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0 0.5 1 1.5 2+ Mortality, 12ng/ml 18% Improvement Relative Risk Mortality, 20ng/ml 14% Death/ICU, 12ng/ml 16% Death/ICU, 20ng/ml 11% Vitamin D for COVID-19  Bianconi et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 200 patients in Italy Lower mortality (p=0.59) and death/ICU (p=0.53), not sig. Bianconi et al., Nutrition, July 2021 Favors vitamin D Favors control

Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19

Bianconi et al., Nutrition, doi:10.1016/j.nut.2021.111408
Jul 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Prospective study of 200 hospitalized patients in Italy, showing 80% of patients had vitamin D deficiency. There was no significant differences in outcomes based on vitamin D levels. There was also no significant difference in vitamin D levels when compared with sepsis patients.
This is the 78th of 192 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 611 vigintillion).
risk of death, 17.5% lower, HR 0.82, p = 0.58, high D levels (≥12ng/ml) 94, low D levels (<12ng/ml) 106, model 3, Table S2, Cox proportional hazards.
risk of death, 13.9% lower, HR 0.86, p = 0.73, high D levels (≥20ng/ml) 40, low D levels (<20ng/ml) 160, model 3, Table S2, Cox proportional hazards.
risk of death/ICU, 15.9% lower, HR 0.84, p = 0.53, high D levels (≥12ng/ml) 94, low D levels (<12ng/ml) 106, model 3, Cox proportional hazards.
risk of death/ICU, 10.9% lower, HR 0.89, p = 0.73, high D levels (≥20ng/ml) 40, low D levels (<20ng/ml) 160, model 3, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bianconi et al., 1 Jul 2021, prospective, Italy, peer-reviewed, 12 authors.
This PaperVitamin DAll
Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
MD Vanessa Bianconi, MD Massimo R Mannarino, MD a , Filippo Figorilli, MD a , Elena Cosentini, MD a , Ettore Marini MD a , Giuseppe Batori, Ettore Marini, Rita Lombardini, PhD Marco Gargaro, PhD Francesca Fallarino, MD Anna Maria Scarponi, PharmD Amirhossein Sahebkar, MD Matteo Pirro
Nutrition, doi:10.1016/j.nut.2021.111408
Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 , its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The association between Vit-D and the composite endpoint of intensive care unit (ICU) admission/in-hospital death was explored using univariable and multivariable analyses. Also, serum Vit-D level in patients with COVID-19 was compared with that in age-and sex-balanced COVID-19-negative controls (i.e., 50 inpatients with sepsis). Results: Serum Vit-D level was comparable between patients with COVID-19 and COVID-19-negative inpatients with sepsis (P = 0.397). No significant differences were found in serum Vit-D level according to COVID-19 severity at the time of hospital admission (P = 0.299). Incidence rates of the composite endpoint of ICU admission/in-hospital death did not differ significantly between patients with either Vit-D deficiency (i.e., Vit-D <20 ng/mL) or severe Vit-D deficiency (i.e., Vit-D <12 ng/mL) and those without (31% vs 35% with P = 0.649, and 34% vs 30% with P = 0.593, respectively). Vit-D level and status (i.e., Vit-D deficiency and severe Vit-D deficiency) were not prospectively associated with the risk of the composite endpoint of ICU admission/in-hospital death (P > 0.05 for all Cox regression models). Conclusions: Regardless of the potential usefulness of Vit-D measurement to guide appropriate supplementation, Vit-D does not appear to provide helpful information for the stratification of in-hospital prognosis in patients with COVID-19.
Supplementary materials Supplementary material associated with this article can be found in the online version at doi:10.1016/j.nut.2021.111408.
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