Probiotics: A potential immunomodulator in COVID-19 infection management
Kuljit Singh, Alka Rao
Nutrition Research, doi:10.1016/j.nutres.2020.12.014
COVID-19 caused by SARS-CoV-2 is an ongoing global pandemic. SARS-CoV-2 affects the human respiratory tract's epithelial cells, leading to a proinflammatory cytokine storm and chronic lung inflammation. With numerous patients dying daily, a vaccine and specific antiviral drug regimens are being explored. Probiotics are live microorganisms with proven beneficial effects on human health. While probiotics as nutritional supplements are long practiced in different cuisines across various countries, the emerging scientific evidence supports the antiviral and general immune-strengthening health effects of the probiotics. Here, we present an overview of the experimental studies published in the last 10 years that provide a scientific basis for unexplored probiotics as a preventive approach to respiratory viral infections. Based on collated insights from these experimental data, we identify promising microbial strains that may serve as lead prophylactic and immune-boosting probiotics in COVID-19 management.
References
Abdelhamid, El-Masry, El-Dougdoug, Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining, EPMA J
Allam, Salem, Elbatae, Nabieh, Lactobacillus acidophilus and bifidobacteria spp having antibacterial and antiviral effects on chronic hcv infection, African J Microbiol Res
An, Lee, Kim, Lee, Cha et al., Antiviral activity of Bifidobacterium adolescentis SPM 0214 against herpes simplex virus type 1, Arch Pharm Res
Ang, Too, Tan, Chow, Shek et al., Antiviral activity of Lactobacillus reuteri protectis against coxsackievirus a and enterovirus 71 infection in human skeletal muscle and colon cell lines, Virol J
Antunes, Vinderola, Xavier-Santos, Sivieri, Potential contribution of beneficial microbes to face the covid-19 pandemic, Food Res Int
Azad, Kalam, Sarker, Immunomodulatory effects of probiotics on cytokine profiles, Biomed Res Int
Bibiloni, Fedorak, Tannock, Madsen, Gionchetti et al., VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis, Am J Gastroenterol
Bo, Li, Tao, Bai, Ye et al., Probiotics for preventing ventilator-associated pneumonia, Cochrane Database Syst Rev
Botic, Dana, Weingartl, Cencia, A novel eukaryotic cell culture model to study antiviral activity of potential probiotic bacteria, Int J Food Microbiol
Cascella, Rajnik, Cuomo, Dulebohn, Napoli, COVID-19)
Chapman, Plosker, Figgitt, VSL#3 probiotic mixture: a review of its use in chronic inflammatory bowel diseases, Drugs
Chen, Weng, Huang, Liu, Tseng et al., Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections, Mucosal Immunol
Choi, Song, Ahn, Baek, Kwon, Antiviral activities of cell-free supernatants of yogurts metabolites against some rna viruses, Eur Food Res Technol
Coperchini, Chiovato, Croce, Magri, Rotondi, The cytokine storm in covid-19: an overview of the involvement of the chemokine/chemokine-receptor system, Cytokine Growth Factor Rev,
doi:10.1016/j.cytogfr.2020.05.003Dietrich, Kottmann, Alavi, Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea, World J Gastroenterol
Duan, Liu, Li, Zhang, Yu et al., Effectiveness of convalescent plasma therapy in severe Covid-19 patients, Proc Natl Acad Sci
Eguchi, Fujitani, Nakagawa, Miyazaki, Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055, Sci Rep
Goto, Sagitani, Ashida, Kato, Hirota et al., Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus l-92 accompanied by the activation of innate immunity, Br J Nutr
Groeger, 'mahony, Murphy, Bourke, Dinan, Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut, Gut Microbes
Hardy, Harris, Lyon, Beal, Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology, Nutrients
Hassan, Sheikh, Jamal, Ezeh, Akhtar, Coronavirus (covid-19): a review of clinical features, diagnosis, and treatment, Cureus
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet North Am Ed
Hui, Shuhua, Houzhong, Fengxia, Jie et al., Mechanism of probiotic VSL#3 inhibiting nf-κb and tnf-α on colitis through tlr4-nf-κb signal pathway, Iran J Public health
Infusino, Marazzato, Mancone, Fedele, Mastroianni et al., Diet supplementation, probiotics, and nutraceuticals in sars-cov-2 infection: a scoping review, Nutrients
Isidro, Lopez, Cruz, Torres, Chompre et al., The probiotic VSL#3 modulates colonic macrophages, inflammation, and microflora in acute trinitrobenzene sulfonic acid colitis, J Histochem Cytochem
Izumo, Maekawa, Ida, Noguchi, Kitagawa et al., Effect of intranasal administration of Lactobacillus pentosus s-pt84 on influenza virus infection in mice, Int Immunopharmacol
Jin, Lian, Hu, Gao, Zheng et al., Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (Covid-19) with gastrointestinal symptoms, Gut
Jung, Lee, Ngo, Cho, Ko et al., Heat-killed Lactobacillus casei confers broad protection against influenza a virus primary infection and develops heterosubtypic immunity against future secondary infection, Sci Rep
Kanauchi, Andoh, Abubakar, Yamamoto, Probiotics and paraprobiotics in viral infection: clinical application and effects on the innate and acquired immune systems, Curr Pharm Des
Kassaa, New insights on antiviral probiotics: From research to applications
Kawase, He, Kubota, Harata, Hiramatsu, Oral administration of Lactobacilli from human intestinal tract protects mice against influenza virus infection, Lett Appl Microbiol
Kawashima, Hayashi, Kosaka, Kawashima, Igarashi et al., Lactobacillus plantarum strain yu from fermented foods activates Th1 and protective immune responses, Int Immunopharmacol
Kechaou, Chain, Gratadoux, Blugeon, Bertho et al., Identification of one novel candidate probiotic Lactobacillus plantarum strain active against influenza virus infection in mice by a large-scale screening, Appl Environ Microbiol
King, Tancredi, Lenoir-Wijnkoop, Gould, Vann et al., Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis, Eur J Public Health
Kitazawa, Villena, Modulation of respiratory tlr3-anti-viral response by probiotic microorganisms: Lessons learned from Lactobacillus rhamnosus CRL1505, Front Immunol
Kobayashi, Saito, Uematsu, Kishi, Toba et al., Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice, Int Immunopharmacol
Kwak, Liu, Kwon, Kim, Kim et al., Cyclic dipeptides from lactic acid bacteria inhibit proliferation of the influenza a virus, J Microbiol
Latvala, Miettinen, Kekkonen, Korpela, Julkunen, Potentially probiotic bacteria induce cytokine production and suppressor of cytokine signaling 3 gene expression in human monocyte-derived macrophages, Cytokine
Lee, Kim, Lee, Park, Dead nano-sized Lactobacillus plantarum inhibits azoxymethane/dextran sulfate sodium-induced colon cancer in balb/c mice, J Med Food
Lehtoranta, Pitkaranta, Korpela, Probiotics in respiratory virus infections, Eur J Clin Microbiol Infect Dis
Liu, Tran, Rhoads, Probiotics in disease prevention and treatment, J Clin Pharmacol
Lu, Drug treatment options for the 2019-new coronavirus (2019-ncov), Bioscience trends
Mahooti, Abdolalipour, Salehzadeh, Mohebbi, Gorji et al., Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice, World J Microbiol Biotechnol
Mehta, Mcauley, Brown, Sanchez, Tattersall et al., Covid-19: consider cytokine storm syndromes and immunosuppression, Lancet North Am Ed
Mishra, Shah, Mokashe, Chavan, Yadav et al., Probiotics as potential antioxidants: a systematic review, J Agric Food Chem
Munoz-Carrillo, Contreras-Cordero, Gutiarrez-Coronado, Villalobos-Gutiarrez, Ramos-Gracia et al., Cytokine profiling plays a crucial role in activating immune system to clear infectious pathogens; Immune response activation and immunomodulation, IntechOpen,
doi:10.5772/intechopen.80843Na, Moeller, Å¡ek, Jakobsen, Weingartl et al., Nitric oxide (no) production in mammalian non-tumorigenic epithelial cells of the small intestine and macrophages induced by individual strains of Lactobacilli and Bifidobacteria, Int Dairy J
Nakayama, Moriya, Sakai, Ikeda, Shiozaki et al., Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice, Sci Rep
Oliva, Nardo, Ferrari, Mallardo, Rossi et al., Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis, Aliment Pharmacol Ther
Park, Kim, Bae, Yoo, Kim et al., Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice, J Microbiol
Patel, Shah, Prajapati, Immunomodulatory effects of probiotics in the treatment of human immunodeficiency virus (HIV) infection, Biomed Prevent Nutr
Pu, Guo, Li, Zhu, Wang et al., Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: a randomized controlled open-label trial, Clin Interv Aging
Rautava, Salminen, Isolauri, Specific probiotics in reducing the risk of acute infections in infancy-a randomised, double-blind, placebo-controlled study, Br J Nutr
Ruan, Yang, Wang, Jiang, Song, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive Care Med
Sadiq, Is it time for microbiome-based therapies in viral infections?, Virus Res
Saeterdal, Underland, Nilsen, The effect of probiotics for preventing acute upper respiratory tract infections, Glob Adv Health Med
Servin, Antagonistic activities of Lactobacilli and Bifidobacteria against microbial pathogens, FEMS Microbiol Rev
Shanmugaraj, Siriwattananon, Wangkanont, Phoolcharoen, Perspectives on monoclonal antibody therapy as potential therapeutic intervention for coronavirus disease-19 (COVID-19), Asian Pac J Allergy Immunol
Shida, Sato, Iizuka, Hoshi, Watanabe et al., Daily intake of fermented milk with Lactobacillus casei strain shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers, Eur J Nutr
Shojadoost, Kulkarni, Brisbin, Quinteiro-Filho, Alkie et al., Interactions between Lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus, Res Vet Sci
Smith, Rigassio-Radler, Denmark, Haley, Touger-Decker, Effect of Lactobacillus rhamnosus LGG(r) and Bifidobacterium animalis ssp. lactis bb-12(r) on health-related quality of life in college students affected by upper respiratory infections, Br J Nutr
Song, Kim, Hong, Lee, Lee et al., Oral intake of Lactobacillus rhamnosus M21 enhances the survival rate of mice lethally infected with influenza virus, J Microbiol Immunol Infect
Starosila, Rybalko, Varbanetz, Ivanskaya, Sorokulova, Anti-influenza activity of a Bacillus subtilis probiotic strain, Antimicrob Agents Chemother
Sumi, Yang, Yeo, Hahm, Antimicrobial peptides of the genus Bacillus : a new era for antibiotics, Can J Microbiol
Sundararaman, Ray, Ravindra, Halami, Role of probiotics to combat viral infections with emphasis on COVID-19, Appl Microbiol Biotechnol
Taipale, Pienihakkinen, Isolauri, Larsen, Brockmann et al., Bifidobacterium animalis subsp. Lactis bb-12 in reducing the risk of infections in infancy, Br J Nutr
Veckman, Miettinen, Pirhonen, Siran, Matikainen et al., Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of th1-type cytokines and chemokines in human monocyte-derived dendritic cells, J Leukoc Biol
Verity, Okell, Dorigatti, Winskill, Whittaker et al., Estimates of the severity of coronavirus disease 2019: a model-based analysis, Lancet Infect Dis,
doi:10.1016/S1473-3099(1020Wan, Shang, Graham, Baric, Li, Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of sars coronavirus, J Virol
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-ncov) in vitro, Cell Res
Wang, Horby, Hayden, Gao, A novel coronavirus outbreak of global health concern, Lancet North Am Ed
Wang, Li, Ge, Xiao, Liao et al., Probiotics for prevention and treatment of respiratory tract infections in children: a systematic review and meta-analysis of randomized controlled trials, Medicine
Wang, Wu, Wang, Xu, Mei et al., Antioxidant properties of probiotic bacteria, Nutrients
Weiss, Rasmussen, Zeuthen, Nielsen, Jarmer et al., Hanne: Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a toll-like receptor-2-dependent mechanism, Immunology
Wieers, Belkhir, Enaud, Leclercq, De Foy, How probiotics affect the microbiota, Front Cell Infect Microbiol
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of covid-19 associated with acute respiratory distress syndrome, Lancet Respir Med
Youn, Lee, Lee, Park, Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice, Antiviral Res
Zelaya, Tsukida, Chiba, Marranzino, Alvarez et al., Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions, Int Immunopharmacol
Zeng, Shen, Bo, Peng, Xu et al., Cutting edge: probiotics and fecal microbiota transplantation in immunomodulation, J Immunol Res
Zhang, Yeh, Ding, Liu, Zhang, Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate, Synth Systems Biotechnol
Zuo, Zhang, Lui, Yeoh, Li et al., Alterations in gut microbiota of patients with covid-19 during time of hospitalization, Gastroenterology
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'10.1016/S1473-3099(1020)30243-30247.'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0011',
'article-title': 'Cytokine profiling plays a crucial role in activating immune system to '
'clear infectious pathogens; Immune response activation and '
'immunomodulation',
'author': 'Munoz-Carrillo',
'year': '2018',
'journal-title': 'IntechOpen'},
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'first-page': '1557',
'article-title': 'Cytokines in the balance',
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'journal-title': 'Nat Immunol'},
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'doi-asserted-by': 'crossref',
'first-page': '454',
'DOI': '10.3389/fcimb.2019.00454',
'article-title': 'How probiotics affect the microbiota',
'volume': '9',
'author': 'Wieers',
'year': '2020',
'journal-title': 'Front Cell Infect Microbiol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0014',
'doi-asserted-by': 'crossref',
'first-page': '1869',
'DOI': '10.3390/nu5061869',
'article-title': 'Probiotics, prebiotics and immunomodulation of gut mucosal defences: '
'homeostasis and immunopathology',
'volume': '5',
'author': 'Hardy',
'year': '2013',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0015',
'series-title': 'New insights on antiviral probiotics: From research to applications',
'author': 'Al Kassaa',
'year': '2017'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0016',
'doi-asserted-by': 'crossref',
'first-page': '2017',
'DOI': '10.1016/j.intimp.2011.08.013',
'article-title': 'Lactobacillus plantarum strain yu from fermented foods activates Th1 '
'and protective immune responses',
'volume': '11',
'author': 'Kawashima',
'year': '2011',
'journal-title': 'Int Immunopharmacol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0017',
'doi-asserted-by': 'crossref',
'DOI': '10.1128/AAC.00539-17',
'article-title': 'Anti-influenza activity of a Bacillus subtilis probiotic strain',
'volume': '61',
'author': 'Starosila',
'year': '2017',
'journal-title': 'Antimicrob Agents Chemother'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0018',
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'article-title': 'Heat-killed Lactobacillus casei confers broad protection against '
'influenza a virus primary infection and develops heterosubtypic '
'immunity against future secondary infection',
'volume': '7',
'author': 'Jung',
'year': '2017',
'journal-title': 'Sci Rep'},
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'doi-asserted-by': 'crossref',
'first-page': '145',
'DOI': '10.1007/s12275-018-7411-1',
'article-title': 'Effects of heat-killed Lactobacillus plantarum against influenza '
'viruses in mice',
'volume': '56',
'author': 'Park',
'year': '2018',
'journal-title': 'J Microbiol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0020',
'doi-asserted-by': 'crossref',
'first-page': '91',
'DOI': '10.1007/s11274-019-2667-0',
'article-title': 'Immunomodulatory and prophylactic effects of Bifidobacterium bifidum '
'probiotic strain on influenza infection in mice',
'volume': '35',
'author': 'Mahooti',
'year': '2019',
'journal-title': 'World J Microbiol Biotechnol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0021',
'doi-asserted-by': 'crossref',
'first-page': '1289',
'DOI': '10.1007/s10096-014-2086-y',
'article-title': 'Probiotics in respiratory virus infections',
'volume': '33',
'author': 'Lehtoranta',
'year': '2014',
'journal-title': 'Eur J Clin Microbiol Infect Dis'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0022',
'doi-asserted-by': 'crossref',
'first-page': '227',
'DOI': '10.1016/j.ijfoodmicro.2006.10.044',
'article-title': 'A novel eukaryotic cell culture model to study antiviral activity of '
'potential probiotic bacteria',
'volume': '115',
'author': 'Botic',
'year': '2007',
'journal-title': 'Int J Food Microbiol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0023',
'doi-asserted-by': 'crossref',
'first-page': '710',
'DOI': '10.2174/1381612824666180116163411',
'article-title': 'Probiotics and paraprobiotics in viral infection: clinical application '
'and effects on the innate and acquired immune systems',
'volume': '24',
'author': 'Kanauchi',
'year': '2018',
'journal-title': 'Curr Pharm Des'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0024',
'doi-asserted-by': 'crossref',
'first-page': '138',
'DOI': '10.1016/j.antiviral.2011.11.004',
'article-title': 'Intranasal administration of live Lactobacillus species facilitates '
'protection against influenza virus infection in mice',
'volume': '93',
'author': 'Youn',
'year': '2012',
'journal-title': 'Antiviral Res'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0025',
'doi-asserted-by': 'crossref',
'first-page': '1491',
'DOI': '10.1128/AEM.03075-12',
'article-title': 'Identification of one novel candidate probiotic Lactobacillus plantarum '
'strain active against influenza virus infection in mice by a '
'large-scale screening',
'volume': '79',
'author': 'Kechaou',
'year': '2013',
'journal-title': 'Appl Environ Microbiol'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0026',
'doi-asserted-by': 'crossref',
'first-page': '1810',
'DOI': '10.1017/S0007114513001104',
'article-title': 'Anti-influenza virus effects of both live and non-liveLactobacillus '
'acidophilus l-92 accompanied by the activation of innate immunity',
'volume': '110',
'author': 'Goto',
'year': '2013',
'journal-title': 'Br J Nutr'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0027',
'doi-asserted-by': 'crossref',
'first-page': '4638',
'DOI': '10.1038/srep04638',
'article-title': 'Oral administration of Lactobacillus gasseri SBT2055 is effective for '
'preventing influenza in mice',
'volume': '4',
'author': 'Nakayama',
'year': '2014',
'journal-title': 'Sci Rep'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0028',
'doi-asserted-by': 'crossref',
'first-page': '1400',
'DOI': '10.1089/jmf.2015.3577',
'article-title': 'Dead nano-sized Lactobacillus plantarum inhibits azoxymethane/dextran '
'sulfate sodium-induced colon cancer in balb/c mice',
'volume': '18',
'author': 'Lee',
'year': '2015',
'journal-title': 'J Med Food'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0029',
'doi-asserted-by': 'crossref',
'first-page': '16',
'DOI': '10.1016/j.jmii.2014.07.011',
'article-title': 'Oral intake of Lactobacillus rhamnosus M21 enhances the survival rate '
'of mice lethally infected with influenza virus',
'volume': '49',
'author': 'Song',
'year': '2016',
'journal-title': 'J Microbiol Immunol Infect'},
{ 'key': '10.1016/j.nutres.2020.12.014_bib0030',
'doi-asserted-by': 'crossref',
'first-page': '111',
'DOI': '10.1186/s12985-016-0567-6',
'article-title': 'Antiviral activity of Lactobacillus reuteri protectis against '
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'and colon cell lines',
'volume': '13',
'author': 'Ang',
'year': '2016',
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'and enterovirus 71 infections',
'volume': '10',
'author': 'Chen',
'year': '2017',
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'first-page': '93',
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'author': 'Sumi',
'year': '2015',
'journal-title': 'Can J Microbiol'},
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'first-page': '441',
'DOI': '10.1016/j.rvsc.2017.10.007',
'article-title': 'Interactions between Lactobacilli and chicken macrophages induce '
'antiviral responses against avian influenza virus',
'volume': '125',
'author': 'Shojadoost',
'year': '2019',
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'volume': '9',
'author': 'Eguchi',
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'first-page': '1665',
'DOI': '10.1007/s12272-012-0918-9',
'article-title': 'Antiviral activity of Bifidobacterium adolescentis SPM 0214 against '
'herpes simplex virus type 1',
'volume': '35',
'author': 'An',
'year': '2012',
'journal-title': 'Arch Pharm Res'},
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'first-page': '337',
'DOI': '10.1007/s13167-019-00184-z',
'article-title': 'Probiotic Lactobacillus and Bifidobacterium strains possess safety '
'characteristics, antiviral activities and host adherence factors '
'revealed by genome mining',
'volume': '10',
'author': 'Abdelhamid',
'year': '2019',
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'first-page': '81',
'DOI': '10.1016/j.bionut.2013.04.003',
'article-title': 'Immunomodulatory effects of probiotics in the treatment of human '
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'volume': '4',
'author': 'Patel',
'year': '2014',
'journal-title': 'Biomed Prevent Nutr'},
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'first-page': '77',
'DOI': '10.5897/AJMR2018.9028',
'article-title': 'Lactobacillus acidophilus and bifidobacteria spp having antibacterial '
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'volume': '13',
'author': 'Allam',
'year': '2019',
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'first-page': '1',
'DOI': '10.3390/nu12061718',
'article-title': 'Diet supplementation, probiotics, and nutraceuticals in sars-cov-2 '
'infection: a scoping review',
'volume': '12',
'author': 'Infusino',
'year': '2020',
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'article-title': 'Role of probiotics to combat viral infections with emphasis on COVID-19',
'volume': '104',
'author': 'Sundararaman',
'year': '2020',
'journal-title': 'Appl Microbiol Biotechnol'},
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'first-page': '113',
'DOI': '10.1016/j.synbio.2018.03.001',
'article-title': 'Prospective study of probiotic supplementation results in immune '
'stimulation and improvement of upper respiratory infection rate',
'volume': '3',
'author': 'Zhang',
'year': '2018',
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'volume': '101',
'author': 'Rautava',
'year': '2009',
'journal-title': 'Br J Nutr'},
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'first-page': '15837',
'DOI': '10.3748/wjg.v20.i42.15837',
'article-title': 'Commercially available probiotic drinks containing Lactobacillus casei '
'DN-114001 reduce antibiotic-associated diarrhea',
'volume': '20',
'author': 'Dietrich',
'year': '2014',
'journal-title': 'World J Gastroenterol'},
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'first-page': '409',
'DOI': '10.1017/S0007114510003685',
'article-title': 'Bifidobacterium animalis subsp. Lactis bb-12 in reducing the risk of '
'infections in infancy',
'volume': '105',
'author': 'Taipale',
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'first-page': 'S164',
'DOI': '10.1002/jcph.1121',
'article-title': 'Probiotics in disease prevention and treatment',
'volume': '58',
'author': 'Liu',
'year': '2018',
'journal-title': 'J Clin Pharmacol'},
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'first-page': '494',
'DOI': '10.1093/eurpub/cky185',
'article-title': 'Does probiotic consumption reduce antibiotic utilization for common '
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'volume': '29',
'author': 'King',
'year': '2019',
'journal-title': 'Eur J Public Health'},
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'article-title': 'Probiotics for preventing ventilator-associated pneumonia',
'volume': '11',
'author': 'Bo',
'year': '2014',
'journal-title': 'Cochrane Database Syst Rev'},
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'doi-asserted-by': 'crossref',
'first-page': '124',
'DOI': '10.7453/gahmj.2012.1.2.014',
'article-title': 'The effect of probiotics for preventing acute upper respiratory tract '
'infections',
'volume': '1',
'author': 'Saeterdal',
'year': '2012',
'journal-title': 'Glob Adv Health Med'},
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'first-page': '1999',
'DOI': '10.1017/S0007114512004138',
'article-title': 'Effect of Lactobacillus rhamnosus LGG(r) and Bifidobacterium animalis '
'ssp. lactis bb-12(r) on health-related quality of life in college '
'students affected by upper respiratory infections',
'volume': '109',
'author': 'Smith',
'year': '2013',
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'controlled trials',
'volume': '95',
'author': 'Wang',
'year': '2016',
'journal-title': 'Medicine (Baltimore)'},
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'first-page': '1223',
'DOI': '10.2147/CIA.S141518',
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'volume': '12',
'author': 'Pu',
'year': '2017',
'journal-title': 'Clin Interv Aging'},
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'first-page': '45',
'DOI': '10.1007/s00394-015-1056-1',
'article-title': 'Daily intake of fermented milk with Lactobacillus casei strain shirota '
'reduces the incidence and duration of upper respiratory tract '
'infections in healthy middle-aged office workers',
'volume': '56',
'author': 'Shida',
'year': '2017',
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'doi-asserted-by': 'crossref',
'first-page': '327',
'DOI': '10.1111/j.1365-2036.2011.04939.x',
'article-title': 'Randomised clinical trial: the effectiveness of Lactobacillus reuteri '
'ATCC 55730 rectal enema in children with active distal ulcerative '
'colitis',
'volume': '35',
'author': 'Oliva',
'year': '2012',
'journal-title': 'Aliment Pharmacol Ther'},
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'doi-asserted-by': 'crossref',
'first-page': '325',
'DOI': '10.4161/gmic.25487',
'article-title': 'Bifidobacterium infantis 35624 modulates host inflammatory processes '
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'volume': '4',
'author': 'Groeger',
'year': '2013',
'journal-title': 'Gut Microbes'},
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'doi-asserted-by': 'crossref',
'first-page': '1539',
'DOI': '10.1111/j.1572-0241.2005.41794.x',
'article-title': 'VSL#3 probiotic-mixture induces remission in patients with active '
'ulcerative colitis',
'volume': '100',
'author': 'Bibiloni',
'year': '2005',
'journal-title': 'Am J Gastroenterol'},
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'first-page': '1371',
'DOI': '10.2165/00003495-200666100-00006',
'article-title': 'VSL#3 probiotic mixture: a review of its use in chronic inflammatory '
'bowel diseases',
'volume': '66',
'author': 'Chapman',
'year': '2006',
'journal-title': 'Drugs'},
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'first-page': '445',
'DOI': '10.1369/0022155417718542',
'article-title': 'The probiotic VSL#3 modulates colonic macrophages, inflammation, and '
'microflora in acute trinitrobenzene sulfonic acid colitis',
'volume': '65',
'author': 'Isidro',
'year': '2017',
'journal-title': 'J Histochem Cytochem'},
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'first-page': '1292',
'article-title': 'Mechanism of probiotic VSL#3 inhibiting nf-κb and tnf-α on colitis '
'through tlr4-nf-κb signal pathway',
'volume': '48',
'author': 'Hui',
'year': '2019',
'journal-title': 'Iran J Public health'},
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'doi-asserted-by': 'crossref',
'first-page': '1101',
'DOI': '10.1016/j.intimp.2010.06.012',
'article-title': 'Effect of intranasal administration of Lactobacillus pentosus s-pt84 on '
'influenza virus infection in mice',
'volume': '10',
'author': 'Izumo',
'year': '2010',
'journal-title': 'Int Immunopharmacol'},
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'first-page': '6',
'article-title': 'Oral administration ofLactobacilli from human intestinal tract protects '
'mice against influenza virus infection',
'volume': '51',
'author': 'Kawase',
'year': '2010',
'journal-title': 'Lett Appl Microbiol'},
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'doi-asserted-by': 'crossref',
'first-page': '199',
'DOI': '10.1016/j.intimp.2010.11.019',
'article-title': 'Oral administration of heat-killed Lactobacillus pentosus strain b240 '
'augments protection against influenza virus infection in mice',
'volume': '11',
'author': 'Kobayashi',
'year': '2011',
'journal-title': 'Int Immunopharmacol'},
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'doi-asserted-by': 'crossref',
'first-page': '836',
'DOI': '10.1007/s12275-013-3521-y',
'article-title': 'Cyclic dipeptides from lactic acid bacteria inhibit proliferation of '
'the influenza a virus',
'volume': '51',
'author': 'Kwak',
'year': '2013',
'journal-title': 'J Microbiol'},
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'doi-asserted-by': 'crossref',
'first-page': '161',
'DOI': '10.1016/j.intimp.2013.12.020',
'article-title': 'Immunobiotic lactobacilli reduce viral-associated pulmonary damage '
'through the modulation of inflammation-coagulation interactions',
'volume': '19',
'author': 'Zelaya',
'year': '2014',
'journal-title': 'Int Immunopharmacol'},
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'series-title': 'Features, evaluation and treatment coronavirus (COVID-19); Statpearls '
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'year': '2020'},
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'DOI': '10.1128/JVI.00127-20',
'article-title': 'Receptor recognition by the novel coronavirus from wuhan: an analysis '
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'volume': '94',
'author': 'Wan',
'year': '2020',
'journal-title': 'J Virol'},
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'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.arcmed.2020.04.019',
'article-title': 'Oxidative stress as key player in severe acute respiratory syndrome '
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'author': 'Delgado-Roche',
'year': '2020',
'journal-title': 'Arch Med Res'},
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'doi-asserted-by': 'crossref',
'first-page': '497',
'DOI': '10.1016/S0140-6736(20)30183-5',
'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in '
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'volume': '395',
'author': 'Huang',
'year': '2020',
'journal-title': 'Lancet North Am Ed'},
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'first-page': '1033',
'DOI': '10.1016/S0140-6736(20)30628-0',
'article-title': 'Covid-19: consider cytokine storm syndromes and immunosuppression',
'volume': '395',
'author': 'Mehta',
'year': '2020',
'journal-title': 'Lancet North Am Ed'},
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'first-page': '1',
'article-title': 'Clinical predictors of mortality due to COVID-19 based on an analysis '
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'author': 'Ruan',
'year': '2020',
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'first-page': '420',
'DOI': '10.1016/S2213-2600(20)30076-X',
'article-title': 'Pathological findings of covid-19 associated with acute respiratory '
'distress syndrome',
'volume': '8',
'author': 'Xu',
'year': '2020',
'journal-title': 'Lancet Respir Med'},
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'DOI': '10.1016/j.cytogfr.2020.05.003',
'article-title': 'The cytokine storm in covid-19: an overview of the involvement of the '
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'author': 'Coperchini',
'year': '2020',
'journal-title': 'Cytokine Growth Factor Rev'},
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'doi-asserted-by': 'crossref',
'first-page': '1002',
'DOI': '10.1136/gutjnl-2020-320926',
'article-title': 'Epidemiological, clinical and virological characteristics of 74 cases '
'of coronavirus-infected disease 2019 (Covid-19) with gastrointestinal '
'symptoms',
'volume': '69',
'author': 'Jin',
'year': '2020',
'journal-title': 'Gut'},
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'doi-asserted-by': 'crossref',
'first-page': '944',
'DOI': '10.1053/j.gastro.2020.05.048',
'article-title': 'Alterations in gut microbiota of patients with covid-19 during time of '
'hospitalization',
'volume': '159',
'author': 'Zuo',
'year': '2020',
'journal-title': 'Gastroenterology'},
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'doi-asserted-by': 'crossref',
'first-page': '201',
'DOI': '10.3389/fimmu.2014.00201',
'article-title': 'Modulation of respiratory tlr3-anti-viral response by probiotic '
'microorganisms: Lessons learned from Lactobacillus rhamnosus CRL1505',
'volume': '5',
'author': 'Kitazawa',
'year': '2014',
'journal-title': 'Front Immunol'},
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'first-page': '1',
'article-title': 'Immunomodulatory effects of probiotics on cytokine profiles',
'volume': '2018',
'author': 'Azad',
'year': '2018',
'journal-title': 'Biomed Res Int'},
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'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1155/2019/1603758',
'article-title': 'Cutting edge: probiotics and fecal microbiota transplantation in '
'immunomodulation',
'volume': '2019',
'author': 'Zeng',
'year': '2019',
'journal-title': 'J Immunol Res'},
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'doi-asserted-by': 'crossref',
'first-page': '521',
'DOI': '10.3390/nu9050521',
'article-title': 'Antioxidant properties of probiotic bacteria',
'volume': '9',
'author': 'Wang',
'year': '2017',
'journal-title': 'Nutrients'},
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'doi-asserted-by': 'crossref',
'first-page': '3615',
'DOI': '10.1021/jf506326t',
'article-title': 'Probiotics as potential antioxidants: a systematic review',
'volume': '63',
'author': 'Mishra',
'year': '2015',
'journal-title': 'J Agric Food Chem'},
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'doi-asserted-by': 'crossref',
'first-page': '405',
'DOI': '10.1016/j.femsre.2004.01.003',
'article-title': 'Antagonistic activities of Lactobacilli and Bifidobacteria against '
'microbial pathogens',
'volume': '28',
'author': 'Servin',
'year': '2004',
'journal-title': 'FEMS Microbiol Rev'},
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'doi-asserted-by': 'crossref',
'first-page': '945',
'DOI': '10.1007/s00217-009-1009-0',
'article-title': 'Antiviral activities of cell-free supernatants of yogurts metabolites '
'against some rna viruses',
'volume': '228',
'author': 'Choi',
'year': '2009',
'journal-title': 'Eur Food Res Technol'},
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'doi-asserted-by': 'crossref',
'first-page': '166',
'DOI': '10.1016/j.idairyj.2008.09.003',
'article-title': 'Nitric oxide (no) production in mammalian non-tumorigenic epithelial '
'cells of the small intestine and macrophages induced by individual '
'strains of Lactobacilli and Bifidobacteria',
'volume': '19',
'author': 'Pipenbaher',
'year': '2009',
'journal-title': 'Int Dairy J'},
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'doi-asserted-by': 'crossref',
'first-page': '764',
'DOI': '10.1189/jlb.1003461',
'article-title': 'Streptococcus pyogenes and Lactobacillus rhamnosus differentially '
'induce maturation and production of th1-type cytokines and chemokines '
'in human monocyte-derived dendritic cells',
'volume': '75',
'author': 'Veckman',
'year': '2004',
'journal-title': 'J Leukoc Biol'},
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'doi-asserted-by': 'crossref',
'first-page': '268',
'DOI': '10.1111/j.1365-2567.2010.03301.x',
'article-title': 'Hanne: Lactobacillus acidophilus induces virus immune defence genes in '
'murine dendritic cells by a toll-like receptor-2-dependent mechanism',
'volume': '131',
'author': 'Weiss',
'year': '2010',
'journal-title': 'Immunology'},
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'doi-asserted-by': 'crossref',
'first-page': '100',
'DOI': '10.1016/j.cyto.2009.07.423',
'article-title': 'Potentially probiotic bacteria induce cytokine production and '
'suppressor of cytokine signaling 3 gene expression in human '
'monocyte-derived macrophages',
'volume': '48',
'author': 'Latvala',
'year': '2009',
'journal-title': 'Cytokine'}],
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{'value': 'Nutrition Research', 'name': 'journaltitle', 'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.nutres.2020.12.014',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2020 Elsevier Inc. All rights reserved.',
'name': 'copyright',
'label': 'Copyright'}]}
