{ 'indexed': {'date-parts': [[2023, 9, 29]], 'date-time': '2023-09-29T08:46:55Z', 'timestamp': 1695977215482},
'reference-count': 49,
'publisher': 'MDPI AG',
'issue': '10',
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'date-time': '2023-09-28T00:00:00Z',
'timestamp': 1695859200000},
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'URL': 'https://creativecommons.org/licenses/by/4.0/'}],
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'abstract': '<jats:p>The spread of COVID-19 continues, expressed by periodic wave-like increases in '
'morbidity and mortality. The reason for the periodic increases in morbidity is the emergence '
'and spread of novel genetic variants of SARS-CoV-2. A decrease in the efficacy of monoclonal '
'antibodies (mAbs) has been reported, especially against Omicron subvariants. There have been '
'reports of a decrease in the efficacy of specific antiviral drugs as a result of mutations in '
'the genes of non-structural proteins. This indicates the urgent need for practical healthcare '
'to constantly monitor pathogen variability and its effect on the efficacy of preventive and '
'therapeutic drugs. As part of this study, we report the results of the continuous monitoring '
'of COVID-19 in Moscow using genetic and virological methods. As a result of this monitoring, '
'we determined the dominant genetic variants and identified the variants that are most '
'widespread, not only in Moscow, but also in other countries. A collection of viruses from '
'more than 500 SARS-CoV-2 isolates has been obtained and characterized. The genetic lines '
'XBB.1.9.1, XBB.1.9.3, XBB.1.5, XBB.1.16, XBB.2.4, BQ.1.1.45, CH.1.1, and CL.1, representing '
'the greatest concern, were identified among the dominant variants. We studied the in vitro '
'efficacy of mAbs Tixagevimab + Cilgavimab (Evusheld), Sotrovimab, Regdanvimab, Casirivimab + '
'Imdevimab (Ronapreve), and Bebtelovimab, as well as the specific antiviral drugs Remdesivir, '
'Molnupiravir, and Nirmatrelvir, against these genetic lines. At the current stage of the '
'COVID-19 pandemic, the use of mAbs developed against early SARS-CoV-2 variants has little '
'prospect. Specific antiviral drugs retain their activity, but further monitoring is needed to '
'assess the risk of their efficacy being reduced and adjust recommendations for their '
'use.</jats:p>',
'DOI': '10.3390/vaccines11101533',
'type': 'journal-article',
'created': {'date-parts': [[2023, 9, 28]], 'date-time': '2023-09-28T05:42:12Z', 'timestamp': 1695879732000},
'page': '1533',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'In Vitro Efficacy of Antivirals and Monoclonal Antibodies against SARS-CoV-2 Omicron Lineages '
'XBB.1.9.1, XBB.1.9.3, XBB.1.5, XBB.1.16, XBB.2.4, BQ.1.1.45, CH.1.1, and CL.1',
'prefix': '10.3390',
'volume': '11',
'author': [ { 'ORCID': 'http://orcid.org/0000-0003-1107-9351',
'authenticated-orcid': False,
'given': 'Andrei A.',
'family': 'Pochtovyi',
'sequence': 'first',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'},
{ 'name': 'Department of Virology, Biological Faculty, Lomonosov Moscow '
'State University, 119991 Moscow, Russia'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-8382-275X',
'authenticated-orcid': False,
'given': 'Daria D.',
'family': 'Kustova',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'},
{ 'name': 'Department of Virology, Biological Faculty, Lomonosov Moscow '
'State University, 119991 Moscow, Russia'}]},
{ 'ORCID': 'http://orcid.org/0000-0001-7576-2059',
'authenticated-orcid': False,
'given': 'Andrei E.',
'family': 'Siniavin',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'},
{ 'name': 'Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian '
'Academy of Sciences, 117997 Moscow, Russia'}]},
{ 'given': 'Inna V.',
'family': 'Dolzhikova',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Elena V.',
'family': 'Shidlovskaya',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Olga G.',
'family': 'Shpakova',
'sequence': 'additional',
'affiliation': [{'name': 'Moscow Healthcare Department, 127006 Moscow, Russia'}]},
{ 'given': 'Lyudmila A.',
'family': 'Vasilchenko',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Arina A.',
'family': 'Glavatskaya',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-7399-7628',
'authenticated-orcid': False,
'given': 'Nadezhda A.',
'family': 'Kuznetsova',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Anna A.',
'family': 'Iliukhina',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Artem Y.',
'family': 'Shelkov',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Olesia M.',
'family': 'Grinkevich',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Andrei G.',
'family': 'Komarov',
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'affiliation': [{'name': 'Moscow Healthcare Department, 127006 Moscow, Russia'}]},
{ 'given': 'Denis Y.',
'family': 'Logunov',
'sequence': 'additional',
'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'}]},
{ 'given': 'Vladimir A.',
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'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'},
{ 'name': 'Department of Virology, Biological Faculty, Lomonosov Moscow '
'State University, 119991 Moscow, Russia'}]},
{ 'given': 'Alexander L.',
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'affiliation': [ { 'name': 'Federal State Budget Institution “National Research Centre for '
'Epidemiology and Microbiology Named after Honorary Academician '
'N. F. Gamaleya” of the Ministry of Health of the Russian '
'Federation, 123098 Moscow, Russia'},
{ 'name': 'Department of Infectiology and Virology, Federal State '
'Autonomous Educational Institution of Higher Education I.M. '
'Sechenov, First Moscow State Medical University of the Ministry '
'of Health of the Russian Federation (Sechenov University), '
'119435 Moscow, Russia'}]}],
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