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0 0.5 1 1.5 2+ Severe case 39% Improvement Relative Risk Vitamin D  Rodríguez-Vidales et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 297 patients in Mexico (March - September 2020) Lower severe cases with higher vitamin D levels (p=0.05) Rodríguez-Vidales et al., Nutrición Ho.., Feb 2022 Favors vitamin D Favors control

Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico

Rodríguez-Vidales et al., Nutrición Hospitalaria, doi:10.20960/nh.03731
Feb 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 181 diagnostic center patients and 116 ICU patients in Mexico, showing higher risk of severity with vitamin D levels <10ng/mL.
This is the 123rd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of severe case, 38.9% lower, RR 0.61, p = 0.05, high D levels (≥10ng/mL) 89 of 265 (33.6%), low D levels (<10ng/mL) 27 of 32 (84.4%), NNT 2.0, adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rodríguez-Vidales et al., 24 Feb 2022, retrospective, Mexico, peer-reviewed, 8 authors, study period March 2020 - September 2020.
This PaperVitamin DAll
Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico
Manuel Enrique De La O-Cavazos, Edgar Paolo Rodríguez Vidales, Denise Garza Carrillo, Ana María Salinas Martínez, Olivia Abigail Robles Rodríguez, Roberto Montes De Oca Luna, Consuelo Treviño Garza, Alma Rosa Marroquín Escamilla
Nutrición Hospitalaria, doi:10.20960/nh.03731
Objective: the association between vitamin D and COVID-19 severity is not consistent. We compared prevalences and analyzed the association between vitamin D deficiency and COVID-19 severity in Northeast Mexico. Methods : this was a cross-sectional study with individuals consecutively included at a referral diagnostic center during March-September 2020 (n = 181). Concurrently, every patient admitted to intensive care was also consecutively included (n = 116). Serum 25(OH)D < 20 ng/mL was considered vitamin D deficiency. Descriptive, ANOVA, and multivariate ordinal regression analyses were performed. Results: vitamin D deficiency prevalence was 63.8 % (95 % CI, 54.7, 72.0) in severe COVID-19; 25.6 % (95 % CI, 17.4, 36.0) in mild COVID-19; and 42.4 % (95 % CI, 33.2, 52.3) in non-diseased individuals. Vitamin D deficiency increased 5 times the odds of severe COVID-19 (95 % CI, 1.1, 24.3), independently of sex, age, body mass index, and inflammatory markers. Conclusions: this study is the first report of vitamin D deficiency in Northeast Mexico. Vitamin D deficiency was associated with COVID-19 severity.
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