Abstract: The Journal of Maternal-Fetal & Neonatal Medicine ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/ijmf20 Correlation between 25-hydroxy vitamin D levels and COVID-19 severity in pregnant women: a cross-sectional study B. Seven, O. Gunduz, A. S. Ozgu-Erdinc, Dilek Sahin, O. Moraloglu Tekin & H. L. Keskin To cite this article: B. Seven, O. Gunduz, A. S. Ozgu-Erdinc, Dilek Sahin, O. Moraloglu Tekin & H. L. Keskin (2021): Correlation between 25-hydroxy vitamin D levels and COVID-19 severity in pregnant women: a cross-sectional study, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.2005564 To link to this article: https://doi.org/10.1080/14767058.2021.2005564 Published online: 23 Nov 2021. Submit your article to this journal Article views: 52 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ijmf20 THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE https://doi.org/10.1080/14767058.2021.2005564 ORIGINAL ARTICLE Correlation between 25-hydroxy vitamin D levels and COVID-19 severity in pregnant women: a cross-sectional study B. Sevena Keskina,b a , O. Gunduza , A. S. Ozgu-Erdinca,b , Dilek Sahina,b , O. Moraloglu Tekina,b and H. L. Department of Ob&Gyn, Ankara City Hospital, Ankara, Turkey; bDepartment of Ob&Gyn, University of Health Sciences, Turkey ABSTRACT ARTICLE HISTORY Objective: To evaluate the relationship between 25-hydroxy vitamin D (25(OH)D) levels and disease severity in hospitalized COVID-19 positive pregnant women Methods: The COVID-19 (þ) pregnant women (confirmed by PCR test) were classified as asymptomatic, mild symptomatic, and severe disease according to their symptoms and laboratory results. Severe COVID-19 criteria were respiratory symptoms and/or findings. The following laboratory results were considered as poor prognostic factors: the number of lymphocytes <800/ml and/or CRP value >10 times the upper limit of the normal range and/or ferritin value >500 ng/ml and/or D-Dimer value >1000 mg/l. The patients were divided into two groups; asymptomatic or mild symptomatic group (Group 1), and severe disease and/or poor prognostic factor group (Group 2). The 25(OH)D levels were compared between groups. ROC curve analysis was used to analyze the cutoff value for vitamin D to predict the severity of COVID-19. Results: 25(OH)D levels were found to be statistically significantly lower in group 2 (15.5 (10.25) ng/ml in Group 1, 13 (12) ng/ml in Group 2, p ¼ .010). The 25(OH)D level under 14.5 ng/ml was associated with severe COVID-19 and/or poor prognostic factors (p ¼ .010). The risk of severe COVID-19 and/or having poor prognostic factors was 1.87 times higher among pregnant women who had 25(OH)D levels below 14.5 ng/ml. This value was found to have 54.1% sensitivity and 61.3% specificity in predicting severe COVID-19 and/or poor prognostic laboratory findings in pregnant women Conclusion: There is a relationship between vitamin D status and the severity of COVID-19 in pregnant women. During the pandemic period, vitamin D supplementation for pregnant women should gain more importance. Received 10 June 2021 Revised 19 September 2021 Accepted 9 November 2021