Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 A Randomized Platform Trial
MD, PhD; Gilmar Reis, Eduardo Augusto, Moreira Santos, MD, PhD; Daniela Silva, Medeiros Carla, MD Silva, PhD Lehana Thabane, PhD Vitoria Helena, Souza Campos, ; Thiago, MD Santiago Ferreira, Castilho Vitor Quirino, Ana Santos, Ribeiro Maria, MD Ana Paula Nogueira, Guimaraes Figueiredo, MD Leonardo Almeida, Monteiro Cançado, MD Savassi, PhD Adhemar Dias, MD, PhD Figueiredo Neto, RN Carina Bitarães, RN Aline Cruz Milagres, MD ; Eduardo Diniz Callegari, Maria Izabel Campos Simplicio, Bscpharm ; Luciene, RN, MPH Barra Ribeiro, Rosemary Oliveira, PhD Ofir Harari, MSc Lindsay A Wilson, PhD, MPH Jamie I Forrest, MSc Hinda Ruton, PhD Sheila Sprague, MSc Paula Mckay, Christina M Guo, MD Gordon H Guyatt, PharmD Craig R Rayner, MD, MPH David R Boulware, MDCM, MPH Nicole Ezer, MD, MPH Todd C Lee, MD, MSc Emily Gibson Mcdonald, MBChB Mona Bafadhel, PhD Christopher Butler, MD Josue Rodrigues Silva, MD, MSc Mark Dybul, MD Edward J Mills
doi:10.7326/M22-3305
Background: Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19. Objective: To determine whether the combination of fluvoxamine and inhaled budesonide would increase treatment effects in a highly vaccinated population.
Author contributions are available at Annals.org.
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doi:10.1016/S0140-6736(21)01744-XDOI record:
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