Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
Sinaci et al.,
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study,
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964
Retrospective 159 COVID-19+ pregnant women in Turkey and 332 healthy pregnant controls, showing significantly lower vitamin D levels in COVID-19+ patients. 23% of COVID-19 patients where on vitamin D supplementation, while none of the 7 severe cases were on supplementation.
risk of severe case, 90.0% lower, RR 0.10, p = 0.35, treatment 0 of 36 (0.0%), control 7 of 123 (5.7%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), supplementation.
|
risk of moderate/severe case, 18.8% higher, RR 1.19, p = 0.64, treatment 8 of 36 (22.2%), control 23 of 123 (18.7%), supplementation.
|
risk of moderate/severe case, 79.5% lower, RR 0.21, p < 0.001, high D levels (≥10ng/mL) 8 of 100 (8.0%), low D levels (<10ng/mL) 23 of 59 (39.0%), NNT 3.2, cutoff ≥10ng/mL, outcome based on serum levels.
|
risk of case, 59.9% lower, RR 0.40, p < 0.001, high D levels (≥10ng/mL) 100 of 397 (25.2%), low D levels (<10ng/mL) 59 of 94 (62.8%), NNT 2.7, cutoff ≥10ng/mL, outcome based on serum levels.
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Sinaci et al., 11 Aug 2021, retrospective, Turkey, peer-reviewed, 10 authors, dosage not specified.
Abstract: Journal of Steroid Biochemistry and Molecular Biology 213 (2021) 105964
Contents lists available at ScienceDirect
Journal of Steroid Biochemistry and Molecular Biology
journal homepage: www.elsevier.com/locate/jsbmb
Impact of vitamin D on the course of COVID-19 during pregnancy: A case
control study
Selcan Sinaci a, *, Doga Fatma Ocal a, Didem Fatma Yucel Yetiskin a, Derya Uyan Hendem a,
Gul Nihal Buyuk a, Sule Goncu Ayhan a, Atakan Tanacan a, A. Seval Ozgu-Erdinc a,
Ozlem Moraloglu Tekin a, b, Dilek Sahin a, b
a
b
Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
University of Health Sciences, Ankara City Hospital, Ankara, Turkey
A R T I C L E I N F O
A B S T R A C T
Keywords:
COVID-19
Pregnancy
Vitamin D deficiency
Immune system
Cytokine storm
Objective: We aimed to evaluate the vitamin D status of pregnant women with COVID-19, and the association
between vitamin D level and severity of COVID-19.
Methods: In this case control study, 159 women with a single pregnancy and tested positive for SARS-CoV-2, and
randomly selected 332 healthy pregnant women with similar gestational ages were included. COVID-19 patients
were classified as mild, moderate, and severe. Vitamin D deficiency was defined as 25-hydroxycholecalciferol
<20 ng/mL (50 nmol/L), and 25-OH D vitamin <10 ng/mL was defined as severe vitamin D deficiency, also
25-OH D vitamin level between 20− 29 ng/mL (525− 725 nmol/L) was defined as vitamin D insufficiency.
Results: Vitamin D levels of the pregnant women in the COVID-19 group (12.46) were lower than the control
group (18.76). 25-OH D vitamin levels of those in the mild COVID-19 category (13.69) were significantly higher
than those in the moderate/severe category (9.06). In terms of taking vitamin D supplementation, there was no
statistically significant difference between the groups. However, it was observed that all of those who had severe
COVID-19 were the patients who did not take vitamin D supplementation.
Conclusion: The vitamin D levels are low in pregnant women with COVID-19. Also, there is a significant dif
ference regarding to vitamin D level and COVID-19 severity in pregnant women. Maintenance of adequate
vitamin D level can be useful as an approach for the prevention of an aggressive course of the inflammation
induced by this novel coronavirus in pregnant women.
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit