Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All andrographolide studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAndrographolideAndrographol.. (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method

Ningrum et al., Proceedings Universitas Muhammadiyah Yogyakarta Undergraduate Conference, doi:10.18196/umygrace.v2i2.418
Jun 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
In Silico study showing that andrographolide, L-mimosine, and asiaticoside compounds from Andrographis paniculata, Mimosa pudica and Centella asiatica plants have potential as COVID-19 antivirals by binding to SARS-CoV-2 3CLpro, NSP3, and PD-ACE2 proteins. Asiaticoside had the best docking scores, stronger than favipiravir and almost as strong as remdesivir, but may have bioavailability issues based on Lipinski's rule of 5. Andrographolide and L-mimosine also showed good binding and complied with Lipinski's rule, suggesting they have potential for further development as COVID-19 antivirals.
19 preclinical studies support the efficacy of andrographolide for COVID-19:
Ningrum et al., 30 Jun 2022, peer-reviewed, 4 authors. Contact: dhecella.winy.fkik19@mail.umy.ac.id1, dita.dwi.fkik20@mail.umy.ac.id2, melisa.j.fkik21@mail.umy.ac.id3, rifki.febriansah@mail.ac.id4.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperAndrographol..All
"Strengthening Youth Potential for Sustainable Innovation" 1 Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method
Dhecella Winy, Cintya Ningrum, Dita Dwi, Zanatus Nur Aini, Melisa Juniananda, Rifki Febriansah
Introduction -COVID-19 is an infectious disease that is a global challenge, making it necessary for innovation and the development of antiviral agents in prevention and treatment efforts. Indonesia is known as a country rich in potential plants as medicine, a potential antiviral plant among them Andrographis paniculata , Mimosa pudica and Centella asiatica. The compound that have antiviral activity in each of these plants are andrographolide (Andrographis paniculata), L-mimosine (Mimosa pudica) and asiaticoside (Centella asiatica). The purpose of this study is to identify the potential of the andrographolide, l-mimosine and asiaticoside to inhibit SARS COV-2 protein and to predict the molecular drug profile which refers to lipinski's rule of 5. Purpose -The purpose of this study was to determine the potential of Andrographis paniculata , Mimosa pudica and Centella asiatica compounds in inhibiting the SARS CoV-2 protein and to determine the prediction of drug profiles such as molecules referring to Lipinski's rule of 5. Methodology -The methods used in this research by molecular docking and lipinski's Ro5 using PKCSM. The control compounds used are favipiravir and remdesivir. Results -The results of the affinity of target protein bonds using molecular docking obtained the best results in NSP3 proteins with An Asiaticoside docking score of -10.1 kcal / mol stronger than favipiravir -5.3 kcal/mol and remdesivir -8.6 kcal/mol. As for the compounds L-mimosine -6.1 kcal / mol and Andrographolide -7.7 kcal / mol. The compounds of andrographolide and L-mimosine showed good results and met the 5 aspects of Lipinski's Ro5, but asiaticoside compounds did not good enough. . Conclusion - The Research has concluded that the compound of the Andrographis paniculata , Mimosa pudica and Centella asiatica have a good potential in inhibiting SARS cov2 protein that is stronger than favipiravir and almost the same with remdesivir activity.
References
Astuti, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response, Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Astuti, Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response, Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Chen, Epidimiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7
Chen, Epidimiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7
Dai, Overview of pharmacological activities od Androgaphis paniculata and its major compound andrographolide, Crit Rev Food Sci Nutr
Dai, Overview of pharmacological activities od Androgaphis paniculata and its major compound andrographolide, Crit Rev Food Sci Nutr
Dany, Stellar Superfluids. Inspire
Dany, Stellar Superfluids. Inspire
Docherty, Features of 2013 UK Patients in Hospital with COVID-19 Using the ISARIC WHO Clinical Characterisation Protocol: Prospective Observational Cohort Study, BMJ
Docherty, Features of 2013 UK Patients in Hospital with COVID-19 Using the ISARIC WHO Clinical Characterisation Protocol: Prospective Observational Cohort Study, BMJ
Dona, Studi In Silico, Sintesis, dan Uji Sitotoksik Senyawa P-Metoksi Kalkon terhadap Sel Kanker Payudara MCF-7, J Sains Farm Klin
Dona, Studi In Silico, Sintesis, dan Uji Sitotoksik Senyawa P-Metoksi Kalkon terhadap Sel Kanker Payudara MCF-7, J Sains Farm Klin
Glowacki, Hydrogen-bonds in molecular solids-from biological systems to organic electronics, J Mater Chem
Glowacki, Hydrogen-bonds in molecular solids-from biological systems to organic electronics, J Mater Chem
Gupta, Broad-spectrum antiviral properties of andrograpolide, Arch Virol
Gupta, Broad-spectrum antiviral properties of andrograpolide, Arch Virol
Hardjono, Sintesis dan Uji Aktivitas Antikanker Senyawa 1-(2-Klorobenzoiloksi)urea dan 1-(4klorobenzoiloksi)urea, Berk Ilm Kim Farm
Hardjono, Sintesis dan Uji Aktivitas Antikanker Senyawa 1-(2-Klorobenzoiloksi)urea dan 1-(4klorobenzoiloksi)urea, Berk Ilm Kim Farm
Jessen, Introduction to Computational Chemistry 2nd Ed
Jessen, Introduction to Computational Chemistry 2nd Ed
Malayan, Anti-mumps virus activity by extracts Proceedings The 3 rd UMY Grace 2022 (Universitas Muhammadiyah Yogyakarta Undergraduate Conference) Health and Nursing Volume 2 Issue 2, Indian J Virol, doi:10.1007/s13337-013-0143-2
Malayan, Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant, Indian J Virol, doi:10.1007/s13337-013-0143-2
Ruswanto, Molecular docking empat turunan isonicotino hydrazide pada mycobacterium tuberculosis enoyl-acyl carrier protein reductase, InhA)
Ruswanto, Molecular docking empat turunan isonicotino hydrazide pada mycobacterium tuberculosis enoyl-acyl carrier protein reductase, InhA)
Shah, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive stud, Lancet, doi:10.1016/S0140-6736(20)30211-7
Shah, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive stud, Lancet, doi:10.1016/S0140-6736(20)30211-7
Susilo, TINJAUAN PUSTAKA Review of Current Literatures, J Penyakit Dalam Indonesia
Susilo, TINJAUAN PUSTAKA Review of Current Literatures, J Penyakit Dalam Indonesia
Thanigaivel, Comparative evaluation of the anti-Hepatitis B virus activity of Centella asiatica and Camellia sinensis (green tea), BMC Infect Dis, doi:10.1186/1471-2334-14-s3-p21
Thanigaivel, Comparative evaluation of the anti-Hepatitis B virus activity of Centella asiatica and Camellia sinensis (green tea), BMC Infect Dis, doi:10.1186/1471-2334-14-s3-p21
Yu, Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor, Peptides
Yu, Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor, Peptides
{ 'indexed': {'date-parts': [[2024, 2, 16]], 'date-time': '2024-02-16T08:10:40Z', 'timestamp': 1708071040009}, 'reference-count': 0, 'publisher': 'Universitas Muhammadiyah Yogyakarta', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2022, 6, 30]], 'date-time': '2022-06-30T00:00:00Z', 'timestamp': 1656547200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by-sa/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Introduction - COVID-19 is an infectious disease that is a global challenge, making ' 'it necessary for innovation and the development of antiviral agents in prevention and ' 'treatment efforts. Indonesia is known as a country rich in potential plants as medicine, a ' 'potential antiviral plant among them Andrographis paniculata , Mimosa pudica and Centella ' 'asiatica. The compound that have antiviral activity in each of these plants are ' 'andrographolide (Andrographis paniculata), L-mimosine (Mimosa pudica) and asiaticoside ' '(Centella asiatica). The purpose of this study is to identify the potential of the ' 'andrographolide, l-mimosine and asiaticoside to inhibit SARS COV-2 protein and to predict the ' "molecular drug profile which refers to lipinski's rule of 5.&#x0D;\n" 'Purpose - The purpose of this study was to determine the potential of Andrographis paniculata ' ', Mimosa pudica and Centella asiatica compounds in inhibiting the SARS CoV-2 protein and to ' "determine the prediction of drug profiles such as molecules referring to Lipinski's rule of " '5.&#x0D;\n' "Methodology - The methods used in this research by molecular docking and lipinski's Ro5 using " 'PKCSM. The control compounds used are favipiravir and remdesivir.&#x0D;\n' 'Results - The results of the affinity of target protein bonds using molecular docking ' 'obtained the best results in NSP3 proteins with An Asiaticoside docking score of -10.1 kcal / ' 'mol stronger than favipiravir -5.3 kcal/mol and remdesivir -8.6 kcal/mol. As for the ' 'compounds L-mimosine -6.1 kcal / mol and Andrographolide -7.7 kcal / mol. The compounds of ' "andrographolide and L-mimosine showed good results and met the 5 aspects of Lipinski's Ro5, " 'but asiaticoside compounds did not good enough. .&#x0D;\n' 'Conclusion - The Research has concluded that the compound of the Andrographis paniculata , ' 'Mimosa pudica and Centella asiatica have a good potential in inhibiting SARS cov2 protein ' 'that is stronger than favipiravir and almost the same with remdesivir activity.</jats:p>', 'DOI': '10.18196/umygrace.v2i2.418', 'type': 'journal-article', 'created': {'date-parts': [[2023, 6, 27]], 'date-time': '2023-06-27T07:35:31Z', 'timestamp': 1687851331000}, 'page': '1-11', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based ' 'On In Silico Method', 'prefix': '10.18196', 'volume': '2', 'author': [ {'given': 'Dhecella', 'family': 'Ningrum', 'sequence': 'first', 'affiliation': []}, {'given': 'Dita', 'family': 'Aini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Melisa', 'family': 'Juniananda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rifki', 'family': 'Febriansah', 'sequence': 'additional', 'affiliation': []}], 'member': '7508', 'published-online': {'date-parts': [[2022, 6, 30]]}, 'container-title': 'Proceedings Universitas Muhammadiyah Yogyakarta Undergraduate Conference', 'original-title': [], 'link': [ { 'URL': 'https://prosiding.umy.ac.id/grace/index.php/pgrace/article/download/418/491', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://prosiding.umy.ac.id/grace/index.php/pgrace/article/download/418/491', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 2, 16]], 'date-time': '2024-02-16T07:57:07Z', 'timestamp': 1708070227000}, 'score': 1, 'resource': {'primary': {'URL': 'https://prosiding.umy.ac.id/grace/index.php/pgrace/article/view/418'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 6, 30]]}, 'references-count': 0, 'journal-issue': {'issue': '2', 'published-online': {'date-parts': [[2022, 11, 15]]}}, 'URL': 'http://dx.doi.org/10.18196/umygrace.v2i2.418', 'relation': {}, 'ISSN': ['2961-7758'], 'subject': [], 'container-title-short': 'UMYGrace', 'published': {'date-parts': [[2022, 6, 30]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit