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0 0.5 1 1.5 2+ ICU admission 82% Improvement Relative Risk Moderate/severe case 89% Case 63% c19early.org/d Ferrer-Sánchez et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 82 patients in Spain Fewer cases with higher vitamin D levels (p=0.01) Ferrer-Sánchez et al., Int. J. Environmental Res.., doi:10.3390/ijerph19073965 Favors vitamin D Favors control
Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study
Ferrer-Sánchez et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19073965
Ferrer-Sánchez et al., Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study, International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19073965
Mar 2022   Source   PDF  
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Retrospective 256 pregnant women, 82 with COVID-19 and 174 controls, showing significantly lower vitamin D levels for COVID-19 patients.
risk of ICU admission, 81.8% lower, RR 0.18, p = 1.00, high D levels (≥20ng/mL) 0 of 9 (0.0%), low D levels (<20ng/mL) 4 of 73 (5.5%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), excluded in exclusion analyses: unadjusted results with no group details.
risk of moderate/severe case, 88.7% lower, RR 0.11, p = 1.00, high D levels (≥20ng/mL) 0 of 9 (0.0%), low D levels (<20ng/mL) 7 of 73 (9.6%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), excluded in exclusion analyses: unadjusted results with no group details.
risk of case, 62.7% lower, OR 0.37, p = 0.01, cutoff 20ng/mL, adjusted per study, inverted to make OR<1 favor high D levels (≥20ng/mL), multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ferrer-Sánchez et al., 26 Mar 2022, retrospective, Spain, peer-reviewed, 7 authors.
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Abstract: International Journal of Environmental Research and Public Health Article Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study Nazaret Ferrer-Sánchez 1, *, Marina Díaz-Goicoechea 1 , Victoria Mayoral-Cesar 1 , Silvia García-Solbas 2 , Bruno José Nievas-Soriano 3, * , Tesifón Parrón-Carreño 3 and Ana María Fernández-Alonso 1,2 1 2 3 *   Citation: Ferrer-Sánchez, N.; Díaz-Goicoechea, M.; Mayoral-Cesar, V.; García-Solbas, S.; Nievas-Soriano, B.J.; Parrón-Carreño, T.; Fernández-Alonso, A.M. Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease Obstetrics and Gynaecology Unit, Torrecárdenas Hospital, 04009 Almería, Spain; marinadiazgoicoechea@gmail.com (M.D.-G.); mayoral.87@hotmail.com (V.M.-C.); anafernandez.alonso@gmail.com (A.M.F.-A.) Obstetrics and Gynaecology Unit, Vithas Virgen del Mar Hospital, 04120 Almería, Spain; silviagarsol@gmail.com Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain; tpc468@ual.es Correspondence: nfs792@inlumine.ual.es (N.F.-S.); brunonievas@ual.es (B.J.N.-S.) Abstract: The physiological changes during pregnancy may increase the risk of complications in pregnant women with coronavirus disease 2019 (COVID-19). Vitamin D is a fat-soluble secosteroid hormone and its role in immunity is appears to be of particular importance in this recent pandemic. Nevertheless, there is little research about the role of vitamin D levels regarding COVID-19 in pregnant women to date. This study aimed to establish a relationship between serum 25-hydroxyvitamin D (25(OH)D) levels in pregnant women and COVID-19. A comparative case-control study was performed with a study population of 256 pregnant women (82 pregnant women with infection and 174 women in control group). Serum 25(OH)D levels were significantly lower in pregnant women with COVID-19 infection than in those without infection. In addition, 89% of COVID-19-positive pregnant women had 25(OH)D deficiency, while in the control group the percentage was 75.30%, finding statistically significant differences (ORa = 2.68; 95% CI 1.19–6.06; p = 0.01). Our results find a relationship between vitamin D deficiency in pregnant women and COVID-19 infection. This finding could be relevant for actual clinical practice. Thus, more research is needed in this field. 2019 (COVID-19): A Case-Control Study. Int. J. Environ. Res. Public Keywords: vitamin D; COVID-19; coronavirus; pregnant women Health 2022, 19, 3965. https:// doi.org/10.3390/ijerph19073965 Academic Editor: Paul B. Tchounwou
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