Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy
Vásquez-Procopio et al.,
Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy,
Frontiers in Cell and Developmental Biology, doi:10.3389/fcell.2022.935363
Prospective study of 163 COVID+ and 34 COVID- pregnant women in Mexico, showing significantly lower zinc levels in patients with severe COVID-19.
Vásquez-Procopio et al., 9 Aug 2022, prospective, Mexico, peer-reviewed, 15 authors, study period July 2020 - March 2021.
Contact:
gpestrad@gmail.com.
Abstract: ORIGINAL RESEARCH
published: 09 August 2022
doi: 10.3389/fcell.2022.935363
Inflammatory-Metal Profile as a
Hallmark for COVID-19 Severity During
Pregnancy
Edited by:
Teresita Padilla-Benavides,
Wesleyan University, United States
Reviewed by:
Mauricio Comas-Garcia,
Universidad Autónoma de San Luis
Potosí, Mexico
Odette Verdejo-Torres,
University of Massachusetts Medical
School, United States
*Correspondence:
Guadalupe Estrada-Gutierrez
gpestrad@gmail.com
Fanis Missirlis
fanis@fisio.cinvestav.mx
†
These authors have contributed
equally to this work and share senior
authorship
Specialty section:
This article was submitted to
Cellular Biochemistry,
a section of the journal
Frontiers in Cell and Developmental
Biology
Received: 03 May 2022
Accepted: 14 June 2022
Published: 09 August 2022
Citation:
Vásquez-Procopio J, Espejel-Nuñez A,
Torres-Torres J, Martinez-Portilla RJ,
Espino Y. Sosa S, Mateu-Rogell P,
Ortega-Castillo V,
Tolentino-Dolores M,
Perichart-Perera O,
Franco-Gallardo JO,
Carranco-Martínez JA,
Prieto-Rodríguez S,
Guzmán-Huerta M, Missirlis F and
Estrada-Gutierrez G (2022)
Inflammatory-Metal Profile as a
Hallmark for COVID-19 Severity
During Pregnancy.
Front. Cell Dev. Biol. 10:935363.
doi: 10.3389/fcell.2022.935363
Johana Vásquez-Procopio 1,2, Aurora Espejel-Nuñez 1, Johnatan Torres-Torres 3,
Raigam Jafet Martinez-Portilla 3, Salvador Espino Y. Sosa 3, Paloma Mateu-Rogell 3,
Veronica Ortega-Castillo 4, Maricruz Tolentino-Dolores 5, Otilia Perichart-Perera 5,
José Osman Franco-Gallardo 6, José Alberto Carranco-Martínez 7,
Scarleth Prieto-Rodríguez 7, Mario Guzmán-Huerta 7, Fanis Missirlis 2*† and
Guadalupe Estrada-Gutierrez 8*†
1
Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, Mexico, 2Department of Physiology,
Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico, 3Clinical Research
Division, Instituto Nacional de Perinatología, Mexico City, Mexico, 4Department of Obstetrics, Instituto Nacional de Perinatología,
Mexico City, Mexico, 5Department of Nutrition and Bioprogramming, Instituto Nacional de Perinatología, Mexico City, Mexico,
6
Data Science Department, Openlab, Mexico City, Mexico, 7Department of Translational Medicine, Instituto Nacional de
Perinatología, Mexico City, Mexico, 8Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico
Pregnancy makes women more susceptible to infectious agents; however, available data
on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory
responses and changes in serum metal concentration have been reported in COVID-19
patients, but few associations between metal ions and cytokines have been described.
The aim of this study was to evaluate correlations between inflammatory markers and
serum metal ions in third-trimester pregnant women with varying COVID-19 disease
severity. Patients with severe symptoms had increased concentrations of serum
magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and
sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the
severe presentation of COVID-19 during pregnancy. Robust negative correlations
between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP10 were observed in pregnant women with the severe form of the disease. Thus,
coordinated alterations of serum metal..
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