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The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics

Nguyen et al., Bioinformatics and Biology Insights, doi:10.1177/11779322221149622
Jan 2023  
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In Silico study identifying multiple compounds including andrographolide, quercetin, and hydroxychloroquine (used as a reference) as promising inhibitors of SARS-CoV-2. Authors note the potential synergistic effect of multiple compounds.
16 preclinical studies support the efficacy of andrographolide for COVID-19:
Study covers quercetin, andrographolide, and HCQ.
Nguyen et al., 12 Jan 2023, peer-reviewed, 4 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperAndrographol..All
The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics
Hien Thi Nguyen, Van Mai Do, Thanh Thuy Phan, Dung Tam Nguyen Huynh
Bioinformatics and Biology Insights, doi:10.1177/11779322221149622
The current coronavirus disease 2019 (COVID-19) outbreak is alarmingly escalating and raises challenges in finding efficient compounds for treatment. Repurposing phytochemicals in herbs is an ideal and economical approach for screening potential herbal components against COVID-19. Andrographis paniculata, also known as Chuan Xin Lian, has traditionally been used as an anti-inflammatory and antibacterial herb for centuries and has recently been classified as a promising herbal remedy for adjuvant therapy in treating respiratory diseases. This study aimed to screen Chuan Xin Lian's bioactive components and elicit the potential pharmacological mechanisms and plausible pathways for treating COVID-19 using network pharmacology combined with molecular docking. The results found terpenoid (andrographolide) and flavonoid (luteolin, quercetin, kaempferol, and wogonin) derivatives had remarkable potential against COVID-19 and sequelae owing to their high degrees in the component-target-pathway network and strong binding capacities in docking scores. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the PI3K-AKT signaling pathway might be the most vital molecular pathway in the pathophysiology of COVID-19 and long-term sequelae whereby therapeutic strategies can intervene.
Author Contribution DTNH was in charge of the entire research and responsible for developing hypotheses, interpreting results, and performing the network analysis. DTNH, HTN, VMD, and TTP participated in the manuscript's writing and discussion. Data collection and screening were carried out by HTN, VMD, and TTP. All authors have read and agreed to the published version of the manuscript. Supplemental Material Supplemental material for this article is available online.
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