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0 0.5 1 1.5 2+ Severe case 39% Improvement Relative Risk Rodríguez-Vidales et al. Vitamin D Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 297 patients in Mexico (March - September 2020) Lower severe cases with higher vitamin D levels (not stat. sig., p=0.21) Rodríguez-Vidales et al., Nutrición Hospitalaria, doi:10.20960/nh.03731 Favors vitamin D Favors control
Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico
Rodríguez-Vidales et al., Nutrición Hospitalaria, doi:10.20960/nh.03731
Rodríguez-Vidales et al., Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico, Nutrición Hospitalaria, doi:10.20960/nh.03731
Feb 2022   Source   PDF  
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Retrospective 181 diagnostic center patients and 116 ICU patients in Mexico, showing higher risk of severity with vitamin D levels <10ng/mL.
risk of severe case, 38.9% lower, RR 0.61, p = 0.21, high D levels (≥10ng/mL) 89 of 265 (33.6%), low D levels (<10ng/mL) 27 of 32 (84.4%), NNT 2.0, adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rodríguez-Vidales et al., 24 Feb 2022, retrospective, Mexico, peer-reviewed, 8 authors, study period March 2020 - September 2020.
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Abstract: Los pacientes graves con COVID-19 tienen deficiencia grave de vitamina D en el noreste de México Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico 10.20960/nh.03731 02/24/2022 OR 3731 Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico Los pacientes graves con COVID-19 tienen deficiencia grave de vitamina D en el noreste de México Edgar P. Rodríguez-Vidales1, Denise Garza-Carrillo1, Ana M. SalinasMartínez2,3, Olivia A. Robles-Rodríguez1, Roberto Montes de Oca-Luna 1, Consuelo Treviño-Garza4, Alma R. Marroquín-Escamilla1, and Manuel E. de la O-Cavazos4 Secretaría de Salud de Nuevo León. 1 Unidad de Investigación en 2 Epidemiología y Servicios de Salud. Instituto Mexicano del Seguro Social. Facultad de Salud Publica y Nutrición. Universidad Autónoma de Nuevo 3 León. Departamento de Pediatría. Hospital Universitario Dr. José 4 Eleuterio González. Universidad Autónoma de Nuevo León. Monterrey, Nuevo León. Mexico Received: 23/08/2021 Accepted: 18/01/2022 Correspondence: Manuel E. De la O-Cavazos; Alma R. MarroquínEscamilla. Torre Administrativa, Piso 8. Calle Washington, 2000. Col. Obrera. 64000 Monterrey, Nuevo León. Mexico e-mail:; Conflicts of interests: the authors declare no conflicts of interest. Author contributions: conceptualization, methodology and formal analysis: ERV, RMDOL, and DGC; writing—original draft preparation, data curation, formal analysis: ORR and ASM; design, analysis, writing— review and editing: MDOC, CTG and AME. All authors have read and agreed to the published version of the manuscript. ABSTRACT Objective: the association between vitamin D and COVID-19 severity is not consistent. We compared prevalences and analyzed the association between vitamin D deficiency and COVID-19 severity in Northeast Mexico. Methods: this was a cross-sectional study with individuals consecutively included at a referral diagnostic center during March-September 2020 (n = 181). Concurrently, every patient admitted to intensive care was also consecutively included (n = 116). Serum 25(OH)D < 20 ng/mL was considered vitamin D deficiency. Descriptive, ANOVA, and multivariate ordinal regression analyses were performed. Results: vitamin D deficiency prevalence was 63.8 % (95 % CI, 54.7, 72.0) in severe COVID-19; 25.6 % (95 % CI, 17.4, 36.0) in mild COVID-19; and 42.4 % (95 % CI, 33.2, 52.3) in non-diseased individuals. Vitamin D deficiency increased 5 times the odds of severe COVID-19 (95 % CI, 1.1, 24.3), independently of sex, age, body mass index, and inflammatory markers. Conclusions: this study is the first report of vitamin D deficiency in Northeast Mexico. Vitamin D deficiency was associated with COVID-19 severity. Keywords. Vitamin D deficiency. SARS-CoV-2. Laboratory parameters. COVID-19. Serum 25(OH)D. RESUMEN Objetivo: la asociación entre la vitamina D y la gravedad de la COVID19 no es consistente. Se comparó la prevalencia y se analizó la asociación de la deficiencia de vitamina D con la gravedad de los pacientes con COVID-19 en el noreste de México. Métodos: este fue un estudio transversal. Se incluyó consecutivamente a individuos de un centro de diagnóstico de referencia durante marzoseptiembre de 2020 (n = 181). Paralelamente, se reclutó a todos los pacientes que ingresaron a cuidados intensivos en ese mismo periodo (n = 116). Se consideró que había deficiencia de vitamina D ante cifras..
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