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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 56% Improvement Relative Risk Azvudine for COVID-19  Shao et al.  LATE TREATMENT Is late treatment with azvudine beneficial for COVID-19? Retrospective 686 patients in China (December 2022 - February 2023) Lower mortality with azvudine (p=0.0069) c19early.org Shao et al., Microorganisms, July 2023 Favors azvudine Favors control

Composite Interventions on Outcomes of Severely and Critically Ill Patients with COVID-19 in Shanghai, China

Shao et al., Microorganisms, doi:10.3390/microorganisms11071859
Jul 2023  
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Azvudine for COVID-19
41st treatment shown to reduce risk in July 2023
 
*, now known with p = 0.00014 from 18 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 1,082 severely and critically ill COVID-19 patients in China showing lower 60 day mortality with azvudine. Mortality was also lower with paxlovid, but without statistical significance, and health related quality of life was significantly lower for paxlovid patients at 60 days.
Study covers paxlovid and azvudine.
risk of death, 56.0% lower, HR 0.44, p = 0.007, treatment 177, control 509, adjusted per study, day 60.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shao et al., 23 Jul 2023, retrospective, China, peer-reviewed, 9 authors, study period 8 December, 2022 - 9 February, 2023. Contact: huanggang@sumhs.edu.cn (corresponding author), shaojiasheng@jdhospital.com, rfan1@tulane.edu, cnguo22@m.fudan.edu.cn, huangxuyuan@jdhospital.com, guorunsheng@jdhospital.com, zhangfengdi@126.com, hujianrong@jdhospital.com, caoliou@jdhospital.com.
This PaperAzvudineAll
Composite Interventions on Outcomes of Severely and Critically Ill Patients with COVID-19 in Shanghai, China
Jiasheng Shao, Rong Fan, Chengnan Guo, Xuyuan Huang, Runsheng Guo, Fengdi Zhang, Jianrong Hu, Gang Huang, Liou Cao
Microorganisms, doi:10.3390/microorganisms11071859
Background: The sixty-day effects of initial composite interventions for the treatment of severely and critically ill patients with COVID-19 are not fully assessed. Methods: Using a Bayesian piecewise exponential model, we analyzed the 60-day mortality, health-related quality of life (HRQoL), and disability in 1082 severely and critically ill patients with COVID-19 between 8 December 2022 and 9 February 2023 in Shanghai, China. The final 60-day follow-up was completed on 10 April 2023. Results: Among 1082 patients (mean age, 78.0 years, 421 [38.9%] women), 139 patients (12.9%) died within 60 days. Azvudine had a 99.8% probability of improving 2-month survival (adjusted HR, 0.44 [95% credible interval, 0.24-0.79]), and Paxlovid had a 91.9% probability of improving 2-month survival (adjusted HR, 0.71 [95% credible interval, 0.44-1.14]) compared with the control. IL-6 receptor antagonist, baricitinib and a-thymosin each had a high probability of benefit (99.5%, 99.4%, and 97.5%, respectively) compared to their controls, while the probability of trail-defined statistical futility (HR > 0.83) was high for therapeutic anticoagulation (99.8%; HR, 1.64 [95% CrI, 1.06-2.50]) and glucocorticoid (91.4%; HR, 1.20 [95% CrI,). Paxlovid, Azvudine, and therapeutic anticoagulation showed a significant reduction in disability (p < 0.05) Conclusions: Among severely and critically ill patients with COVID-19 who received 1 or more therapeutic interventions, treatment with Azvudine had a high probability of improved 60-day mortality compared with the control, indicating its potential in a resource-limited scenario. Treatment with an IL-6 receptor antagonist, baricitinib, and a-thymosin also had high probabilities of benefit in improving 2-month survival, among which a-thymosin could improve HRQoL. Treatment with Paxlovid, Azvudine, and therapeutic anticoagulation could significantly reduce disability at day 60.
Conflicts of Interest: The authors declare no conflict of interest.
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Late treatment
is less effective
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