Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes
et al., Science China Life Sciences, doi:10.1007/s11427-023-2369-3, Oct 2023
In vitro study using adult human primary cardiomyocytes showing remdesivir-induced mitochondrial toxicity, identifying mitochondrial ROS as the primary mediator, and showing action potential prolongation consistent with clinical QT prolongation reports.
Gérard, Zhou, Wu, Kamo, Choi, Kim show increased risk of acute kidney injury, Leo, Briciu, Muntean, Petrov, Arch show increased risk of liver injury, Negru, Cheng, Mohammed, Kwok, Zhu show increased risk of cardiac disorders, and Kwok, Merches, Akinci, Tang, Bagheri show increased risk of mitochondrial toxicity with remdesivir.
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Tang et al., 18 Oct 2023, peer-reviewed, 11 authors.
In vitro studies are an important part of preclinical research, however results may be very different in vivo.
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"title": "Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes",
"type": "journal-article",
"update-policy": "https://doi.org/10.1007/springer_crossmark_policy",
"volume": "67"
}