All Studies Meta Analysis

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Petrariu et al., Frontiers in Microbiology, doi:10.3389/fmicb.2023.1296447

Jan 2024

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Probiotics for COVID-19

18th treatment shown to reduce risk in March 2021, now with p = 0.0000011 from 28 studies.

Lower risk for mortality, hospitalization, progression, recovery, and cases.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

Review of the role of probiotics in managing various human diseases including potential benefits for COVID-19. Probiotics may help restore equilibrium in the gut microbiota disrupted by COVID-19. Probiotic consumption can reduce viral loads and enhance immune responses. The lung-gut axis, mediated by probiotics, might play a role in managing the disease. Meta-analyses suggest probiotics can positively impact symptoms, restore intestinal microbiota equilibrium, decrease diarrhea duration, and reduce hospitalization length. The multifactorial mechanism of action of beneficial bacteria through immunomodulatory properties, such as interferon production and cytokine storm inhibition, highlights the potential of probiotics in COVID-19 therapy.

Probiotic efficacy depends on the specific strains used. Specific microbes may decrease or increase COVID-19 risk1.

Reviews covering probiotics for COVID-19 include2-15.

Important missing comments or errors? Let us know.

1. Li et al., Large-scale genetic correlation studies explore the causal relationship and potential mechanism between gut microbiota and COVID-19-associated risks, BMC Microbiology, doi:10.1186/s12866-024-03423-0.biomedcentral.com, doi.org.

2. Fazli et al., Possible Link between Gut Microbiota, Diet, and COVID-19 Infection, Journal of Medical Bacteriology, 12:4, jmb.tums.ac.ir/index.php/jmb/article/view/525.ac.ir.

3. Santa et al., Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality—A systematic review and meta-analysis, Frontiers in Nutrition, doi:10.3389/fnut.2024.1465324.frontiersin.org, doi.org.

4. Kaushal, A., Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections, Journal of Translational Medicine, doi:10.1186/s12967-024-05587-9.biomedcentral.com, doi.org.

5. Mu et al., Anti-inflammatory and Nutritional Interventions Against SARS-CoV-2: A Comprehensive Review, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2024.101422.sciencedirect.com, doi.org.

6. Taufer et al., Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies, Microorganisms, doi:10.3390/microorganisms12020284.mdpi.com, doi.org.

7. Righi et al., Gut Microbiome Disruption Following SARS-CoV-2: A Review, Microorganisms, doi:10.3390/microorganisms12010131.mdpi.com, doi.org.

8. Petrariu et al., Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1296447.frontiersin.org, doi.org.

9. Taufer (B) et al., The Role of Bifidobacterium in COVID-19: A Systematic Review, Life, doi:10.3390/life13091847.mdpi.com, doi.org.

10. Di Pierro, F., A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SARS-CoV-2, Minerva Medica, doi:10.23736/S0026-4806.20.06570-2.minervamedica.it, doi.org.

11. Kurian et al., Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects, Archives of Medical Research, doi:10.1016/j.arcmed.2021.03.002.sciencedirect.com, doi.org.

12. Singh et al., Probiotics: A potential immunomodulator in COVID-19 infection management, Nutrition Research, doi:10.1016/j.nutres.2020.12.014.sciencedirect.com, doi.org.

13. Stavropoulou et al., Probiotics as a Weapon in the Fight Against COVID-19, Frontiers in Nutrition, doi:10.3389/fnut.2020.614986.frontiersin.org, doi.org.

14. Olaimat et al., The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19, npj Science of Food, doi:10.1038/s41538-020-00078-9.nature.com, doi.org.

15. Baud et al., Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic, Frontiers in Public Health, doi:10.3389/fpubh.2020.00186.frontiersin.org, doi.org.

Petrariu et al., 5 Jan 2024, peer-reviewed, 8 authors. Contact: grigore.georgiana-alexandra@s.bio.unibuc.ro.

This Paper Probiotics All

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Oana-Alina Petrariu, Ilda Czobor Barbu, Adelina-Gabriela Niculescu, Marian Constantin, Georgiana Alexandra Grigore, Roxana-Elena Cristian, Grigore Mihaescu, Corneliu Ovidiu Vrancianu

Frontiers in Microbiology, doi:10.3389/fmicb.2023.1296447

The imbalance of microbial composition and diversity in favor of pathogenic microorganisms combined with a loss of beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known for their capacity to improve health by stimulating the indigenous gut microbiota, enhancing host immunity resistance to infection, helping digestion, and carrying out various other functions. Concurrently, the metabolites produced by these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, and hydrogen peroxide, contribute to inhibiting a wide range of pathogenic bacteria. This review presents an update on using probiotics in managing and treating various human diseases, including complications that may emerge during or after a COVID-19 infection.

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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