Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID-19 infections during the third trimester of pregnancy: A retrospective study in Metz, France
Schmitt et al.
, Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID-19 infections during..
, Journal of Medical Virology, doi:10.1002/jmv.27606
Retrospective 15 COVID+ pregnant women and 20 healthy controls in France, showing that all COVID+ patients were vitamin D deficient, and vitamin D levels were significantly lower in symptomatic patients compared to controls or asymptomatic patients.
Schmitt et al., 27 Jan 2022, France, peer-reviewed, 5 authors.
Abstract: Received: 19 November 2021
Accepted: 17 January 2022
Oxidative stress status and vitamin D levels of asymptomatic
to mild symptomatic COVID‐19 infections during the third
trimester of pregnancy: A retrospective study in Metz, France
Guillaume Schmitt1,2 | Sary Labdouni2 |
Catherine Delamare2 | Jaouad Bouayed1
Université de Lorraine, LCOMS
/Neurotoxicologie Alimentaire et Bioactivité,
It is believed that the subtle equilibrium between tolerance and immunity during the
CHR Metz‐Thionvillle Hôpital de Mercy, Ars‐
unique biological state of pregnancy, which is characterized by further physiological
and hormonal changes, rends pregnant women more vulnerable to coronavirus
Jaouad Bouayed, Université de Lorraine,
LCOMS/Neurotoxicologie Alimentaire et
Bioactivité, Metz 57000, France.
disease 2019 (COVID‐19). In this retrospective study, confirmed COVID‐19‐positive
pregnant women (n = 15) during their third trimester, comprising asymptomatic
(n = 7) and mild symptomatic (n = 8), and healthy pregnant controls (n = 20), were
enrolled between June 1, 2020 and June 1, 2021 from the Hospital CHR Metz‐
Thionville in Metz, France. Vitamin D concentrations, C‐reactive protein (CRP), and
oxidative stress markers including superoxide dismutase (SOD), catalase (CAT), reduced (GSH) and oxidized (GSSG) glutathione levels, hydrogen peroxide (H2O2), and
the total antioxidant capacity, measured the ferric reducing ability of plasma (FRAP),
were evaluated in the serum of patients and controls. Results showed that all
pregnant women (patients and controls) enrolled in this study were vitamin D deficient (<20 ng/ml). However, mild COVID‐19 pregnant women were severely vitamin D deficient (<12 ng/ml), which may suggest a link between vitamin D deficiency
and the symptomatology of COVID‐19 illness in singleton pregnancy. No differences
between the levels of CRP and the majority of the studied oxidative stress markers
in COVID‐19‐positive pregnant women (asymptomatic and/or mildly symptomatic
patients) versus COVID‐19‐negative pregnant women were found, suggesting the
absence or a low magnitude of oxidative stress in pregnant women with COVID‐19.
This may also explain the absence of severe courses of COVID‐19 infection. More
studies are warranted to investigate the role of vitamin D supplementation and
antioxidant‐rich diets in the prevention against severe forms of COVID‐19 in
COVID‐19, C‐reactive protein (CRP), oxidative stress, pregnancy, SARS‐CoV‐2, vitamin D
J Med Virol. 2022;1–7.
© 2022 Wiley Periodicals LLC
In this retrospective study, healthy control pregnant women and
confirmed COVID‐19 patients without comorbidities including mildly
The coronavirus disease 2019 (COVID‐19) caused by the severe acute
symptomatic and asymptomatic patients were enrolled in their third
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel betacor-
trimester. We retrospectively evaluated the serum oxidative stress
onavirus, has been declared as a global pandemic by the World Health
status of pregnant women with and without COVID‐19, their in-
Organization (WHO) on March 11, 2020.1 Until today, the ongoing
flammatory status, and also their serum vitamin D levels. To the best
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