Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico
et al., Nutrición Hospitalaria, doi:10.20960/nh.03731
, Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico, Nutrición Hospitalaria, doi:10.20960/nh.03731
Retrospective 181 diagnostic center patients and 116 ICU patients in Mexico, showing higher risk of severity with vitamin D levels <10ng/mL.
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risk of severe case, 38.9% lower, RR 0.61, p = 0.21, high D levels (≥10ng/mL) 89 of 265 (33.6%), low D levels (<10ng/mL) 27 of 32 (84.4%), NNT 2.0, adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, multivariable.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Rodríguez-Vidales et al., 24 Feb 2022, retrospective, Mexico, peer-reviewed, 8 authors, study period March 2020 - September 2020.
Abstract: Los pacientes graves con
COVID-19 tienen deficiencia
grave de vitamina D en el noreste
de México
Severe COVID-19 patients have
severe vitamin D deficiency in
Northeast Mexico
10.20960/nh.03731
02/24/2022
OR 3731
Severe COVID-19 patients have severe vitamin D deficiency in
Northeast Mexico
Los pacientes graves con COVID-19 tienen deficiencia grave de vitamina
D en el noreste de México
Edgar P. Rodríguez-Vidales1, Denise Garza-Carrillo1, Ana M. SalinasMartínez2,3, Olivia A. Robles-Rodríguez1, Roberto Montes de Oca-Luna 1,
Consuelo Treviño-Garza4, Alma R. Marroquín-Escamilla1, and Manuel E.
de la O-Cavazos4
Secretaría de Salud de Nuevo León.
1
Unidad de Investigación en
2
Epidemiología y Servicios de Salud. Instituto Mexicano del Seguro Social.
Facultad de Salud Publica y Nutrición. Universidad Autónoma de Nuevo
3
León.
Departamento de Pediatría. Hospital Universitario Dr. José
4
Eleuterio González. Universidad Autónoma de Nuevo León. Monterrey,
Nuevo León. Mexico
Received: 23/08/2021
Accepted: 18/01/2022
Correspondence: Manuel E. De la O-Cavazos; Alma R. MarroquínEscamilla. Torre Administrativa, Piso 8. Calle Washington, 2000. Col.
Obrera. 64000 Monterrey, Nuevo León. Mexico
e-mail:
publicacion.investssnl@gmail.com;
alma.marroquin@saludnl.gob.mx
Conflicts of interests: the authors declare no conflicts of interest.
Author
contributions:
conceptualization,
methodology
and
formal
analysis: ERV, RMDOL, and DGC; writing—original draft preparation, data
curation, formal analysis: ORR and ASM; design, analysis, writing—
review and editing: MDOC, CTG and AME. All authors have read and
agreed to the published version of the manuscript.
ABSTRACT
Objective: the association between vitamin D and COVID-19 severity is
not consistent. We compared prevalences and analyzed the association
between vitamin D deficiency and COVID-19 severity in Northeast
Mexico.
Methods: this was a cross-sectional study with individuals consecutively
included at a referral diagnostic center during March-September 2020 (n
= 181). Concurrently, every patient admitted to intensive care was also
consecutively included (n = 116). Serum 25(OH)D < 20 ng/mL was
considered vitamin D deficiency. Descriptive, ANOVA, and multivariate
ordinal regression analyses were performed.
Results: vitamin D deficiency prevalence was 63.8 % (95 % CI, 54.7,
72.0) in severe COVID-19; 25.6 % (95 % CI, 17.4, 36.0) in mild COVID-19;
and 42.4 % (95 % CI, 33.2, 52.3) in non-diseased individuals. Vitamin D
deficiency increased 5 times the odds of severe COVID-19 (95 % CI, 1.1,
24.3), independently of sex, age, body mass index, and inflammatory
markers.
Conclusions: this study is the first report of vitamin D deficiency in
Northeast Mexico. Vitamin D deficiency was associated with COVID-19
severity.
Keywords. Vitamin D deficiency. SARS-CoV-2. Laboratory parameters.
COVID-19. Serum 25(OH)D.
RESUMEN
Objetivo: la asociación entre la vitamina D y la gravedad de la COVID19 no es consistente. Se comparó la prevalencia y se analizó la
asociación de la deficiencia de vitamina D con la gravedad de los
pacientes con COVID-19 en el noreste de México.
Métodos: este fue un estudio transversal. Se incluyó consecutivamente
a individuos de un centro de diagnóstico de referencia durante marzoseptiembre de 2020 (n = 181). Paralelamente, se reclutó a todos los
pacientes que ingresaron a cuidados intensivos en ese mismo periodo (n
= 116). Se consideró que había deficiencia de vitamina D ante cifras..
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