Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial

DOI record: { "DOI": "10.1016/j.lana.2021.100142", "ISSN": [ "2667-193X" ], "URL": "http://dx.doi.org/10.1016/j.lana.2021.100142", "alternative-id": [ "S2667193X21001381" ], "article-number": "100142", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial" }, { "label": "Journal Title", "name": "journaltitle", "value": "The Lancet Regional Health - Americas" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.lana.2021.100142" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2021 The Authors. Published by Elsevier Ltd." } ], "author": [ { "ORCID": "http://orcid.org/0000-0002-4847-1034", "affiliation": [], "authenticated-orcid": false, "family": "Reis", "given": "Gilmar", "sequence": "first" }, { "affiliation": [], "family": "dos Santos Moreira Silva", "given": "Eduardo Augusto", "sequence": "additional" }, { "affiliation": [], "family": "Medeiros Silva", "given": "Daniela Carla", "sequence": "additional" }, { "affiliation": [], "family": "Thabane", "given": "Lehana", "sequence": "additional" }, { "affiliation": [], "family": "Cruz Milagres", "given": "Aline", "sequence": "additional" }, { "affiliation": [], "family": "Ferreira", "given": "Thiago Santiago", "sequence": "additional" }, { "affiliation": [], "family": "Quirino dos Santos", "given": "Castilho Vitor", "sequence": "additional" }, { "affiliation": [], "family": "de Figueiredo Neto", "given": "Adhemar Dias", "sequence": "additional" }, { "affiliation": [], "family": "Diniz Callegari", "given": "Eduardo", "sequence": "additional" }, { "affiliation": [], "family": "Monteiro Savassi", "given": "Leonardo Cançado", "sequence": "additional" }, { "affiliation": [], "family": "Campos Simplicio", "given": "Maria Izabel", "sequence": "additional" }, { "affiliation": [], "family": "Barra Ribeiro", "given": "Luciene", "sequence": "additional" }, { "affiliation": [], "family": "Oliveira", "given": "Rosemary", "sequence": "additional" }, { "affiliation": [], "family": "Harari", "given": "Ofir", "sequence": "additional" }, { "affiliation": [], "family": "Bailey", "given": "Holly", "sequence": "additional" }, { "affiliation": [], "family": "Forrest", "given": "Jamie I", "sequence": "additional" }, { "affiliation": [], "family": "Glushchenko", "given": "Alla", "sequence": "additional" }, { "affiliation": [], "family": "Sprague", "given": "Sheila", "sequence": "additional" }, { "affiliation": [], "family": "McKay", "given": "Paula", "sequence": "additional" }, { "affiliation": [], "family": "Rayner", "given": "Craig R.", "sequence": "additional" }, { "affiliation": [], "family": "Ruton", "given": "Hinda", "sequence": "additional" }, { "affiliation": [], "family": "Guyatt", "given": "Gordon H.", "sequence": "additional" }, { "affiliation": [], "family": "Mills", "given": "Edward J.", "sequence": "additional" } ], "container-title": "The Lancet Regional Health - Americas", "container-title-short": "The Lancet Regional Health - Americas", "content-domain": { "crossmark-restriction": true, "domain": [ "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2021, 12, 14 ] ], "date-time": "2021-12-14T04:48:44Z", "timestamp": 1639457324000 }, "deposited": { "date-parts": [ [ 2022, 2, 17 ] ], "date-time": "2022-02-17T14:15:26Z", "timestamp": 1645107326000 }, "indexed": { "date-parts": [ [ 2024, 3, 26 ] ], "date-time": "2024-03-26T11:01:57Z", "timestamp": 1711450917393 }, "is-referenced-by-count": 9, "issued": { "date-parts": [ [ 2022, 2 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 2, 1 ] ], "date-time": "2022-02-01T00:00:00Z", "timestamp": 1643673600000 } }, { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 11, 24 ] ], "date-time": "2021-11-24T00:00:00Z", "timestamp": 1637712000000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S2667193X21001381?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S2667193X21001381?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "100142", "prefix": "10.1016", "published": { "date-parts": [ [ 2022, 2 ] ] }, "published-print": { "date-parts": [ [ 2022, 2 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1016/j.bbadis.2017.05.027", "article-title": "Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock", "author": "Matsiukevich", "doi-asserted-by": "crossref", "first-page": "2680", "issue": "10 Pt B", "journal-title": "Biochim Biophys Acta Mol Basis Dis", "key": "10.1016/j.lana.2021.100142_bib0001", "volume": "1863", "year": "2017" }, { "DOI": "10.3748/wjg.v23.i28.5196", "article-title": "Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients", "author": "Park", "doi-asserted-by": "crossref", "first-page": "5196", "issue": "28", "journal-title": "World J Gastroenterol", "key": "10.1016/j.lana.2021.100142_bib0002", "volume": "23", "year": "2017" }, { "DOI": "10.1016/j.jdiacomp.2016.01.013", "article-title": "Gender-related different effects of a combined therapy of exenatide and metformin on overweight or obesity patients with type 2 diabetes mellitus", "author": "Quan", "doi-asserted-by": "crossref", "first-page": "686", "issue": "4", "journal-title": "J Diabetes Complic", "key": "10.1016/j.lana.2021.100142_bib0003", "volume": "30", "year": "2016" }, { "DOI": "10.3389/fimmu.2020.02056", "article-title": "Immunomodulatory and antiviral activity of metformin and its potential implications in treating coronavirus disease 2019 and lung injury", "author": "Chen", "doi-asserted-by": "crossref", "first-page": "2056", "journal-title": "Front Immunol", "key": "10.1016/j.lana.2021.100142_bib0004", "volume": "11", "year": "2020" }, { "DOI": "10.1016/S2666-7568(20)30033-7", "article-title": "Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis", "author": "Bramante", "doi-asserted-by": "crossref", "first-page": "e34", "issue": "1", "journal-title": "Lancet Healthy Longev", "key": "10.1016/j.lana.2021.100142_bib0005", "volume": "2", "year": "2021" }, { "DOI": "10.1016/j.cmet.2020.08.013", "article-title": "Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes", "author": "Cheng", "doi-asserted-by": "crossref", "first-page": "537", "issue": "4", "journal-title": "Cell Metab", "key": "10.1016/j.lana.2021.100142_bib0006", "volume": "32", "year": "2020" }, { "DOI": "10.1007/s40121-020-00349-8", "article-title": "Early treatment of COVID-19 disease: a missed opportunity", "author": "Forrest", "doi-asserted-by": "crossref", "first-page": "715", "issue": "4", "journal-title": "Infect Dis Ther", "key": "10.1016/j.lana.2021.100142_bib0007", "volume": "9", "year": "2020" }, { "DOI": "10.12688/gatesopenres.13304.2", "article-title": "A multi-center, adaptive, randomized, platform trial to evaluate the effect of repurposed medicines in outpatients with early coronavirus disease 2019 (COVID-19) and high-risk for complications: the TOGETHER master trial protocol", "author": "Reis", "doi-asserted-by": "crossref", "first-page": "117", "issue": "117", "journal-title": "Gates Open Res", "key": "10.1016/j.lana.2021.100142_bib0008", "volume": "5", "year": "2021" }, { "DOI": "10.1136/bmj.m115", "article-title": "The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design", "author": "Dimairo", "doi-asserted-by": "crossref", "first-page": "m115", "journal-title": "BMJ", "key": "10.1016/j.lana.2021.100142_bib0009", "volume": "369", "year": "2020" }, { "DOI": "10.1001/jamanetworkopen.2021.6468", "article-title": "Effect of early treatment with hydroxychloroquine or lopinavir and ritonavir on risk of hospitalization among patients with COVID-19: the TOGETHER randomized clinical trial", "author": "Reis", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "JAMA Netw Open", "key": "10.1016/j.lana.2021.100142_bib0010", "volume": "4", "year": "2021" }, { "DOI": "10.1016/j.jclinepi.2020.04.025", "article-title": "An overview of platform trials with a checklist for clinical readers", "author": "Park", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "J Clin Epidemiol", "key": "10.1016/j.lana.2021.100142_bib0011", "volume": "125", "year": "2020" }, { "DOI": "10.7326/0003-4819-146-12-200706190-00010", "article-title": "Stopping at nothing? Some dilemmas of data monitoring in clinical trials", "author": "Goodman", "doi-asserted-by": "crossref", "first-page": "882", "issue": "12", "journal-title": "Ann Intern Med", "key": "10.1016/j.lana.2021.100142_bib0012", "volume": "146", "year": "2007" }, { "DOI": "10.1016/S2589-7500(20)30086-8", "article-title": "A real-time dashboard of clinical trials for COVID-19", "author": "Thorlund", "doi-asserted-by": "crossref", "first-page": "e286", "issue": "6", "journal-title": "Lancet Digit Health", "key": "10.1016/j.lana.2021.100142_bib0013", "volume": "2", "year": "2020" } ], "reference-count": 13, "references-count": 13, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2667193X21001381" } }, "score": 1, "short-title": [], "source": "Crossref", "subtitle": [], "title": "Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "6" }