Conv. Plasma
Nigella Sativa
Peg.. Lambda

All probiotics studies
Meta analysis
Home COVID-19 treatment researchProbioticsProbiotics (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  

Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

Kurian et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.03.002
Mar 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Review of probiotics role in regulating the immune system and use in viral infections, and studies on the association of microbiota with COVID-19 patients. Authors suggest that probiotics supplementation could reduce COVID-19 morbidity and mortality, and they note that probiotics may suppress the inflammatory cytokine response.
Kurian et al., 19 Mar 2021, peer-reviewed, 11 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperProbioticsAll
Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects
Shilia Jacob Kurian, Mazhuvancherry Kesavan Unnikrishnan, Sonal Sekhar Miraj, Debasis Bagchi, Mithu Banerjee, B Shrikar Reddy, Gabriel Sunil Rodrigues, Mohan K Manu, Kavitha Saravu, Chiranjay Mukhopadhyay, Mahadev Rao
Archives of Medical Research, doi:10.1016/j.arcmed.2021.03.002
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Source of Financial Support None Competing Interests The authors report no conflicts of interest Authors' Contribution Dr.Shilia Jacob Kurian and Dr.Sonal Sekhar Miraj conducted the literature search and wrote the manuscript. Dr. B Shrikar Reddy drew the figure I. Dr. Mazhuvancheny Kesavan Unnikrishnan, Dr. Debasis Bagchi, Dr. Mithu Banerjce. Dr. Gabriel Sunil Rodrigues, Dr. Mohan K Manu, Dr. Kavitha Saravu, Dr. Chiranjay Mukhopadhyay and Dr. Mahadev Rao critically evaluated the manuscript. All the authors participated in literature collection and review. All the authors approved the final draft of the manuscript. Supplementary Materials Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.arcmed.2021. 03.002.
Adnan, Dewi, Potential effects immunomodulators on probiotics in COVID-19 preventing infection in the future. A narrative review, Int J Med Stud, doi:10.5195/ijms.2020.486
Appel-Da-Silva, Narvaez, Perez, Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment, Med Mycol Case Rep
Azad, Sarker, Immunomodulatory effects of probiotics on cytokine profiles, Biomed Res Int
Becker, COVID-19 update: Covid-19-associated coagulopathy, J Thromb Thrombolysis
Bermudez-Brito, Plaza-Díaz, Muñoz-Quezada, Probiotic mechanisms of action, Ann Nutr Metab
Briguglio, Pregliasco, Lombardi, The malnutritional status of the host as a virulence factor for new coronavirus SARS-CoV-2, Front Med
Budden, Gellatly, Wood, Emerging pathogenic links between microbiota and the gut-lung axis, Nat Rev Microbiol
Carabotti, Scirocco, Maselli, The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems, Ann Gastroenterol
Chai, Burwinkel, Wang, Antiviral effects of a probiotic Enterococcus faecium strain against transmissible gastroenteritis coronavirus, Arch Virol
Chen, Zuo, Xue, Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9, J Dairy Sci
Cheung, Hung, Chan, Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis, Gastroenterology, doi:10.1053/j.gastro.2020.03.065
Dabke, Hendrick, Devkota, The gut microbiome and metabolic syndrome, J Clin Invest
Dai, Wang, Wang, Potential beneficial effects of probiotics on human migraine headache: A literature review, Pain Physician
Daneshkhah, Agrawal, Eshein, The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients, MedRxiv, doi:10.1101/2020.04.08.20058578v4
Dhar, Mohanty, Gut microbiota and covid-19-possible link and implications, Virus Res
Dickson, Arbor, The microbiome and critical illness, Lancet Respir Med
Dinan, Quigley, Ahmed, Hypothalamic-pituitary gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?, Gastroenterology
Dumas, Bernard, Poquet, The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases, Cell Microbiol
Eguchi, Fujitani, Nakagawa, Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055, Sci Rep
Ellul, Benjamin, Singh, Neurological associations of COVID-19, Lancet Neurol, doi:10.1016/S1474-4422(20)30221-0
Enaud, Prevel, Ciarlo, The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks, Front Cell Infect Microbiol
Evrard, Coudeyras, Dosgilbert, Dose-dependent immunomodulation of human dendritic cells by the probiotic Lactobacillus rhamnosus Lcr35, PLoS One
Feng, Wang, Qi, The small intestine, an underestimated site of SARS-CoV-2 infection: from red queen effect to probiotics, doi:10.20944/preprints202003.0161.v1
Fornell, Kawasaki-like inflammatory disease affects children with COVID-19
Foster, Neufeld, Gut-brain axis: how the microbiome influences anxiety and depression, Trends Neurosci
Fujii, Ohtsuka, Lee, Bifidobacterium breve enhances transforming growth factor beta1 signaling by regulating Smad7 expression in preterm infants, J Pediatr Gastroenterol Nutr
Garcia-Crespo, Chan, Gabryszewski, Lactobacillus priming of the respiratory tract: heterologous immunity and protection against lethal pneumovirus infection, Antiviral Res
Gargar, Divinagracia, When good things go bad: a case series of bacteremia from probiotics, Chest
Gill, Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019, Am J Clin Nutr
Gou, Fu, Yue, Gut microbiota may underlie the predisposition of healthy individuals to COVID-19, medRxiv, doi:10.1101/2020.04.22.20076091v1
Gu, Chen, Wu, Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza, Clin Infect Dis, doi:10.1093/cid/ciaa709
Guan, Liang, Zhao, Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis, Eur Respir J
Gurung, Li, You, Role of gut microbiota in type 2 diabetes pathophysiology, EBioMedicine
Hanada, Pirzadeh, Carver, Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia, Front Immunol
Harata, He, Hiruta, Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses, Lett Appl Microbiol
Hill, Guarner, Reid, Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic, Nat Rev Gastroenterol Hepatol
Horby, Landray, Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 (RECOVERY Trial)
Jayawardena, Sooriyaarachchi, Chourdakis, Enhancing immunity in viral infections, with special emphasis on COVID-19: a review, Diabetes Metab Syndr
Jiang, Li, Huang, The gut microbiota and Alzheimer's disease, J Alzheimers Dis
Jones, Martoni, Prakash, Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial, J Clin Endocrinol Metab
Jung, Lee, Ngo, Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection, Sci Rep
Kang, Kim, Hwang, The effect of probiotics on prevention of common cold: a meta-analysis of randomized controlled trial studies, Korean J Fam Med
Kang, Lee, Ha, Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model, J Microbiol
Kennedy, King, Baldridge, Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria, Front Physiol
Kishino, Takemura, Masaki, Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice, Biosci Microbiota Food Health
Konieczna, Groeger, Ziegler, Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells, Gut
Kumova, Fike, Thayer, Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG, PLoS Pathog
Lake, What we know so far: COVID-19 current clinical knowledge and research, Clin Med Lond (Lond), doi:10.7861/clinmed.2019-coron
Lee, Kang, Shin, Antiviral activity of Bifidobacterium adolescentis SPM0212 against hepatitis B virus, Arch Pharm Res
Li, Zhao, Wang, Novel angiotensin-converting enzyme-inhibitory peptides from fermented bovine milk started by Lactobacillus helveticus KLDS.31 and Lactobacillus casei KLDS.105: purification, identification, and interaction mechanisms, Front Microbiol
Liang, Feng, Rao, Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus, Gut
Liu, Katovich, ACE2 and Microbiota: emerging targets for cardiopulmonary disease therapy, J Cardiovasc Pharmacol
Liu, Ye, Zhu, Gastrointestinal disturbance and effect of fecal microbiota transplantation in discharged COVID-19 patients, J Med Case Rep
Locke, UK COVID-19 Update: Dexamethasone praise & scepticism -Medscape
Mak, Chan, Ng, Probiotics and COVID-19: one size does not fit all, Lancet Gastroenterol Hepatol
Mammen, Sethi, COPD and the microbiome, Respirology
Meijnikman, Gerdes, Nieuwdorp, Herrema, Evaluating causality of gut microbiota in obesity and diabetes in humans, Endocr Rev
Messaoudi, Lalonde, Violle, Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects, Br J Nutr
Minato, Nirasawa, Sato, B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction, Nat Commun
Morshedi, Hashemi, Moazzen, Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review, J Neuroinflammation
Nagpal, Mainali, Ahmadi, Gut microbiome, and aging: physiological and mechanistic insights, Nutr Healthy Aging
Namasivayam, Sher, Glickman, Wipperman, The microbiome and tuberculosis: early evidence for cross talk, mBio
Negi, Das, Pahari, Potential role of gut microbiota in induction and regulation of innate immune memory, Front Immunol
Nishida, Inoue, Inatomi, Gut microbiota in the pathogenesis of inflammatory bowel disease, Clin J Gastroenterol
Ostaff, Stange, Wehkamp, Antimicrobial peptides and gut microbiota in homeostasis and pathology, EMBO Mol Med
Park, Ngo, Kwon, Lactobacillus plantarum DK119 as a probiotic confers protection against influenza virus by modulating innate immunity, PLoS One
Plaza-Diaz, Ruiz-Ojeda, Gil-Campos, Mechanisms of action of probiotics, Adv Nutr
Pourhossein, Moravejolahkami, Probiotics in viral infections, with a focus on COVID-19: a systematic review, Prepints, doi:10.22541/au.158938616.61042433
Pradhan, Guha, Naik, and B. clausii modulate gut microbiota in Th1-and Th2-biased mice to ameliorate Salmonella typhimurium-induced diarrhea, Probiotics Antimicrob Proteins
Rai, Sanjukta, Jeyaram, Production of angiotensin I converting enzyme inhibitory (ACE-I) peptides during milk fermentation and their role in reducing hypertension, Crit Rev Food Sci Nutr
Renzo, Merra, Esposito, Are probiotics effective adjuvant therapeutic choice in patients with COVID-19?, Eur Rev Med Pharmacol Sci, doi:10.26355/eurrev_202004_20977
Rooks, Garrett, Gut microbiota, metabolites and host immunity, Nat Rev Immunol, doi:10.1038/nri.2016.42
Shang, Sun, Vitamin D/VDR, probiotics, and gastrointestinal diseases, Curr Med Chem
Shivakumar, Smibert, Trubiano, Immunosuppression for COVID-19: repurposing medicines in a pandemic, Aust. Prescr, doi:10.18773/austprescr.2020.037
Su, Jia, Li, Probiotics for the prevention of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials, Respir Care
Tang, Kitai, Hazen, Gut microbiota in cardiovascular health and disease, Circ Res
Thaiss, Zmora, Levy, The microbiome and innate immunity, Nature
Thushara, Gangadaran, Solati, Cardiovascular benefits of probiotics: a review of experimental and clinical studies, Food Funct
Tian, Rong, Nian, Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission, Aliment Pharmacol Ther
Tillisch, Labus, Kilpatrick, Consumption of fermented milk product with probiotic modulates brain activity, Gastroenterology
Umbrello, Esposito, Microbiota and neurologic diseases: potential effects of probiotics, J Transl Med
Undela, Gudi, Assumptions for disparities in case-fatality rates of coronavirus disease (COVID-19) across the globe, Eur Rev Med Pharmacol Sci
Varatharaj, Thomas, Ellul, Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UKwide surveillance study, Lancet Psychiatry, doi:10.1016/S2215-0366(20)30287-X
Ver Heul, Planer, Kau, The human microbiota and asthma, Clin Rev Allergy Immunol
Waki, Matsumoto, Fukui, Effects of probiotic Lactobacillus brevis KB290 on incidence of influenza infection among schoolchildren: an open-label pilot study, Lett Appl Microbiol
Wang, Wu, Wang, Antioxidant properties of probiotic bacteria, Nutrients
Wang, Zhu, Qin, Gut microbiota modulation on intestinal mucosal adaptive immunity, J Immunol Res
Weiss, Rasmussen, Zeuthen, Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll-like receptor-2-dependent mechanism, Immunology
West, Jenmalm, Prescott, The gut microbiota and its role in the development of allergic disease: a wider perspective, Clin Exp Allergy
Wu, Liu, Yang, Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-induced inflammation and cell damage via attenuation of ASC-independent NLRP3 inflammasome activation, Appl Environ Microbiol
Wu, Yoon, Zhang, Vitamin D receptor pathway is required for probiotic protection in colitis, Am J Physiol Gastrointest Liver Physiol
Xie, Nie, Yu, Lactobacillus plantarum NCU116 attenuates cyclophosphamide-induced immunosuppression and regulates Th17/Treg cell immune responses in mice, J Agric Food Chem
Xu, Cai, Shen, Management of corona virus disease-19 (COVID-19): the Zhejiang experience, Zhejiang Da Xue Xue Bao Yi Xue Ban, doi:10.3785/j.issn.1008-9292.2020.02.02
Yan, Zhang, Li, Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2, Science
Yeoh, Zuo, Lui, Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19, Gut
Yoon, Wu, Zhang, Probiotic regulation of vitamin D receptor in intestinal inflammation, Gastroenterology
Yoon, Zhang, Lu, Probiotic regulation of vitamin D receptor in intestinal inflammation, Gastroenterology
Zelaya, Villena, Lopez, Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: role of Toll-like receptor 2, Microbiol Immunol
Zeng, Shen, Bo, Cutting edge: probiotics and fecal microbiota transplantation in immunomodulation, J Immunol Res
Zhang, Kang, Gong, The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes, bioRxiv, doi:10.1101/2020.01.30.927806v1
Zhao, Zhang, Li, Incidence, clinical characteristics, and prognostic factor of patients with COVID-19: a systematic review and meta-analysis, MedRxiv, doi:10.1101/2020.03.17.20037572v1
Zhou, Chi, Lv, Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (COVID-19), Diabetes Metab Res Rev, doi:10.1002/dmrr.3377
Zuo, Zhang, Lui, Alterations in gut microbiota of patients with COVID-19 during time of hospitalization, Gastroenterology, doi:10.1053/j.gastro.2020.05.048
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop