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0 0.5 1 1.5 2+ Mortality 32% Improvement Relative Risk Hospitalization time 22% c19early.org/d Ramirez-Sandoval et al. Vitamin D Sufficiency Favors vitamin D Favors control
Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19
Ramirez-Sandoval et al., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
Ramirez-Sandoval et al., Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe.., Archives of Medical Research, doi:10.1016/j.arcmed.2021.09.006
Oct 2021   Source   PDF  
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Retrospective 2,908 hospitalized patients in Mexico with vitamin D levels measured on admission, showing significantly lower mortality for patients without vitamin D deficiency.
risk of death, 31.5% lower, HR 0.68, p < 0.001, high D levels 2,337, low D levels 571, adjusted per study, inverted to make HR<1 favor high D levels, >12.5ng/mL, 30 day in-hospital mortality.
hospitalization time, 22.2% lower, relative time 0.78, p < 0.001, high D levels 2,337, low D levels 571.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ramirez-Sandoval et al., 15 Oct 2021, retrospective, Mexico, peer-reviewed, 7 authors.
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Abstract: Hypovitaminosis D and COVID-19 mortality Journal Pre-proof ORIGINAL ARTICLEVery Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19 Juan C. Ramirez-Sandoval , Valeria Jocelyne Castillos-Ávalos , Armando Paz-Cortés , Airy Santillan-Ceron , Sergio Hernandez-Jimenez , Roopa Mehta , Correa-Rotter Ricardo PII: DOI: Reference: S0188-4409(21)00198-3 https://doi.org/10.1016/j.arcmed.2021.09.006 ARCMED 2702 To appear in: Archives of Medical Research Received date: Revised date: Accepted date: July 23, 2021 August 31, 2021 September 30, 2021 Please cite this article as: Juan C. Ramirez-Sandoval , Valeria Jocelyne Castillos-Ávalos , Armando Paz-Cortés , Airy Santillan-Ceron , Sergio Hernandez-Jimenez , Roopa Mehta , Correa-Rotter Ricardo , ORIGINAL ARTICLEVery Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19, Archives of Medical Research (2021), doi: https://doi.org/10.1016/j.arcmed.2021.09.006 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2021 Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS). Highlights:  This observational retrospective study found a strong independent association between serum 25-hydroxyvitamin D levels at the moment of hospital admission and adverse clinical outcomes (in-hospital mortality, mechanical ventilation requirement, and length of stay) in a large Mexican cohort of 2908 hospitalized patients with severe COVID-19. NAME FOR TOP OF PAGES: Ramirez-Sandoval, et al./Archives of Medical Research 53 (2022) x– x Running Title: Hypovitaminosis D and COVID-19 mortality Archives of Medical Research 53 (2022) x–x ORIGINAL ARTICLE Very Low Vitamin D Levels are a Strong Independent Predictor of Mortality in Hospitalized Patients with Severe COVID-19 Juan C. Ramirez-Sandoval,a Valeria Jocelyne Castillos-Ávalos,a Armando Paz-Cortés,a Airy Santillan-Ceron,a Sergio Hernandez-Jimenez,b Roopa Mehta,c and Correa-Rotter Ricardoa a Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México b Centro de Atención Integral al Paciente con Diabetes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México c Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México Received for publication July 23, 2021; accepted September 29, 2021 (ARCMED-D-21-00956). Address reprint requests to: Juan C Ramirez-Sandoval, MD, PhD, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Dominguez Sección XVI, Tlalpan, 14080 Mexico City, Mexico; Phone: (+52) (55) 54870900 ext. 4141 or ext. 2524; E-mail: carlos.ramirezs@incmnsz.mx Background. There is controversy regarding the association between hypovitaminosis..
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