Ramirez-Sandoval: Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19

Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19

Ramirez-Sandoval et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006

Ramirez-Sandoval et al., Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe.., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006

Oct 2021 Source PDF

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Retrospective 2,908 hospitalized patients in Mexico with vitamin D levels measured on admission, showing significantly lower mortality for patients without vitamin D deficiency.

This is the 97th of 175 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 18 vigintillion).

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risk of death, 31.5% lower, HR 0.68, p < 0.001, high D levels 2,337, low D levels 571, adjusted per study, inverted to make HR<1 favor high D levels, >12.5ng/mL, 30 day in-hospital mortality.

hospitalization time, 22.2% lower, relative time 0.78, p < 0.001, high D levels 2,337, low D levels 571.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Ramirez-Sandoval et al., 15 Oct 2021, retrospective, Mexico, peer-reviewed, 7 authors.

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Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19

MD Juan C Ramirez-Sandoval, Valeria Jocelyne Castillos-Ávalos, Armando Paz-Cortés, Airy Santillan-Ceron, Sergio Hernandez-Jimenez, Roopa Mehta, Ricardo Correa-Rotter

Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006

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References

Aatsinki, Elkhwanky, Kummu, Fasting-induced transcription factors repress Vitamin D bioactivation, a mechanism for Vitamin D deficiency in diabetes, Diabetes

Autier, Boniol, Pizot, Mullie, Vitamin D status and ill health: A systematic review, Lancet Diabetes Endocrinol

Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J

Bianconi, Mannarino, Figorilli, Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19, Nutrition

Bouillon, Bikle, Vitamin D Metabolism Revised: Fall of Dogmas, J Bone Miner Res

Charlson, Pompei, Ales, Mc, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis

Demir, Demir, Aygun, Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease, J Med Virol

Ge, Trujillo, Miller, Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells, Immunobiology

Grove, Osokogu, Al-Khudairy, Association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19 including clinical course, morbidity and mortality outcomes? A systematic review, BMJ Open

Güven, Gültekin, Association of 25-Hydroxyvitamin D Level with COVID-19-Related in-Hospital Mortality: A Retrospective Cohort Study, J Am Coll Nutr

Harvey, Cooper, Raisi-Estabragh, Vitamin D and COVID-19 disease: don't believe everything you read in the papers! Reply to Dr William B. Grant, Aging Clin Exp Res

Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr Clin Res Rev

Hernández, Nan, Fernandez-Ayala, Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection, J Clin Endocrinol Metab

Horby, Lim, Emberson, Effect of Dexamethasone in Hospitalized Patients with COVID-19 -Preliminary Report. Prepr medRxiv, doi:10.1101/2020.06.22.20137273

Khoo, Chai, Koenen, Joosten, Netea et al., Translating the role of vitamin D 3 in infectious diseases, Crit Rev Microbiol

Kuba, Imai, Penninger, Angiotensin-converting enzyme 2 in lung diseases, Curr Opin Pharmacol

Lakkireddy, Gadiga, Malathi, Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease, Sci Rep

Manson, Brannon, Rosen, Vitamin D Deficiency -Is There Really a Pandemic?, N Engl J Med

Martineau, Forouhi, Vitamin D for COVID-19: a case to answer?, Lancet Diabetes Endocrinol

Mazahery, Hurst, Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation, Nutrients

Munshi, Hussein, Toraih, Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J Med Virol

Murai, Fernandes, Sales, Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients with Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA

Nimavat, Singh, Singh, Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India, Ann Med Surg

Pan, Sze, Minhas, The impact of ethnicity on clinical outcomes in COVID-19: A systematic review, E Clin Med

Raisi-Estabragh, Martineau, Curtis, Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review, Aging Clin Exp Res

Rajan, Dashti, In-hospital Mortality in SARS-CoV-2 stratified by serum 25-Hydroxy-Vitamin D levels: A Retrospective Study, J Med Virol, doi:10.1002/jmv.27133

Reid, Towards a trial-based definition of vitamin D deficiency, Lancet Diabetes Endocrinol

Roizen, Long, Casella, Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D, J Bone Min Res

Rubin, Sorting out Whether Vitamin D Deficiency Raises COVID-19 Risk, JAMA

Shinkyo, Sakaki, Kamakura, Metabolism of vitamin D by human microsomal CYP2R1, Biochem Biophys Res Commun

Snellman, Melhus, Gedeborg, Determining vitamin D status: A comparison between commercially available assays, PLoS One

Vanegas-Cedillo, Bello-Chavolla, Ramírez-Pedraza, Serum Vitamin D levels are associated with increased COVID-19 severity and mortality independent of visceral adiposity, medRxiv

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