Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections

{ 'indexed': {'date-parts': [[2024, 9, 18]], 'date-time': '2024-09-18T19:40:25Z', 'timestamp': 1726688425884}, 'reference-count': 95, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 9, 18]], 'date-time': '2024-09-18T00:00:00Z', 'timestamp': 1726617600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 9, 18]], 'date-time': '2024-09-18T00:00:00Z', 'timestamp': 1726617600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Scope</jats:title>\n' ' <jats:p>The underlying medical conditions and gut dysbiosis is known to ' 'influence COVID-19 severity in high-risk patients. The current review proposed the optimal ' 'usage of nutraceuticals &amp; pharmacological interventions can help regulate the protective ' 'immune response and balance the regulatory functionality of gut microbiota.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Summary</jats:title>\n' ' <jats:p>Many studies have revealed that the probiotic interventions viz., ' '<jats:italic>Lactobacillus rhamnosus</jats:italic>, <jats:italic>L. plantarum</jats:italic> ' '&amp; other bacterial spp. reduce IFNγ &amp; TNF-α and increase IL-4 &amp; IL-10 secretions ' 'to control the immunostimulatory effects in upper respiratory tract infection. Dietary fibres ' 'utilized by beneficial microbiota and microbial metabolites can control the NF-kB regulation. ' 'Vitamin C halts the propagation of pathogens and vitamin D and A modulate the GM. Selenium ' 'and Flavonoids also control the redox regulations. Interferon therapy can antagonize the ' 'viral replications, while corticosteroids may reduce the death rates. BCG vaccine reprograms ' 'the monocytes to build trained immunity. <jats:italic>Bifidobacterium</jats:italic> and ' 'related microbes were found to increase the vaccine efficacy. Vaccines against COVID-19 and ' 'season flu also boost the immunity profile for robust protection. Over all, the collective ' 'effects of these therapeutics could help increase the opportunities for faster recovery from ' 'infectious diseases.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>The nutraceutical supplements and pharmacological medicines mediate ' 'the modulatory functionalities among beneficial microbes of gut, which in turn eliminate ' 'pathogens, harmonize the activity of immune cells to secrete essential regulatory molecular ' 'receptors and adaptor proteins establishing the homeostasis in the body organs through ' 'essential microbiome. Therefore, the implementation of this methodology could control the ' 'severity events during clinical sickness and reduce the mortalities.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s12967-024-05587-9', 'type': 'journal-article', 'created': {'date-parts': [[2024, 9, 18]], 'date-time': '2024-09-18T19:01:48Z', 'timestamp': 1726686108000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity ' 'during COVID-19 and other viral infections', 'prefix': '10.1186', 'volume': '22', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-0902-5461', 'authenticated-orcid': False, 'given': 'Anju', 'family': 'Kaushal', 'sequence': 'first', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 9, 18]]}, 'reference': [ { 'issue': '12', 'key': '5587_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1115', 'DOI': '10.1016/j.molmed.2021.09.009', 'volume': '27', 'author': 'A Sarkar', 'year': '2021', 'unstructured': 'Sarkar A, Harty S, Moeller AH, Klein SL, Erdman SE, Friston KJ, Carmody ' 'RN. The gut microbiome as a biomarker of differential susceptibility to ' 'SARS-CoV-2. Trends Mol Med. 2021;27(12):1115-34.', 'journal-title': 'Trends Mol Med'}, { 'key': '5587_CR2', 'doi-asserted-by': 'publisher', 'first-page': '184', 'DOI': '10.1007/s00284-022-02877-7', 'volume': '79', 'author': 'A Kaushal', 'year': '2022', 'unstructured': 'Kaushal A, Noor R. Association of gut microbiota with inflammatory bowel ' 'disease and COVID-19 severity: a possible outcome of the altered immune ' 'response. Curr Microbiol. 2022;79:184. ' 'https://doi.org/10.1007/s00284-022-02877-7.', 'journal-title': 'Curr Microbiol'}, { 'key': '5587_CR3', 'doi-asserted-by': 'crossref', 'unstructured': 'Lordan R, Rando HM. COVID-19 Review Consortium, Greene CS. Dietary ' 'Supplements and nutraceuticals under investigation for COVID-19 ' 'prevention and treatment. ArXiv. arXiv:2102.02250v1. Msystems. ' '2021;6(3).', 'DOI': '10.1128/mSystems.00122-21'}, { 'key': '5587_CR4', 'doi-asserted-by': 'publisher', 'first-page': '92', 'DOI': '10.31080/ASMI.2020.03.0682', 'volume': '3', 'author': 'A Kaushal', 'year': '2020', 'unstructured': 'Kaushal A. Immune response and pathogenesis of COVID-19 and strategies ' 'for developing the target drugs. Acta Sci Microbiol. 2020;3(9):92-102.', 'journal-title': 'Acta Sci Microbiol'}, { 'issue': '6', 'key': '5587_CR5', 'doi-asserted-by': 'publisher', 'first-page': '1305', 'DOI': '10.3390/nu14061305', 'volume': '14', 'author': 'L Barrea', 'year': '2022', 'unstructured': 'Barrea L, Grant WB, Frias-Toral E, Vetrani C, Verde L, de Alteriis G, ' 'Docimo A, Savastano S, Calao A, Muscogiuri G. Dietary recommendations ' 'for post-COVID-19 syndrome. Nutrients. 2022;14(6):1305. ' 'https://doi.org/10.3390/nu14061305.', 'journal-title': 'Nutrients'}, { 'key': '5587_CR6', 'doi-asserted-by': 'publisher', 'first-page': '2839232', 'DOI': '10.1155/2016/2839232', 'volume': '2016', 'author': 'W Ren', 'year': '2016', 'unstructured': 'Ren W, Chen S, Zhang L, Liu G, Hussain T, Hao X, Yin J, Duan J, Tan B, ' 'Wu G, Bazar FW, Yin Y. Interferon tau affects mouse intestinal ' 'microbiota and expression of IL-17. Mediators Inflamm. ' '2016;2016:2839232.', 'journal-title': 'Mediators Inflamm'}, { 'issue': '7', 'key': '5587_CR7', 'doi-asserted-by': 'crossref', 'first-page': '495', 'DOI': '10.1016/j.nrl.2018.04.006', 'volume': '36', 'author': 'F Castillo-Alvarez', 'year': '2016', 'unstructured': 'Castillo-Alvarez F, Perez-Matute P, Oteo JA, Marzo-Sola ME. The ' 'influence of interferon β-1b on gut microbiota composition in patients ' 'with multiple sclerosis. Neurologia (Engl ED). 2021;36(7):495–503.', 'journal-title': 'Neurologia'}, { 'issue': '9', 'key': '5587_CR8', 'doi-asserted-by': 'publisher', 'first-page': '1039', 'DOI': '10.1097/CM9.0000000000000774', 'volume': '133', 'author': 'Y Ling', 'year': '2020', 'unstructured': 'Ling Y, Xu SB, Lin YX, Tian D, Zhu ZQ, Dai FH, Wu F, Song ZG, Huang W, ' 'Chen J, Hu BJ, Wang S, Mao EQ, Zhu L, Zhang WH, Lu HZ. Persistence and ' 'clearance of viral RNA in 2019 novel coronavirus disease rehabilitation ' 'patients. Chin Med J (Engl). 2020; 133(9):1039–1043.', 'journal-title': 'Chin Med J (Engl)'}, { 'key': '5587_CR9', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.pupt.2021.102107', 'volume': '72', 'author': 'FE Chaharom', 'year': '2022', 'unstructured': 'Chaharom FE, Pourafkari L, Chaharom AAE, Nader ND. Effects of ' 'corticosteroids on COVID-19 patients: a systematic review and meta ' '-analysis on clinical outcomes. Pulm Pharmacol Ther. 2022;72:102107. ' 'https://doi.org/10.1016/j.pupt.2021.102107.', 'journal-title': 'Pulm Pharmacol Ther'}, { 'issue': '1', 'key': '5587_CR10', 'doi-asserted-by': 'publisher', 'first-page': '33', 'DOI': '10.1038/s41577-021-00554-7', 'volume': '22', 'author': 'DJ Lynn', 'year': '2022', 'unstructured': 'Lynn DJ, Benson SC, Lynn MA, Pulendran B. Modulation of immune responses ' 'to vaccination by the microbiota: implications and potential mechanisms. ' 'Nat Rev Immunol. 2022;22(1):33–46.', 'journal-title': 'Nat Rev Immunol'}, { 'key': '5587_CR11', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.prp.2023.154497', 'volume': '246', 'author': 'C-A May', 'year': '2023', 'unstructured': 'Scholkmann F, and May CA. COVID-19, post-acute COVID-19 syndrome (PACS, ' '“long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVID ' 'vac-syndrome”): similarities and differences. Pathology Res Pract. ' '2023;246:154497.', 'journal-title': 'Pathology Res Pract'}, { 'key': '5587_CR12', 'doi-asserted-by': 'publisher', 'first-page': '61', 'DOI': '10.38042/biotechstudies.1159166', 'volume': '31', 'author': 'Y Gezginç', 'year': '2022', 'unstructured': 'Gezginç Y, Karabekmez-Erdem T, Tatar HD, Ayman S, Ganiyusufoglu E, ' 'Dayisoylu KS. Health promoting benefits of postbiotics produced by ' 'lactic acid bacteria: exopolysaccharide. Biotech Stud. 2022;31:61–70. ' 'https://doi.org/10.38042/biotechstudies.1159166.', 'journal-title': 'Biotech Stud'}, { 'issue': '19', 'key': '5587_CR13', 'doi-asserted-by': 'publisher', 'first-page': '3094', 'DOI': '10.3390/foods11193094', 'volume': '11', 'author': 'P Thorakkattu', 'year': '2022', 'unstructured': 'Thorakkattu P, Khanashyam AC, Shah K, Babu KS, Mundanat AS, Deliephan A, ' 'Deokar GS, , Santivarangkna C, Nirmal NP. Postbiotics: current trends in ' 'food and pharmaceutical industry. Foods. 2022;11(19):3094. ' 'https://doi.org/10.3390/foods11193094.', 'journal-title': 'Foods'}, { 'key': '5587_CR14', 'doi-asserted-by': 'publisher', 'first-page': '1974', 'DOI': '10.1136/gutjnl-2017-314968', 'volume': '67', 'author': 'H Watson', 'year': '2018', 'unstructured': 'Watson H, Mitra S, Croden FC, Taylor M, Wood HM, Perry SL, Spencer JA, ' 'Quirke P, Toogood GJ, Lawton CL, Dye L, Loadman PM, Hull MA. Arandomised ' 'trial of the effect of omega-3 polyunsaturated fatty acid supplements on ' 'the human intestinal microbiota. Gut. 2018;67(11):1974–83.', 'journal-title': 'Gut'}, { 'key': '5587_CR15', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.lfs.2022.120489', 'volume': '229', 'author': 'A Mazidimoradi', 'year': '2022', 'unstructured': 'Mazidimoradi A, Alemzahdeh E, Alemzadeh E, Salehiniya H. The effect of ' 'polyunsaturated fatty acids on the severity and mortality of COVID-19 ' 'patients: a systematic review. Life Sci. 2022;299:120489.', 'journal-title': 'Life Sci'}, { 'issue': '3', 'key': '5587_CR16', 'doi-asserted-by': 'publisher', 'first-page': '499', 'DOI': '10.1046/j.1365-2249.2001.01627.x', 'volume': '125', 'author': 'JL Arrington', 'year': '2001', 'unstructured': 'Arrington JL, Chapkin RS, Switzer KC, Morris JS, McMurray DN. Dietary ' 'n-3 polyunsaturated fatty acids modulate purified murine T-cell subset ' 'activation. Clin Exp Immunol. 2001;125(3):499–507. ' 'https://doi.org/10.1046/j.1365-2249.2001.01627.x.', 'journal-title': 'Clin Exp Immunol'}, { 'issue': '4', 'key': '5587_CR17', 'doi-asserted-by': 'publisher', 'first-page': '438', 'DOI': '10.3390/nu10040438', 'volume': '10', 'author': 'H Alkhalidy', 'year': '2018', 'unstructured': 'Alkhalidy H, Wang Y, and Liu D. Dietary flavonoids in the prevention of ' 'T2D: an overview. Nutrients. 2018;10(4):438.', 'journal-title': 'Nutrients'}, { 'issue': '12', 'key': '5587_CR18', 'doi-asserted-by': 'publisher', 'first-page': '7577', 'DOI': '10.1007/s13197-015-1921-1', 'volume': '52', 'author': 'KR Pandey', 'year': '2015', 'unstructured': 'Pandey KR, Naik SR, Vakil BV. Probiotics, prebiotics and synbiotics- a ' 'review. J Food Sci Technol. 2015;52(12):7577–87.', 'journal-title': 'J Food Sci Technol'}, { 'issue': '3', 'key': '5587_CR19', 'doi-asserted-by': 'publisher', 'first-page': '229', 'DOI': '10.1111/lam.13334', 'volume': '71', 'author': 'A Akour', 'year': '2020', 'unstructured': 'Akour A. Probiotics and COVID-19: is there any link? Lett Appl ' 'Microbiol. 2020;71(3):229–34.', 'journal-title': 'Lett Appl Microbiol'}, { 'issue': '9', 'key': '5587_CR20', 'doi-asserted-by': 'publisher', 'first-page': '1021', 'DOI': '10.3390/nu9091021', 'volume': '9', 'author': 'P Markowiak', 'year': '2017', 'unstructured': 'Markowiak P, Slizewska K. Effects of probiotics, prebiotics, and ' 'synbiotics on human health. Nutrients. 2017;9(9):1021.', 'journal-title': 'Nutrients'}, { 'issue': '9', 'key': '5587_CR21', 'doi-asserted-by': 'publisher', 'first-page': '3172', 'DOI': '10.3390/nu13093172', 'volume': '13', 'author': 'M Jabczyk', 'year': '2021', 'unstructured': 'Jabczyk M, Nowak J, Hudzik B, Zubelewicz-Szkodzińska B. Diet, probiotics ' 'and their impact on the gut microbiota during the COVID-19 pandemic. ' 'Nutrients. 2021;13(9):3172.', 'journal-title': 'Nutrients'}, { 'issue': '8', 'key': '5587_CR22', 'doi-asserted-by': 'publisher', 'first-page': '1058', 'DOI': '10.1164/rccm.200912-1853OC', 'volume': '182', 'author': 'LE Morrow', 'year': '2010', 'unstructured': 'Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ' 'ventilator-associated pneumonia: a blinded, randomized, controlled ' 'trial. Am J Respir Crit Care Med. 2010;182(8):1058–64.', 'journal-title': 'Am J Respir Crit Care Med'}, { 'issue': '1', 'key': '5587_CR23', 'doi-asserted-by': 'publisher', 'first-page': '156', 'DOI': '10.1002/ncp.10191', 'volume': '34', 'author': 'A Mahmoodpoor', 'year': '2019', 'unstructured': 'Mahmoodpoor A, Hamishehkar H, Asghari R, Abri R, Shadvar K, Sanaie S. ' 'Effect of a probiotic preparation on ventilator-associated pneumonia in ' 'critically ill patients admitted to the intensive care unit: a ' 'prospective double-blind randomized controlled trial. Nutr Clin Pract. ' '2019;34(1):156–162.', 'journal-title': 'Nutr Clin Pract'}, { 'issue': '4', 'key': '5587_CR24', 'doi-asserted-by': 'publisher', 'first-page': '979', 'DOI': '10.1093/advances/nmaa003', 'volume': '11', 'author': 'CKY Chan', 'year': '2020', 'unstructured': 'Chan CKY, Tao J, Chan OS, Li HB, Pang H. Preventing respiratory tract ' 'infections by synbiotic interventions: a systematic review and ' 'meta-analysis of randomized controlled trials. Adv Nutr. ' '2020;11(4):979–88.', 'journal-title': 'Adv Nutr'}, { 'issue': '4', 'key': '5587_CR25', 'doi-asserted-by': 'publisher', 'first-page': '799', 'DOI': '10.1007/s00705-012-1543-0', 'volume': '158', 'author': 'W Chai', 'year': '2013', 'unstructured': 'Chai W, Burwinkel M, Wang Z, Palissa C, Esch B, Twardziok S, Rieger J, ' 'Wrede P, Schmidt MF. Antiviral effects of a probiotic Enterococcus ' 'faecium strain against transmissible gastroenteritis coronavirus. Arch ' 'Virol. 2013;158(4):799–807.', 'journal-title': 'Arch Virol'}, { 'key': '5587_CR26', 'doi-asserted-by': 'publisher', 'unstructured': 'Crouch LI, Liberato MV, Urbanowicz PA, Basle A, Lamb CA, Stewart CJ, ' 'Cooke K, Doona M, Needham S, Brady RR, Berrington JE, Madunic K,Wuhrer ' 'M, Chater P, Pearson JP, Glowacki R, Martens EC, Zhang F, Linhardt RJ, ' 'Spencer DIR, Bolam DN. Prominent members of human gut microbiota express ' 'endo -acting O-glycanases to initiate mucin breakdown. Nat Commun. Nat ' 'Commun. 2020;11(4017). https://doi.org/10.1038/s41467-020-17847-5.', 'DOI': '10.1038/s41467-020-17847-5'}, { 'key': '5587_CR27', 'doi-asserted-by': 'publisher', 'first-page': '186', 'DOI': '10.3389/fpubh.2020.00186', 'volume': '8', 'author': 'D Baud', 'year': '2020', 'unstructured': 'Baud D, Agri DV, Gibson GR, Reid G Giannoni E. Using probiotics to ' 'flatten the curve of coronavirus disease COVID-2019 pandemic. Front ' 'Public Health. 2020;8:186.', 'journal-title': 'Front Public Health'}, { 'key': '5587_CR28', 'doi-asserted-by': 'publisher', 'first-page': '381', 'DOI': '10.3390/nu12020381', 'volume': '12', 'author': 'Q Yang', 'year': '2020', 'unstructured': 'Yang Q, Liang Q, Balakrishnan B,Belobrajdic DP, Feng QJ, Zhang W. Role ' 'of dietary nutrients in the modulation of gut microbiota: a narrative ' 'review. Nutrients. 2020;12(2):381.', 'journal-title': 'Nutrients'}, { 'issue': '10', 'key': '5587_CR29', 'doi-asserted-by': 'publisher', 'first-page': '1514', 'DOI': '10.3390/microorganisms8101514', 'volume': '8', 'author': 'C Ferreira', 'year': '2020', 'unstructured': 'Ferreira C, Viana SD, Reis F. Gut microbiota dysbiosis-immune ' 'hyperresponse-inflammation triad in coronavirus disease-2019 (COVID-19): ' 'impact of pharmacological and nutraceutical approaches. Microorganisms. ' '2020;8(10):1514. https://doi.org/10.3390/microorganisms8101514.', 'journal-title': 'Microorganisms'}, { 'issue': '6', 'key': '5587_CR30', 'doi-asserted-by': 'publisher', 'first-page': '1562', 'DOI': '10.3390/nu12061562', 'volume': '12', 'author': 'M Idir', 'year': '2020', 'unstructured': 'Iddir M, Brito A, Dingeo G, Campo SSFD, Samouda H, Frano MRL, Bohn T. ' 'Strengthening the immune system and reducing inflammation and oxidative ' 'stress through diet and nutrition: considerations during the COVID-19 ' 'crisis. Nutrients. 2020;12(6):1562.', 'journal-title': 'Nutrients'}, { 'key': '5587_CR31', 'doi-asserted-by': 'publisher', 'first-page': '420', 'DOI': '10.1007/s12088-020-00908-0', 'volume': '60', 'author': 'P Rishi', 'year': '2020', 'unstructured': 'Rishi P, Thakur K, Vij S, Rishi L, Singh A, Kaur IP, Patel SKS, Lee JK, ' 'Kalia VC. Diet, gut microbiota and COVID-19. Indian J Microbiol. ' '2020;60(4):420–9.', 'journal-title': 'Indian J Microbiol'}, { 'issue': '4', 'key': '5587_CR32', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/cti.2016.17', 'volume': '5', 'author': 'R Corrêa Oliveira', 'year': '2016', 'unstructured': 'Corrêa Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MAR. Regulation ' 'of immune cell function by short-chain fatty acids. Clin Transl Immunol. ' '2016;5(4):e73. https://doi.org/10.1038/cti.2016.17.', 'journal-title': 'Clin Transl Immunol'}, { 'issue': '1', 'key': '5587_CR33', 'first-page': '1', 'volume': '66', 'author': 'W Ratajczak', 'year': '2019', 'unstructured': 'Ratajczak W, Rył A, Mizerski A, Walczakiewicz K, Sipak O, Laszczynska M. ' 'Immunomodulatory potential of gut microbiome-derived short-chain fatty ' 'acids (SCFAs). Acta Biochim Pol. 2019;66(1):1–12.', 'journal-title': 'Acta Biochim Pol'}, { 'key': '5587_CR34', 'doi-asserted-by': 'publisher', 'first-page': '277', 'DOI': '10.1016/j.nutres.2014.02.008', 'volume': '34', 'author': 'MM Root', 'year': '2014', 'unstructured': 'Root MM, Houser SM, Anderson JJB, Dawson HR. Healthy Eating Index 2005 ' 'and selected macronutrients are correlated with improved lung function ' 'in humans. Nutr Res. 2014;34(4):277–84.', 'journal-title': 'Nutr Res'}, { 'key': '5587_CR35', 'doi-asserted-by': 'publisher', 'first-page': '21', 'DOI': '10.1186/s40813-022-00264-z', 'volume': '8', 'author': 'R Saleri', 'year': '2022', 'unstructured': 'Saleri R, Borghetti P, Ravanetti F, Cavalli V, Ferrari L, De Angelis E, ' 'Andrani M, Martelli P. Effects of different short chained fatty acids ' '(SCFA) on gene expression of proteins involved in barrier function in ' 'IPEC-J2. Porcine Health Manag. 2022;8:21.', 'journal-title': 'Porcine Health Manag'}, { 'issue': '12', 'key': '5587_CR36', 'doi-asserted-by': 'publisher', 'first-page': '933', 'DOI': '10.1093/jmcb/mjaa043', 'volume': '12', 'author': 'Q Yang', 'year': '2020', 'unstructured': 'Yang Q, Tang J, Xu C, Zhao H, Zhou Y, Wang Y, Yang M, Chen X, Chen J. ' 'Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα ' 'sumoylation. J Mol Cell Biol. 2020;12(12):933–45.', 'journal-title': 'J Mol Cell Biol'}, { 'key': '5587_CR37', 'doi-asserted-by': 'publisher', 'first-page': '174', 'DOI': '10.1016/j.tifs.2021.12.033', 'volume': '120', 'author': 'D Xavier-Santos', 'year': '2022', 'unstructured': 'Xavier-Santos D, Padilha M, Fabiano GA, Vinderola G, Cruz AG, Sivieri K, ' 'Antunes AEC. Evidences and perspectives of the use of probiotics, ' 'prebiotics, synbiotics, and postbiotics as adjuvants for prevention and ' 'treatment of COVID-19: a bibliometric analysis and systematic review. ' 'Trends Food Sci Technol. 2022;120:174–92.', 'journal-title': 'Trends Food Sci Technol'}, { 'key': '5587_CR38', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.i6583', 'volume': '356', 'author': 'AR Martineau', 'year': '2017', 'unstructured': 'Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, ' 'Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, ' 'Griffiths CJ, Janssens W, Laaksi I, Manaseki- Holland S, Mauger D, ' 'Murdoch DR, Neale R, Rees JR, Simpson Jr S, Stelmach I, Kumar GT, ' 'Urashima M, Camargo Jr CA. Vitamin D supplementation to prevent acute ' 'respiratory tract infections: systematic review and meta-analysis of ' 'individual participant data. BMJ. 2017;356:i6583.', 'journal-title': 'BMJ'}, { 'issue': '3', 'key': '5587_CR39', 'doi-asserted-by': 'publisher', 'first-page': '181', 'DOI': '10.7762/cnr.2021.10.3.181', 'volume': '10', 'author': 'H Tangestani', 'year': '2021', 'unstructured': 'Tangestani H, Boroujeni HK, Djafarian K, Emamat H, Shab-Bidar S. Vitamin ' 'D and the gut microbiota: a narrative literature review. Clin Nutr Res. ' '2021;10(3):181–91.', 'journal-title': 'Clin Nutr Res'}, { 'key': '5587_CR40', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jsbmb.2020.105751', 'volume': '203', 'author': 'M Entrenas Castillo', 'year': '2020', 'unstructured': 'Castillo ME, Costa LME, Barrios JMV, Díaz JFA, Miranda JL, Bouillon R, ' 'and Gomez JMQ. Effect of calcifediol treatment and best available ' 'therapy versus best available therapy on intensive care unit admission ' 'and mortality among patients hospitalized for COVID-19: a pilot ' 'randomized clinical study. 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