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0 0.5 1 1.5 2+ Severe case 90% treatment Improvement Relative Risk Moderate/severe case -19% treatment Moderate/severe case.. 79% levels Case 60% levels Vitamin D for COVID-19  Sinaci et al.  Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? Retrospective 491 patients in Turkey Lower severe cases with vitamin D (not stat. sig., p=0.35) Sinaci et al., The J. Steroid Biochemi.., Aug 2021 Favors vitamin D Favors control

Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study

Sinaci et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964
Aug 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 159 COVID-19+ pregnant women in Turkey and 332 healthy pregnant controls, showing significantly lower vitamin D levels in COVID-19+ patients. 23% of COVID-19 patients where on vitamin D supplementation, while none of the 7 severe cases were on supplementation.
This is the 46th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 248 sextillion).
29 studies are RCTs, which show efficacy with p=0.0000024.
risk of severe case, 90.0% lower, RR 0.10, p = 0.35, treatment 0 of 36 (0.0%), control 7 of 123 (5.7%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), supplementation.
risk of moderate/severe case, 18.8% higher, RR 1.19, p = 0.64, treatment 8 of 36 (22.2%), control 23 of 123 (18.7%), supplementation.
risk of moderate/severe case, 79.5% lower, RR 0.21, p < 0.001, high D levels (≥10ng/mL) 8 of 100 (8.0%), low D levels (<10ng/mL) 23 of 59 (39.0%), NNT 3.2, outcome based on serum levels.
risk of case, 59.9% lower, RR 0.40, p < 0.001, high D levels (≥10ng/mL) 100 of 397 (25.2%), low D levels (<10ng/mL) 59 of 94 (62.8%), NNT 2.7, outcome based on serum levels.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sinaci et al., 11 Aug 2021, retrospective, Turkey, peer-reviewed, 10 authors, dosage not specified.
This PaperVitamin DAll
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
Selcan Sinaci, Doga Fatma Ocal, Didem Fatma Yucel Yetiskin, Derya Uyan Hendem, Gul Nihal Buyuk, Sule Goncu Ayhan, Atakan Tanacan, A Seval Ozgu-Erdinc, Ozlem Moraloglu Tekin, Dilek Sahin
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964
We aimed to evaluate the vitamin D status of pregnant women with COVID-19, and the association between vitamin D level and severity of COVID-19. Methods: In this case control study, 159 women with a single pregnancy and tested positive for SARS-CoV-2, and randomly selected 332 healthy pregnant women with similar gestational ages were included. COVID-19 patients were classified as mild, moderate, and severe. Vitamin D deficiency was defined as 25-hydroxycholecalciferol <20 ng/mL (50 nmol/L), and 25-OH D vitamin <10 ng/mL was defined as severe vitamin D deficiency, also 25-OH D vitamin level between 20− 29 ng/mL (525− 725 nmol/L) was defined as vitamin D insufficiency. Results: Vitamin D levels of the pregnant women in the COVID-19 group (12.46) were lower than the control group (18.76). 25-OH D vitamin levels of those in the mild COVID-19 category (13.69) were significantly higher than those in the moderate/severe category (9.06). In terms of taking vitamin D supplementation, there was no statistically significant difference between the groups. However, it was observed that all of those who had severe COVID-19 were the patients who did not take vitamin D supplementation. Conclusion: The vitamin D levels are low in pregnant women with COVID-19. Also, there is a significant difference regarding to vitamin D level and COVID-19 severity in pregnant women. Maintenance of adequate vitamin D level can be useful as an approach for the prevention of an aggressive course of the inflammation induced by this novel coronavirus in pregnant women.
Author contributions SS: conceptualization, methodology, data collection, investigation, visualization and writing the article; DFO: reviewing and editing; FDYY, DUH, GBU, SGA: data collection; AT, SOE: formal analysis, visualization; OMT: supervision; DS: conceptualization, methodology, reviewing, and editing, project administration. Ethics approval This study was approved by the Ethics Committee of the Ankara City Hospital on December 23, 2020, with the number E1-20-1192. Consent to participate Written informed consent was obtained from all individual participants included in the study. Declaration of Competing Interest The authors report no declarations of interest.
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