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Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico

Rodríguez-Vidales et al., Nutrición Hospitalaria, doi:10.20960/nh.03731

Feb 2022

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.

Lower risk for mortality, ICU admission, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

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Retrospective 181 diagnostic center patients and 116 ICU patients in Mexico, showing higher risk of severity with vitamin D levels <10ng/mL.

This is the 123rd of 209 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 293,154,636 vigintillion).

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risk of severe case, 38.9% lower, RR 0.61, p = 0.05, high D levels (≥10ng/mL) 89 of 265 (33.6%), low D levels (<10ng/mL) 27 of 32 (84.4%), NNT 2.0, adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, multivariable.

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Rodríguez-Vidales et al., 24 Feb 2022, retrospective, Mexico, peer-reviewed, 8 authors, study period March 2020 - September 2020.

This Paper Vitamin D All

Severe COVID-19 patients have severe vitamin D deficiency in Northeast Mexico

Manuel Enrique De La O-Cavazos, Edgar Paolo Rodríguez Vidales, Denise Garza Carrillo, Ana María Salinas Martínez, Olivia Abigail Robles Rodríguez, Roberto Montes De Oca Luna, Consuelo Treviño Garza, Alma Rosa Marroquín Escamilla

Nutrición Hospitalaria, doi:10.20960/nh.03731

Objective: the association between vitamin D and COVID-19 severity is not consistent. We compared prevalences and analyzed the association between vitamin D deficiency and COVID-19 severity in Northeast Mexico. Methods : this was a cross-sectional study with individuals consecutively included at a referral diagnostic center during March-September 2020 (n = 181). Concurrently, every patient admitted to intensive care was also consecutively included (n = 116). Serum 25(OH)D < 20 ng/mL was considered vitamin D deficiency. Descriptive, ANOVA, and multivariate ordinal regression analyses were performed. Results: vitamin D deficiency prevalence was 63.8 % (95 % CI, 54.7, 72.0) in severe COVID-19; 25.6 % (95 % CI, 17.4, 36.0) in mild COVID-19; and 42.4 % (95 % CI, 33.2, 52.3) in non-diseased individuals. Vitamin D deficiency increased 5 times the odds of severe COVID-19 (95 % CI, 1.1, 24.3), independently of sex, age, body mass index, and inflammatory markers. Conclusions: this study is the first report of vitamin D deficiency in Northeast Mexico. Vitamin D deficiency was associated with COVID-19 severity.

References

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