Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Johana Vásquez-Procopio, Johnatan Torres-Torres, Hector Borboa-Olivares, Salvador Espino Y Sosa, Raigam Jafet Martínez-Portilla, Mario Solis-Paredes, Mari-Cruz Tolentino-Dolores, Addy Cecilia Helguera-Repetto, Karla Cecilia Marrufo-Gallegos, Fanis Missirlis, Otilia Perichart-Perera, Guadalupe Estrada-Gutierrez
International Journal of Molecular Sciences, doi:10.3390/ijms232315188
Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108-30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.
Conflicts of Interest: The authors declare no conflict of interest.
References
Aguilar-Cordero, Lasserrot-Cuadrado, Mur-Villar, León-Ríos, Rivero-Blanco et al., preeclampsia and prematurity: A systematic review and meta-analysis of observational and interventional studies, Midwifery,
doi:10.1016/j.midw.2020.102707Alkhafaji, Argan, Albaker, Elq, Hariri et al., The Impact of Vitamin D Level on the Severity and Outcome of Hospitalized Patients with COVID-19
Annweiler, Beaudenon, Simon, Guenet, Otekpo et al., Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2021.105958Annweiler, Hanotte, Eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: A quasi-experimental study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2020.105771Bae, Choe, Holick, Lim, Association of vitamin D status with COVID-19 and its severity: Vitamin D and COVID-19: A narrative review, Rev. Endocr. Metab. Disord,
doi:10.1007/s11154-021-09705-6Belderbos, Houben, Wilbrink, Lentjes, Bloemen et al., Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis, Pediatrics,
doi:10.1542/peds.2010-3054Bui, Zhu, Hawkins, Cortez-Resendiz, Bellon, Vitamin D regulation of the immune system and its implications for COVID-19: A mini review, SAGE Open Med,
doi:10.1177/20503121211014073Bushnaq, Algethami, Qadhi, Mustafa, Ghafouri et al., The Impact of Vitamin D Status on COVID-19 Severity among Hospitalized Patients in the Western Region of Saudi Arabia: A Retrospective Cross-Sectional Study, Int. J. Environ. Res. Public Health,
doi:10.3390/ijerph19031901Chen, Mei, Xie, Yuan, Ma et al., Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: A meta-analysis and GRADE assessment of cohort studies and RCTs, Nutr. J,
doi:10.1186/s12937-021-00744-yChen, Pang, Li, Zhou, Lin et al., Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: A retrospective cohort study, BMC Pregnancy Childbirth,
doi:10.1186/s12884-020-03158-6Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet,
doi:10.1016/S0140-6736(20)30211-7Christoph, Challande, Raio, Surbek, High prevalence of severe vitamin D deficiency during the first trimester in pregnant women in Switzerland and its potential contributions to adverse outcomes in the pregnancy, Swiss Med. Wkly,
doi:10.4414/smw.2020.20238Cui, Zhao, Zhang, Guo, Guo et al., A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19), J. Med. Virol,
doi:10.1002/jmv.26398Cyprian, Lefkou, Varoudi, Girardi, Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond, Front. Immunol,
doi:10.3389/fimmu.2019.02739Dadras, Seyedalinaghi, Karimi, Shamsabadi, Qaderi et al., COVID-19 mortality and its predictors in the elderly: A systematic review, Health Sci. Rep
Dobson, Giovannoni, Ramagopalan, The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude, J. Neurol. Neurosurg. Psychiatry,
doi:10.1136/jnnp-2012-303934Drucker, Coronavirus Infections and Type 2 Diabetes-Shared Pathways with Therapeutic Implications, Endocr. Rev,
doi:10.1210/endrev/bnaa011El Mouhayyar, Dewald, Cabrales, Tighiouart, Moraco et al., Factors Associated with Severity of Acute Kidney Injury and Adverse Outcomes in Critically Ill Patients with COVID-19, Nephron,
doi:10.1159/000524657Ergür, Berbero Glu, Atasay, Şıklar, Bilir et al., Vitamin D deficiency in Turkish mothers and their neonates and in women of reproductive age, J. Clin. Res. Pediatr. Endocrinol,
doi:10.4274/jcrpe.v1i6.266Ferrer-Sánchez, Díaz-Goicoechea, Mayoral-Cesar, García-Solbas, Nievas-Soriano et al., Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study, Int. J. Environ. Res. Public Health,
doi:10.3390/ijerph19073965Gong, Zhou, Hu, Ren, Ren et al., Elastic net-based identification of GAMT as potential diagnostic marker for early-stage gastric cancer, Biochem. Biophys. Res. Commun,
doi:10.1016/j.bbrc.2021.12.055Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab. Syndr
Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2
Hewison, Vitamin D and immune function: Autocrine, paracrine or endocrine?, Scand. J. Clin. Lab. Investig. Suppl
Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline, J. Clin. Endocrinol. Metab,
doi:10.1210/jc.2011-0385Jevalikar, Mithal, Singh, Sharma, Farooqui et al., Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19, Sci. Rep,
doi:10.1038/s41598-021-85809-yJolliffe, Camargo, Jr, Sluyter, Aglipay et al., Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol,
doi:10.1016/S2213-8587(21)00051-6Kastora, Patel, Carter, Delibegovic, Myint, Impact of diabetes on COVID-19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta-analysis, Endocrinol. Diabetes Metab
Kucirka, Norton, Sheffield, Severity of COVID-19 in pregnancy: A review of current evidence, Am. J. Reprod. Immunol,
doi:10.1111/aji.13332Kulda, Vitamin D metabolism, Vnitr Lek
Lin, Mulick, Mathur, Smeeth, Warren-Gash et al., The association between vitamin D status and COVID-19 in England: A cohort study using UK Biobank, PLoS ONE,
doi:10.1371/journal.pone.0269064Loy, Lek, Yap, Soh, Padmapriya et al., Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study, PLoS ONE,
doi:10.1371/journal.pone.0142239Mansur, Oliveri, Giacoia, Fusaro, Costanzo et al., Before, during and after Pregnancy: Effect on Neonates and Children, Nutrients,
doi:10.3390/nu14091900Maugeri, Barchitta, Blanco, Agodi, Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrients,
doi:10.3390/nu11020442Meltzer, Best, Zhang, Vokes, Arora et al., Association of Vitamin D Levels, Race/Ethnicity, and Clinical Characteristics With COVID-19 Test Results, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2021.4117Merzon, Tworowski, Gorohovski, Vinker, Cohen et al., Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study, FEBS J,
doi:10.1111/febs.15495Metz, Clifton, Hughes, Sandoval, Grobman et al., Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications, JAMA,
doi:10.1001/jama.2022.1190Meyyazhagan, Pushparaj, Balasubramanian, Bhotla, Pappusamy et al., COVID-19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis, Int. J. Gynaecol. Obstet,
doi:10.1002/ijgo.14007Mor, Aldo, Alvero, The unique immunological and microbial aspects of pregnancy, Nat. Rev. Immunol,
doi:10.1038/nri.2017.64Nguyen, Raju, Da Graca, Wang, Mohamed et al., 25-hydroxyvitamin D is a predictor of COVID-19 severity of hospitalized patients, PLoS ONE
Ovies, Semmes, Coyne, Pregnancy influences immune responses to SARS-CoV-2, Sci. Transl. Med
Perichart-Perera, González-Leyva, González-Ludlow, Tolentino-Dolores, Solis-Paredes et al., Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?, Nutrients,
doi:10.3390/nu12092517Pham, Rahman, Majidi, Waterhouse, Neale, Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis, Int. J. Environ. Res. Public Health,
doi:10.3390/ijerph16173020Ramirez-Sandoval, Castillos-Ávalos, Paz-Cortés, Santillan-Ceron, Hernandez-Jimenez et al., Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19, Arch. Med. Res,
doi:10.1016/j.arcmed.2021.09.006Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study), Postgrad. Med. J,
doi:10.1136/postgradmedj-2020-139065Roffe-Vazquez, Huerta-Delgado, Castillo, Villarreal-Calderón, Gonzalez-Gil et al., Correlation of Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up Study, Int. J. Mol. Sci,
doi:10.3390/ijms20225811Sappenfield, Jamieson, Kourtis, Pregnancy and susceptibility to infectious diseases, Infect. Dis. Obstet. Gynecol,
doi:10.1155/2013/752852Schmitt, Labdouni, Soulimani, Delamare, Bouayed, Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID-19 infections during the third trimester of pregnancy: A retrospective study in Metz, France, J. Med. Virol,
doi:10.1002/jmv.27606Seven, Gunduz, Erdinc, Sahin, Tekin et al., Correlation between 25-hydroxy vitamin D levels and COVID-19 severity in pregnant women: A cross-sectional study, J. Matern. Fetal Neonatal Med,
doi:10.1080/14767058.2021.2005564Shin, Choi, Longtine, Nelson, Vitamin D effects on pregnancy and the placenta, Placenta
Sinaci, Ocal, Yetiskin, Hendem, Buyuk et al., Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2021.105964Sánchez-Zuno, González-Estevez, Matuz-Flores, Macedo-Ojeda, Hernández-Bello et al., Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation, J. Clin. Med,
doi:10.3390/jcm10112378Takase, Tsugawa, Sugiyama, Ikesue, Eto et al., Association between 25-hydroxyvitamin D levels and COVID-19 severity, Clin. Nutr. ESPEN,
doi:10.1016/j.clnesp.2022.04.003Tekin, Yassa, Birol, Unlu, Sahin et al., Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women, Eur. J. Nutr,
doi:10.1007/s00394-021-02709-7Tiwari, Pratyush, Gupta, Singh, Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection, Br. J. Nutr,
doi:10.1017/S0007114514003018Torres-Torres, Martinez-Portilla, Espino Y Sosa, Solis-Paredes, Hernández-Pacheco et al., Maternal Death by COVID-19 Associated with Elevated Troponin T Levels, Viruses,
doi:10.3390/v14020271Umar, Sastry, Chouchane, Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies, Int. J. Mol. Sci,
doi:10.3390/ijms19061618Vanegas-Cedillo, Bello-Chavolla, Ramírez-Pedraza, Encinas, Pérez Carrión et al., Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral Adiposity, Front. Nutr
Venkatakrishnan, Pawlowski, Zemmour, Hughes, Anand et al., Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications, NPJ Digit. Med,
doi:10.1038/s41746-021-00484-7Vásquez-Procopio, Espejel-Nuñez, Torres-Torres, Martinez-Portilla, Espino Y Sosa et al., Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy, Front. Cell Dev. Biol,
doi:10.3389/fcell.2022.935363Wei, Bilodeau, Julien, Luo, Abenhaim et al., Maternal vitamin D, oxidative stress, and pre-eclampsia, Int. J. Gynaecol. Obstet,
doi:10.1002/ijgo.13559Wei, Bilodeau-Bertrand, Liu, Auger, The impact of COVID-19 on pregnancy outcomes: A systematic review and meta-analysis, CMAJ,
doi:10.1503/cmaj.202604Wei, Qi, Luo, Fraser, Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis, J. Matern. Fetal Neonatal Med,
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'doi-asserted-by': 'crossref',
'first-page': '1057',
'DOI': '10.1002/jmv.26398',
'article-title': 'A systematic review and meta-analysis of children with coronavirus '
'disease 2019 (COVID-19)',
'volume': '93',
'author': 'Cui',
'year': '2021',
'journal-title': 'J. Med. Virol.'},
{ 'key': 'ref_2',
'doi-asserted-by': 'crossref',
'first-page': 'e657',
'DOI': '10.1002/hsr2.657',
'article-title': 'COVID-19 mortality and its predictors in the elderly: A systematic '
'review',
'volume': '5',
'author': 'Dadras',
'year': '2022',
'journal-title': 'Health Sci. Rep.'},
{ 'key': 'ref_3',
'doi-asserted-by': 'crossref',
'first-page': '216',
'DOI': '10.1002/ijgo.14007',
'article-title': 'COVID-19 in pregnant women and children: Insights on clinical '
'manifestations, complexities, and pathogenesis',
'volume': '156',
'author': 'Meyyazhagan',
'year': '2022',
'journal-title': 'Int. J. Gynaecol. Obstet.'},
{ 'key': 'ref_4',
'doi-asserted-by': 'crossref',
'first-page': '469',
'DOI': '10.1038/nri.2017.64',
'article-title': 'The unique immunological and microbial aspects of pregnancy',
'volume': '17',
'author': 'Mor',
'year': '2017',
'journal-title': 'Nat. Rev. Immunol.'},
{ 'key': 'ref_5',
'doi-asserted-by': 'crossref',
'first-page': '752852',
'DOI': '10.1155/2013/752852',
'article-title': 'Pregnancy and susceptibility to infectious diseases',
'volume': '2013',
'author': 'Sappenfield',
'year': '2013',
'journal-title': 'Infect. Dis. Obstet. Gynecol.'},
{ 'key': 'ref_6',
'doi-asserted-by': 'crossref',
'first-page': '896',
'DOI': '10.1097/AOG.0000000000001978',
'article-title': 'Emerging Infectious Diseases in Pregnancy',
'volume': '129',
'author': 'Beigi',
'year': '2017',
'journal-title': 'Obstet. Gynecol.'},
{ 'key': 'ref_7',
'doi-asserted-by': 'crossref',
'first-page': 'eabm2070',
'DOI': '10.1126/scitranslmed.abm2070',
'article-title': 'Pregnancy influences immune responses to SARS-CoV-2',
'volume': '13',
'author': 'Ovies',
'year': '2021',
'journal-title': 'Sci. Transl. Med.'},
{ 'key': 'ref_8',
'doi-asserted-by': 'crossref',
'unstructured': 'Torres-Torres, J., Martinez-Portilla, R.J., Espino Y Sosa, S., '
'Solis-Paredes, J.M., Hernández-Pacheco, J.A., Mateu-Rogell, P., '
'Cravioto-Sapien, A., Zamora-Madrazo, A., Estrada-Gutierrez, G., and '
'Nares-Torices, M.A. (2022). Maternal Death by COVID-19 Associated with '
'Elevated Troponin T Levels. Viruses, 14.',
'DOI': '10.3390/v14020271'},
{ 'key': 'ref_9',
'doi-asserted-by': 'crossref',
'first-page': 'E540',
'DOI': '10.1503/cmaj.202604',
'article-title': 'The impact of COVID-19 on pregnancy outcomes: A systematic review and '
'meta-analysis',
'volume': '193',
'author': 'Wei',
'year': '2021',
'journal-title': 'CMAJ'},
{ 'key': 'ref_10',
'doi-asserted-by': 'crossref',
'first-page': '748',
'DOI': '10.1001/jama.2022.1190',
'article-title': 'Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and '
'Mortality From Obstetric Complications',
'volume': '327',
'author': 'Metz',
'year': '2022',
'journal-title': 'JAMA'},
{ 'key': 'ref_11',
'doi-asserted-by': 'crossref',
'first-page': '935363',
'DOI': '10.3389/fcell.2022.935363',
'article-title': 'Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During '
'Pregnancy',
'volume': '10',
'year': '2022',
'journal-title': 'Front. Cell Dev. Biol.'},
{ 'key': 'ref_12',
'first-page': '400',
'article-title': 'Vitamin D metabolism',
'volume': '58',
'author': 'Kulda',
'year': '2012',
'journal-title': 'Vnitr Lek'},
{ 'key': 'ref_13',
'doi-asserted-by': 'crossref',
'first-page': '1689s',
'DOI': '10.1093/ajcn/80.6.1689S',
'article-title': 'Overview of general physiologic features and functions of vitamin D',
'volume': '80',
'author': 'DeLuca',
'year': '2004',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'key': 'ref_14',
'doi-asserted-by': 'crossref',
'first-page': '265',
'DOI': '10.1007/s11154-021-09679-5',
'article-title': 'Vitamin D, infections and immunity',
'volume': '23',
'author': 'Ismailova',
'year': '2022',
'journal-title': 'Rev. Endocr. Metab. Disord.'},
{ 'key': 'ref_15',
'doi-asserted-by': 'crossref',
'unstructured': 'Umar, M., Sastry, K.S., and Chouchane, A.I. (2018). Role of Vitamin D '
'Beyond the Skeletal Function: A Review of the Molecular and Clinical '
'Studies. Int. J. Mol. Sci., 19.',
'DOI': '10.3390/ijms19061618'},
{ 'key': 'ref_16',
'doi-asserted-by': 'crossref',
'first-page': '1911',
'DOI': '10.1210/jc.2011-0385',
'article-title': 'Evaluation, treatment, and prevention of vitamin D deficiency: An '
'Endocrine Society clinical practice guideline',
'volume': '96',
'author': 'Holick',
'year': '2011',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': 'ref_17',
'doi-asserted-by': 'crossref',
'first-page': '138',
'DOI': '10.1016/j.jsbmb.2013.11.003',
'article-title': 'Is vitamin D deficiency a major global public health problem?',
'volume': '144',
'author': 'Palacios',
'year': '2014',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'key': 'ref_18',
'doi-asserted-by': 'crossref',
'first-page': '720',
'DOI': '10.1016/j.mayocp.2013.05.011',
'article-title': 'Vitamin D for health: A global perspective',
'volume': '88',
'author': 'Holick',
'year': '2013',
'journal-title': 'Mayo Clin. Proc.'},
{ 'key': 'ref_19',
'doi-asserted-by': 'crossref',
'first-page': 'e00338',
'DOI': '10.1002/edm2.338',
'article-title': 'Impact of diabetes on COVID-19 mortality and hospital outcomes from a '
'global perspective: An umbrella systematic review and meta-analysis',
'volume': '5',
'author': 'Kastora',
'year': '2022',
'journal-title': 'Endocrinol. Diabetes Metab.'},
{ 'key': 'ref_20',
'doi-asserted-by': 'crossref',
'unstructured': 'El Mouhayyar, C., Dewald, J., Cabrales, J., Tighiouart, H., Moraco, '
'A.H., Jaber, B.L., and Balakrishnan, B.S. (2022). Factors Associated '
'with Severity of Acute Kidney Injury and Adverse Outcomes in Critically '
'Ill Patients with COVID-19. Nephron, 1–9.',
'DOI': '10.1159/000524657'},
{ 'key': 'ref_21',
'doi-asserted-by': 'crossref',
'first-page': '117',
'DOI': '10.1038/s41746-021-00484-7',
'article-title': 'Mapping each pre-existing condition’s association to short-term and '
'long-term COVID-19 complications',
'volume': '4',
'author': 'Venkatakrishnan',
'year': '2021',
'journal-title': 'NPJ Digit. Med.'},
{ 'key': 'ref_22',
'doi-asserted-by': 'crossref',
'first-page': '384',
'DOI': '10.1111/j.1749-6632.2009.04875.x',
'article-title': 'Vitamin D metabolites as clinical markers in autoimmune and chronic '
'disease',
'volume': '1173',
'author': 'Blaney',
'year': '2009',
'journal-title': 'Ann. N. Y. Acad. Sci.'},
{ 'key': 'ref_23',
'doi-asserted-by': 'crossref',
'first-page': '1080s',
'DOI': '10.1093/ajcn/87.4.1080S',
'article-title': 'Vitamin D deficiency: A worldwide problem with health consequences',
'volume': '87',
'author': 'Holick',
'year': '2008',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'key': 'ref_24',
'doi-asserted-by': 'crossref',
'unstructured': 'Pham, H., Rahman, A., Majidi, A., Waterhouse, M., and Neale, R.E. '
'(2019). Acute Respiratory Tract Infection and 25-Hydroxyvitamin D '
'Concentration: A Systematic Review and Meta-Analysis. Int. J. Environ. '
'Res. Public Health, 16.',
'DOI': '10.3390/ijerph16173020'},
{ 'key': 'ref_25',
'doi-asserted-by': 'crossref',
'first-page': '1373',
'DOI': '10.1016/j.jiph.2020.06.021',
'article-title': 'Role of vitamin D in preventing of COVID-19 infection, progression and '
'severity',
'volume': '13',
'author': 'Ali',
'year': '2020',
'journal-title': 'J. Infect. Public Health'},
{ 'key': 'ref_26',
'doi-asserted-by': 'crossref',
'first-page': '3693',
'DOI': '10.1111/febs.15495',
'article-title': 'Low plasma 25(OH) vitamin D level is associated with increased risk of '
'COVID-19 infection: An Israeli population-based study',
'volume': '287',
'author': 'Merzon',
'year': '2020',
'journal-title': 'FEBS J.'},
{ 'key': 'ref_27',
'doi-asserted-by': 'crossref',
'first-page': 'e214117',
'DOI': '10.1001/jamanetworkopen.2021.4117',
'article-title': 'Association of Vitamin D Levels, Race/Ethnicity, and Clinical '
'Characteristics With COVID-19 Test Results',
'volume': '4',
'author': 'Meltzer',
'year': '2021',
'journal-title': 'JAMA Netw. Open'},
{ 'key': 'ref_28',
'doi-asserted-by': 'crossref',
'unstructured': 'Nguyen, N.N., Raju, M.N.P., da Graca, B., Wang, D., Mohamed, N.A., '
'Mutnal, M.B., Rao, A., Bennett, B., Gokingco, M., and Pham, H. (2022). '
'25-hydroxyvitamin D is a predictor of COVID-19 severity of hospitalized '
'patients. PLoS ONE, 17.',
'DOI': '10.1371/journal.pone.0268038'},
{ 'key': 'ref_29',
'doi-asserted-by': 'crossref',
'first-page': '215',
'DOI': '10.1016/j.arcmed.2021.09.006',
'article-title': 'Very Low Vitamin D Levels are a Strong Independent Predictor of '
'Mortality in Hospitalized Patients with Severe COVID-19',
'volume': '53',
'author': 'Mehta',
'year': '2022',
'journal-title': 'Arch. Med. Res.'},
{ 'key': 'ref_30',
'doi-asserted-by': 'crossref',
'first-page': '813485',
'DOI': '10.3389/fnut.2022.813485',
'article-title': 'Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity '
'and Mortality Independent of Whole-Body and Visceral Adiposity',
'volume': '9',
'author': 'Encinas',
'year': '2022',
'journal-title': 'Front. Nutr.'},
{ 'key': 'ref_31',
'doi-asserted-by': 'crossref',
'first-page': '579',
'DOI': '10.1007/s11154-021-09705-6',
'article-title': 'Association of vitamin D status with COVID-19 and its severity: Vitamin '
'D and COVID-19: A narrative review',
'volume': '23',
'author': 'Bae',
'year': '2022',
'journal-title': 'Rev. Endocr. Metab. Disord.'},
{ 'key': 'ref_32',
'doi-asserted-by': 'crossref',
'first-page': 'bnaa011',
'DOI': '10.1210/endrev/bnaa011',
'article-title': 'Coronavirus Infections and Type 2 Diabetes-Shared Pathways with '
'Therapeutic Implications',
'volume': '41',
'author': 'Drucker',
'year': '2020',
'journal-title': 'Endocr. Rev.'},
{ 'key': 'ref_33',
'doi-asserted-by': 'crossref',
'first-page': '256',
'DOI': '10.1016/j.clnesp.2022.04.003',
'article-title': 'Association between 25-hydroxyvitamin D levels and COVID-19 severity',
'volume': '49',
'author': 'Takase',
'year': '2022',
'journal-title': 'Clin. Nutr. ESPEN'},
{ 'key': 'ref_34',
'doi-asserted-by': 'crossref',
'first-page': '89',
'DOI': '10.1186/s12937-021-00744-y',
'article-title': 'Low vitamin D levels do not aggravate COVID-19 risk or death, and '
'vitamin D supplementation does not improve outcomes in hospitalized '
'patients with COVID-19: A meta-analysis and GRADE assessment of cohort '
'studies and RCTs',
'volume': '20',
'author': 'Chen',
'year': '2021',
'journal-title': 'Nutr. J.'},
{ 'key': 'ref_35',
'doi-asserted-by': 'crossref',
'first-page': '6258',
'DOI': '10.1038/s41598-021-85809-y',
'article-title': 'Lack of association of baseline 25-hydroxyvitamin D levels with disease '
'severity and mortality in Indian patients hospitalized for COVID-19',
'volume': '11',
'author': 'Jevalikar',
'year': '2021',
'journal-title': 'Sci. Rep.'},
{ 'key': 'ref_36',
'doi-asserted-by': 'crossref',
'first-page': '561',
'DOI': '10.1016/j.dsx.2020.04.050',
'article-title': 'Vitamin D concentrations and COVID-19 infection in UK Biobank',
'volume': '14',
'author': 'Hastie',
'year': '2020',
'journal-title': 'Diabetes Metab. Syndr.'},
{ 'key': 'ref_37',
'doi-asserted-by': 'crossref',
'unstructured': 'Lin, L.Y., Mulick, A., Mathur, R., Smeeth, L., Warren-Gash, C., and '
'Langan, S.M. (2022). The association between vitamin D status and '
'COVID-19 in England: A cohort study using UK Biobank. PLoS ONE, 17.',
'DOI': '10.1371/journal.pone.0269064'},
{ 'key': 'ref_38',
'doi-asserted-by': 'crossref',
'first-page': 'e1343',
'DOI': '10.1210/clinem/dgaa733',
'article-title': 'Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection',
'volume': '106',
'author': 'Nan',
'year': '2021',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': 'ref_39',
'doi-asserted-by': 'crossref',
'first-page': '1027',
'DOI': '10.1016/j.placenta.2010.08.015',
'article-title': 'Vitamin D effects on pregnancy and the placenta',
'volume': '31',
'author': 'Shin',
'year': '2010',
'journal-title': 'Placenta'},
{ 'key': 'ref_40',
'doi-asserted-by': 'crossref',
'first-page': '201',
'DOI': '10.1080/10641955.2019.1647231',
'article-title': 'Role of vitamin D in influencing angiogenesis in preeclampsia',
'volume': '38',
'author': 'Nema',
'year': '2019',
'journal-title': 'Hypertens. Pregnancy'},
{ 'key': 'ref_41',
'doi-asserted-by': 'crossref',
'first-page': '2739',
'DOI': '10.3389/fimmu.2019.02739',
'article-title': 'Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond',
'volume': '10',
'author': 'Cyprian',
'year': '2019',
'journal-title': 'Front. Immunol.'},
{ 'key': 'ref_42',
'doi-asserted-by': 'crossref',
'first-page': '444',
'DOI': '10.1002/ijgo.13559',
'article-title': 'Maternal vitamin D, oxidative stress, and pre-eclampsia',
'volume': '154',
'author': 'Wei',
'year': '2021',
'journal-title': 'Int. J. Gynaecol. Obstet.'},
{ 'key': 'ref_43',
'doi-asserted-by': 'crossref',
'unstructured': 'Chen, G.D., Pang, T.T., Li, P.S., Zhou, Z.X., Lin, D.X., Fan, D.Z., Guo, '
'X.L., and Liu, Z.P. (2020). Early pregnancy vitamin D and the risk of '
'adverse maternal and infant outcomes: A retrospective cohort study. BMC '
'Pregnancy Childbirth, 20.',
'DOI': '10.1186/s12884-020-03158-6'},
{ 'key': 'ref_44',
'doi-asserted-by': 'crossref',
'unstructured': 'Mansur, J.L., Oliveri, B., Giacoia, E., Fusaro, D., and Costanzo, P.R. '
'(2022). Vitamin D: Before, during and after Pregnancy: Effect on '
'Neonates and Children. Nutrients, 14.',
'DOI': '10.3390/nu14091900'},
{ 'key': 'ref_45',
'doi-asserted-by': 'crossref',
'first-page': 'e1513',
'DOI': '10.1542/peds.2010-3054',
'article-title': 'Cord blood vitamin D deficiency is associated with respiratory '
'syncytial virus bronchiolitis',
'volume': '127',
'author': 'Belderbos',
'year': '2011',
'journal-title': 'Pediatrics'},
{ 'key': 'ref_46',
'doi-asserted-by': 'crossref',
'unstructured': 'Loy, S.L., Lek, N., Yap, F., Soh, S.E., Padmapriya, N., Tan, K.H., '
'Biswas, A., Yeo, G.S.H., Kwek, K., and Gluckman, P.D. (2015). '
'Association of Maternal Vitamin D Status with Glucose Tolerance and '
'Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in '
'Singapore Towards Healthy Outcomes Study. PLoS ONE, 10.',
'DOI': '10.1371/journal.pone.0142239'},
{ 'key': 'ref_47',
'doi-asserted-by': 'crossref',
'first-page': '427',
'DOI': '10.1136/jnnp-2012-303934',
'article-title': 'The month of birth effect in multiple sclerosis: Systematic review, '
'meta-analysis and effect of latitude',
'volume': '84',
'author': 'Dobson',
'year': '2013',
'journal-title': 'J. Neurol. Neurosurg. Psychiatry'},
{ 'key': 'ref_48',
'doi-asserted-by': 'crossref',
'first-page': '266',
'DOI': '10.4274/jcrpe.v1i6.266',
'article-title': 'Vitamin D deficiency in Turkish mothers and their neonates and in women '
'of reproductive age',
'volume': '1',
'author': 'Atasay',
'year': '2009',
'journal-title': 'J. Clin. Res. Pediatr. Endocrinol.'},
{ 'key': 'ref_49',
'first-page': 'w20238',
'article-title': 'High prevalence of severe vitamin D deficiency during the first '
'trimester in pregnant women in Switzerland and its potential '
'contributions to adverse outcomes in the pregnancy',
'volume': '150',
'author': 'Christoph',
'year': '2020',
'journal-title': 'Swiss Med. Wkly.'},
{ 'key': 'ref_50',
'doi-asserted-by': 'crossref',
'unstructured': 'Perichart-Perera, O., González-Leyva, C.P., González-Ludlow, I., '
'Tolentino-Dolores, M., Solis-Paredes, M., Reyes-Muñoz, E., '
'Borboa-Olivares, H., Sánchez-Martínez, M., Parra-Hernández, S., and '
'Monterrubio-Flores, E. (2020). Vitamin D Deficiency in Mexican Pregnant '
'Women: Is Supplementation with ≤400 IU/day Enough?. Nutrients, 12.',
'DOI': '10.3390/nu12092517'},
{ 'key': 'ref_51',
'doi-asserted-by': 'crossref',
'first-page': '105964',
'DOI': '10.1016/j.jsbmb.2021.105964',
'article-title': 'Impact of vitamin D on the course of COVID-19 during pregnancy: A case '
'control study',
'volume': '213',
'author': 'Sinaci',
'year': '2021',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'key': 'ref_52',
'doi-asserted-by': 'crossref',
'first-page': '2167',
'DOI': '10.1002/jmv.27606',
'article-title': 'Oxidative stress status and vitamin D levels of asymptomatic to mild '
'symptomatic COVID-19 infections during the third trimester of '
'pregnancy: A retrospective study in Metz, France',
'volume': '94',
'author': 'Schmitt',
'year': '2022',
'journal-title': 'J. Med. Virol.'},
{ 'key': 'ref_53',
'first-page': '1',
'article-title': 'Correlation between 25-hydroxy vitamin D levels and COVID-19 severity '
'in pregnant women: A cross-sectional study',
'volume': '35',
'author': 'Seven',
'year': '2021',
'journal-title': 'J. Matern. Fetal Neonatal Med.'},
{ 'key': 'ref_54',
'doi-asserted-by': 'crossref',
'first-page': '1035',
'DOI': '10.1007/s00394-021-02709-7',
'article-title': 'Vitamin D status is not associated with clinical severity of COVID-19 '
'in pregnant women',
'volume': '61',
'author': 'Tekin',
'year': '2022',
'journal-title': 'Eur. J. Nutr.'},
{ 'key': '#cr-split#-ref_55.1',
'unstructured': 'Ferrer-Sánchez, N., Díaz-Goicoechea, M., Mayoral-Cesar, V., '
'García-Solbas, S., Nievas-Soriano, B.J., Parrón-Carreño, T., and '
'Fernández-Alonso, A.M. (2022). Serum 25'},
{ 'key': '#cr-split#-ref_55.2',
'unstructured': '(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 '
'(COVID-19): A Case-Control Study. Int. J. Environ. Res. Public Health, '
'19.'},
{ 'key': 'ref_56',
'doi-asserted-by': 'crossref',
'first-page': '105771',
'DOI': '10.1016/j.jsbmb.2020.105771',
'article-title': 'Vitamin D and survival in COVID-19 patients: A quasi-experimental study',
'volume': '204',
'author': 'Annweiler',
'year': '2020',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'key': 'ref_57',
'doi-asserted-by': 'crossref',
'first-page': '343',
'DOI': '10.2147/IJGM.S346169',
'article-title': 'The Impact of Vitamin D Level on the Severity and Outcome of '
'Hospitalized Patients with COVID-19 Disease',
'volume': '15',
'author': 'AlKhafaji',
'year': '2022',
'journal-title': 'Int. J. Gen. Med.'},
{ 'key': 'ref_58',
'doi-asserted-by': 'crossref',
'unstructured': 'Bushnaq, T., Algethami, F., Qadhi, A., Mustafa, R., Ghafouri, K., Azhar, '
'W., and Malki, A.A. (2022). The Impact of Vitamin D Status on COVID-19 '
'Severity among Hospitalized Patients in the Western Region of Saudi '
'Arabia: A Retrospective Cross-Sectional Study. Int. J. Environ. Res. '
'Public Health, 19.',
'DOI': '10.3390/ijerph19031901'},
{ 'key': 'ref_59',
'doi-asserted-by': 'crossref',
'first-page': '889',
'DOI': '10.3109/14767058.2013.765849',
'article-title': 'Maternal vitamin D status and adverse pregnancy outcomes: A systematic '
'review and meta-analysis',
'volume': '26',
'author': 'Wei',
'year': '2013',
'journal-title': 'J. Matern. Fetal Neonatal Med.'},
{ 'key': 'ref_60',
'doi-asserted-by': 'crossref',
'unstructured': 'Roffe-Vazquez, D.N., Huerta-Delgado, A.S., Castillo, E.C., '
'Villarreal-Calderón, J.R., Gonzalez-Gil, A.M., Enriquez, C., '
'Garcia-Rivas, G., and Elizondo-Montemayor, L. (2019). Correlation of '
'Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and '
'Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up '
'Study. Int. J. Mol. Sci., 20.',
'DOI': '10.3390/ijms20225811'},
{ 'key': 'ref_61',
'doi-asserted-by': 'crossref',
'first-page': '1938',
'DOI': '10.1017/S0007114514003018',
'article-title': 'Vitamin D deficiency is associated with inflammatory cytokine '
'concentrations in patients with diabetic foot infection',
'volume': '112',
'author': 'Tiwari',
'year': '2014',
'journal-title': 'Br. J. Nutr.'},
{ 'key': 'ref_62',
'first-page': '92',
'article-title': 'Vitamin D and immune function: Autocrine, paracrine or endocrine?',
'volume': '243',
'author': 'Hewison',
'year': '2012',
'journal-title': 'Scand. J. Clin. Lab. Investig. Suppl.'},
{ 'key': 'ref_63',
'first-page': '87',
'article-title': 'Short term, high-dose vitamin D supplementation for COVID-19 disease: A '
'randomised, placebo-controlled, study (SHADE study)',
'volume': '98',
'author': 'Rastogi',
'year': '2022',
'journal-title': 'Postgrad. Med. J.'},
{ 'key': 'ref_64',
'doi-asserted-by': 'crossref',
'first-page': '105958',
'DOI': '10.1016/j.jsbmb.2021.105958',
'article-title': 'Vitamin D supplementation prior to or during COVID-19 associated with '
'better 3-month survival in geriatric patients: Extension phase of the '
'GERIA-COVID study',
'volume': '213',
'author': 'Annweiler',
'year': '2021',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'key': 'ref_65',
'doi-asserted-by': 'crossref',
'unstructured': 'Sánchez-Zuno, G.A., González-Estevez, G., Matuz-Flores, M.G., '
'Macedo-Ojeda, G., Hernández-Bello, J., Mora-Mora, J.C., Pérez-Guerrero, '
'E.E., García-Chagollán, M., Vega-Magaña, N., and Turrubiates-Hernández, '
'F.J. (2021). Vitamin D Levels in COVID-19 Outpatients from Western '
'Mexico: Clinical Correlation and Effect of Its Supplementation. J. Clin. '
'Med., 10.',
'DOI': '10.3390/jcm10112378'},
{ 'key': 'ref_66',
'doi-asserted-by': 'crossref',
'first-page': '276',
'DOI': '10.1016/S2213-8587(21)00051-6',
'article-title': 'Vitamin D supplementation to prevent acute respiratory infections: A '
'systematic review and meta-analysis of aggregate data from randomised '
'controlled trials',
'volume': '9',
'author': 'Jolliffe',
'year': '2021',
'journal-title': 'Lancet Diabetes Endocrinol.'},
{ 'key': 'ref_67',
'doi-asserted-by': 'crossref',
'unstructured': 'Maugeri, A., Barchitta, M., Blanco, I., and Agodi, A. (2019). Effects of '
'Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic '
'Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 11.',
'DOI': '10.3390/nu11020442'},
{ 'key': 'ref_68',
'first-page': 'Cd008873',
'article-title': 'Vitamin D supplementation for women during pregnancy',
'volume': '7',
'author': 'Palacios',
'year': '2019',
'journal-title': 'Cochrane Database Syst. Rev.'},
{ 'key': 'ref_69',
'doi-asserted-by': 'crossref',
'first-page': '102707',
'DOI': '10.1016/j.midw.2020.102707',
'article-title': 'Vitamin D, preeclampsia and prematurity: A systematic review and '
'meta-analysis of observational and interventional studies',
'volume': '87',
'year': '2020',
'journal-title': 'Midwifery'},
{ 'key': 'ref_70',
'doi-asserted-by': 'crossref',
'first-page': '20503121211014073',
'DOI': '10.1177/20503121211014073',
'article-title': 'Vitamin D regulation of the immune system and its implications for '
'COVID-19: A mini review',
'volume': '9',
'author': 'Bui',
'year': '2021',
'journal-title': 'SAGE Open Med.'},
{ 'key': 'ref_71',
'doi-asserted-by': 'crossref',
'first-page': '507',
'DOI': '10.1016/S0140-6736(20)30211-7',
'article-title': 'Epidemiological and clinical characteristics of 99 cases of 2019 novel '
'coronavirus pneumonia in Wuhan, China: A descriptive study',
'volume': '395',
'author': 'Chen',
'year': '2020',
'journal-title': 'Lancet'},
{ 'key': 'ref_72',
'doi-asserted-by': 'crossref',
'first-page': '141',
'DOI': '10.1038/s41579-020-00459-7',
'article-title': 'Characteristics of SARS-CoV-2 and COVID-19',
'volume': '19',
'author': 'Hu',
'year': '2021',
'journal-title': 'Nat. Rev. Microbiol.'},
{ 'key': 'ref_73',
'doi-asserted-by': 'crossref',
'first-page': '1757',
'DOI': '10.1056/NEJMcp2009249',
'article-title': 'Mild or Moderate COVID-19',
'volume': '383',
'author': 'Gandhi',
'year': '2020',
'journal-title': 'N. Engl. J. Med.'},
{ 'key': 'ref_74',
'doi-asserted-by': 'crossref',
'first-page': 'e13332',
'DOI': '10.1111/aji.13332',
'article-title': 'Severity of COVID-19 in pregnancy: A review of current evidence',
'volume': '84',
'author': 'Kucirka',
'year': '2020',
'journal-title': 'Am. J. Reprod. Immunol.'},
{ 'key': 'ref_75',
'doi-asserted-by': 'crossref',
'unstructured': 'Furqan, M.S., and Siyal, M.Y. (2016). Elastic-Net Copula Granger '
'Causality for Inference of Biological Networks. PLoS ONE, 11.',
'DOI': '10.1371/journal.pone.0165612'},
{ 'key': 'ref_76',
'doi-asserted-by': 'crossref',
'first-page': '7',
'DOI': '10.1016/j.bbrc.2021.12.055',
'article-title': 'Elastic net-based identification of GAMT as potential diagnostic marker '
'for early-stage gastric cancer',
'volume': '591',
'author': 'Gong',
'year': '2022',
'journal-title': 'Biochem. Biophys. Res. Commun.'}],
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'ISSN': ['1422-0067'],
'subject': [ 'Inorganic Chemistry', 'Organic Chemistry', 'Physical and Theoretical Chemistry',
'Computer Science Applications', 'Spectroscopy', 'Molecular Biology', 'General Medicine',
'Catalysis'],
'container-title-short': 'IJMS',
'published': {'date-parts': [[2022, 12, 2]]}}
