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0 0.5 1 1.5 2+ Mortality -12% Improvement Relative Risk Ventilation 16% ICU admission 28% Severe case -68% Davoudi et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 153 patients in Iran (February - March 2020) Higher severe cases with higher vitamin D levels (not stat. sig., p=0.3) Davoudi et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06168-7 Favors vitamin D Favors control
Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection
Davoudi et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06168-7
Davoudi et al., Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection, BMC Infectious Diseases, doi:10.1186/s12879-021-06168-7
May 2021   Source   PDF  
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Retrospective 153 hospitalized patients in Iran, showing no significant difference in outcomes based on vitamin D levels. Adjusted results are only provided for vitamin D as a continuous variable. This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
risk of death, 12.3% higher, RR 1.12, p = 1.00, high D levels (≥30ng/mL) 2 of 57 (3.5%), low D levels (<30ng/mL) 3 of 96 (3.1%).
risk of mechanical ventilation, 15.8% lower, RR 0.84, p = 1.00, high D levels (≥30ng/mL) 1 of 57 (1.8%), low D levels (<30ng/mL) 2 of 96 (2.1%), NNT 304.
risk of ICU admission, 27.8% lower, RR 0.72, p = 0.74, high D levels (≥30ng/mL) 3 of 57 (5.3%), low D levels (<30ng/mL) 7 of 96 (7.3%), NNT 49.
risk of severe case, 68.4% higher, RR 1.68, p = 0.30, high D levels (≥30ng/mL) 9 of 57 (15.8%), low D levels (<30ng/mL) 9 of 96 (9.4%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Davoudi et al., 18 May 2021, retrospective, Iran, peer-reviewed, 11 authors, study period February 2020 - March 2020.
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Abstract: Davoudi et al. BMC Infectious Diseases (2021) 21:450 RESEARCH Open Access Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection Alireza Davoudi1, Narges Najafi1, Mohsen Aarabi2, Atefeh Tayebi1, Roja Nikaeen3, Hamideh Izadyar1, Zahra Salar4, Leila Delavarian1, Narges Vaseghi5, Zahra Daftarian1 and Fatemeh Ahangarkani1* Abstract Background: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. Methods: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. Results: One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). Conclusions: Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection. Keywords: Vitamin D, SARS-CoV-2, COVID-19, Coronavirus, Sufficiency, Insufficiency
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