Risk factors for hospitalization or mortality for COVID-19 in patients with rheumatic diseases: Results of a nation-wide JCR COVID-19 registry in Japan

{ 'indexed': {'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T13:12:12Z', 'timestamp': 1662469932803}, 'reference-count': 0, 'publisher': 'Oxford University Press (OUP)', 'license': [ { 'start': { 'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T00:00:00Z', 'timestamp': 1662422400000}, 'content-version': 'am', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by-nc/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>ABSTRACT</jats:title>\n' ' <jats:p>Background: The incidence and prognosis of COVID-19 and rheumatic ' 'disease vary among ethnicities and regions. COVID-19 outcomes in rheumatic disease patients ' 'remain unclear, especially in the Asia-Pacific region. This study aimed to clarify the ' 'demographic and clinical factors that may influence COVID-19 prognosis in rheumatic disease ' 'patients.</jats:p>\n' ' <jats:p>Methods: This was a case series of patients registered with the ' 'COVID-19 national registry of Japan College of Rheumatology between June 3, 2020, and June ' '30, 2021. Multivariable logistic regression was used to estimate the risk of hospitalization ' 'or death. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities, and rheumatic ' 'disease medications are taken immediately before infection was analyzed.</jats:p>\n' ' <jats:p>Results: A total of 220 patients from 55 institutions in Japan were ' 'included in the study, among whom 186 (84.5%) were hospitalized and 11 (5.0%) died. COVID-19 ' 'treatments were provided to 126 patients (57.3%), and mainly comprised glucocorticoids, ' 'favipiravir, remdesivir, and tocilizumab.</jats:p>\n' ' <jats:p>In the multiple logistic regression model, older age and a history of ' 'hypertension were associated with hospitalization, while older age was associated with ' 'mortality. No specific treatment was correlated with mortality or hospitalization by the ' 'multi-variate analysis.</jats:p>\n' ' <jats:p>Conclusions: Older age and hypertension were associated with a poor ' 'prognosis in Japanese COVID-19 patients with CTD. Factors not directly related to CTD were ' 'closely associated with the prognosis.</jats:p>', 'DOI': '10.1093/mr/roac104', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T12:57:08Z', 'timestamp': 1662469028000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Risk factors for hospitalization or mortality for COVID-19 in patients with rheumatic diseases: ' 'Results of a nation-wide JCR COVID-19 registry in Japan', 'prefix': '10.1093', 'author': [ { 'given': 'Kenji', 'family': 'Oku', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Rheumatology and Infectious Diseases, Kitasato ' 'University , Kanagawa, Japan'}]}, { 'given': 'Yasutaka', 'family': 'Kimoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Kyushu University Beppu ' 'Hospital , Oita, Japan'}]}, { 'given': 'Takahiko', 'family': 'Horiuchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Kyushu University Beppu ' 'Hospital , Oita, Japan'}]}, { 'given': 'Mari', 'family': 'Yamamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology and Nephrology, Chubu Rosai Hospital ' ', Aichi, Japan'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1566-2088', 'authenticated-orcid': False, 'given': 'Yasushi', 'family': 'Kondo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Rheumatology, Department of Internal Medicine, Keio ' 'University School of Medicine , Tokyo, Japan'}]}, { 'given': 'Masashi', 'family': 'Okamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine and Clinical Immunology, ' 'Osaka University Graduate School of Medicine , Osaka, Japan'}]}, { 'given': 'Tatsuya', 'family': 'Atsumi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, Endocrinology and Nephrology, ' 'Faculty of Medicine and Graduate School of Medicine , Hokkaido, ' 'Japan'}]}, { 'given': 'Tsutomu', 'family': 'Takeuchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Rheumatology, Department of Internal Medicine, Keio ' 'University School of Medicine , Tokyo, Japan'}]}], 'member': '286', 'published-online': {'date-parts': [[2022, 9, 6]]}, 'container-title': 'Modern Rheumatology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/roac104/45718326/roac104.pdf', 'content-type': 'application/pdf', 'content-version': 'am', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/roac104/45718326/roac104.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T12:57:09Z', 'timestamp': 1662469029000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://academic.oup.com/mr/advance-article/doi/10.1093/mr/roac104/6692611'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 9, 6]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.1093/mr/roac104', 'relation': {}, 'ISSN': ['1439-7595', '1439-7609'], 'subject': ['Rheumatology'], 'published': {'date-parts': [[2022, 9, 6]]}}