Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
Sieglinde Zelzer, Florian Prüller, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, Harald Mangge
Nutrients, doi:10.3390/nu13072129
Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients.
Conflicts of Interest: The authors declare no conflict of interest.
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'abstract': '<jats:p>(1) Background: Vitamin D, a well-established regulator of calcium and phosphate '
'metabolism, also has immune-modulatory functions. An uncontrolled immune response and '
'cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective '
'study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a '
'mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. '
'(2) Methods: The serum concentrations of 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, and 25,26(OH)2D3 '
'were determined by a validated liquid-chromatography tandem mass-spectrometry method in '
'leftover serum samples from 148 COVID-19 patients that were admitted to the University '
'Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric '
'and clinical data, as well as outcomes were obtained from the laboratory and hospital '
'information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after '
'admission. The frequency of fatal outcomes did not differ between males and females. '
'Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 '
'and CRP, and required mechanical ventilation more frequently. The serum concentrations of all '
'vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly '
'between survivors and non-survivors. Additionally, the need for res-piratory support was '
'unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, '
'as well as the VMR. (4) Conclusion: The present results do not support a relevant role of '
'vitamin D for the course and outcome of COVID-19.</jats:p>',
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