Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects
Kurian et al.,
Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects,
Archives of Medical Research, doi:10.1016/j.arcmed.2021.03.002 (Review)
Review of probiotics role in regulating the immune system and use in viral infections, and studies on the association of microbiota with COVID-19 patients. Authors suggest that probiotics supplementation could reduce COVID-19 morbidity and mortality, and they note that probiotics may suppress the inflammatory cytokine response.
Kurian et al., 19 Mar 2021, peer-reviewed, 11 authors.
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Archives of Medical Research 52 (2021) 582–594
REVIEW ARTICLE
Probiotics in Prevention and Treatment of COVID-19: Current Perspective
and Future Prospects
Shilia Jacob Kurian,a,b Mazhuvancherry Kesavan Unnikrishnan,c Sonal Sekhar Miraj,a,b
Debasis Bagchi,d Mithu Banerjee,e B. Shrikar Reddy,a Gabriel Sunil Rodrigues,f Mohan K. Manu,b,g
Kavitha Saravu,b,h Chiranjay Mukhopadhyay,i and Mahadev Raoa
a Department
of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India
Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India
c National College of Pharmacy, Mukkam, Kozhikode, Kerala, India
d College of Pharmacy and Health Sciences, Texas Southern University, Houston, USA
e Department of Biochemistry, All India Institute of Medical Sciences,Jodhpur, Rajasthan, India
f Department of Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
g Department of Respiratory Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
h Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
i Department of Microbiology and Center for Emerging and Tropical Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher
Education, Manipal, Karnataka, India
b Manipal
Received for publication September 2, 2020; accepted March 12, 2021 (ARCMED_2020_1615).
Saving lives and flattening the curve are the foremost priorities during the ongoing
pandemic spread of SARS-CoV-2. Developing cutting-edge technology and collating
available evidence would support frontline health teams. Nutritional adequacy improves
general health and immunity to prevent and assuage infections. This review aims to
outline the potential role of probiotics in fighting the COVID-19 by covering recent
evidence on the association between microbiota, probiotics, and COVID-19, the role
of probiotics as an immune-modulator and antiviral agent. The high basic reproduction
number (R0) of SARS-CoV-2, absence of conclusive remedies, and the pleiotropic effect
of probiotics in fighting influenza and other coronaviruses together favour probiotics
supplements. However, further support from preclinical and clinical studies and reviews
outlining the role of probiotics in COVID-19 are critical. Results are awaited from
many ongoing clinical trials investigating the benefits of probiotics in COVID-19. ©
2021 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights
reserved.
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