Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies

Dec 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Meta-analysis of 62 studies with 19,600 COVID-19 cases showing certain genetic polymorphisms associated with COVID-19 infection risk, severity, and mortality. Specifically, the ACE I/D polymorphism was associated with lower COVID-19 infection risk, while IFITM3 rs12252 and TMPRSS2 rs12329760 polymorphisms were associated with higher infection risk. For COVID-19 severity, polymorphisms in ACE2, IFITM3, TMPRSS2, and VDR genes were associated with increased or decreased severity risk. Finally, the IFITM3 rs12252 variant C allele was associated with significantly higher COVID-19 mortality risk. The findings indicate these genetic factors may help predict COVID-19 susceptibility and outcomes, and could potentially inform personalized treatment approaches, though further research is still needed.
Patients with VDR genetic variants may potentially benefit more from vitamin D treatment, and patients with TMPRSS2 variants may potentially benefit more from TMPRSS2 inhibitors.
19 meta analyses show significant improvements with vitamin D treatment for mortality1-14, mechanical ventilation1,6,7,12,15,16, ICU admission1,3,6,7,10,12,14-18, hospitalization5,12, severity2,4,6,11,19, and cases8,18,19.
Currently there are 122 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 19% lower ventilation [-3‑36%], 45% lower ICU admission [28‑58%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
Ren et al., 14 Dec 2023, Iran, peer-reviewed, 6 authors. Contact: deqingluo2012@163.com, zhangcb@jmsu.edu.cn.
This PaperVitamin DAll
Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies
Hongyue Ren, Yanyan Lin, Lifeng Huang, Wenxin Xu, Deqing Luo, Chunbin Zhang
Heliyon, doi:10.1016/j.heliyon.2023.e23662
Background: The relationship between genetic polymorphisms and coronavirus disease 2019 remains to be inconsistent. This meta-analysis aimed to provide an updated evaluation of the role of genetic polymorphisms in the infection, severity and mortality of COVID-19 based on all available published studies. Methods: A systematic search was performed using six databases: PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. Summary odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to calculate the genotypic comparison. All statistical analyses were conducted in Stata 12.0. Results: A total of 62 studies with 19600 cases and 28899 controls was included in this metaanalysis. For COVID-19 infection, ACE Ins/Del polymorphism might be related with significantly decreased risk of COVID-19 infection under dominant, homozygote and allelic models. Meanwhile, the IFITM3 rs12252 and TMPRSS2 rs12329760 polymorphisms were significantly associated with the increased risk of COVID-19 infection under one or more models. Regarding COVID-19 severity, ACE2 rs2074192, ACE2 rs2106809, IFITM3 rs12252 and VDR rs1544410 polymorphisms might be related with significantly increased risk of COVID-19 severity in one or more models. Moreover, the analysis of TMPRSS2 rs2070788 indicated that a variant A allele decreased the risk of COVID-19 severity in recessive model. For COVID-19 mortality, the variant C allele of IFITM3 rs12252 polymorphism might be related with significantly increased risk of COVID-19 mortality under all genetic models. Conclusions: This meta-analysis indicated that he infection, severity or mortality of COVID-19 were related to the above genetic polymorphisms, which might provide an important theoretical basis for understanding the clinical feature of COVID-19 disease.
Declaration of competing interest The author (s) declare that they have no competing interests. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi.org/10.1016/j.heliyon.2023.e23662.
References
Abbaszadeh, Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of Iran, Clin. Chim. Acta
Abdelsattar, ACE2 and TMPRSS2 SNPs as determinants of susceptibility to, and severity of, a COVID-19 infection, Br. J. Biomed. Sci
Abdollahzadeh, Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients, Infect. Genet. Evol
Abobaker, The impact of certain genetic variants (single nucleotide polymorphisms) on incidence and severity of COVID-19, J. Gene Med
Agwa, Association between interferon-lambda-3 rs12979860, TLL1 rs17047200 and DDR1 rs4618569 variant polymorphisms with the course and outcome of SARS-CoV-2 patients, Genes
Ahmadi, Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality, Cytokine
Akbari, Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patients, Vascul Pharmacol
Al-Anouti, Associations between genetic variants in the vitamin D petabolism rathway and severity of COVID-19 among UAE lesidents, Nutrients
Aladag, Human cce D/I polymorphism could affect the Clinicobiological course of COVID-19, J Renin Angiotensin Aldosterone Syst
Aladawy, Polymorphism in promotor region of IL6 gene as a predictor for severity in COVID -19 patients, Egypt, J. Immunol
Alghamdi, Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality, Genomics
Ali, Association of tumor necrosis factor alpha -308 single nucleotide polymorphism with SARS CoV-2 infection in an Iraqi Kurdish population, J. Clin. Lab. Anal
Alimoradi, SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease, Virol. J
Amodio, SARS-CoV-2 viral ooad, IFN lambda polymorphisms and the course of COVID-19: an ibservational study, J. Clin. Med
Amoroso, HLA and AB0 polymorphisms may influence SARS-CoV-2 infection and COVID-19 severity, Transplantation
Angulo-Aguado, Association between the LZTFL1 rs11385942 polymorphism and COVID-19 severity in Colombian population, Front. Med
Annunziata, The angiotensin converting enzyme deletion/deletion genotype is a risk factor for severe COVID-19: umplication and atility for patients edmitted to dmergency Department, Medicina-Lithuania
Apaydin, Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID-19, Clin. Endocrinol
Balzanelli, Analysis of gene single nucleotide polymorphisms in COVID-19 disease sighlighting the susceptibility and the severity towards the infection, Diagnostics
Bas, Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study, Anatol, J. Cardiol
Beheshti Shirazi, rs12329760 polymorphism in transmembrane serine protease 2 gene and risk of coronavirus disease 2019 mortality, BioMed Res. Int
Cafiero, Angiotensin system polymorphisms' in SARS-CoV-2 positive patients: assessment between iymptomatic and asymptomatic patients: a pilot study, Pharmacogenomics Personalized Med
Chilamakuri, Agarwal, COVID-19: characteristics and therapeutics, Cells
De Andrade, A polymorphism in the TMPRSS2 gene dncreases the risk of heath in older patients rospitalized with COVID-19, Viruses
Diamond, Farzan, The broad-spectrum antiviral functions of IFIT and IFITM proteins, Nat. Rev. Immunol
Dieter, Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: a systematic review and meta-analysis, PLoS One
Djaharuddin, Comorbidities and mortality in COVID-19 patients, Gac. Sanit
Dobrijevic, The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity: a systematic review and metaanalysis, Excli j
Falahi, Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population, Cytokine
Faridzadeh, The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian COVID-19 patients: a case-control study, Front. Genet
Gong, Angiotensin-converting enzyme genotype-specific immune cesponse nontributes to the susceptibility of COVID-19: a rested case-control study, Front. Pharmacol
Gunal, Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study, Ann. Saudi Med
Gómez, Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome, Gene
Gómez, The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19, Cytokine
Hubacek, ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors, Clin. Chim. Acta
Jafarpoor, VDR gene polymorphisms are associated with the increased susceptibility to COVID-19 among iranian population: a case-control study, Int. J. Immunogenet
Jevnikar, The role of ACE, ACE2, and AGTR2 polymorphisms in COVID-19 severity and the presence of COVID-19-related detinopathy, Genes
Jin, Gender differences in patients with COVID-19: rocus on severity and mortality, Front. Public Health
Karakas, Çelik, Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: a case study, J. Med. Virol
Kerget, Kerget, Frequency of interleukin-6 rs1800795 (-174G/C) and rs1800797 (-597G/A) polymorphisms in COVID-19 patients in Turkey who mevelop aacrophage zctivation syndrome, Jpn. J. Infect. Dis
Khalilzadeh, Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID-19 severity in Iranian population, Int. J. Immunogenet
Knobloch, Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias, J. Cranio-Maxillo-Fac. Surg
Kotur, Association of vitamin D, sinc and helenium related genetic variants with COVID-19 disease severity, Front. Nutr
Lapić, Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: a pilot study, J. Med. Virol
Mahdi, Assessing the potential correlation of polymorphisms in the TMPRSS2 gene with severity of COVID 19 patients, Biomedicine
Martínez-Gómez, ACE and ACE2 gene variants are associated with severe outcomes of COVID-19 in men, Front. Immunol
Meltzer, Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence
Mir, Strong association of angiotensin converting enzyme-2 gene insertion/deletion polymorphism with susceptibility to SARS-CoV-2, aypertension, coronary Artery disease and COVID-19 disease mortality, Pharmacogenetics Genom
Mohlendick, ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19, Mol. Genet. Genom
Molina, Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease, PLoS One
Mortazavi-Tabatabaei, Pattern of rntibacterial uesistance in trinary Tract infections: a systematic review and meta-analysis, Int. J. Prev. Med
Najafi, Mahdavi, Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease, Mol Genet Genomics
Nhung, Host genetic risk factors associated with COVID-19 susceptibility and severity in Vietnamese, Genes
Organization, Clinical Management of COVID-19, Living Guideline
Pan, Association between rs12252 polymorphism in IFITM3 gene and COVID-19, Int. J. Virol
Papadopoulou, Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: a rather controversial hypothesis. A case-control study, J. Med. Virol
Peralta, TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients, Egyptian Journal of Medical Human Genetics
Posadas-Sanchez, Association of the transmembrane serine protease-2 (TMPRSS2) polymorphisms with COVID-19, Vasc. Pharmacol
Rahimi, The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients, Virol. J
Ren, None
Ren, None
Reviono, Frequency of Interleukin-6 rs 1800796 (-572G/C) TNF-? rs1800750 (-376G/A), and 1800629 (-308G/A) polymorphism in COVID-19 patients with clinical degrees in Central Java, Bali Med. J
Rokni, Association of TMPRSS2 gene polymorphisms with COVID-19 severity and mortality: a case-control study with pomputational analyses, Appl. Biochem. Biotechnol
Saad, The role of angiotensin converting enzyme 1 insertion/deletion genetic polymorphism in the risk and severity of COVID-19 infection, Front. Med
Saengsiwaritt, Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID-19 severity: a systematic review with meta-analysis, Rev. Med. Virol
Saleh, Association of TNF-alpha G-308 a oromoter polymorphism with the course and outcome of COVID-19 patients, Immunol. Invest
Schoenfelder, Transmembrane serine protease 2 polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus type 2 infection: a German case-control study, Front. Genet
Schönfelder, The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19, Cytokine
Sekiya, TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility, Front. Microbiol
Shang, Cell entry mechanisms of SARS-CoV-2, Proc Natl Acad Sci U S A
Shi, An overview of COVID-19, J. Zhejiang Univ. -Sci. B
Sienko, Association of ACE2 gene variants with the severity of COVID-19 disease-A prospective Observational study, Int J Environ Res Public Health
Sotomayor-Lugo, The role of tumor necrosis factor alpha-308A > G polymorphism on the clinical states of SARS-CoV-2 infection, Hum. Genom
Stang, Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses, Eur. J. Epidemiol
Tipnis, A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase, J. Biol. Chem
Verma, Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity, Int. J. Immunogenet
Verma, Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients, Infect. Genet. Evol
Vitello, Allelic variations in the human genes TMPRSS2 and CCR5, and the Resistance to viral infection by SARS-CoV-2, Int. J. Mol. Sci
Wu, Mcgoogan, Characteristics of and important oessons from the coronavirus disease 2019 (COVID-19) sutbreak in China: pummary of a report of 72 314 cases from the Chinese center for disease control and frevention, JAMA
Wulandari, Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients, Hum Genomics
Zeidan, Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19, Pediatr. Res
Zhang, Interferon-induced transmembrane protein 3 genetic variant rs12252-C associated with disease severity in coronavirus disease 2019, J. Infect. Dis
{ 'indexed': {'date-parts': [[2024, 1, 7]], 'date-time': '2024-01-07T00:13:19Z', 'timestamp': 1704586399003}, 'reference-count': 80, 'publisher': 'Elsevier BV', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 1, 1]], 'date-time': '2024-01-01T00:00:00Z', 'timestamp': 1704067200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2023, 12, 9]], 'date-time': '2023-12-09T00:00:00Z', 'timestamp': 1702080000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': ['cell.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 1]]}, 'DOI': '10.1016/j.heliyon.2023.e23662', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 12, 14]], 'date-time': '2023-12-14T23:51:02Z', 'timestamp': 1702597862000}, 'page': 'e23662', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated ' 'meta-analysis based on 62 studies', 'prefix': '10.1016', 'volume': '10', 'author': [ {'given': 'Hongyue', 'family': 'Ren', 'sequence': 'first', 'affiliation': []}, {'given': 'Yanyan', 'family': 'Lin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lifeng', 'family': 'Huang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wenxin', 'family': 'Xu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deqing', 'family': 'Luo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chunbin', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib1', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/cells10020206', 'article-title': 'COVID-19: characteristics and therapeutics', 'volume': '10', 'author': 'Chilamakuri', 'year': '2021', 'journal-title': 'Cells'}, { 'issue': '5', 'key': '10.1016/j.heliyon.2023.e23662_bib2', 'doi-asserted-by': 'crossref', 'first-page': '343', 'DOI': '10.1631/jzus.B2000083', 'article-title': 'An overview of COVID-19', 'volume': '21', 'author': 'Shi', 'year': '2020', 'journal-title': 'J. Zhejiang Univ. - Sci. B'}, { 'issue': '13', 'key': '10.1016/j.heliyon.2023.e23662_bib3', 'doi-asserted-by': 'crossref', 'first-page': '1239', 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and important oessons from the coronavirus disease ' '2019 (COVID-19) sutbreak in China: pummary of a report of 72 314 cases ' 'from the Chinese center for disease control and frevention', 'volume': '323', 'author': 'Wu', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib4', 'doi-asserted-by': 'crossref', 'first-page': '152', 'DOI': '10.3389/fpubh.2020.00152', 'article-title': 'Gender differences in patients with COVID-19: rocus on severity and ' 'mortality', 'volume': '8', 'author': 'Jin', 'year': '2020', 'journal-title': 'Front. Public Health'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib5', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/jgm.3310', 'article-title': 'The impact of certain genetic variants (single nucleotide ' 'polymorphisms) on incidence and severity of COVID-19', 'volume': '23', 'author': 'Abobaker', 'year': '2021', 'journal-title': 'J. Gene Med.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib6', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/bjbs.2021.10238', 'article-title': 'ACE2 and TMPRSS2 SNPs as determinants of susceptibility to, and ' 'severity of, a COVID-19 infection', 'volume': '79', 'author': 'Abdelsattar', 'year': '2022', 'journal-title': 'Br. J. Biomed. Sci.'}, { 'issue': '16', 'key': '10.1016/j.heliyon.2023.e23662_bib7', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ijms23169171', 'article-title': 'Allelic variations in the human genes TMPRSS2 and CCR5, and the ' 'Resistance to viral infection by SARS-CoV-2', 'volume': '23', 'author': 'Vitello', 'year': '2022', 'journal-title': 'Int. J. Mol. Sci.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib8', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmicb.2022.943877', 'article-title': 'TMPRSS2 gene polymorphism common in East Asians confers decreased ' 'COVID-19 susceptibility', 'volume': '13', 'author': 'Sekiya', 'year': '2022', 'journal-title': 'Front. Microbiol.'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2023.e23662_bib9', 'article-title': 'Association of the transmembrane serine protease-2 (TMPRSS2) ' 'polymorphisms with COVID-19', 'volume': '14', 'author': 'Posadas-Sanchez', 'year': '2022', 'journal-title': 'Vasc. Pharmacol.'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2023.e23662_bib10', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0270627', 'article-title': 'Genetic polymorphisms associated with susceptibility to COVID-19 ' 'disease and severity: a systematic review and meta-analysis', 'volume': '17', 'author': 'Dieter', 'year': '2022', 'journal-title': 'PLoS One'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2023.e23662_bib11', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/rmv.2323', 'article-title': 'Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with ' 'COVID-19 severity: a systematic review with meta-analysis', 'volume': '32', 'author': 'Saengsiwaritt', 'year': '2022', 'journal-title': 'Rev. Med. Virol.'}, { 'issue': '5', 'key': '10.1016/j.heliyon.2023.e23662_bib12', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/jcla.24400', 'article-title': 'Association of tumor necrosis factor alpha -308 single nucleotide ' 'polymorphism with SARS CoV-2 infection in an Iraqi Kurdish population', 'volume': '36', 'author': 'Ali', 'year': '2022', 'journal-title': 'J. Clin. Lab. Anal.'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2023.e23662_bib13', 'doi-asserted-by': 'crossref', 'first-page': '243', 'DOI': '10.1111/iji.12585', 'article-title': 'VDR gene polymorphisms are associated with the increased susceptibility ' 'to COVID-19 among iranian population: a case-control study', 'volume': '49', 'author': 'Jafarpoor', 'year': '2022', 'journal-title': 'Int. J. Immunogenet.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib14', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.vph.2021.106934', 'article-title': 'Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 ' 'patients', 'volume': '142', 'author': 'Akbari', 'year': '2022', 'journal-title': 'Vascul Pharmacol'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib15', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cyto.2022.155957', 'article-title': 'Impact of interferon-induced transmembrane protein 3 gene rs12252 ' 'polymorphism on COVID-19 mortality', 'volume': '157', 'author': 'Ahmadi', 'year': '2022', 'journal-title': 'Cytokine'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib16', 'doi-asserted-by': 'crossref', 'first-page': '91', 'DOI': '10.1016/j.jcms.2010.11.001', 'article-title': 'Preferred reporting items for systematic reviews and meta-analyses ' '(PRISMA) statement and publication bias', 'volume': '39', 'author': 'Knobloch', 'year': '2011', 'journal-title': 'J. Cranio-Maxillo-Fac. Surg.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib17', 'series-title': 'Clinical Management of COVID-19: Living Guideline, 23 June 2022', 'author': 'Organization', 'year': '2022'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2023.e23662_bib18', 'doi-asserted-by': 'crossref', 'first-page': '603', 'DOI': '10.1007/s10654-010-9491-z', 'article-title': 'Critical evaluation of the Newcastle-Ottawa scale for the assessment of ' 'the quality of nonrandomized studies in meta-analyses', 'volume': '25', 'author': 'Stang', 'year': '2010', 'journal-title': 'Eur. J. Epidemiol.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib19', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.1016/j.cca.2022.09.006', 'article-title': 'Angiotensin-converting enzyme 1 and voltage-gated potassium ' 'channel-interacting protein 4 gene polymorphisms in COVID-19 patients ' 'from east of Iran', 'volume': '536', 'author': 'Abbaszadeh', 'year': '2022', 'journal-title': 'Clin. Chim. Acta'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib20', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.meegid.2021.105098', 'article-title': 'Association of Vitamin D receptor gene polymorphisms and ' 'clinical/severe outcomes of COVID-19 patients', 'volume': '96', 'author': 'Abdollahzadeh', 'year': '2021', 'journal-title': 'Infect. Genet. Evol.'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2023.e23662_bib21', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/genes12060830', 'article-title': 'Association between interferon-lambda-3 rs12979860, TLL1 rs17047200 and ' 'DDR1 rs4618569 variant polymorphisms with the course and outcome of ' 'SARS-CoV-2 patients', 'volume': '12', 'author': 'Agwa', 'year': '2021', 'journal-title': 'Genes'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib22', 'doi-asserted-by': 'crossref', 'DOI': '10.1155/2021/5509280', 'article-title': 'Human cce D/I polymorphism could affect the Clinicobiological course of ' 'COVID-19', 'volume': '2021', 'author': 'Aladag', 'year': '2021', 'journal-title': 'J Renin Angiotensin Aldosterone Syst'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib23', 'first-page': '1', 'article-title': 'Polymorphism in promotor region of IL6 gene as a predictor for severity ' 'in COVID -19 patients, Egypt', 'volume': '29', 'author': 'Aladawy', 'year': '2022', 'journal-title': 'J. Immunol.'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2023.e23662_bib24', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu13113680', 'article-title': 'Associations between genetic variants in the vitamin D petabolism ' 'rathway and severity of COVID-19 among UAE lesidents', 'volume': '13', 'author': 'Al-Anouti', 'year': '2021', 'journal-title': 'Nutrients'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2023.e23662_bib25', 'doi-asserted-by': 'crossref', 'first-page': '1733', 'DOI': '10.1016/j.ygeno.2021.04.002', 'article-title': 'Interferon-induced transmembrane protein-3 genetic variant rs12252 is ' 'associated with COVID-19 mortality', 'volume': '113', 'author': 'Alghamdi', 'year': '2021', 'journal-title': 'Genomics'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib26', 'doi-asserted-by': 'crossref', 'first-page': '48', 'DOI': '10.1186/s12985-022-01782-6', 'article-title': 'SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to ' 'SARS-CoV-2 infection but not with the severity of disease', 'volume': '19', 'author': 'Alimoradi', 'year': '2022', 'journal-title': 'Virol. J.'}, { 'issue': '10', 'key': '10.1016/j.heliyon.2023.e23662_bib27', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/jcm9103315', 'article-title': 'SARS-CoV-2 viral ooad, IFN lambda polymorphisms and the course of ' 'COVID-19: an ibservational study', 'volume': '9', 'author': 'Amodio', 'year': '2020', 'journal-title': 'J. Clin. Med.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib28', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2022.910098', 'article-title': 'Association between the LZTFL1 rs11385942 polymorphism and COVID-19 ' 'severity in Colombian population', 'volume': '9', 'author': 'Angulo-Aguado', 'year': '2022', 'journal-title': 'Front. Med.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2023.e23662_bib29', 'article-title': 'The angiotensin converting enzyme deletion/deletion genotype is a risk ' 'factor for severe COVID-19: umplication and atility for patients ' 'edmitted to dmergency Department', 'volume': '57', 'author': 'Annunziata', 'year': '2021', 'journal-title': 'Medicina-Lithuania'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2023.e23662_bib30', 'doi-asserted-by': 'crossref', 'first-page': '819', 'DOI': '10.1111/cen.14664', 'article-title': 'Effects of vitamin D receptor gene polymorphisms on the prognosis of ' 'COVID-19', 'volume': '96', 'author': 'Apaydin', 'year': '2022', 'journal-title': 'Clin. Endocrinol.'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2023.e23662_bib31', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/diagnostics12112824', 'article-title': 'Analysis of gene single nucleotide polymorphisms in COVID-19 disease ' 'sighlighting the susceptibility and the severity towards the infection', 'volume': '12', 'author': 'Balzanelli', 'year': '2022', 'journal-title': 'Diagnostics'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib32', 'doi-asserted-by': 'crossref', 'first-page': '133', 'DOI': '10.5152/AnatolJCardiol.2021.502', 'article-title': 'Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated ' 'with the clinical severity of COVID-19 pneumonia? A single-center ' 'cohort study', 'volume': '26', 'author': 'Baştuğ', 'year': '2022', 'journal-title': 'Anatol. J. Cardiol.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib33', 'doi-asserted-by': 'crossref', 'DOI': '10.1155/2022/7841969', 'article-title': 'rs12329760 polymorphism in transmembrane serine protease 2 gene and ' 'risk of coronavirus disease 2019 mortality', 'volume': '2022', 'author': 'Beheshti Shirazi', 'year': '2022', 'journal-title': 'BioMed Res. Int.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib34', 'doi-asserted-by': 'crossref', 'first-page': '621', 'DOI': '10.2147/PGPM.S303666', 'article-title': "Angiotensin system polymorphisms' in SARS-CoV-2 positive patients: " 'assessment between iymptomatic and asymptomatic patients: a pilot study', 'volume': '14', 'author': 'Cafiero', 'year': '2021', 'journal-title': 'Pharmacogenomics Personalized Med.'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2023.e23662_bib35', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/v14112557', 'article-title': 'A polymorphism in the TMPRSS2 gene dncreases the risk of heath in older ' 'patients rospitalized with COVID-19', 'volume': '14', 'author': 'de Andrade', 'year': '2022', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib36', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cyto.2022.155889', 'article-title': 'Evaluation of the relationship between IL-6 gene single nucleotide ' 'polymorphisms and the severity of COVID-19 in an Iranian population', 'volume': '154', 'author': 'Falahi', 'year': '2022', 'journal-title': 'Cytokine'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib37', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fgene.2022.955965', 'article-title': 'The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian ' 'COVID-19 patients: a case-control study', 'volume': '13', 'author': 'Faridzadeh', 'year': '2022', 'journal-title': 'Front. Genet.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib38', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cyto.2020.155354', 'article-title': 'The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C ' 'variant is associated with COVID-19', 'volume': '137', 'author': 'Gómez', 'year': '2021', 'journal-title': 'Cytokine'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib39', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.gene.2020.145102', 'article-title': 'Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 ' 'outcome', 'volume': '762', 'author': 'Gómez', 'year': '2020', 'journal-title': 'Gene'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib40', 'article-title': 'Angiotensin-converting enzyme genotype-specific immune cesponse ' 'nontributes to the susceptibility of COVID-19: a rested case-control ' 'study', 'volume': '12', 'author': 'Gong', 'year': '2021', 'journal-title': 'Front. Pharmacol.'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2023.e23662_bib41', 'doi-asserted-by': 'crossref', 'first-page': '141', 'DOI': '10.5144/0256-4947.2021.141', 'article-title': 'Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism ' 'may be associated with COVID-19 clinical severity: a prospective cohort ' 'study', 'volume': '41', 'author': 'Gunal', 'year': '2021', 'journal-title': 'Ann. Saudi Med.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib42', 'doi-asserted-by': 'crossref', 'first-page': '206', 'DOI': '10.1016/j.cca.2021.04.024', 'article-title': 'ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors', 'volume': '519', 'author': 'Hubacek', 'year': '2021', 'journal-title': 'Clin. Chim. Acta'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2023.e23662_bib43', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/genes13071111', 'article-title': 'The role of ACE, ACE2, and AGTR2 polymorphisms in COVID-19 severity and ' 'the presence of COVID-19-related detinopathy', 'volume': '13', 'author': 'Jevnikar', 'year': '2022', 'journal-title': 'Genes'}, { 'issue': '10', 'key': '10.1016/j.heliyon.2023.e23662_bib44', 'doi-asserted-by': 'crossref', 'first-page': '5947', 'DOI': '10.1002/jmv.27160', 'article-title': 'Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, ' 'Rs2285666) are not related to the clinical course of COVID-19: a case ' 'study', 'volume': '93', 'author': 'Karakaş Çelik', 'year': '2021', 'journal-title': 'J. Med. Virol.'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2023.e23662_bib45', 'doi-asserted-by': 'crossref', 'first-page': '543', 'DOI': '10.7883/yoken.JJID.2021.046', 'article-title': 'Frequency of interleukin-6 rs1800795 (-174G/C) and rs1800797 (-597G/A) ' 'polymorphisms in COVID-19 patients in Turkey who mevelop aacrophage ' 'zctivation syndrome', 'volume': '74', 'author': 'Kerget', 'year': '2021', 'journal-title': 'Jpn. J. Infect. Dis.'}, { 'issue': '5', 'key': '10.1016/j.heliyon.2023.e23662_bib46', 'doi-asserted-by': 'crossref', 'first-page': '325', 'DOI': '10.1111/iji.12598', 'article-title': 'Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical ' 'parameters as the determinants of COVID-19 severity in Iranian ' 'population', 'volume': '49', 'author': 'Khalilzadeh', 'year': '2022', 'journal-title': 'Int. J. Immunogenet.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib47', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fnut.2021.689419', 'article-title': 'Association of vitamin D, sinc and helenium related genetic variants ' 'with COVID-19 disease severity', 'volume': '8', 'author': 'Kotur', 'year': '2021', 'journal-title': 'Front. Nutr.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2023.e23662_bib48', 'doi-asserted-by': 'crossref', 'first-page': '3669', 'DOI': '10.1002/jmv.27774', 'article-title': 'Association of polymorphisms in genes encoding prothrombotic and ' 'cardiovascular risk factors with disease severity in COVID-19 patients: ' 'a pilot study', 'volume': '94', 'author': 'Lapić', 'year': '2022', 'journal-title': 'J. Med. Virol.'}, { 'issue': '5', 'key': '10.1016/j.heliyon.2023.e23662_bib49', 'doi-asserted-by': 'crossref', 'first-page': '1034', 'DOI': '10.51248/.v42i5.2279', 'article-title': 'Assessing the potential correlation of polymorphisms in the TMPRSS2 ' 'gene with severity of COVID 19 patients', 'volume': '42', 'author': 'Mahdi', 'year': '2022', 'journal-title': 'Biomedicine'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib50', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2022.812940', 'article-title': 'ACE and ACE2 gene variants are associated with severe outcomes of ' 'COVID-19 in men', 'volume': '13', 'author': 'Martínez-Gómez', 'year': '2022', 'journal-title': 'Front. Immunol.'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2023.e23662_bib51', 'article-title': 'Strong association of angiotensin converting enzyme-2 gene ' 'insertion/deletion polymorphism with susceptibility to SARS-CoV-2, ' 'aypertension, coronary Artery disease and COVID-19 disease mortality', 'volume': '11', 'author': 'Mir', 'year': '2021', 'journal-title': 'Pharmacogenetics Genom.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2023.e23662_bib52', 'first-page': '165', 'article-title': 'ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and ' 'severity of COVID-19', 'volume': '31', 'author': 'Mohlendick', 'year': '2021', 'journal-title': 'Mol. Genet. Genom.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib53', 'first-page': '1', 'article-title': 'Association investigations between ACE1 and ACE2 polymorphisms and ' 'severity of COVID-19 disease', 'author': 'Najafi', 'year': '2022', 'journal-title': 'Mol Genet Genomics'}, { 'issue': '10', 'key': '10.1016/j.heliyon.2023.e23662_bib54', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/genes13101884', 'article-title': 'Host genetic risk factors associated with COVID-19 susceptibility and ' 'severity in Vietnamese', 'volume': '13', 'author': 'Nhung', 'year': '2022', 'journal-title': 'Genes'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2023.e23662_bib55', 'first-page': '192', 'article-title': 'Association between rs12252 polymorphism in IFITM3 gene and COVID-19', 'volume': '28', 'author': 'Pan', 'year': '2021', 'journal-title': 'Int. J. Virol.'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2023.e23662_bib56', 'doi-asserted-by': 'crossref', 'first-page': '1050', 'DOI': '10.1002/jmv.27417', 'article-title': 'Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE ' 'activity, and COVID-19: a rather controversial hypothesis. A ' 'case-control study', 'volume': '94', 'author': 'Papadopoulou', 'year': '2022', 'journal-title': 'J. Med. Virol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib57', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s43042-021-00206-4', 'article-title': 'TaqI polymorphism of the VDR gene: aspects related to the clinical ' 'behavior of COVID-19 in Cuban patients', 'volume': '22', 'author': 'Peralta', 'year': '2021', 'journal-title': 'Egyptian Journal of Medical Human Genetics'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib58', 'doi-asserted-by': 'crossref', 'first-page': '221', 'DOI': '10.1186/s12985-021-01692-z', 'article-title': 'The association between interferon lambda 3 and 4 gene ' 'single-nucleotide polymorphisms and the recovery of COVID-19 patients', 'volume': '18', 'author': 'Rahimi', 'year': '2021', 'journal-title': 'Virol. J.'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2023.e23662_bib59', 'doi-asserted-by': 'crossref', 'first-page': '1364', 'DOI': '10.15562/bmj.v11i3.3552', 'article-title': 'Frequency of Interleukin-6 rs 1800796 (-572G/C) TNF-? rs1800750 ' '(-376G/A), and 1800629 (-308G/A) polymorphism in COVID-19 patients with ' 'clinical degrees in Central Java', 'volume': '11', 'author': 'Reviono', 'year': '2022', 'journal-title': 'Bali Med. J.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2023.e23662_bib60', 'doi-asserted-by': 'crossref', 'first-page': '3507', 'DOI': '10.1007/s12010-022-03885-w', 'article-title': 'Association of TMPRSS2 gene polymorphisms with COVID-19 severity and ' 'mortality: a case-control study with pomputational analyses', 'volume': '194', 'author': 'Rokni', 'year': '2022', 'journal-title': 'Appl. Biochem. Biotechnol.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib61', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2021.798571', 'article-title': 'The role of angiotensin converting enzyme 1 insertion/deletion genetic ' 'polymorphism in the risk and severity of COVID-19 infection', 'volume': '8', 'author': 'Saad', 'year': '2021', 'journal-title': 'Front. Med.'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2023.e23662_bib62', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0263140', 'article-title': 'Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 ' 'disease', 'volume': '17', 'author': 'Sabater Molina', 'year': '2022', 'journal-title': 'PLoS One'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2023.e23662_bib63', 'doi-asserted-by': 'crossref', 'first-page': '546', 'DOI': '10.1080/08820139.2020.1851709', 'article-title': 'Association of TNF-alpha G-308 a oromoter polymorphism with the course ' 'and outcome of COVID-19 patients', 'volume': '51', 'author': 'Saleh', 'year': '2022', 'journal-title': 'Immunol. Invest.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib64', 'article-title': 'Transmembrane serine protease 2 polymorphisms and susceptibility to ' 'severe acute respiratory syndrome coronavirus type 2 infection: a ' 'German case-control study', 'volume': '12', 'author': 'Schoenfelder', 'year': '2021', 'journal-title': 'Front. Genet.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib65', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cyto.2021.155492', 'article-title': 'The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 ' 'infection and severity of COVID-19', 'volume': '142', 'author': 'Schönfelder', 'year': '2021', 'journal-title': 'Cytokine'}, { 'issue': '19', 'key': '10.1016/j.heliyon.2023.e23662_bib66', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ijerph191912622', 'article-title': 'Association of ACE2 gene variants with the severity of COVID-19 ' 'disease-A prospective Observational study', 'volume': '19', 'author': 'Sienko', 'year': '2022', 'journal-title': 'Int J Environ Res Public Health'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib67', 'article-title': 'The role of tumor necrosis factor alpha-308A > G polymorphism on the ' 'clinical states of SARS-CoV-2 infection', 'volume': '23', 'author': 'Sotomayor-Lugo', 'year': '2022', 'journal-title': 'Hum. Genom.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib68', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.meegid.2021.104801', 'article-title': 'Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) ' 'gene on the severity of COVID-19 patients', 'volume': '91', 'author': 'Verma', 'year': '2021', 'journal-title': 'Infect. Genet. Evol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib69', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1111/iji.12605', 'article-title': 'Genetic polymorphisms of IL6 gene -174G > C and -597G > A are ' 'associated with the risk of COVID-19 severity', 'volume': '50', 'author': 'Verma', 'year': '2023', 'journal-title': 'Int. J. Immunogenet.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib70', 'doi-asserted-by': 'crossref', 'first-page': '29', 'DOI': '10.1186/s40246-021-00330-7', 'article-title': 'Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 ' 'patients', 'volume': '15', 'author': 'Wulandari', 'year': '2021', 'journal-title': 'Hum Genomics'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib71', 'unstructured': 'N.M.S. Zeidan, et al., Vitamin D deficiency and vitamin D receptor FokI ' 'polymorphism as risk factors for COVID-19, Pediatr. Res.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib72', 'doi-asserted-by': 'crossref', 'first-page': '34', 'DOI': '10.1093/infdis/jiaa224', 'article-title': 'Interferon-induced transmembrane protein 3 genetic variant rs12252-C ' 'associated with disease severity in coronavirus disease 2019', 'volume': '222', 'author': 'Zhang', 'year': '2020', 'journal-title': 'J. Infect. Dis.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib73', 'doi-asserted-by': 'crossref', 'first-page': '169', 'DOI': '10.4103/ijpvm.IJPVM_419_17', 'article-title': 'Pattern of rntibacterial uesistance in trinary Tract infections: a ' 'systematic review and meta-analysis', 'volume': '10', 'author': 'Mortazavi-Tabatabaei', 'year': '2019', 'journal-title': 'Int. J. Prev. Med.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib74', 'doi-asserted-by': 'crossref', 'first-page': '193', 'DOI': '10.1097/TP.0000000000003507', 'article-title': 'HLA and AB0 polymorphisms may influence SARS-CoV-2 infection and ' 'COVID-19 severity', 'volume': '105', 'author': 'Amoroso', 'year': '2021', 'journal-title': 'Transplantation'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib75', 'first-page': '818', 'article-title': 'The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms ' 'with COVID-19 severity: a systematic review and meta-analysis', 'volume': '21', 'author': 'Dobrijevic', 'year': '2022', 'journal-title': 'Excli j'}, { 'issue': '43', 'key': '10.1016/j.heliyon.2023.e23662_bib76', 'doi-asserted-by': 'crossref', 'first-page': '33238', 'DOI': '10.1074/jbc.M002615200', 'article-title': 'A human homolog of angiotensin-converting enzyme. Cloning and ' 'functional expression as a captopril-insensitive carboxypeptidase', 'volume': '275', 'author': 'Tipnis', 'year': '2000', 'journal-title': 'J. Biol. Chem.'}, { 'issue': '21', 'key': '10.1016/j.heliyon.2023.e23662_bib77', 'doi-asserted-by': 'crossref', 'first-page': '11727', 'DOI': '10.1073/pnas.2003138117', 'article-title': 'Cell entry mechanisms of SARS-CoV-2', 'volume': '117', 'author': 'Shang', 'year': '2020', 'journal-title': 'Proc Natl Acad Sci U S A'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2023.e23662_bib78', 'doi-asserted-by': 'crossref', 'first-page': '46', 'DOI': '10.1038/nri3344', 'article-title': 'The broad-spectrum antiviral functions of IFIT and IFITM proteins', 'volume': '13', 'author': 'Diamond', 'year': '2013', 'journal-title': 'Nat. Rev. Immunol.'}, { 'key': '10.1016/j.heliyon.2023.e23662_bib79', 'series-title': 'Association of Vitamin D Deficiency and Treatment with COVID-19 ' 'Incidence', 'author': 'Meltzer', 'year': '2020'}, { 'issue': 'Suppl 2', 'key': '10.1016/j.heliyon.2023.e23662_bib80', 'doi-asserted-by': 'crossref', 'first-page': 'S530', 'DOI': '10.1016/j.gaceta.2021.10.085', 'article-title': 'Comorbidities and mortality in COVID-19 patients', 'volume': '35', 'author': 'Djaharuddin', 'year': '2021', 'journal-title': 'Gac. Sanit.'}], 'container-title': 'Heliyon', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S240584402310870X?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S240584402310870X?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 1, 6]], 'date-time': '2024-01-06T20:35:09Z', 'timestamp': 1704573309000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S240584402310870X'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 1]]}, 'references-count': 80, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2024, 1]]}}, 'alternative-id': ['S240584402310870X'], 'URL': 'http://dx.doi.org/10.1016/j.heliyon.2023.e23662', 'relation': {}, 'ISSN': ['2405-8440'], 'subject': ['Multidisciplinary'], 'container-title-short': 'Heliyon', 'published': {'date-parts': [[2024, 1]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Association of genetic polymorphisms with COVID-19 infection and outcomes: An ' 'updated meta-analysis based on 62 studies', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Heliyon', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.heliyon.2023.e23662', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2023 The Authors. Published by Elsevier Ltd.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': 'e23662'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit