Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
Sieglinde Zelzer, Florian Prüller, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, Harald Mangge
Nutrients, doi:10.3390/nu13072129
Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients.
Conflicts of Interest: The authors declare no conflict of interest.
References
Abrishami, Dalili, Torbati, Asgari, Arab-Ahmadi et al., Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: A retrospective study, Eur. J. Nutr,
doi:10.1007/s00394-020-02411-0Akbar, Wibowo, Pranata, Setiabudiawan, Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis, Front. Nutr
Al-Daghri, Amer, Alotaibi, Aldisi, Enani et al., Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: A multi-centre case-control study, J. Transl. Med,
doi:10.1186/s12967-021-02838-xAlguwaihes, Sabico, Hasanato, Al-Sofiani, Megdad et al., Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: A retrospective case-control study in an Arab Gulf country, Aging Clin. Exp. Res
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J. Infect. Public Health
Amrein, Scherkl, Hoffmann, Neuwersch-Sommeregger, Köstenberger et al., deficiency 2.0: An update on the current status worldwide, Eur. J. Clin. Nutr,
doi:10.1038/s41430-020-0558-yAnnweiler, Hanotte, Grandin De L'eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: A quasi-experimental study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2020.105771Baeke, Korf, Overbergh, Van Etten, Verstuyf et al., Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D 3 in the immune system, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2010.03.037Baeke, Korf, Overbergh, Verstuyf, Thorrez et al., The vitamin D analog, TX527, promotes a human CD4 + CD25 high CD127 low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation, J. Immunol,
doi:10.4049/jimmunol.1000695Bennouar, Cherif, Kessira, Bennouar, Abdi, Vitamin D Deficiency and Low Serum Calcium as Predictors of Poor Prognosis in Patients with Severe COVID-19, J. Am. Coll. Nutr,
doi:10.1080/07315724.2020.1856013Brenner, Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths-Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action, Nutrients,
doi:10.3390/nu13020411Buonpane, Therapeutic drug monitoring of cyclosporine (CSA), Conn. Med
Cavalier, Fraser, Bhattoa, Heijboer, Makris et al., Analytical Performance Specifications for 25-Hydroxyvitamin D Examinations, Nutrients,
doi:10.3390/nu13020431Cavalier, Huyghebaert, Rousselle, Bekaert, Kovacs et al., Simultaneous measurement of 25(OH)-vitamin D and 24, 25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects, Clin. Chem. Lab Med,
doi:10.1515/cclm-2019-0996Cereda, Bogliolo, Lobascio, Barichella, Zecchinelli et al., Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy, Nutrition
Charoenngam, Holick, Immunologic Effects of Vitamin D on Human Health and Disease, Nutrients
Coldwell, Trafford, Makin, Varley, Specific mass fragmentographic assay for 25, 26-dihydroxyvitamin D in human plasma using a deuterated internal standard, J. Chromatogr,
doi:10.1016/0378-4347(85)80100-6De Haan, Groeneveld, De Geus, Egal, Struijs, Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: Systematic review and meta-analysis, Crit. Care,
doi:10.1186/s13054-014-0660-4Deluca, Suda, Schnoes, Tanaka, Holick, 26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity, Biochemistry,
doi:10.1021/bi00826a022Enko, Kriegshauser, Stolba, Worf, Halwachs-Baumann, Method evaluation study of a new generation of vitamin D assays, Biochem. Med,
doi:10.11613/BM.2015.020Farrell, Soldo, Williams, Herrmann, 25-Hydroxyvitamin D testing: Challenging the performance of current automated immunoassays, Clin. Chem. Lab Med,
doi:10.1515/cclm-2012-0522Gimenez, Sanz, Maron, Ferder, Manucha, Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders, Curr. Protein Pept. Sci,
doi:10.2174/1389203721666200606220719Gombart, Pierre, Maggini, A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, Nutrients,
doi:10.3390/nu12010236Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients,
doi:10.3390/nu12040988Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2
Holick, The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention, Rev. Endocr. Metab. Disord,
doi:10.1007/s11154-017-9424-1Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci. Rep,
doi:10.1038/s41598-020-77093-zJoshi, Pantalena, Liu, Gaffen, Liu et al., 1,25-dihydroxyvitamin D 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A, Mol. Cell. Biol,
doi:10.1128/MCB.05020-11Livingston, Plant, Dunmore, Hartland, Jones et al., Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D levels and high social deprivation, Int. J. Clin. Pract,
doi:10.1111/ijcp.14166Loeffelholz, Alland, Butler-Wu, Pandey, Perno et al., Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 Test, J. Clin. Microbiol,
doi:10.1128/JCM.00926-20Luo, Liao, Shen, Li, Cheng, Vitamin D Deficiency Is Associated with COVID-19 Incidence and Disease Severity in Chinese People
Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE,
doi:10.1371/journal.pone.0239799Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data, BMJ,
doi:10.1136/bmj.i6583Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA,
doi:10.1001/jama.2020.26848Pairo-Castineira, Clohisey, Klaric, Bretherick, Rawlik et al., Genetic mechanisms of critical illness in COVID-19, Nature,
doi:10.1038/s41586-020-03065-yPenna, Amuchastegui, Cossetti, Aquilano, Mariani et al., Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol, J. Immunol
Rahme, Al-Shaar, Singh, Baddoura, Halaby et al., Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making, Metabolism,
doi:10.1016/j.metabol.2018.09.003Szeto, Zucker, Lasota, Rubin, Walker et al., Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients, Endocr. Res,
doi:10.1080/07435800.2020.1867162Thickett, Moromizato, Litonjua, Amrein, Quraishi et al., Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: A retrospective cohort study, BMJ Open Respir. Res,
doi:10.1136/bmjresp-2014-000074Wolters, Grünberg, Huber, Kessler, Prüller et al., European multicenter evaluation of Xpert ® Xpress SARS-CoV-2/Flu/RSV test, J. Med. Virol,
doi:10.1002/jmv.27111Yisak, Ewunetei, Kefale, Mamuye, Teshome et al., Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review, Risk Manag. Healthc. Policy,
doi:10.2147/RMHP.S291584Zelzer, Hofer, Meinitzer, Fritz-Petrin, Simstich et al., Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals-The Austrian stroke prevention study, Aging,
doi:10.18632/aging.202930Zelzer, Meinitzer, Enko, Simstich, Le Goff et al., Simultaneous determination of 24, 25-and 25, 26-dihydroxyvitamin D 3 in serum samples with liquid-chromatography mass spectrometry-A useful tool for the assessment of vitamin D metabolism, J. Chromatogr. B Anal. Technol. Biomed. Life Sci,
doi:10.1016/j.jchromb.2020.122394DOI record:
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"abstract": "<jats:p>(1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, and 25,26(OH)2D3 were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19.</jats:p>",
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