Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

DOI record: { "DOI": "10.3389/fcell.2022.935363", "ISSN": [ "2296-634X" ], "URL": "http://dx.doi.org/10.3389/fcell.2022.935363", "abstract": "<jats:p>Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers – suggestive of underlying pathophysiological interactions—occur during SARS-CoV-2 infection in pregnancy.</jats:p>", "alternative-id": [ "10.3389/fcell.2022.935363" ], "author": [ { "affiliation": [], "family": "Vásquez-Procopio", "given": "Johana", "sequence": "first" }, { "affiliation": [], "family": "Espejel-Nuñez", "given": "Aurora", "sequence": "additional" }, { "affiliation": [], "family": "Torres-Torres", "given": "Johnatan", "sequence": "additional" }, { "affiliation": [], "family": "Martinez-Portilla", "given": "Raigam Jafet", "sequence": "additional" }, { "affiliation": [], "family": "Espino Y. Sosa", "given": "Salvador", "sequence": "additional" }, { "affiliation": [], "family": "Mateu-Rogell", "given": "Paloma", "sequence": "additional" }, { "affiliation": [], "family": "Ortega-Castillo", "given": "Veronica", "sequence": "additional" }, { "affiliation": [], "family": "Tolentino-Dolores", "given": "Maricruz", "sequence": "additional" }, { "affiliation": [], "family": "Perichart-Perera", "given": "Otilia", "sequence": "additional" }, { "affiliation": [], "family": "Franco-Gallardo", "given": "José Osman", "sequence": "additional" }, { "affiliation": [], "family": "Carranco-Martínez", "given": "José Alberto", "sequence": "additional" }, { "affiliation": [], "family": "Prieto-Rodríguez", "given": "Scarleth", "sequence": "additional" }, { "affiliation": [], "family": "Guzmán-Huerta", "given": "Mario", "sequence": "additional" }, { "affiliation": [], "family": "Missirlis", "given": "Fanis", "sequence": "additional" }, { "affiliation": [], "family": "Estrada-Gutierrez", "given": "Guadalupe", "sequence": "additional" } ], "container-title": "Frontiers in Cell and Developmental Biology", "container-title-short": "Front. 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Biol.", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2022, 8, 9 ] ], "date-time": "2022-08-09T06:52:16Z", "timestamp": 1660027936000 }, "deposited": { "date-parts": [ [ 2022, 8, 9 ] ], "date-time": "2022-08-09T06:52:25Z", "timestamp": 1660027945000 }, "indexed": { "date-parts": [ [ 2022, 8, 10 ] ], "date-time": "2022-08-10T04:09:52Z", "timestamp": 1660104592496 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 8, 9 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 8, 9 ] ], "date-time": "2022-08-09T00:00:00Z", "timestamp": 1660003200000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fcell.2022.935363/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2022, 8, 9 ] ] }, "published-online": { "date-parts": [ [ 2022, 8, 9 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.1001/jamanetworkopen.2020.29256", "article-title": "Pregnancy Outcomes Among Women with and without Severe Acute Respiratory Syndrome Coronavirus 2 Infection", "author": "Adhikari", "doi-asserted-by": "publisher", "first-page": "e2029256", "journal-title": "JAMA Netw. 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