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All Studies   Meta Analysis       

Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method

Ningrum et al., Proceedings Universitas Muhammadiyah Yogyakarta Undergraduate Conference, doi:10.18196/umygrace.v2i2.418
Jun 2022  
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In Silico study showing that andrographolide, L-mimosine, and asiaticoside compounds from Andrographis paniculata, Mimosa pudica and Centella asiatica plants have potential as COVID-19 antivirals by binding to SARS-CoV-2 3CLpro, NSP3, and PD-ACE2 proteins. Asiaticoside had the best docking scores, stronger than favipiravir and almost as strong as remdesivir, but may have bioavailability issues based on Lipinski's rule of 5. Andrographolide and L-mimosine also showed good binding and complied with Lipinski's rule, suggesting they have potential for further development as COVID-19 antivirals.
22 preclinical studies support the efficacy of andrographolide for COVID-19:
Ningrum et al., 30 Jun 2022, peer-reviewed, 4 authors. Contact: dhecella.winy.fkik19@mail.umy.ac.id1, dita.dwi.fkik20@mail.umy.ac.id2, melisa.j.fkik21@mail.umy.ac.id3, rifki.febriansah@mail.ac.id4.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperAndrographol..All
"Strengthening Youth Potential for Sustainable Innovation" 1 Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method
Dhecella Winy, Cintya Ningrum, Dita Dwi, Zanatus Nur Aini, Melisa Juniananda, Rifki Febriansah
Introduction -COVID-19 is an infectious disease that is a global challenge, making it necessary for innovation and the development of antiviral agents in prevention and treatment efforts. Indonesia is known as a country rich in potential plants as medicine, a potential antiviral plant among them Andrographis paniculata , Mimosa pudica and Centella asiatica. The compound that have antiviral activity in each of these plants are andrographolide (Andrographis paniculata), L-mimosine (Mimosa pudica) and asiaticoside (Centella asiatica). The purpose of this study is to identify the potential of the andrographolide, l-mimosine and asiaticoside to inhibit SARS COV-2 protein and to predict the molecular drug profile which refers to lipinski's rule of 5. Purpose -The purpose of this study was to determine the potential of Andrographis paniculata , Mimosa pudica and Centella asiatica compounds in inhibiting the SARS CoV-2 protein and to determine the prediction of drug profiles such as molecules referring to Lipinski's rule of 5. Methodology -The methods used in this research by molecular docking and lipinski's Ro5 using PKCSM. The control compounds used are favipiravir and remdesivir. Results -The results of the affinity of target protein bonds using molecular docking obtained the best results in NSP3 proteins with An Asiaticoside docking score of -10.1 kcal / mol stronger than favipiravir -5.3 kcal/mol and remdesivir -8.6 kcal/mol. As for the compounds L-mimosine -6.1 kcal / mol and Andrographolide -7.7 kcal / mol. The compounds of andrographolide and L-mimosine showed good results and met the 5 aspects of Lipinski's Ro5, but asiaticoside compounds did not good enough. . Conclusion - The Research has concluded that the compound of the Andrographis paniculata , Mimosa pudica and Centella asiatica have a good potential in inhibiting SARS cov2 protein that is stronger than favipiravir and almost the same with remdesivir activity.
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