "key": "10.1016/j.heliyon.2023.e23662_bib26", "volume": "19", "year": "2022" }, { "DOI": "10.3390/jcm9103315", "article-title": "SARS-CoV-2 viral ooad, IFN lambda polymorphisms and the course of COVID-19: an ibservational study", "author": "Amodio", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "J. Clin. Med.", "key": "10.1016/j.heliyon.2023.e23662_bib27", "volume": "9", "year": "2020" }, { "DOI": "10.3389/fmed.2022.910098", "article-title": "Association between the LZTFL1 rs11385942 polymorphism and COVID-19 severity in Colombian population", "author": "Angulo-Aguado", "doi-asserted-by": "crossref", "journal-title": "Front. Med.", "key": "10.1016/j.heliyon.2023.e23662_bib28", "volume": "9", "year": "2022" }, { "article-title": "The angiotensin converting enzyme deletion/deletion genotype is a risk factor for severe COVID-19: umplication and atility for patients edmitted to dmergency Department", "author": "Annunziata", "issue": "8", "journal-title": "Medicina-Lithuania", "key": "10.1016/j.heliyon.2023.e23662_bib29", "volume": "57", "year": "2021" }, { "DOI": "10.1111/cen.14664", "article-title": "Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID-19", "author": "Apaydin", "doi-asserted-by": "crossref", "first-page": "819", "issue": "6", "journal-title": "Clin. Endocrinol.", "key": "10.1016/j.heliyon.2023.e23662_bib30", "volume": "96", "year": "2022" }, { "DOI": "10.3390/diagnostics12112824", "article-title": "Analysis of gene single nucleotide polymorphisms in COVID-19 disease sighlighting the susceptibility and the severity towards the infection", "author": "Balzanelli", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "Diagnostics", "key": "10.1016/j.heliyon.2023.e23662_bib31", "volume": "12", "year": "2022" }, { "DOI": "10.5152/AnatolJCardiol.2021.502", "article-title": "Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study", "author": "Baştuğ", "doi-asserted-by": "crossref", "first-page": "133", "issue": "2", "journal-title": "Anatol. J. Cardiol.", "key": "10.1016/j.heliyon.2023.e23662_bib32", "volume": "26", "year": "2022" }, { "DOI": "10.1155/2022/7841969", "article-title": "rs12329760 polymorphism in transmembrane serine protease 2 gene and risk of coronavirus disease 2019 mortality", "author": "Beheshti Shirazi", "doi-asserted-by": "crossref", "journal-title": "BioMed Res. Int.", "key": "10.1016/j.heliyon.2023.e23662_bib33", "volume": "2022", "year": "2022" }, { "DOI": "10.2147/PGPM.S303666", "article-title": "Angiotensin system polymorphisms' in SARS-CoV-2 positive patients: assessment between iymptomatic and asymptomatic patients: a pilot study", "author": "Cafiero", "doi-asserted-by": "crossref", "first-page": "621", "journal-title": "Pharmacogenomics Personalized Med.", "key": "10.1016/j.heliyon.2023.e23662_bib34", "volume": "14", "year": "2021" }, { "DOI": "10.3390/v14112557", "article-title": "A polymorphism in the TMPRSS2 gene dncreases the risk of heath in older patients rospitalized with COVID-19", "author": "de Andrade", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "Viruses", "key": "10.1016/j.heliyon.2023.e23662_bib35", "volume": "14", "year": "2022" }, { "DOI": "10.1016/j.cyto.2022.155889", "article-title": "Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population", "author": "Falahi", "doi-asserted-by": "crossref", "journal-title": "Cytokine", "key": "10.1016/j.heliyon.2023.e23662_bib36", "volume": "154", "year": "2022" }, { "DOI": "10.3389/fgene.2022.955965", "article-title": "The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian COVID-19 patients: a case-control study", "author": "Faridzadeh", "doi-asserted-by": "crossref", "journal-title": "Front. Genet.", "key": "10.1016/j.heliyon.2023.e23662_bib37", "volume": "13", "year": "2022" }, { "DOI": "10.1016/j.cyto.2020.155354", "article-title": "The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19", "author": "Gómez", "doi-asserted-by": "crossref", "journal-title": "Cytokine", "key": "10.1016/j.heliyon.2023.e23662_bib38", "volume": "137", "year": "2021" }, { "DOI": "10.1016/j.gene.2020.145102", "article-title": "Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome", "author": "Gómez", "doi-asserted-by": "crossref", "journal-title": "Gene", "key": "10.1016/j.heliyon.2023.e23662_bib39", "volume": "762", "year": "2020" }, { "article-title": "Angiotensin-converting enzyme genotype-specific immune cesponse nontributes to the susceptibility of COVID-19: a rested case-control study", "author": "Gong", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.heliyon.2023.e23662_bib40", "volume": "12", "year": "2021" }, { "DOI": "10.5144/0256-4947.2021.141", "article-title": "Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study", "author": "Gunal", "doi-asserted-by": "crossref", "first-page": "141", "issue": "3", "journal-title": "Ann. Saudi Med.", "key": "10.1016/j.heliyon.2023.e23662_bib41", "volume": "41", "year": "2021" }, { "DOI": "10.1016/j.cca.2021.04.024", "article-title": "ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors", "author": "Hubacek", "doi-asserted-by": "crossref", "first-page": "206", "journal-title": "Clin. Chim. Acta", "key": "10.1016/j.heliyon.2023.e23662_bib42", "volume": "519", "year": "2021" }, { "DOI": "10.3390/genes13071111", "article-title": "The role of ACE, ACE2, and AGTR2 polymorphisms in COVID-19 severity and the presence of COVID-19-related detinopathy", "author": "Jevnikar", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "Genes", "key": "10.1016/j.heliyon.2023.e23662_bib43", "volume": "13", "year": "2022" }, { "DOI": "10.1002/jmv.27160", "article-title": "Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: a case study", "author": "Karakaş Çelik", "doi-asserted-by": "crossref", "first-page": "5947", "issue": "10", "journal-title": "J. Med. Virol.", "key": "10.1016/j.heliyon.2023.e23662_bib44", "volume": "93", "year": "2021" }, { "DOI": "10.7883/yoken.JJID.2021.046", "article-title": "Frequency of interleukin-6 rs1800795 (-174G/C) and rs1800797 (-597G/A) polymorphisms in COVID-19 patients in Turkey who mevelop aacrophage zctivation syndrome", "author": "Kerget", "doi-asserted-by": "crossref", "first-page": "543", "issue": "6", "journal-title": "Jpn. J. Infect. Dis.", "key": "10.1016/j.heliyon.2023.e23662_bib45", "volume": "74", "year": "2021" }, { "DOI": "10.1111/iji.12598", "article-title": "Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID-19 severity in Iranian population", "author": "Khalilzadeh", "doi-asserted-by": "crossref", "first-page": "325", "issue": "5", "journal-title": "Int. J. Immunogenet.", "key": "10.1016/j.heliyon.2023.e23662_bib46", "volume": "49", "year": "2022" }, { "DOI": "10.3389/fnut.2021.689419", "article-title": "Association of vitamin D, sinc and helenium related genetic variants with COVID-19 disease severity", "author": "Kotur", "doi-asserted-by": "crossref", "journal-title": "Front. Nutr.", "key": "10.1016/j.heliyon.2023.e23662_bib47", "volume": "8", "year": "2021" }, { "DOI": "10.1002/jmv.27774", "article-title": "Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: a pilot study", "author": "Lapić", "doi-asserted-by": "crossref", "first-page": "3669", "issue": "8", "journal-title": "J. Med. Virol.", "key": "10.1016/j.heliyon.2023.e23662_bib48", "volume": "94", "year": "2022" }, { "DOI": "10.51248/.v42i5.2279", "article-title": "Assessing the potential correlation of polymorphisms in the TMPRSS2 gene with severity of COVID 19 patients", "author": "Mahdi", "doi-asserted-by": "crossref", "first-page": "1034", "issue": "5", "journal-title": "Biomedicine", "key": "10.1016/j.heliyon.2023.e23662_bib49", "volume": "42", "year": "2022" }, { "DOI": "10.3389/fimmu.2022.812940", "article-title": "ACE and ACE2 gene variants are associated with severe outcomes of COVID-19 in men", "author": "Martínez-Gómez", "doi-asserted-by": "crossref", "journal-title": "Front. Immunol.", "key": "10.1016/j.heliyon.2023.e23662_bib50", "volume": "13", "year": "2022" }, { "article-title": "Strong association of angiotensin converting enzyme-2 gene insertion/deletion polymorphism with susceptibility to SARS-CoV-2, aypertension, coronary Artery disease and COVID-19 disease mortality", "author": "Mir", "issue": "11", "journal-title": "Pharmacogenetics Genom.", "key": "10.1016/j.heliyon.2023.e23662_bib51", "volume": "11", "year": "2021" }, { "article-title": "ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19", "author": "Mohlendick", "first-page": "165", "issue": "8", "journal-title": "Mol. Genet. Genom.", "key": "10.1016/j.heliyon.2023.e23662_bib52", "volume": "31", "year": "2021" }, { "article-title": "Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease", "author": "Najafi", "first-page": "1", "journal-title": "Mol Genet Genomics", "key": "10.1016/j.heliyon.2023.e23662_bib53", "year": "2022" }, { "DOI": "10.3390/genes13101884", "article-title": "Host genetic risk factors associated with COVID-19 susceptibility and severity in Vietnamese", "author": "Nhung", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "Genes", "key": "10.1016/j.heliyon.2023.e23662_bib54", "volume": "13", "year": "2022" }, { "article-title": "Association between rs12252 polymorphism in IFITM3 gene and COVID-19", "author": "Pan", "first-page": "192", "issue": "3", "journal-title": "Int. J. Virol.", "key": "10.1016/j.heliyon.2023.e23662_bib55", "volume": "28", "year": "2021" }, { "DOI": "10.1002/jmv.27417", "article-title": "Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: a rather controversial hypothesis. A case-control study", "author": "Papadopoulou", "doi-asserted-by": "crossref", "first-page": "1050", "issue": "3", "journal-title": "J. Med. Virol.", "key": "10.1016/j.heliyon.2023.e23662_bib56", "volume": "94", "year": "2022" }, { "DOI": "10.1186/s43042-021-00206-4", "article-title": "TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients", "author": "Peralta", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Egyptian Journal of Medical Human Genetics", "key": "10.1016/j.heliyon.2023.e23662_bib57", "volume": "22", "year": "2021" }, { "DOI": "10.1186/s12985-021-01692-z", "article-title": "The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients", "author": "Rahimi", "doi-asserted-by": "crossref", "first-page": "221", "issue": "1", "journal-title": "Virol. J.", "key": "10.1016/j.heliyon.2023.e23662_bib58", "volume": "18", "year": "2021" }, { "DOI": "10.15562/bmj.v11i3.3552", "article-title": "Frequency of Interleukin-6 rs 1800796 (-572G/C) TNF-? rs1800750 (-376G/A), and 1800629 (-308G/A) polymorphism in COVID-19 patients with clinical degrees in Central Java", "author": "Reviono", "doi-asserted-by": "crossref", "first-page": "1364", "issue": "3", "journal-title": "Bali Med. J.", "key": "10.1016/j.heliyon.2023.e23662_bib59", "volume": "11", "year": "2022" }, { "DOI": "10.1007/s12010-022-03885-w", "article-title": "Association of TMPRSS2 gene polymorphisms with COVID-19 severity and mortality: a case-control study with pomputational analyses", "author": "Rokni", "doi-asserted-by": "crossref", "first-page": "3507", "issue": "8", "journal-title": "Appl. Biochem. Biotechnol.", "key": "10.1016/j.heliyon.2023.e23662_bib60", "volume": "194", "year": "2022" }, { "DOI": "10.3389/fmed.2021.798571", "article-title": "The role of angiotensin converting enzyme 1 insertion/deletion genetic polymorphism in the risk and severity of COVID-19 infection", "author": "Saad", "doi-asserted-by": "crossref", "journal-title": "Front. Med.", "key": "10.1016/j.heliyon.2023.e23662_bib61", "volume": "8", "year": "2021" }, { "DOI": "10.1371/journal.pone.0263140", "article-title": "Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease", "author": "Sabater Molina", "doi-asserted-by": "crossref", "issue": "2", "journal-title": "PLoS One", "key": "10.1016/j.heliyon.2023.e23662_bib62", "volume": "17", "year": "2022" }, { "DOI": "10.1080/08820139.2020.1851709", "article-title": "Association of TNF-alpha G-308 a oromoter polymorphism with the course and outcome of COVID-19 patients", "author": "Saleh", "doi-asserted-by": "crossref", "first-page": "546", "issue": "3", "journal-title": "Immunol. Invest.", "key": "10.1016/j.heliyon.2023.e23662_bib63", "volume": "51", "year": "2022" }, { "article-title": "Transmembrane serine protease 2 polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus type 2 infection: a German case-control study", "author": "Schoenfelder", "journal-title": "Front. Genet.", "key": "10.1016/j.heliyon.2023.e23662_bib64", "volume": "12", "year": "2021" }, { "DOI": "10.1016/j.cyto.2021.155492", "article-title": "The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19", "author": "Schönfelder", "doi-asserted-by": "crossref", "journal-title": "Cytokine", "key": "10.1016/j.heliyon.2023.e23662_bib65", "volume": "142", "year": "2021" }, { "DOI": "10.3390/ijerph191912622", "article-title": "Association of ACE2 gene variants with the severity of COVID-19 disease-A prospective Observational study", "author": "Sienko", "doi-asserted-by": "crossref", "issue": "19", "journal-title": "Int J Environ Res Public Health", "key": "10.1016/j.heliyon.2023.e23662_bib66", "volume": "19", "year": "2022" }, { "article-title": "The role of tumor necrosis factor alpha-308A > G polymorphism on the clinical states of SARS-CoV-2 infection", "author": "Sotomayor-Lugo", "issue": "1", "journal-title": "Hum. Genom.", "key": "10.1016/j.heliyon.2023.e23662_bib67", "volume": "23", "year": "2022" }, { "DOI": "10.1016/j.meegid.2021.104801", "article-title": "Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients", "author": "Verma", "doi-asserted-by": "crossref", "journal-title": "Infect. Genet. Evol.", "key": "10.1016/j.heliyon.2023.e23662_bib68", "volume": "91", "year": "2021" }, { "DOI": "10.1111/iji.12605", "article-title": "Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity", "author": "Verma", "doi-asserted-by": "crossref", "first-page": "5", "issue": "1", "journal-title": "Int. J. Immunogenet.", "key": "10.1016/j.heliyon.2023.e23662_bib69", "volume": "50", "year": "2023" }, { "DOI": "10.1186/s40246-021-00330-7", "article-title": "Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients", "author": "Wulandari", "doi-asserted-by": "crossref", "first-page": "29", "issue": "1", "journal-title": "Hum Genomics", "key": "10.1016/j.heliyon.2023.e23662_bib70", "volume": "15", "year": "2021" }, { "key": "10.1016/j.heliyon.2023.e23662_bib71", "unstructured": "N.M.S. Zeidan, et al., Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19, Pediatr. Res." }, { "DOI": "10.1093/infdis/jiaa224", "article-title": "Interferon-induced transmembrane protein 3 genetic variant rs12252-C associated with disease severity in coronavirus disease 2019", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "34", "issue": "1", "journal-title": "J. Infect. Dis.", "key": "10.1016/j.heliyon.2023.e23662_bib72", "volume": "222", "year": "2020" }, { "DOI": "10.4103/ijpvm.IJPVM_419_17", "article-title": "Pattern of rntibacterial uesistance in trinary Tract infections: a systematic review and meta-analysis", "author": "Mortazavi-Tabatabaei", "doi-asserted-by": "crossref", "first-page": "169", "journal-title": "Int. J. Prev. Med.", "key": "10.1016/j.heliyon.2023.e23662_bib73", "volume": "10", "year": "2019" }, { "DOI": "10.1097/TP.0000000000003507", "article-title": "HLA and AB0 polymorphisms may influence SARS-CoV-2 infection and COVID-19 severity", "author": "Amoroso", "doi-asserted-by": "crossref", "first-page": "193", "issue": "1", "journal-title": "Transplantation", "key": "10.1016/j.heliyon.2023.e23662_bib74", "volume": "105", "year": "2021" }, { "article-title": "The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity: a systematic review and meta-analysis", "author": "Dobrijevic", "first-page": "818", "journal-title": "Excli j", "key": "10.1016/j.heliyon.2023.e23662_bib75", "volume": "21", "year": "2022" }, { "DOI": "10.1074/jbc.M002615200", "article-title": "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase", "author": "Tipnis", "doi-asserted-by": "crossref", "first-page": "33238", "issue": "43", "journal-title": "J. Biol. Chem.", "key": "10.1016/j.heliyon.2023.e23662_bib76", "volume": "275", "year": "2000" }, { "DOI": "10.1073/pnas.2003138117", "article-title": "Cell entry mechanisms of SARS-CoV-2", "author": "Shang", "doi-asserted-by": "crossref", "first-page": "11727", "issue": "21", "journal-title": "Proc Natl Acad Sci U S A", "key": "10.1016/j.heliyon.2023.e23662_bib77", "volume": "117", "year": "2020" }, { "DOI": "10.1038/nri3344", "article-title": "The broad-spectrum antiviral functions of IFIT and IFITM proteins", "author": "Diamond", "doi-asserted-by": "crossref", "first-page": "46", "issue": "1", "journal-title": "Nat. Rev. Immunol.", "key": "10.1016/j.heliyon.2023.e23662_bib78", "volume": "13", "year": "2013" }, { "author": "Meltzer", "key": "10.1016/j.heliyon.2023.e23662_bib79", "series-title": "Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence", "year": "2020" }, { "DOI": "10.1016/j.gaceta.2021.10.085", "article-title": "Comorbidities and mortality in COVID-19 patients", "author": "Djaharuddin", "doi-asserted-by": "crossref", "first-page": "S530", "issue": "Suppl 2", "journal-title": "Gac. Sanit.", "key": "10.1016/j.heliyon.2023.e23662_bib80", "volume": "35", "year": "2021" } ], "reference-count": 80, "references-count": 80, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S240584402310870X" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Multidisciplinary" ], "subtitle": [], "title": "Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "10" }