Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19
et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
, Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe.., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
Retrospective 2,908 hospitalized patients in Mexico with vitamin D levels measured on admission, showing significantly lower mortality for patients without vitamin D deficiency.
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risk of death, 31.5% lower, HR 0.68, p < 0.001, high D levels 2,337, low D levels 571, adjusted per study, inverted to make HR<1 favor high D levels, >12.5ng/mL, 30 day in-hospital mortality.
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hospitalization time, 22.2% lower, relative time 0.78, p < 0.001, high D levels 2,337, low D levels 571.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ramirez-Sandoval et al., 15 Oct 2021, retrospective, Mexico, peer-reviewed, 7 authors.
Abstract: Hypovitaminosis D and COVID-19 mortality
Journal Pre-proof
ORIGINAL ARTICLEVery Low Vitamin D Levels are a Strong
Independent Predictor of Mortality in Hospitalized Patients with
Severe COVID-19
Juan C. Ramirez-Sandoval , Valeria Jocelyne Castillos-Ávalos ,
Armando Paz-Cortés , Airy Santillan-Ceron ,
Sergio Hernandez-Jimenez , Roopa Mehta ,
Correa-Rotter Ricardo
PII:
DOI:
Reference:
S0188-4409(21)00198-3
https://doi.org/10.1016/j.arcmed.2021.09.006
ARCMED 2702
To appear in:
Archives of Medical Research
Received date:
Revised date:
Accepted date:
July 23, 2021
August 31, 2021
September 30, 2021
Please cite this article as: Juan C. Ramirez-Sandoval , Valeria Jocelyne Castillos-Ávalos ,
Armando Paz-Cortés ,
Airy Santillan-Ceron ,
Sergio Hernandez-Jimenez ,
Roopa Mehta ,
Correa-Rotter Ricardo , ORIGINAL ARTICLEVery Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19, Archives of Medical
Research (2021), doi: https://doi.org/10.1016/j.arcmed.2021.09.006
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© 2021 Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS).
Highlights:
This observational retrospective study found a strong independent association
between serum 25-hydroxyvitamin D levels at the moment of hospital admission and
adverse clinical outcomes (in-hospital mortality, mechanical ventilation requirement,
and length of stay) in a large Mexican cohort of 2908 hospitalized patients with
severe COVID-19.
NAME FOR TOP OF PAGES: Ramirez-Sandoval, et al./Archives of Medical Research 53 (2022) x–
x
Running Title: Hypovitaminosis D and COVID-19 mortality
Archives of Medical Research 53 (2022) x–x
ORIGINAL ARTICLE
Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients
with Severe COVID-19
Juan C. Ramirez-Sandoval,a Valeria Jocelyne Castillos-Ávalos,a Armando Paz-Cortés,a Airy
Santillan-Ceron,a Sergio Hernandez-Jimenez,b Roopa Mehta,c and Correa-Rotter Ricardoa
a
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y
Nutrición Salvador Zubirán, Ciudad de México, México
b
Centro de Atención Integral al Paciente con Diabetes, Instituto Nacional de Ciencias Médicas y
Nutrición Salvador Zubirán, Ciudad de México, México
c
Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y
Nutrición Salvador Zubirán, Ciudad de México, México
Received for publication July 23, 2021; accepted September 29, 2021 (ARCMED-D-21-00956).
Address reprint requests to: Juan C Ramirez-Sandoval, MD, PhD, Instituto Nacional de Ciencias
Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Dominguez Sección XVI,
Tlalpan, 14080 Mexico City, Mexico; Phone: (+52) (55) 54870900 ext. 4141 or ext. 2524; E-mail:
carlos.ramirezs@incmnsz.mx
Background. There is controversy regarding the association between hypovitaminosis..
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