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0 0.5 1 1.5 2+ Mortality 70% Improvement Relative Risk Vitamin D for COVID-19  De Smet et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 186 patients in Belgium Lower mortality with higher vitamin D levels (p=0.015) De Smet et al., American J. Clinical P.., Nov 2020 Favors vitamin D Favors control

Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

De Smet et al., American Journal of Clinical Pathology, doi:10.1093/ajcp/aqaa252
Nov 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 118 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 186 hospitalized patients in Belgium showing that 59% of patients were vitamin D deficient, and that non-vitamin D deficient patients had significantly lower mortality risk, RR 0.26, p = 0.015.
This is the 29th of 192 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 611 vigintillion).
risk of death, 70.1% lower, RR 0.30, p = 0.02, high D levels 7 of 77 (9.1%), low D levels 20 of 109 (18.3%), adjusted per study, odds ratio converted to relative risk, >20ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
De Smet et al., 25 Nov 2020, retrospective, Belgium, peer-reviewed, 5 authors.
This PaperVitamin DAll
Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality
MD Dieter De Smet, MD Kristof De Smet, MSc Pauline Herroelen, MD Stefaan Gryspeerdt, MD, PhD Geert A Martens
American Journal of Clinical Pathology, doi:10.1093/ajcp/aqaa252
Objectives: Vitamin D deficiency was previously correlated with incidence and severity of coronavirus disease 2019 (COVID-19). We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) level on admission and radiologic stage and outcome of COVID-19 pneumonia. Methods: A retrospective observational trial was done on 186 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals hospitalized from March 1, 2020, to April 7, 2020, with combined chest computed tomography (CT) and 25(OH)D measurement on admission. Multivariate regression analysis was performed to study if vitamin D deficiency (25(OH)D <20 ng/mL) correlates with survival independently of confounding comorbidities. Results: Of the patients with COVID-19, 59% were vitamin D deficient on admission: 47% of females and 67% of males. In particular, male patients with COVID-19 showed progressively lower 25(OH)D with advancing radiologic stage, with deficiency rates increasing from 55% in stage 1 to 74% in stage 3. Vitamin D deficiency on admission was not confounded by age, ethnicity, chronic lung disease, coronary artery disease/hypertension, or diabetes and was associated with mortality (odds ratio [
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