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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 23% Improvement Relative Risk Ventilation -45% Discharge 33% Hospitalization time 22% c19early.org/d Reis et al. Vitamin D for COVID-19 Sufficiency Favors vitamin D Favors control
Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study
Reis et al., The American Journal of Clinical Nutrition, doi:10.1093/ajcn/nqab151
21 May 2021    Source   PDF   Share   Tweet
Prospective study of 220 hospitalized patients in Brazil, showing no significant differences based on vitamin D levels. There was a trend (p=0.057) towards longer hospital stay for patients with levels <10ng/mL.
risk of death, 23.0% lower, HR 0.77, p = 0.82, high D levels (≥10ng/mL) 198, low D levels (<10ng/mL) 16, model 2, Cox proportional hazards.
risk of mechanical ventilation, 45.0% higher, HR 1.45, p = 0.77, high D levels (≥10ng/mL) 198, low D levels (<10ng/mL) 16, adjusted per study, model 2, multivariable, Cox proportional hazards.
risk of no hospital discharge, 33.3% lower, HR 0.67, p = 0.18, high D levels (≥10ng/mL) 198, low D levels (<10ng/mL) 16, adjusted per study, inverted to make HR<1 favor high D levels (≥10ng/mL), model 2, multivariable, Cox proportional hazards.
hospitalization time, 22.2% lower, relative time 0.78, p = 0.06, high D levels (≥10ng/mL) 191, low D levels (<10ng/mL) 15, model 2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Reis et al., 21 May 2021, prospective, Brazil, peer-reviewed, 19 authors.
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