Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
Sinaci et al.
, Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
, The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964
Retrospective 159 COVID-19+ pregnant women in Turkey and 332 healthy pregnant controls, showing significantly lower vitamin D levels in COVID-19+ patients. 23% of COVID-19 patients where on vitamin D supplementation, while none of the 7 severe cases were on supplementation.
risk of severe case, 90.0% lower, RR 0.10, p = 0.35, treatment 0 of 36 (0.0%), control 7 of 123 (5.7%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), supplementation.
risk of moderate/severe case, 18.8% higher, RR 1.19, p = 0.64, treatment 8 of 36 (22.2%), control 23 of 123 (18.7%), supplementation.
risk of moderate/severe case, 79.5% lower, RR 0.21, p < 0.001, high D levels (≥10ng/mL) 8 of 100 (8.0%), low D levels (<10ng/mL) 23 of 59 (39.0%), NNT 3.2, cutoff ≥10ng/mL, outcome based on serum levels.
risk of case, 59.9% lower, RR 0.40, p < 0.001, high D levels (≥10ng/mL) 100 of 397 (25.2%), low D levels (<10ng/mL) 59 of 94 (62.8%), NNT 2.7, cutoff ≥10ng/mL, outcome based on serum levels.
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Sinaci et al., 11 Aug 2021, retrospective, Turkey, peer-reviewed, 10 authors, dosage not specified.
Abstract: Journal of Steroid Biochemistry and Molecular Biology 213 (2021) 105964
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Journal of Steroid Biochemistry and Molecular Biology
journal homepage: www.elsevier.com/locate/jsbmb
Impact of vitamin D on the course of COVID-19 during pregnancy: A case
Selcan Sinaci a, *, Doga Fatma Ocal a, Didem Fatma Yucel Yetiskin a, Derya Uyan Hendem a,
Gul Nihal Buyuk a, Sule Goncu Ayhan a, Atakan Tanacan a, A. Seval Ozgu-Erdinc a,
Ozlem Moraloglu Tekin a, b, Dilek Sahin a, b
Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
University of Health Sciences, Ankara City Hospital, Ankara, Turkey
A R T I C L E I N F O
A B S T R A C T
Vitamin D deficiency
Objective: We aimed to evaluate the vitamin D status of pregnant women with COVID-19, and the association
between vitamin D level and severity of COVID-19.
Methods: In this case control study, 159 women with a single pregnancy and tested positive for SARS-CoV-2, and
randomly selected 332 healthy pregnant women with similar gestational ages were included. COVID-19 patients
were classified as mild, moderate, and severe. Vitamin D deficiency was defined as 25-hydroxycholecalciferol
<20 ng/mL (50 nmol/L), and 25-OH D vitamin <10 ng/mL was defined as severe vitamin D deficiency, also
25-OH D vitamin level between 20− 29 ng/mL (525− 725 nmol/L) was defined as vitamin D insufficiency.
Results: Vitamin D levels of the pregnant women in the COVID-19 group (12.46) were lower than the control
group (18.76). 25-OH D vitamin levels of those in the mild COVID-19 category (13.69) were significantly higher
than those in the moderate/severe category (9.06). In terms of taking vitamin D supplementation, there was no
statistically significant difference between the groups. However, it was observed that all of those who had severe
COVID-19 were the patients who did not take vitamin D supplementation.
Conclusion: The vitamin D levels are low in pregnant women with COVID-19. Also, there is a significant dif
ference regarding to vitamin D level and COVID-19 severity in pregnant women. Maintenance of adequate
vitamin D level can be useful as an approach for the prevention of an aggressive course of the inflammation
induced by this novel coronavirus in pregnant women.
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