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Overview of Clinical Outcome and Therapeutic Effectiveness of Favipiravir in Patients with COVID-19 Admitted to Intensive Care Unit, Riyadh, Saudi Arabia

Al Mutair et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.01.013
Feb 2022  
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Mortality 7% Improvement Relative Risk ARDS -9% ICU time -34% Hospitalization time -37% Favipiravir  Al Mutair et al.  ICU PATIENTS Is very late treatment with favipiravir beneficial for COVID-19? Retrospective 538 patients in Saudi Arabia (April 2020 - March 2021) Study compares with various, results vs. placebo may differ Longer ICU admission (p=0.001) and hospitalization (p=0.001) c19early.org Al Mutair et al., J. Infection and Pub.., Feb 2022 Favorsfavipiravir Favorsvarious 0 0.5 1 1.5 2+
Retrospective 269 favipiravir ICU patients in Saudi Arabia and 269 matched controls receiving different treatments, showing no significant difference.
This study is excluded in the after exclusion results of meta analysis: very late stage, ICU patients.
risk of death, 7.0% lower, RR 0.93, p = 0.49, treatment 119 of 269 (44.2%), control 128 of 269 (47.6%), NNT 30.
risk of ARDS, 8.6% higher, RR 1.09, p = 0.63, treatment 76 of 269 (28.3%), control 70 of 269 (26.0%), severe ARDS.
ICU time, 33.7% higher, relative time 1.34, p = 0.001, treatment 269, control 269.
hospitalization time, 36.6% higher, relative time 1.37, p = 0.001, treatment 269, control 269.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al Mutair et al., 15 Feb 2022, retrospective, Saudi Arabia, peer-reviewed, 14 authors, study period April 2020 - March 2021, this trial compares with another treatment - results may be better when compared to placebo.
This PaperFavipiravirAll
Overview of clinical outcome and therapeutic effectiveness of Favipiravir in patients with COVID-19 admitted to intensive care unit, Riyadh, Saudi Arabia
Abbas Al Mutair, Jinan Shamou, Saad Alhumaid, Laila Layqah, Gasmelseed Y Ahmed, Koritala Thoyaja, Mohammed Al Mohaini, Sana Almahmoud, Mazin Barry, Amjad Khan, Kuldeep Dhama, Lamiaa Hamad Al-Jamea, Alxeander Woodman, Ali A Rabaan
Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.01.013
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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