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Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Petrariu et al., Frontiers in Microbiology, doi:10.3389/fmicb.2023.1296447
Jan 2024  
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Probiotics for COVID-19
18th treatment shown to reduce risk in March 2021
*, now known with p = 0.0000013 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Review of the role of probiotics in managing various human diseases including potential benefits for COVID-19. Probiotics may help restore equilibrium in the gut microbiota disrupted by COVID-19. Probiotic consumption can reduce viral loads and enhance immune responses. The lung-gut axis, mediated by probiotics, might play a role in managing the disease. Meta-analyses suggest probiotics can positively impact symptoms, restore intestinal microbiota equilibrium, decrease diarrhea duration, and reduce hospitalization length. The multifactorial mechanism of action of beneficial bacteria through immunomodulatory properties, such as interferon production and cytokine storm inhibition, highlights the potential of probiotics in COVID-19 therapy.
The immune effects of probiotics are strain-specific.
Reviews covering probiotics for COVID-19 include Baud, Di Pierro, Kurian, Olaimat, Petrariu, Righi, Singh, Stavropoulou, Taufer, Taufer (B).
Petrariu et al., 5 Jan 2024, peer-reviewed, 8 authors. Contact:
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Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases
Oana-Alina Petrariu, Ilda Czobor Barbu, Adelina-Gabriela Niculescu, Marian Constantin, Georgiana Alexandra Grigore, Roxana-Elena Cristian, Grigore Mihaescu, Corneliu Ovidiu Vrancianu
Frontiers in Microbiology, doi:10.3389/fmicb.2023.1296447
The imbalance of microbial composition and diversity in favor of pathogenic microorganisms combined with a loss of beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known for their capacity to improve health by stimulating the indigenous gut microbiota, enhancing host immunity resistance to infection, helping digestion, and carrying out various other functions. Concurrently, the metabolites produced by these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, and hydrogen peroxide, contribute to inhibiting a wide range of pathogenic bacteria. This review presents an update on using probiotics in managing and treating various human diseases, including complications that may emerge during or after a COVID-19 infection.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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