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Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19

Ramirez-Sandoval et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
Oct 2021  
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Mortality 32% Improvement Relative Risk Hospitalization time 22% Vitamin D  Ramirez-Sandoval et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 2,908 patients in Mexico Lower mortality (p<0.0001) and shorter hospitalization (p=0.001) c19early.org Ramirez-Sandoval et al., Archives of M.., Oct 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective 2,908 hospitalized patients in Mexico with vitamin D levels measured on admission, showing significantly lower mortality for patients without vitamin D deficiency.
This is the 100th of 209 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 293,154,636 vigintillion).
risk of death, 31.5% lower, HR 0.68, p < 0.001, high D levels 2,337, low D levels 571, adjusted per study, inverted to make HR<1 favor high D levels, >12.5ng/mL, 30 day in-hospital mortality.
hospitalization time, 22.2% lower, relative time 0.78, p < 0.001, high D levels 2,337, low D levels 571.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ramirez-Sandoval et al., 15 Oct 2021, retrospective, Mexico, peer-reviewed, 7 authors.
This PaperVitamin DAll
Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19
MD Juan C Ramirez-Sandoval, Valeria Jocelyne Castillos-Ávalos, Armando Paz-Cortés, Airy Santillan-Ceron, Sergio Hernandez-Jimenez, Roopa Mehta, Ricardo Correa-Rotter
Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
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Vanegas-Cedillo, Bello-Chavolla, Ramírez-Pedraza, Serum Vitamin D levels are associated with increased COVID-19 severity and mortality independent of visceral adiposity, medRxiv
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