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Single-Nucleotide Polymorphisms Related to Vitamin D Metabolism and Severity or Mortality of COVID-19: A Systematic Review and Meta-analysis

Regina da Silva Correa da Ronda et al., Gene, doi:10.1016/j.gene.2024.148236
Feb 2024  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Systematic review and meta analysis of 12 studies examining associations between 31 single-nucleotide polymorphisms (SNPs) related to four vitamin D metabolism genes (VDR, GC, DHCR7, CYP2R1) and COVID-19 severity or mortality. Meta-analysis showed the VDR rs1544410 genotype and b allele were associated with increased odds of developing severe/critical COVID-19. Several VDR SNPs (rs731236, rs1544410, rs7975232, rs2228570) were associated with increased COVID-19 mortality.
19 meta analyses show significant improvements with vitamin D treatment for mortality1-14, mechanical ventilation1,6,7,12,15,16, ICU admission1,3,6,7,10,12,14-18, hospitalization5,12, severity2,4,6,11,19, and cases8,18,19.
Currently there are 122 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 19% lower ventilation [-3‑36%], 45% lower ICU admission [28‑58%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
Regina da Silva Correa da Ronda et al., 3 Feb 2024, peer-reviewed, 11 authors.
This PaperVitamin DAll
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'Abdollahzadeh', 'year': '2021', 'journal-title': 'Infect Genet Evol.'}, { 'key': '10.1016/j.gene.2024.148236_b0010', 'article-title': 'Effect of vitamin D receptor gene BsmI polymorphism on hospitalization ' 'of SARS-CoV-2 positive patients', 'volume': '1–12', 'author': 'Aci', 'year': '2023', 'journal-title': 'Nucleosides Nucleotides Nucleic Acids.'}, { 'key': '10.1016/j.gene.2024.148236_b0015', 'doi-asserted-by': 'crossref', 'first-page': '3680', 'DOI': '10.3390/nu13113680', 'article-title': 'Associations between Genetic Variants in the Vitamin D Metabolism ' 'Pathway and Severity of COVID-19 among UAE Residents', 'volume': '13', 'author': 'Al-Anouti', 'year': '2021', 'journal-title': 'Nutrients.'}, { 'key': '10.1016/j.gene.2024.148236_b0020', 'doi-asserted-by': 'crossref', 'first-page': '2346', 'DOI': '10.3390/genes13122346', 'article-title': 'Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in ' 'Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate', 'volume': '13', 'author': 'Albu-Mohammed', 'year': '2022', 'journal-title': 'Genes (Basel)'}, { 'key': '10.1016/j.gene.2024.148236_b0025', 'doi-asserted-by': 'crossref', 'first-page': '3612', 'DOI': '10.1038/s41598-023-30859-7', 'article-title': 'Association of ApaI rs7975232 and BsmI rs1544410 in clinical outcomes ' 'of COVID-19 patients according to different SARS-CoV-2 variants', 'volume': '13', 'author': 'Al-Gharrawi', 'year': '2023', 'journal-title': 'Sci Rep.'}, { 'key': '10.1016/j.gene.2024.148236_b0030', 'doi-asserted-by': 'crossref', 'first-page': '1728', 'DOI': '10.1002/cbin.12064', 'article-title': 'Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms ' 'on the vitamin D receptor gene with susceptibility to different ' 'SARS-CoV-2 variants', 'volume': '47', 'author': 'Al-Mohammedawi', 'year': '2023', 'journal-title': 'Cell Biol Int.'}, { 'key': '10.1016/j.gene.2024.148236_b0035', 'doi-asserted-by': 'crossref', 'first-page': '819', 'DOI': '10.1111/cen.14664', 'article-title': 'Effects of vitamin D receptor gene polymorphisms on the prognosis of ' 'COVID-19', 'volume': '96', 'author': 'Apaydin', 'year': '2022', 'journal-title': 'Clin Endocrinol (Oxf).'}, { 'key': '10.1016/j.gene.2024.148236_b0040', 'doi-asserted-by': 'crossref', 'first-page': '881', 'DOI': '10.2310/JIM.0b013e31821b8755', 'article-title': 'Vitamin D and the immune system', 'volume': '59', 'author': 'Aranow', 'year': '2011', 'journal-title': 'J Investig Med.'}, { 'key': '10.1016/j.gene.2024.148236_b0045', 'first-page': '200', 'article-title': 'The relationship between vitamin D and the severity of COVID-19', 'volume': '122', 'author': 'Basaran', 'year': '2021', 'journal-title': 'Bratisl Lek Listy.'}, { 'key': '10.1016/j.gene.2024.148236_b0050', 'doi-asserted-by': 'crossref', 'first-page': 'e1003605', 'DOI': '10.1371/journal.pmed.1003605', 'article-title': 'Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host ' 'Genetics Initiative: A Mendelian randomization study', 'volume': '18', 'author': 'Butler-Laporte', 'year': '2021', 'journal-title': 'PLoS Med.'}, { 'key': '10.1016/j.gene.2024.148236_b0055', 'doi-asserted-by': 'crossref', 'first-page': '492', 'DOI': '10.1097/PHM.0000000000001588', 'article-title': 'Association Between FokI Polymorphism of Vitamin D Receptor Gene and ' 'Lumbar Spine Disc Degeneration: A Systematic Review and Meta-Analysis', 'volume': '100', 'author': 'Castillo-Avila', 'year': '2021', 'journal-title': 'Am J Phys Med Rehabil.'}, { 'key': '10.1016/j.gene.2024.148236_b0060', 'doi-asserted-by': 'crossref', 'first-page': '1634', 'DOI': '10.4049/jimmunol.179.3.1634', 'article-title': 'Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell ' 'differentiation', 'volume': '179', 'author': 'Chen', 'year': '2007', 'journal-title': 'J Immunol.'}, { 'key': '10.1016/j.gene.2024.148236_b0065', 'doi-asserted-by': 'crossref', 'first-page': '211', 'DOI': '10.1046/j.1365-2265.2000.00909.x', 'article-title': 'Consequences of vitamin D receptor gene polymorphisms for growth ' 'inhibition of cultured human peripheral blood mononuclear cells by 1, ' '25-dihydroxyvitamin D3', 'volume': '52', 'author': 'Colin', 'year': '2000', 'journal-title': 'Clin Endocrinol.'}, { 'key': '10.1016/j.gene.2024.148236_b0070', 'doi-asserted-by': 'crossref', 'first-page': '103', 'DOI': '10.21037/tp-20-198', 'article-title': 'Vitamin D receptor gene ApaI and FokI polymorphisms and its association ' 'with inflammation and oxidative stress in vitamin D sufficient ' 'Caucasian Spanish children', 'volume': '10', 'author': 'Ferrer-Suay', 'year': '2021', 'journal-title': 'Transl Pediatr.'}, { 'key': '10.1016/j.gene.2024.148236_b0075', 'first-page': '133', 'article-title': 'Modifying effects of TNF-α, IL-6 and VDR genes on the development risk ' 'and the course of COVID-19', 'volume': '37', 'author': 'Fishchuk', 'year': '2021', 'journal-title': 'Pilot study. Drug Metab Pers Ther.'}, { 'key': '10.1016/j.gene.2024.148236_b0080', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jsbmb.2020.105720', 'article-title': 'The vitamin D receptor Taq I polymorphism is associated with reduced ' 'VDR and increased PDIA3 protein levels in human intestinal fibroblasts', 'volume': '202', 'author': 'Gisbert-Ferrándiz', 'year': '2020', 'journal-title': 'J Steroid Biochem Mol Biol.'}, { 'key': '10.1016/j.gene.2024.148236_b0085', 'doi-asserted-by': 'crossref', 'first-page': '557', 'DOI': '10.1136/bmj.327.7414.557', 'article-title': 'Measuring inconsistency in meta-analyses', 'volume': '327', 'author': 'Higgins', 'year': '2003', 'journal-title': 'BMJ.'}, { 'key': '10.1016/j.gene.2024.148236_b0090', 'doi-asserted-by': 'crossref', 'first-page': '316', 'DOI': '10.1111/j.1525-139X.2007.00302.x', 'article-title': 'Expanding role for vitamin D in chronic kidney disease: importance of ' 'blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the ' 'classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3)', 'volume': '20', 'author': 'Jones', 'year': '2007', 'journal-title': 'Semin Dial.'}, { 'key': '10.1016/j.gene.2024.148236_b0095', 'doi-asserted-by': 'crossref', 'DOI': '10.1155/2013/427818', 'article-title': 'Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with ' 'Systemic Lupus Erythematosus', 'volume': '2013', 'author': 'Kaleta', 'year': '2013', 'journal-title': 'ISRN Endocrinol.'}, { 'key': '10.1016/j.gene.2024.148236_b0100', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fnut.2021.689419', 'article-title': 'Association of Vitamin D, Zinc and Selenium Related Genetic Variants ' 'With COVID-19 Disease Severity', 'volume': '8', 'author': 'Kotur', 'year': '2021', 'journal-title': 'Front Nutr.'}, { 'key': '10.1016/j.gene.2024.148236_b0105', 'doi-asserted-by': 'crossref', 'first-page': '430', 'DOI': '10.1080/03014460.2019.1659851', 'article-title': 'Vitamin D receptor (VDR) gene polymorphism and osteoporosis risk in ' 'White British men', 'volume': '46', 'author': 'Kow', 'year': '2019', 'journal-title': 'Ann Hum Biol.'}, { 'key': '10.1016/j.gene.2024.148236_b0110', 'doi-asserted-by': 'crossref', 'first-page': '597', 'DOI': '10.1016/j.jclinepi.2008.12.004', 'article-title': 'Strengthening the reporting of genetic association studies (STREGA): an ' 'extension of the strengthening the reporting of observational studies ' 'in epidemiology (STROBE) statement', 'volume': '62', 'author': 'Little', 'year': '2009', 'journal-title': 'J Clin Epidemiol.'}, { 'key': '10.1016/j.gene.2024.148236_b0115', 'doi-asserted-by': 'crossref', 'first-page': '3361', 'DOI': '10.3390/nu12113361', 'article-title': 'Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity', 'volume': '12', 'author': 'Mercola', 'year': '2020', 'journal-title': 'Nutrients.'}, { 'key': '10.1016/j.gene.2024.148236_b0120', 'doi-asserted-by': 'crossref', 'first-page': '1230', 'DOI': '10.1097/INF.0b013e31829e4d06', 'article-title': 'Vitamin D-related host genetic variants alter HIV disease progression ' 'in children', 'volume': '32', 'author': 'Moodley', 'year': '2013', 'journal-title': 'Pediatr Infect Dis J.'}, { 'key': '10.1016/j.gene.2024.148236_b0125', 'doi-asserted-by': 'crossref', 'first-page': '10237', 'DOI': '10.3389/bjbs.2021.10237', 'article-title': 'Association of Vitamin D Gene Polymorphisms With HCV Infection Outcome', 'volume': '79', 'author': 'Neamatallah', 'year': '2022', 'journal-title': 'Br J Biomed Sci.'}, { 'key': '10.1016/j.gene.2024.148236_b0130', 'doi-asserted-by': 'crossref', 'first-page': '6931', 'DOI': '10.1007/s11033-022-07338-9', 'article-title': 'Differentially expressed plasmatic microRNAs in Brazilian patients with ' 'Coronavirus disease 2019 (COVID-19): preliminary results', 'volume': '49', 'author': 'Nicoletti', 'year': '2022', 'journal-title': 'Mol Biol Rep.'}, { 'key': '10.1016/j.gene.2024.148236_b0135', 'doi-asserted-by': 'crossref', 'first-page': '210', 'DOI': '10.1186/s13643-016-0384-4', 'article-title': 'Rayyan-a web and mobile app for systematic reviews', 'volume': '5', 'author': 'Ouzzani', 'year': '2016', 'journal-title': 'Syst Rev.'}, { 'key': '10.1016/j.gene.2024.148236_b0140', 'article-title': 'The PRISMA 2020 statement: an updated guideline for reporting ' 'systematic reviews', 'volume': '372', 'author': 'Page', 'year': '2021', 'journal-title': 'BMJ.'}, { 'key': '10.1016/j.gene.2024.148236_b0145', 'doi-asserted-by': 'crossref', 'first-page': '83', 'DOI': '10.1186/s43042-021-00206-4', 'article-title': 'TaqI polymorphism of the VDR gene: aspects related to the clinical ' 'behavior of COVID-19 in Cuban patients', 'volume': '22', 'author': 'Peralta', 'year': '2021', 'journal-title': 'Egypt J Med Hum Genet.'}, { 'key': '10.1016/j.gene.2024.148236_b0150', 'doi-asserted-by': 'crossref', 'first-page': '9626', 'DOI': '10.3390/ijms21249626', 'article-title': 'Association of Vitamin D Metabolism Gene Polymorphisms with ' 'Autoimmunity: Evidence in Population Genetic Studies', 'volume': '21', 'author': 'Ruiz-Ballesteros', 'year': '2020', 'journal-title': 'Int J Mol Sci.'}, { 'key': '10.1016/j.gene.2024.148236_b0155', 'doi-asserted-by': 'crossref', 'first-page': 'e2323', 'DOI': '10.1002/rmv.2323', 'article-title': 'Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with ' 'COVID-19 severity: A systematic review with meta-analysis', 'volume': '32', 'author': 'Saengsiwaritt', 'year': '2022', 'journal-title': 'Rev Med Virol.'}, { 'key': '10.1016/j.gene.2024.148236_b0160', 'series-title': 'GRADE handbook for grading quality of evidence and strength of ' 'recommendations', 'author': 'Schünemann', 'year': '2013'}, { 'key': '10.1016/j.gene.2024.148236_b0165', 'doi-asserted-by': 'crossref', 'first-page': '310', 'DOI': '10.1016/j.arcmed.2023.03.006', 'article-title': 'Role of FokI rs2228570 and Tru9I rs757343 Polymorphisms in the ' 'Mortality of Patients Infected with Different Variants of SARS-CoV-2', 'volume': '54', 'author': 'Shawi', 'year': '2023', 'journal-title': 'Arch Med Res.'}, { 'key': '10.1016/j.gene.2024.148236_b0170', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fnut.2022.996450', 'article-title': 'A meta-analysis suggests the association of reduced serum level of ' 'vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin ' 'D receptor gene with celiac disease', 'volume': '9', 'author': 'Shree', 'year': '2023', 'journal-title': 'Front Nutr.'}, { 'key': '10.1016/j.gene.2024.148236_b0175', 'doi-asserted-by': 'crossref', 'first-page': '213', 'DOI': '10.1007/s40279-014-0266-7', 'article-title': 'Vitamin D: recent advances and implications for athletes', 'volume': '45', 'author': 'Todd', 'year': '2015', 'journal-title': 'Sports Med.'}, { 'key': '10.1016/j.gene.2024.148236_b0180', 'doi-asserted-by': 'crossref', 'first-page': '487', 'DOI': '10.2174/157016210793499330', 'article-title': 'Immunophenotype of vitamin D receptor polymorphism associated to risk ' 'of HIV-1 infection and rate of disease progression', 'volume': '8', 'author': 'Torres', 'year': '2010', 'journal-title': 'Curr HIV Res.'}, { 'key': '10.1016/j.gene.2024.148236_b0185', 'doi-asserted-by': 'crossref', 'first-page': '1785', 'DOI': '10.2217/bmm-2021-0348', 'article-title': 'Role of miRNAs as biomarkers of COVID-19: a scoping review of the ' 'status and future directions for research in this field', 'volume': '15', 'author': 'Visacri', 'year': '2021', 'journal-title': 'Biomark Med.'}, { 'key': '10.1016/j.gene.2024.148236_b0190', 'doi-asserted-by': 'crossref', 'first-page': '1691', 'DOI': '10.3390/genes14091691', 'article-title': 'Vitamin D: An Overview of Gene Regulation, Ranging from Metabolism to ' 'Genomic Effects', 'volume': '14', 'author': 'Voltan', 'year': '2023', 'journal-title': 'Genes (Basel)'}, { 'key': '10.1016/j.gene.2024.148236_b0195', 'doi-asserted-by': 'crossref', 'first-page': '1495', 'DOI': '10.1016/j.ijsu.2014.07.013', 'article-title': 'The Strengthening the Reporting of Observational 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