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Association between 25-hydroxyvitamin D levels and COVID-19 severity

Takase et al., Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2022.04.003
Apr 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 109 treatments. c19early.org
Retrospective 117 consecutive COVID+ hospitalized patients in Japan, showing lower vitamin D levels associated with mechanical ventilation or mortality.
Takase et al., 9 Apr 2022, retrospective, Japan, peer-reviewed, 8 authors, study period 1 October, 2020 - 31 January, 2021.
This PaperVitamin DAll
Association between 25-hydroxyvitamin D levels and COVID-19 severity
Ph.D Tomoki Takase, Naoko Tsugawa, Takayuki Sugiyama, Hiroaki Ikesue, Masaaki Eto, Tohru Hashida, Keisuke Tomii, Nobuyuki Muroi
Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2022.04.003
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Ethics approval and consent on the participation Approval No: zn210703. Competing interests The authors declare that they have no competing interests. Authors' contributions TT and NT conceived and designed this study. ME dispensed blood samples for measuring the serum 25(OH)D levels, whereas TT, NT, and TS pretreated blood samples for that. NT measured the serum 25(OH)D levels. TT and TS collected patient data from electronic medical records. TT and NT analyzed data. HI, TH, KT and NM supervised the conduct of this study. TT and NT drafted the manuscript. All authors have substantially contributed to its revision. All authors have read and approved the final manuscript.
References
Abdrabbo, Birch, Brandt, Cicigoi, Coffey et al., Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection, Protein Sci, doi:10.1002/pro.4190
Afaghi, Tarki, Rahimi, Besharat, Mirhaidari et al., Prevalence and Clinical Outcomes of Vitamin D Deficiency in COVID-19
Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., e -p r o o f, doi:10.1080/07315724.2020.1856013
Angelidi, Belanger, Lorinsky, Karamanis, Chamorro-Pareja et al., Vitamin D status is associated with in-hospital mortality and mechanical ventilation: A cohort of COVID-19 hospitalized patients, Mayo Clin Proc, doi:10.1016/j.mayocp.2021.01.001
Bellido, Perez, COVID-19 and Diabetes, J Clin Med, doi:10.3390/jcm10225341
Ben-Eltriki, Hopefl, Wright, Association between vitamin D status and risk of developing severe COVID-19 infection: A meta-analysis of observational studies, J Am Coll Nutr, doi:10.1080/07315724.2021.1951891
Bennouar, Cherif, Kessira, Bennouar, Abdi, Vitamin D deficiency and low serum calcium as predictors of poor prognosis in patients with severe COVID-19, J Am Coll Nutr, doi:10.1080/07315724.2020.1856013
Bianconi, Mannarino, Figorilli, Cosentini, Batori et al., r n a l P r e -p r o o f Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19, Nutrition, doi:10.1016/j.nut.2021.111408
Cereda, Bogliolo, Klersy, Lobascio, Masi et al., Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital, Nutr, doi:10.1016/j.clnu.2020.10.055
Davoudi, Najafi, Aarabi, Tayebi, Nikaeen et al., Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection, BMC Infect Dis, doi:10.1186/s12879-021-06168-7
Desai, Dirajlal-Fargo, Durieux, Tribout, Labbato et al., Vitamin K & D Deficiencies Are Independently Associated With COVID-19
Gaudio, Murabito, Agodi, Montineri, Castellino et al., Vitamin D levels are reduced at the time of hospital admission in Sicilian SARS-CoV-2-Positive patients, Int J Environ Res Public Health, doi:10.3390/ijerph18073491
Higashi Awada, Shimada, Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by liquid chromatography-tandem mass spectrometry employing derivatization with a Cookson-type reagent, Biol Pharm Bull, doi:10.1248/bpb.24.738
Holick, Vitamin D deficiency, N Engl J Med, doi:10.1056/NEJMra070553
Hossein-Nezhad, Holick, Optimize dietary intake of vitamin D: An epigenetic perspective, Curr Opin Clin Nutr Metab Care, doi:10.1097/mco.0b013e3283594978
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Infante, Buoso, Pieri, Lupisella, Nuccetelli et al., Low vitamin D status at admission as a risk factor for poor survival in hospitalized patients with COVID-19: An Italian retrospective study, J Am Coll Nutr. J o u r n a l P r e -p r o o f, doi:10.1080/07315724.2021.1877580
J O U R N A L P R E, -p r o o f
Karonova, Andreeva, Golovatuk, Bykova, Simanenkova et al., Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19, Nutrients, doi:10.3390/nu13093021
Katzenschlager, Zimmer, Gottschalk, Grafeneder, Schmitz et al., Can we predict the severe course of COVID-19 -A systematic review and meta-analysis of indicators of clinical outcome?, PLOS ONE, doi:10.1371/journal.pone.0255154
Li, Zhong, Wang, Zeng, Luo et al., Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis, PLOS ONE, doi:10.1371/journal.pone.0250602
Lopes, Macedo, De Barros, Santos, Mazza, Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial, JAMA, doi:10.1001/jama.2020.25864
Luo, Liao, Shen, Li, Cheng, Vitamin D Deficiency Is Associated with COVID-19 Incidence and Disease Severity in Chinese People
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: J o u r n a l P r e -p r o o f Systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Mitri, Pittas, Vitamin D and diabetes, Endocrinol Metab Clin North Am, doi:10.1016/j.ecl.2013.09.010
Ng, Tipih, Makoah, Vermeulen, Goedhals et al., Comorbidities in SARS-CoV-2 patients: A systematic review and meta-analysis. J o u r n a l P r e -p r o o f, mBio, doi:10.1128/mbio.03647-20
Pecina, Merry, Park, Td, Vitamin D status and severe COVID-19 disease outcomes in hospitalized patients, J Prim Care Community Health, doi:10.1177/21501327211041206
Pham, Rahman, Majidi, Waterhouse, Neale, Acute respiratory tract infection and 25-hydroxyvitamin D concentration: A systematic review and meta-analysis, Int J Environ Res Public Health, doi:10.3390/ijerph16173020
Pierucci, Quaranta, Dragonieri, Portacci, Tummolo et al., Moderate to severe Vitamin D deficiency increases the risk for COVID-19 mortality in patients treated in a respiratory intensive care unit, Pol Arch Intern Med, doi:10.20452/pamw.16119
Prietl, Treiber, Pieber, Amrein, Vitamin D and immune function, Nutrients, doi:10.3390/nu5072502
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients, doi:10.3390/nu12092757
Raisi-Estabragh, Martineau, Curtis, Moon, Darling et al., Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review, Aging Clin Exp Res, doi:10.1007/s40520-021-01894-z
Rajan, Dashti, Saber, Pan, Zhanna, In-hospital mortality in SARS-CoV-2 stratified by serum 25-hydroxy-vitamin D levels: A retrospective study, J Med Virol, doi:10.1002/jmv.27133
Ramasamy, Vitamin D metabolism and guidelines for vitamin D supplementation, Clin Biochem Rev, doi:10.33176/aacb-20-00006
Ramirez-Sandoval, Vj, Paz-Cortes, Santillan-Ceron, Hernandez-Jimenez et al., Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19, Arch Med Res, doi:10.1016/j.arcmed.2021.09.006
Reis, Fernandes, Sales, Santos, Santos et al., Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: A multicenter prospective cohort study, Am J Clin Nutr, doi:10.1093/ajcn/nqab151
Shi, Wang, Ye, Gu, Wang et al., Predictors of mortality in patients with coronavirus disease 2019: A systematic review and meta-analysis, BMC Infect Dis, doi:10.1186/s12879-021-06369-0
Singh, Gillies, Singh, Singh, Chudasama et al., Prevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis, Diabetes Obes Metab, doi:10.1111/dom.14124
Smet, Smet, Herroelen, Gryspeerdt, Martens, Serum 25(OH)D level on hospital admission associated with COVID-19 stage and mortality, Am J Clin Pathol, doi:10.1093/ajcp/aqaa252
Taylor, Marson, Elhadi, Macleod, Yu et al., Factors associated with mortality in patients with COVID-19 admitted to intensive care: A systematic review and meta-analysis, Anaesthesia, doi:10.1111/anae.15532
Tehrani, Khabiri, Moradi, Mosavat, Khabiri, Evaluation of vitamin D levels in COVID-19 patients referred to Labafinejad hospital in Tehran and its relationship with disease severity and mortality, Clin Nutr ESPEN, doi:10.1016/j.clnesp.2021.01.014
Tsugawa, Cardiovascular diseases and fat soluble vitamins: Vitamin D and vitamin K, J Nutr Sci Vitaminol, doi:10.3177/jnsv.61.s170
Tsugawa, Suhara, Kamao, Okano, Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography--Tandem mass spectrometry, Anal Chem, doi:10.1021/ac048249c
Welfare, None
Who, R&D blueprint novel coronavirus COVID-19 therapeutic trial synopsis, doi:10.1002/jmv.27133
Wise, Tai, Burdette, Camara, Bedner et al., Role of the National Institute of Standards and Technology (NIST) in support of the vitamin D initiative of the National Institutes of Health, Office of Dietary Supplements, J AOAC Int, doi:10.5740/jaoacint.17-0305
Wu, Colombo, Authors reply: Hypoalbuminemia in COVID-19, J Intern Med, doi:10.1111/joim.13403
Wu, Li, Zhang, Liang, Zhang et al., Risk factors for mortality of coronavirus disease 2019 (COVID-19) patients during the early outbreak of COVID-19: A systematic review and meta-analysis, Ann Palliat Med, doi:10.21037/apm-20-2557
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