Abstract: OPINION
published: 08 May 2020
doi: 10.3389/fpubh.2020.00186
Using Probiotics to Flatten the Curve
of Coronavirus Disease COVID-2019
Pandemic
David Baud 1 , Varvara Dimopoulou Agri 2 , Glenn R. Gibson 3 , Gregor Reid 4,5 and
Eric Giannoni 2*
1
Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of
Lausanne, Lausanne, Switzerland, 2 Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital,
University of Lausanne, Lausanne, Switzerland, 3 Food and Nutritional Sciences, St Joseph’s Hospital, The University of
Reading, Reading, United Kingdom, 4 Department of Microbiology and Immunology, The University of Western Ontario,
London, ON, Canada, 5 Canadian R&D Centre for Human Microbiome and Probiotics, Lawson Health Research Institute,
London, ON, Canada
Keywords: COVID 19, probiotics, prebiotics, SARS-CoV-2, pandemics, coronavirus, respiratory infection
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'volume': '49',
'author': 'Szajewska',
'year': '2019',
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